말초성 안면마비 입원환자 250례에 대한 임상적 고찰

강나루,탁명림,변석미,고우신,윤화정,Kang, Na-Ru,Tark, Myoung-Rim,Byun, Soek-Mi,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.3

Objectives : This study was performed to analysis the effect of oriental medical care for inpatients with facial paralysis that had visited Dept. of Otolaryngology Oriental medical hospital Dong-eui university. Methods : From January 2008 to September 2010, a clinical study was done on 250 inpatients who were treated as facial nerve paralysis at the Dept. of Otolaryngology Oriental medical hospital Dong-eui university. This study was assessed using the chart analysis. Results : 1. The distribution of sex : female 54.8%, male 45.2%. The distribution of age was pregented that fifty to sixty was the most in 67 cases(26.8%). 2. The distribution of the period of admission : female 12.5 days, male 9.9 days. 3. The distribution of past history : hypertention(18.8%), diabetes-mellitus(10.85%), facial paralysis(9.25%), cerebrovascular disease(4.4%), liver disease(5.6%), hyperlipidemia(1.2%), otitis media(1.2%), herpes zoster(1.2%), cardiac disease(2.45%), thyroid disease(1.2%). 4. The distribution of the region of facial paralysis : Rt(55.36%), Lt(56.52%). 5. Check the mastoid pain : 66.8%(female 73.91%, male 58.04%). 6. Out of prescription(Ko-Bang, 古方), Galgeun-Tang(葛根湯) and Gaejigeogaegayoungchul-Tang was used most in each 34 cases, Daesiho-Tang(大柴胡湯) 30 cases, Galgeungabanha-Tang(葛根加半夏湯) 27 cases, Sihogaeji-Tang(柴胡桂枝湯) 14 cases, Hwanggigaejiomul-Tang 12 cases, Odu-Tang(烏頭湯) 10 cases, Chijadaehwangsi-Tang 10 cases, Gaejigagalgeun-Tang(桂枝加葛根湯) 7 cases, Banhasasim-Tang(半夏瀉心湯) 5 cases, Injinho-Tang(茵蔯蒿湯) 5 cases in order. 7. The distribution of herb group : Mahwang-Jae(麻黃劑) 31.72%, Gaeji-Jae(桂枝劑) 26.00%, Siho-Gae(柴胡劑) 20.70%, Chija-Gae(梔子劑) 7.49%, Buja-Jae(附子劑) 4.41%, Banhahwanggeum-Gae(半夏黃芩劑) 3.08%, Daehwang-Gae(大黃劑) 2.64%, Bockryeong-Gae(茯笭劑) 1.76%, Jisil-Gae(枳實劑) 1.32%, Insam-Gae(人蔘劑) 0.88% in order. 8. The distribution of House-Brackmann grade of admission : Gr Ⅳ 74.85%, Gr.III 13.6%, Gr.V 11.6% in order. 9. The distribution of House-Brackmann grade of discharge : Gr.III 56%, Gr.IV 38.4%, Gr.II 5.6% in order. 10. The average number of OPD follow up is 6.46. Conclusion : This results indicated that oriental medical treatment with Ko-bang(古方) can be an effective way to treat facial paralysis. The more patients we treat with Ko-bang(古方), the more clinical report is accumulated. Then it would be helpful to map out a systematic treatment on facial paralysis.

화폐상 습진 한방 치험 1례

탁명림,강나루,고우신,윤화정,Tark, Myoung-Rim,Kang, Na-Ru,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2011 한방안이비인후피부과학회지 Vol.24 No.2

Objective : The purpose of this study is to know the effect of Ko-Bang(古方) on nummular eczema. Methods : We decided the treatment principle through the abdominal examination and symptoms. We gave Ko-Bang to the patient and observed the progress. We used visual analogue scale(VAS). Results : After the treatment the grade of VAS was decreased and the symptoms of nummular eczema were significantly improved. Conclusion : After the treatment of Hwanggijakyakgyejigoju-Tang(黃耆芍藥桂枝苦酒湯), the symptoms of nummular eczema were disappeared and Ko-Bang was effective on the treatment of intractable skin diseases.

고방(古方)으로 치료한 두드러기 환자 39례의 임상보고(臨床報告)

탁명림,김미보,변석미,고우신,윤화정,Tark, Myoung-Rim,Kim, Mi-Bo,Byun, Seok-Mi,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2009 한방안이비인후피부과학회지 Vol.22 No.3

Objectives : This study was designed to investigate the chronical features of urticaria and the effects of urticaria treatment with Ko-Bang(古方). Methods : We treated 39 patients for urticaria with Ko-Bang(古方), who visited to care urticaria at the Dept. of Dermatology Oriental medical hospital Dong-eui university from Jan, 2008 to Sep, 2009. This study was assessed using the chart analysis and the follow-up survey by telephone. Results & Conclusions : 1. 39 outpatients were surveyed, who were 20 males and 19 females. And patients who were ages 21-30 were the largest group, 11(28.21%). Among the 39 patients, acute urticaria patients were 8(20.5%), chronic urticaria patients were 31(79.5%), and contraction of a disease period between 6 weeks with 3 months was 17.9%. 2. The causes of urticaria were measured unknown 37.5%, foods 37.5%, drugs 25% in acute and unknown 35.5%, a change of temperature 29%, foods 16% in chronic. And suspected provocation factors were measured unknown and foods each 12 cases. The most of accompanied symptoms was itching sign(34 cases), the second most was self-conscious fever(10 cases). 3. Out of treat prescription(Ko-Bang,古方), Injinho-Tang(茵蔯蒿湯) was used most in 5 cases, Daehwanghwangryunsasim-Tang(大黃黃連瀉心湯), Hwangryun-Tang(黃連湯), Daesiho-Tang(大柴胡湯) were used in each 4 cases, Galgeun-Tang(葛根湯), Chijadaehwangsi-Tang(梔子大黃?湯), Sosiho-Tang(小柴胡湯) were used in each 3 cases, Gaemagakban-Tang(桂麻各半湯), Chijasi-Tang(梔子?湯),Oryeongsan(五笭散) were used in each 2 cases. 4. When the processes of treatment were classified by one poison(一毒), there were the 19 cases (48.7%) which was caused by Bun(煩), the 12 cases(30.8%) by Water(水) and the 4 cases(10.3%) by Gyur(結).

Plyometric Training과 비타민 C 투여가 남고생의 체력, 혈중 젖산, 암모니아 및 젖산탈수소효소에 미치는 영향

장준원,김세종,이현미,서혜림,조현숙,고정림,염종우,예정복,백영호 釜山大學校 附設 體育科學硏究所 2003 體育科學硏究所 論文集 Vol.19 No.-

The purpose of this was to examine the effect of plyometric training and vitamin C ingestion on physical fitness and fatigue substance....

Increased Tolerance to Furfural by Introduction of Polyhydroxybutyrate Synthetic Genes to Escherichia coli

( Hye-rim Jung ),( Ju-hee Lee ),( Yu-mi Moon ),( Tae-rim Choi ),( Soo-yeon Yang ),( Hun-suk Song ),( Jun Young Park ),( Ye Lim Park ),( Shashi Kant Bhatia ),( Ranjit Gurav ),( Byoung Joon Ko ),( Yung- 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.5

Polyhydroxybutyrate (PHB), the most well-known polyhydroxyalkanoate, is a bio-based, biodegradable polymer that has the potential to replace petroleum-based plastics. Lignocellulose hydrolysate, a non-edible resource, is a promising substrate for the sustainable, fermentative production of PHB. However, its application is limited by the generation of inhibitors during the pretreatment processes. In this study, we investigated the feasibility of PHB production in E. coli in the presence of inhibitors found in lignocellulose hydrolysates. Our results show that the introduction of PHB synthetic genes (bktB, phaB, and phaC from Ralstonia eutropha H16) improved cell growth in the presence of the inhibitors such as furfural, 4-hydroxybenzaldehyde, and vanillin, suggesting that PHB synthetic genes confer resistance to these inhibitors. In addition, increased PHB production was observed in the presence of furfural as opposed to the absence of furfural, suggesting that this compound could be used to stimulate PHB production. Our findings indicate that PHB production using lignocellulose hydrolysates in recombinant E. coli could be an innovative strategy for cost-effective PHB production, and PHB could be a good target product from lignocellulose hydrolysates, especially glucose.

Dermoscopic Findings and the Clinicopathologic Correlation of Pigmented Purpuric Dermatosis: A Retrospective Review of 60 Cases

( Ko Eun Kim ),( Hye-rim Moon ),( Hwa Jung Ryu ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.3

Background: Pigmented purpuric dermatosis (PPD) is known as a chronic recurrent eruption which usually presents with petechiae and pigmented macules on the lower extremities. Dermoscopy is a noninvasive diagnostic tool in identifying pigmented and vascular lesions, which can also be beneficial in the evaluation of PPD. Objective: We aimed to analyze the common dermoscopic characteristics of PPD, and correlate those findings with the histopathologic features. Additionally, dermoscopic and pathological findings in this study population were compared with other similar studies from the literature review. Methods: A retrospective analysis was performed using data of 60 patients who were diagnosed as PPD by skin biopsy and had dermoscopic examination. The pathologic analysis was performed by categorizing the pattern into lichenoid, perivascular, interface, and spongiotic subtype, and the dermoscopic assessment was performed by the three authors independently. Results: In dermoscopy, 96.7% of the patients showed red globules and dots, followed by brownish patch, coppery-red pigmentation, and annular comma-like vessels. The pathologic pattern analysis revealed statistically significant association of lichenoid pattern with coppery red pigmentation, perivascular pattern with annular/comma-like vessels, and spongiosis pattern with reticular pigmented network and linear vessels. The interrater similarity test showed total kappa value of 0.811 which referred to “very good”. Conclusion: In this study, the prevalence of dermoscopic features in Asian PPD patients was identified, which was similar with previous studies. The dermoscopic-pathologic correlation was found in four dermoscopic features. We suggest that dermoscopic examination is helpful in clinical diagnosis and pathological prediction of PPD. (Ann Dermatol 33(3) 214∼221, 2021)

Metabolic Risk Profile and Cancer in Korean Men and Women

Ko, Seulki,Yoon, Seok-Jun,Kim, Dongwoo,Kim, A-Rim,Kim, Eun-Jung,Seo, Hye-Young The Korean Society for Preventive Medicine 2016 예방의학회지 Vol.49 No.3

Objectives: Metabolic syndrome is a cluster of risk factors for type 2 diabetes mellitus and cardiovascular disease. Associations between metabolic syndrome and several types of cancer have recently been documented. Methods: We analyzed the sample cohort data from the Korean National Health Insurance Service from 2002, with a follow-up period extending to 2013. The cohort data included 99 565 individuals who participated in the health examination program and whose data were therefore present in the cohort database. The metabolic risk profile of each participant was assessed based on obesity, high serum glucose and total cholesterol levels, and high blood pressure. The occurrence of cancer was identified using Korean National Health Insurance claims data. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusting for age group, smoking status, alcohol intake, and regular exercise. Results: A total of 5937 cases of cancer occurred during a mean follow-up period of 10.4 years. In men with a high-risk metabolic profile, the risk of colon cancer was elevated (HR, 1.40; 95% CI, 1.14 to 1.71). In women, a high-risk metabolic profile was associated with a significantly increased risk of gallbladder and biliary tract cancer (HR, 2.05; 95% CI, 1.24 to 3.42). Non-significantly increased risks were observed in men for pharynx, larynx, rectum, and kidney cancer, and in women for colon, liver, breast, and ovarian cancer. Conclusions: The findings of this study support the previously suggested association between metabolic syndrome and the risk of several cancers. A high-risk metabolic profile may be an important risk factor for colon cancer in Korean men and gallbladder and biliary tract cancer in Korean women.

P025 : Expression of the Notch intracellular domain in various skin fibroproliferative diseases

( Jung Eun Kim ),( Hong Jin Joo ),( Hyun Ju Yoo ),( Hye Rim Ko ),( Ju Hyun Lee ),( Kwan Ho Jeong ),( Kyung Moon Kim ),( Hoon Kang ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: The effect of Notch signaling pathway in skin fibroproliferative diseases has only partially been elucidated Objectives: The aim of this study was to investigate the expression of activated Notch signaling molecule in various skin fibroproliferative diseases. Methods: Immunohistochemical analysis of the Notch intracellular domain (NICD) expression in keloid, hypertrophic scar, morphea, dermatofibroma and normal control skin specimen was performed. Clinical characteristics of patients with various skin fibroproliferative diseases were analyzed. Results: Immunohistochemistry showed that the NICD peptide was strongly expressed in fibroblasts of keloid, moderately to strongly expressed in hypertrophic scar and dermatofibroma, whereas fibroblasts of normal skin and morphea showed no or weak expression. NICD was constitutively expressed in keratinocytes, endothelial cells, and immune cells in the normal skin. Conclusion: NICD was primarily expressed in human skin fibroproliferative disorders, especially in keloid. We suggest that an activated Notch signaling pathway may involve in the pathogenesis of skin fibrosis.

Analysis of treatment results and treatment compliance according to diagnostic tests in onychomycosis

( Ko Eun Kim ),( Sook In Ryu ),( Bo Young Kim ),( Chang Min Kim ),( Hye Rim Moon ),( Hwa Jung Ryu ),( Il-hwan Kim ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Onychomycosis is a fungal infection of toenails and fingernails. It is diagnosed with suggestive clinical findings, but direct microscopy with KOH, fungus culture or nail histopathology are useful methods to confirm definite diagnosis. Misdiagnosis of onychomycosis can cause unnecessary long term antifungal medication, with unexpected costs and side effects such as liver toxicity. Objectives: The aim of our study is to analyze treatment results and compliance of onychomycosis patients according to diagnostic tests in order to suggest appropriate test methods for the patients. Methods: We evaluated patients referred from primary physician from January 2016 to March 2018. The patients diagnosed as onychomycosis were classified into four groups according to the test methods- A, KOH test only, B, nail histopathology only, C, both KOH and histopathology, and D, nail histopathology and fungus culture. We compared each group in treatment results and compliance. Results: Comparing group B with group C and D, the patients who had more than two confirmation tests, chi square test showed statistically significant correlation with treatment outcome(p=0.017). Conclusion: This study revealed that the patient confirmed by more than two diagnostic tests had better treatment outcome than the one with single nail histopathology test. Herein, we suggest necessity of additional confirmation tests such as histopathology or fungus culture in untreatable patients referred from primary physicians.

Platelet-activating factor-induced NF-κB activation enhances VEGF expression through a decrease in p53 activity

Ko, Hyun-Mi,Jung, Hae Hyun,Seo, Kook Heon,Kang, Yeong-Rim,Kim, Han-A,Park, Sung Jun,Lee, Hern-Ku,Im, Suhn-Young Elsevier 2006 FEBS letters Vol.580 No.13

<P><B>Abstract</B></P><P>We investigated the role of p53 in nuclear factor (NF)-κB dependent, platelet-activating factor (PAF)-induced vascular endothelial growth factor (VEGF) expression. Transfected NF-κB subunits in ECV304 cells increased the tumor necrosis factor-α promoter activity, which was completely inhibited by p53. Transfected p53 increased p53RE promoter activity, which was completely inhibited by NF-κB subunits, indicating that cross-regulation occurs between NF-κB and p53. PAF-induced increase in VEGF expression was correlated with decreased p53 activity. These data suggest that NF-κB-dependency of the PAF-induced increase in VEGF expression is due to decreased p53 activity, which is reciprocally regulated by increased NF-κB activity.</P>