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Jung, Im-Hee,Yun, Jeong-Ho,Cho, Ah-Ran,Kim, Chang-Sung,Chung, Won-Gyun,Choi, Seong-Ho Korean Academy of Periodontology 2011 Journal of Periodontal & Implant Science Vol.41 No.1
Purpose: Avulsed tooth can be completely recovered, if sound periodontal ligament (PDL) of tooth is maintained. Although a lot of storage solutions have been explored for the better storage of avulsed tooth, there is a shortcoming that the preservation time is much short. On the other hand, there has been studies that (-)-epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea, which is related to the anti inflammatory, antioxygenic, and antibacterial effects, allows the successful preservations of tissues and cells. This study evaluated the effect of EGCG on avulsed-teeth preservation of Beagle dogs for a period of time. Methods: The atraumatically extracted teeth of Beagle dogs were washed and preserved with 0/10/$100\;{\mu}M$ of EGCG at the time of immediate, period 1 (4 days in EGCG-contained media and additional 1 day in EGCG-free media), period 2 (8 days in EGCG-contained media and additional 2 days in EGCG-free media) and period 3 (12 days in EGCG-contained media and additional 2 days in EGCG-free media). Then, the cell viabilities of preserved teeth was calculated by dividing optical density (OD) of 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay with OD of eosin assay to eliminate the measurement errors caused by the different tissue volumes. Results: From the results, the immediately analyzed group presented the highest cell viability, and the rate of living cells on teeth surface decreased dependent on the preservation period. However, the $100\;{\mu}M$ of EGCG-treated group showed statistically significant positive cell activity than EGCG-free groups throughout preservation periods. Conclusions: Our findings showed that $100\;{\mu}M$ EGCG could maintain PDL cell viability of extracted tooth. These results suggest that although EGCG could not be a perfect additive for tooth preservation, it is able to postpone the period of tooth storage. However, further in-depth studies are required for more plausible use of EGCG.
( Jung Hee Kim ),( Jin Kyu Rhee ),( Dae Gyun Ahn ),( Kwang Pyo Kim ),( Jong Won Oh ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.12
The hepatitis C virus (HCV) RNA genome is replicated by an RNA replicase complex (RC) consisting of cellular proteins and viral nonstructural (NS) proteins, including NS5B, an RNAdependent RNA polymerase (RdRp) and key enzyme for viral RNA genome replication. The HCV RC is known to be associated with an intracellular membrane structure, but the cellular components of the RC and their roles in the formation of the HCV RC have not been well characterized. In this study, we took a proteomic approach to identify stomatin, a member of the integral proteins of lipid rafts, as a cellular protein interacting with HCV NS5B. Coimmunoprecipitation and co-localization studies confirmed the interaction between stomatin and NS5B. We demonstrated that the subcellular fraction containing viral NS proteins and stomatin displays RdRp activity. Membrane flotation assays with the HCV genome replication-competent subcellular fraction revealed that the HCV RdRp and stomatin are associated with the lipid raft-like domain of membranous structures. Stomatin silencing by RNA interference led to the release of NS5B from the detergent-resistant membrane, thereby inhibiting HCV replication in both HCV subgenomic replicon-harboring cells and HCVinfected cells. Our results identify stomatin as a cellular protein that plays a role in the formation of an enzymatically active HCV RC on a detergent-resistant membrane structure.
( Jung Hyun Kwon ),( Young Seok Kim ),( Sang Gyune Kim ),( Jeong Won Jang ),( Tae Hun Kim ),( Young Kul Jung ),( Oh Sang Kwon ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Genotype C is the principal type of hepatitis B virus in Koreans and is associated with poor prognosis for Peginterferon (PEF-IFN) α-2a therapy. The Korea Health Insurance supports only 24 weeks of therapy in HBeAg positive patients, and there is little report of PEG-IFN α-2a therapy in Korea. Authors investigated the efficacy and compliance to PEG-IFN α-2a therapy in Koreans with chronic hepatitis B (CHB) in a real clinical setting. Methods: CHB patients treated with PEG-IFN α-2a from 2008 to 2011 at four tertiary university hospitals were retrospectively enrolled. Laboratory analyses and adverse events were investigated. Treatment outcomes were evaluated at the end of treatment and at 24 weeks after treatment completion. Results: Eighty-eight patients were enrolled; 67 were HBeAg positive and 50 were men. The mean treatment period was 35.1±8.8 weeks. In 27.3% of the patients, treatment was discontinued due to insufficient antiviral effects (10.2%) and adverse events (9.1%). When patients that completed therapy were analyzed 24 weeks after treatment, 31% of HBeAg positive patients achieved HBV DNA suppression to < 104 c/ml (SVR) and 24.1% of patients achieved HBeAg seroconversion. In HBeAg negative patients, 75% of patients achieved SVR, and 86.7% of patients maintained SVR. By multivariate analysis, a week 24 viral load > 5 log copies/ml was only sig-nificant factor for SVR. During the follow-up period (76.1±46.5 weeks), 29.8% of patients developed a breakthrough HBV DNA level of > 107 c/ml after a reduction to < 104 c/ml and 29.4% of patients reversed HBeAg. No deaths or admissions were attributed to adverse events. Conclusions: These results suggest that PEG-IFN α-2a therapy in Koreans with CHB, showed acceptable virologic response and durability. However, the rate of premature discontinuation was higher in real clinical setting of the present study than in previously reported controlled trials.
( Jung Hyun Kwon ),( Young Seok Kim ),( Sang Gyune Kim ),( Jeong Won Jang ),( Tae Hun Kim ),( Young Kul Jung ),( Oh Sang Kwon ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Genotype C is the principal type of hepatitis B virus in Koreans and is associated with poor prognosis for Peginterferon (PEF-IFN) α-2a therapy. The Korea Health Insurance supports only 24 weeks of therapy in HBeAg positive patients, and there is little report of PEG-IFN α-2a therapy in Korea. Authors investigated the efficacy and compliance to PEG-IFN α-2a therapy in Koreans with chronic hepatitis B (CHB) in a real clinical setting. Methods: CHB patients treated with PEG-IFN α-2a from 2008 to 2011 at four tertiary university hospitals were retrospectively enrolled. Laboratory analyses and adverse events were investigated. Treatment outcomes were evaluated at the end of treatment and at 24 weeks after treatment completion. Results: Eighty-eight patients were enrolled; 67 were HBeAg positive and 50 were men. The mean treatment period was 35.1±8.8 weeks. In 27.3% of the patients, treatment was discontinued due to insufficient antiviral effects (10.2%) and adverse events (9.1%). When patients that completed therapy were analyzed 24 weeks after treatment, 31% of HBeAg positive patients achieved HBV DNA suppression to < 104 c/ml (SVR) and 24.1% of patients achieved HBeAg seroconversion. In HBeAg negative patients, 75% of patients achieved SVR, and 86.7% of patients maintained SVR. By multivariate analysis, a week 24 viral load > 5 log copies/ml was only sig- nificant factor for SVR. During the follow-up period (76.1±46.5 weeks), 29.8% of patients developed a breakthrough HBV DNA level of > 107 c/ml after a reduction to < 104 c/ml and 29.4% of patients reversed HBeAg. No deaths or admissions were attributed to adverse events. Conclusions: These results suggest that PEG-IFN α-2a therapy in Koreans with CHB, showed acceptable virologic response and durability. However, the rate of premature discontinuation was higher in real clinical setting of the present study than in previously reported controlled trials.
Jung, You Jin,Jeon, Yeon Jin,Cho, Won Kyoung,Lee, Jae Wook,Chung, Nack-Gyun,Jung, Min Ho,Cho, Bin,Suh, Byung-Kyu The Korean Pediatric Society 2013 Clinical and Experimental Pediatrics (CEP) Vol.56 No.7
Purpose: The purpose of this study was to evaluate short-term thyroid dysfunction and related risk factors in pediatric patients who underwent hematopoietic stem cell transplantation (HSCT) during childhood. Methods: We studied 166 patients (100 boys and 66 girls) who underwent HSCT at the Catholic HSCT Center from January 2004 through December 2009. The mean age at HSCT was $10.0{\pm}4.8$ years. Thyroid function of the patients was tested before and during 3 months of HSCT. Results: Out of 166 patients, 165 (99.4%) underwent allotransplantation. Acute graft-versus-host disease (GVHD, grades II to IV) developed in 76 patients. Conditioning regimens before HSCT include total body irradiation (n=57), busulfan (n=80), and reduced intensity (n=29). Forty-five (27.1%) had thyroid dysfunction during 3 months after HSCT (29 euthyroid sick syndrome [ESS], 6 subclinical hyperthyroidism, 4 subclinical hypothyroidism, 3 hypothyroxinemia, 2 overt hyperthyroidism, and 1 high $T_4$ syndrome). In a univariate logistic regression analysis, age at HSCT (P=0.002) and acute GVHD (P=0.009) had statistically significant relationships with thyroid dysfunction during 3 months after HSCT. Also, in a univariate logistic regression analysis, ESS (P=0.014) showed a strong statistically significant association with mortality. Conclusion: In our study 27.1% patients experienced thyroid dysfunction during 3 months after HSCT. Increase in age and acute GVHD may be risk factors for thyroid dysfunction during 3 months after HSCT. There was a significant association between ESS and mortality.
Development of Real-Time PCR for the Detection of Clostridium perfringens in Meats and Vegetables
( Jung Whan Chon ),( Jong Seok Park ),( Ji Yeon Hyeon ),( Chankyu Park ),( Kwang Young Song ),( Kwang Won Hong ),( In Gyun Hwang ),( Hyosun Kwak ),( Kun Ho Seo ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.4
A real-time PCR assay was developed and validated inhouse specifically for the detection of Clostridium perfringens (Cl. perfringens) in meats and vegetables by comparing with the culture method. The detection limit of the real-time PCR assay in phosphate-buffered saline was 10 2 CFU/ml. When the two methods were compared in food samples inoculated with Cl. perfringens, the culture method detected 52 positives, whereas real-time PCR detected 51 positives out of 160 samples. The difference was without statistical significance (p>0.05). Real-time PCR assay is an option for quality assurance laboratories to perform standard diagnostic tests, considering its detection ability and time-saving efficiency.
( Jung Hyun Kwon ),( Young Seok Kim ),( Sang Gyune Kim ),( Jeong Won Jang ),( Tae Hun Kim ),( Young Kul Jung ),( Oh Sang Kwon ) 대한간학회 2013 Gut and Liver Vol.7 No.2
Background/Aims: Genotype C is the principal type of hepatitis B virus (HBV) in Koreans and is associated with poor prognosis for peginterferon α-2a therapy. The efficacy of and compliance to peginterferon α-2a therapy were investigated in Koreans with hepatitis B in a real clinical setting. Methods: Hepatitis B patients treated with peginterferon α-2a from 2008 to 2011 at four university hospitals were consecutively enrolled. Results: Eighty-eight patients were enrolled; 67 were hepatitis B e antigen (HBeAg)-positive. The mean treatment period was 36.1±15.2 weeks. In 26.1% of patients, treatment was discontinued due to insufficient antiviral effects and adverse events. At 24 weeks after treatment, 10/42 (23.8%) HBeAg-positive patients achieved both HBV DNA suppression to <2,000 IU/mL and HBeAg loss/seroconversion. For HBeAg-negative patients, 10/13 (76.9%) achieved HBV DNA suppression to <2,000 IU/mL at 24 weeks after treatment. During the follow-up period, 15 (30.6%) of the 49 patients who achieved HBV DNA suppression to 2,000 IU/mL developed a breakthrough HBV DNA level of >2×106 IU/mL. Conclusions: Peginterferon α-2a therapy in Koreans with hepatitis B in a real clinical setting resulted in a lower virologic response, as compared to Western individuals, but a favorable durability. There is a need to reduce the high rate of premature discontinuation compared to the controlled studies. (Gut Liver 2013;7:197-205)