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( Junwoo Lee ),( Byoung-soo Choi ),( Donghyun Seong ),( Jewon Lee ),( Sang-hwan Kim ),( Jimin Lee ),( Jang-kyoo Shin ),( Pyung Choi ) 한국센서학회 2018 센서학회지 Vol.27 No.6
A complementary metal oxide semiconductor (CMOS) binary image sensor is proposed for low-power and low-noise operation. The proposed binary image sensor has the advantages of reduced power consumption and fixed pattern noise (FPN). A gate/body-tied (GBT) p-channel metal-oxide-semiconductor field-effect transistor (PMOSFET)-type photodetector is used as the proposed CMOS binary image sensor. The GBT PMOSFET-type photodetector has a floating gate that amplifies the photocurrent generated by incident light. Therefore, the sensitivity of the GBT PMOSFET-type photodetector is higher than that of other photodetectors. The proposed CMOS binary image sensor consists of a pixel array with 394 (H) × 250 (V) pixels, scanners, bias circuits, and column parallel readout circuits for binary image processing. The proposed CMOS binary image sensor was analyzed by simulation. Using the dynamic comparator, a power consumption reduction of approximately 99.7% was achieved, and this performance was verified by the simulation by comparing the results with those of a two-stage comparator. Also, it was confirmed using simulation that the FPN of the proposed CMOS binary image sensor was successfully reduced by use of the double sampling process.
열분석을 이용한 BKNO<SUB>3</SUB> 화약의 장기노화 및 기작예측
이준우(Junwoo Lee),김태완(Taewan Kim),이주현(Joohyeon Lee),편임옥(Limok Pyeon),이승복(Seung Bok Lee),박태호(Taiho Park) 한국추진공학회 2016 한국추진공학회 학술대회논문집 Vol.2016 No.5
파이로 작동기구의 핵심 화약 중 하나인 BKNO3에 대한 장기노화 기작예측을 위하여 thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) 분석 그리고 상업적인 소프트웨어 “Advanced Kinetics and Technology Solution (AKTS)” 프로그램을 이용하였다. Viton을 사용하는 ZPP와 THPP와는 다르게 BKNO3는 Laminac이라는 고분자 바인더를 이용하고 있다. BKNO3 화약의 DSC 분석결과로서 폭발반응에 관여하는 산화반응보다 Laminac의 분해 발열반응이 먼저 일어나는 것을 확인했다. 이 발열반응을 AKTS로 분석한 결과, 120℃ 이상의 고온에서도 상당히 지연된다는 것을 확인하였다. 이는 높은 활성화 에너지와 높은 Laminac의 분해온도 때문으로 여겨진다. Mechanism in aging of BKNO3 (a core initiator in pyrotechnic mechanical device (PMD)) has been predicted using a commercial software (Advanced Kinetics and Technology Solutions (AKTS). The thermodynamic and kinetic data to compute the mechanism in aging were obtained from thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). BKNO3 employs Laminac as a polymer binder. DSC experiments reveal that exothermic reaction related to Laminac decomposition occurred prior to that of oxidation associated with explosion of BKNO3. The exothermic reaction of Laminac was delayed even at the high temperature (~120 ℃). It may be attributed to high decomposition temperature and activation energy of Laminac.
Low-Powered pH-Stable Nano-electrokinetically Enhanced Lateral Flow Assay for COVID-19 Antigen Test
Kim Kang Hyeon,유용경,Lee Na Eun,Lee Junwoo,Kim Cheonjung,Lee Seungmin,Kim Jinhwan,Park Seong Jun,Lee Dongtak,이상원,Kim Hyungseok,허돈,Yoon Dae Sung,Lee Jeong Hoon 한국바이오칩학회 2023 BioChip Journal Vol.17 No.3
Lateral fl ow assay (LFA) is a popular diagnostic system used in point-of-care testing (POCT) due to its low cost and portability. However, LFA has limited sensitivity and detection limits, making it challenging to detect low virus titers. Preconcentration through nano-electrokinetic (NEK) techniques have been proposed as a promising solution to improve the sensitivity of LFA. Nevertheless, the acidic conditions used in NEK operations may reduce the specifi city and sensitivity of LFA immunoassays. To address these limitations, an integrated LFA kit, the NEK-enhanced LFA (PcNEK–LFA), has been introduced. This kit features a pH-controlled structure designed to facilitate sample preconcentration. Biomarkers and AuNPs are electrokinetically preconcentrated in the PcNEK–LFA platform to increase the concentration of the test line and Ag–Ab binding events, resulting in enhanced performance. The pH-controlled PcNEK–LFA platform was evaluated using salivary human chorionic gonadotropin beta (β-hCG) and COVID-19 Ag samples, achieving a preconcentrating factor of approximately 10 and a sensitivity enhancement of 55.42%, and a preconcentrating factor greater than 10, respectively. The pH-controlled PcNEK–LFA platform provides an eff ective solution to overcome the limitations of LFA for POCT. In addition, it improves its sensitivity and detection limit, signifi cantly enhancing the accuracy and reliability of POCT, particularly for COVID-19 screening tests. As a result, this platform may play a pivotal role in addressing current and future healthcare challenges, facilitating rapid diagnosis and treatment of infectious diseases.
Sooah Jang,In-Young Kim,Sun-Woo Choi,Anna Lee,Ju-Yeal Lee,Hyunkyung Shin,Junwoo Lee,Mikyeong Lee,Kyoung-Ryul Lee,Saeeun Jung,Jin Sun Ryu,Jihee Oh,Manjae Kwon,Joohan Kim,Ryunsup Ahn,Young-Chul Jung,Jeo 대한신경정신의학회 2024 PSYCHIATRY INVESTIGATION Vol.21 No.3
Objective This study evaluated the clinical effectiveness of Minds.NAVI, a depression screening kit combining psychometric measures and stress hormone biomarkers, in a prospective clinical trial. The objective was to assess its potential as a depression screening tool and investigate the associations between psychological assessments, salivary hormone staging, and depression severity.Methods Thirty-five participants with major depressive disorder and 12 healthy controls (HCs) were included. The Minds.NAVI software, utilizing the PROtective and Vulnerable factors battEry Test (PROVE) and salivary cortisol/dehydroepiandrosterone (DHEA) analysis, was employed. The PROVE test is a comprehensive self-report questionnaire that assesses depressive symptoms, suicide risk, attachment style, adverse childhood experiences, mentalization capacity, and resilience. In addition, salivary cortisol and DHEA levels were measured to evaluate the functional stage of the hypothalamic–pituitary–adrenal (HPA) axis.Results Minds.NAVI exhibited 100% sensitivity, 91.7% specificity, and 97.9% accuracy in distinguishing depression from HCs within an exploratory small group. Salivary stress hormone phases showed changes with depression stage (p=0.030), and the proportion of patients with “adrenal exhaustion stage” was higher in the moderate/severe depression group (p=0.038). Protective/vulnerable factors differed significantly between controls and depressed groups (p<0.001). Cortisol awakening response inversely correlated with depressive symptom severity (r=-0.31, p=0.034).Conclusion This study suggested possible clinical effectiveness of Minds.NAVI, a depression screening tool that integrates psychometric measures and stress hormone biomarkers. The findings support the potential association between depression, chronic stress, and HPA axis hyporesponsiveness.
Lee, Seryun,Lee, Bokyoung,Kim, Bumjoon J.,Park, Junwoo,Yoo, Misang,Bae, Wan Ki,Char, Kookheon,Hawker, Craig J.,Bang, Joona,Cho, Jinhan American Chemical Society 2009 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.131 No.7
<P>We introduce an innovative and robust method for the preparation of nanocomposite multilayers, which allows accurate control over the placement of functional groups as well as the composition and dimensions of individual layers/internal structure. By employing the photocross-linkable polystyrene (PS-N(3), M(n) = 28.0 kg/mol) with 10 wt % azide groups (-N(3)) for host polymer and/or the PS-N(3)-SH (M(n) = 6.5 kg/mol) with azide and thiol (-SH) groups for capping ligands of inorganic nanoparticles, nanocomposite multilayers were prepared by an efficient photocross-linking layer-by-layer process, without perturbing underlying layers and nanostructures. The thickness of individual layers could be controlled from a few to hundreds of nanometers producing highly ordered internal structure, and the resulting nanocomposite multilayers, consisting of polymer and inorganic nanoparticles (CdSe@ZnS, Au, and Pt), exhibit a variety of interesting physical properties. These include prolonged photoluminescent durability, facile color tuning, and the ability to prepare functional free-standing films that can have the one-dimensional photonic band gap and furthermore be patterned by photolithography. This robust and tailored method opens a new route for the design of functional film devices based on nanocomposite multilayers.</P>