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카이로프랙틱 경추 교정이 주의집중력에 미치는 영향에 대한 연구
Yoon Beom Kook,Joo Hyun Ham,Jin Ok Choi,Jung Soo Yi1 한서대학교 보완대체의학연구소 2016 Research Journal of Complementary and Alternative Vol.- No.7
This study is about the effect chiropractic correction has on the changes in attention cathexis. A total of 20 who are currently students at Hanseo University were selected. The study measured changes in the score for the attention cathexis ability and the changes in delta wave, theta wave, alpha wave, SMR, BetaL wave, and BetaH wave of the prefrontal lobe. The changes in brainwaves of the prefrontal lobe and the score of the attention cathexis ability for the false procedure before and after the treatment did not show much difference statistically(p>.05). The chiropractic correction group showed statistically meaningful results of the decrease of delta wave, theta wave, and BetaH, and the increase of alpha wave, SMR, and BetaL on the left side(p<.05). The decrease of delta wave, theta wave, and BetaH, and the increase of alpha wave, SMR, and BetaL on the right were statistically meaningful as well(p<.05). The increase in the score of the attention cathexis ability was significant statistically as well(p<.05). The chiropractic correction affected the increase of the attention cathexis ability.
간세포암종에 대한 간동맥 화학색전술 후 발생한 급성호흡곤란증후군
조윤원,이정미,최자윤,유동훈,차라리,오혜원,김홍준,민현주,김현진,정운태,이옥재,하창윤,이선영 이화여자대학교 의과학연구소 2013 EMJ (Ewha medical journal) Vol.36 No.1
Transcatheter arterial chemoembolization (TACE) has become an effective alternative treatment strategy for patients with inoperable hepatocellular carcinoma (HCC). Although TACE is relatively safe, acute respiratory distress syndrome associated with pulmonary lipiodol embolism is a rare and potentially fatal complication. We report a rare case of acute respiratory distress syndrome after TACE for inoperable HCC. A 75-year-old man, with huge HCC in right lobe, was treated by TACE for the first time. Seven hours after uneventful TACE procedure, he felt dyspneic and his oxygen saturation recorded by pulse oximetry (SpO2) fell to 80% despite of applying non-rebreathing mask. He underwent mechanical ventilation with a protective ventilatory strategy. We experienced a case of acute respiratory distress syndrome after TACE for HCC.
Jae Jung Ha,Yun Sook Jung,Byung Ki Kim,Dae Jin Jung,Dong Yep Oh,Dae Hyun Kim,Jea Young Lee,Myoung Ok Kim,Oh Kyu Kwon,Sung Hyun Kim,Jun Koo Yi 한국데이터정보과학회 2018 한국데이터정보과학회지 Vol.29 No.6
This study was conducted to produce a statistical effect analysis on the testosterone concentration, carcass grade and ultrasonic measurement at 30-month-old of Hanwoo steers. A total of 186 Hanwoo steers were used. Testosterone concentration, MAR, u-LMA and u-MAR according to grade were statistically significant differenced (p = 0:021, p < :0001, p = 0:003, p < :0001). Correlation analysis showed that MAR, u-LMA and u-MAR had a positive correlation (r = 0:921, 0.475, 0.760), and testosterone was a negative correlation (r = 0:278) between the grade. LMA was positive correlation (r = 0:218), and MAR had a negative correlation (r = 0:322) between the testosterone concentration. Carcass grade (LMA, BFT, MAR) and ultrasonic carcass grade (u-LMA, u-BFT, u-MAR) were positive correlation (r = 0:768, r = 0:691, r = 0:854).
비료의 성분 및 종류와 묘목과의 관계 연구 Ⅱ. 묘목의 부위별 양분 농도에 미치는 영향
황정옥(Jung Ok Hwang),손요환(Yowhan Son),이명종(Myong Jong Yi),변재경(Jae Kyung Byoun),정진현(Jin Hyoun Jung),이천용(Chun Yong Lee) 한국산림바이오에너지학회 2005 산림바이오에너지 Vol.24 No.1
새로운 산림용 복합비료를 개발하기 위하여 소나무, 낙엽송, 자작나무, 상수리나무 묘목을 대상으로 성분비가 다른 비료 및 종류가 다른 고형복합비료를 처리하고 묘목의 부위별 양분 농도를 측정하였다. 질소, 인, 칼륨의 비를 각기 달리한 시비수준별 처리실험에서 질소와 인 시비 후 묘목내 이들 양분의 농도가 증가하였다. 또한 소나무와 상수리나무에서 칼륨 시비량 증가에 따라 묘목내 양분 농도가 증가하는 효과를 보였으나, 나머지 두 수종에서는 처리별 차이가 나타나지 않았다. 산림용 고형복합비료와 UF 고형복합비료를 처리한 비료 종류별 처리실험에서는 시비량이 증가할수록 묘목 내 질소와 인의 농도가 증가하는 현상이 나타났다. 소나무에서의 칼륨 농도와 낙엽송에서의 나트륨과 칼슘 농도도 유사한 현상을 보였으며, 나머지 수종에서는 처리별 차이를 나타내지 않았다. 비료의 종류를 달리하여 처리한 결과 묘목 내 양분 농도 변화 효과는 없는 것으로 나타났다. In order to design new fertilizers for forests, seedlings of Pinus densiflora, Larix leptolepis, Betula platyphylla var. japonica, and Quercus acutissima were treated with different fertilizers, and nutrient concentrations in seedling components were analyzed. In general, nitrogen (N) and phosphorus (P) concentrations in seedling components increased after N and P application. Potassium (K) concentration in seedling components of Pinus densiflora and Quercus acutissima increased after N, P and K application. However, there were no significant changes in calcium (Ca), sodium (Na) and magnesium (Mg) concentrations. Nitrogen and P concentrations in seedling components increased with the amount of solid combination fertilizer and UF combination fertilizer. Potassium concentration for Pinus densiflora and Na and Ca concentrations for Larix leptolepis also increased with the amount of combination fertilizers. However, nutrient concentrations in seedling components showed no significant changes with different combination fertilizers.
Kimchi and an Active Component, β-Sitosterol, Reduce Oncogenic H-Rasv12-Induced DNA Synthesis
Kun-Young Park,Eun-Ju Cho,Sook-Hee Rhee,Keun-Ok Jung,Sun-Ju Yi,Byung H. Jhun 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.3
The Korean fermented vegetable food, kimchi, has been demonstrated to have anticancer functional proper-ties. This study examined the effect of kimchi samples, methanol extracts of commercially grown baechu cabbage kimchi(CK) and organically grown baechu cabbage kimchi (OK), as well as the dichloromethane fraction (DCM fr.) from CK, andthe active compound (AC), which has ben identified as largely b-sitosterol, from DCM fr., on the Ras-dependent signalingpathway. CK, OK, and DCM fr. exhibited a greater inhibition against the proliferation of Rat2 fibroblasts transformed withRasv12 (HO6) than parental Rat2 fibroblasts. In addition, OK and DCM fr. showed a higher inhibitory effect than CK. Fur-thermore, we employed the single-cell microinjection technique, combined with 3 bromo-5’ -deoxyuridine incorporation, toexamine the effects of kimchi samples on DNA synthesis induced by microinjected oncogenic Ras v12. When the DCM fr. andAC were used to treat Rat1 fibroblasts overexpressing human insulin receptors (HIRc-B) and microinjected with oncogenicH-Rasv12, the DNA synthesis of injected cells was decreased, sugesting that kimchi might block the signaling pathway ofoncogenic Ras v12, thus preventing the proliferation of transformed cells. This study provides additional evidence that kimchiand its active components, including b-sitosterol, have potential in both the prevention and treatment of cancer, and presentsconvincing evidence that the anticancer effects may be a result of an inhibition of Ras oncogene signaling.
Yi, Sun-Ju,Kim, Kyung Hwan,Choi, Hyun Jung,Yoo, Je Ok,Jung, Hyo-Il,Han, Jeong-A,Kim, Young-Myeong,Suh, In Bum,Ha, Kwon-Soo Korean Society of Molecular Biology 2006 Molecules and cells Vol.21 No.1
<P>Maitotoxin (MTX) is known as one of the most potent marine toxins involved in Ciguatera poisoning, but intracellular signaling pathways caused by MTX was not fully understood. Thus, we have investigated whether intracellular reactive oxygen species (ROS) are involved in MTX-induced cellular responses in human umbilical vein endothelial cells. MTX induced a dose-dependent increase of intracellular [Ca(2+)]. MTX stimulated the production of intracellular ROS in a dose- and time-dependent manner, which was suppressed by BAPTA-AM, an intracellular Ca(2+) che-lator. Ionomycin also elevated the ROS production in a dose-dependent manner. MTX elevated transamidation activity in a time-dependent manner and the activation was largely inhibited by transfection of tissue transglutaminase siRNA. The activation of tissue transglutaminase and ERK1/2 by MTX was sup-pressed by BAPTA-AM or ROS scavengers. In addition, MTX-induced cell death was significantly de-layed by BAPTA-AM or a ROS scavenger. These results suggest that [Ca(2+)]-dependent generation of in-tracellular ROS, at least in part, play an important role in MTX-stimulated cellular responses, such as activation of tTGase, ERK phosphorylation, and in-duction of cell death, in human umbilical vein endothelial cells.</P>
Jung, Hye Su,Yoon, Jung-Hoon,Kim, Seung-Bum,Yi, Hana,Cho, Jang-Cheon,Joh, Kiseong,Cha, Chang-Jun,Seong, Chi-Nam,Bae, Jin-Woo,Im, Wan-Taek,Kim, Myung Kyum,Lee, Soon Dong,Jeon, Che Ok The National Institute of Biological Resources 2019 Journal of species research Vol.8 No.2
During a comprehensive investigation of indigenous prokaryotic species in Korea, a total of 46 bacterial strains assigned to the classes Alphaproteobacteria, Betaproteobacteria, Deltaproteobacteria, and Epsilonproteobacteria were isolated from a diversity of habitats including freshwater, seawater, brackish water, ginseng soil, plant roots, natural caves, and tidal flats. Based on their high 16S rRNA gene sequence similarities (>98.7%) and formation of strongly-supported phylogenetic clades with the closest type species, each strain was assigned to an independent, predefined bacterial species. Since there were no published or official reports regarding the isolation of these 46 species in Korea, here we report them as new species to Korea: 34 species in 14 families in the five orders of Alphaproteobacteria, 10 species in five families in the three orders of Betaproteobacteria, one species of Deltaproteobacteria and one species of Epsilonproteobacteria. Gram reaction, colony and cell morphology, basic biochemical characteristics, isolation source, and strain IDs are described in the species description section.
Yi, Chin-Ok,Jeon, Byeong Tak,Shin, Hyun Joo,Jeong, Eun Ae,Chang, Ki Churl,Lee, Jung Eun,Lee, Dong Hoon,Kim, Hyun Joon,Kang, Sang Soo,Cho, Gyeong Jae,Choi, Wan Sung,Roh, Gu Seob Korean Association of Anatomists 2011 Anatomy & Cell Biology Vol.44 No.3
<P>AMP-activated protein kinase (AMPK), an enzyme involved in energy homeostasis, regulates inflammatory responses, but its precise mechanisms are not fully understood. Recent evidence has shown that resveratrol (RES), an AMPK activator, reduces prostaglandin E<SUB>2</SUB> production in lipopolysaccharide (LPS)-treated microglia. Here, we examined the effect of RES on nuclear factor kappa B (NF-κB) dependent cyclooxygenase (COX)-2 activation in LPS-treated RWA 264.7 macrophages. We found that treatment with RES increased AMPK activation. AMPK and acetyl CoA carboxylase phosphorylation were attenuated in cells treated with LPS+RES, compared to cells treated with LPS alone. RES inhibited tumor necrosis factor (TNF)-α and TNF receptor 1 in LPS-treated cells. Finally, RES inhibited LPS-induced NF-κB translocation into the nucleus and COX-2 expression. Moreover, the effects of 5-aminoimidazole-4-carboxamide ribose and compound C were consistent with the effects of RES in LPS-treated cells. Taken together, these results suggest that the anti-inflammatory action of RES in RAW 264.7 macrophages is dependent on AMPK activation and is associated with inhibition of the LPS-stimulated NF-κB-dependent COX-2 signaling pathway.</P>
The RNA-binding protein hnRNP Q represses translation of the clock gene <i>Bmal1</i> in murine cells
Jung, Youngseob,Ryu, Hye Guk,Kim, Sung Wook,Lee, Kyung-Ha,Gu, Sohyun,Yi, Hee,Ku, Hyun-Ok,Jang, Sung Key,Kim, Kyong-Tai American Society for Biochemistry and Molecular Bi 2019 The Journal of biological chemistry Vol.294 No.19
<P>Most living creatures have a circadian rhythm that is generated by a precisely regulated transcriptional–translational feedback loop of clock genes. Brain and muscle ARNT-like 1 (BMAL1) is one of the core clock genes and transcription factors that represents a positive arm of this autoregulatory circadian clock system. Despite the indispensable role of BMAL1 in the circadian rhythm, the molecular mechanisms underlying translational control of BMAL1 are largely unknown. Here, using murine NIH-3T3 cells, gene constructs, and a variety of biochemical approaches, including RNAi- and luciferase reporter gene–based assays, along with immunoblotting, <I>in vitro</I> transcription, quantitative real-time PCR, and real-time bioluminescence experiments, we show that translation of <I>Bmal1</I> is negatively regulated by an RNA-binding protein, heterogeneous nuclear ribonucleoprotein Q (hnRNP Q). Interestingly, we found that hnRNP Q rhythmically binds to a specific region of the <I>Bmal1</I> mRNA 5′ UTR and controls its time-dependent expression. Moreover, we demonstrate that knockdown of hnRNP Q modulates BMAL1 protein oscillation amplitude without affecting mRNA rhythmic patterns. Furthermore, hnRNP Q depletion increases the mRNA oscillation amplitudes of BMAL1-regulated target genes. Together, our results suggest that hnRNP Q plays a pivotal role in both <I>Bmal1</I> translation and BMAL1-regulated gene expression.</P>