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Eun-Jae Lee,Sun U. Kwon,Jong-Ho Park,Yong-Jae Kim,Keun-Sik Hong,Sungwook Yu,Yang-Ha Hwang,Ji Sung Lee,Juneyoung Lee,Joung-Ho Rha,Sung Hyuk Heo,Sung Hwan Ahn,Woo-Keun Seo,Jong-Moo Park,Ju-Hun Lee,Jee-H 대한뇌졸중학회 2020 Journal of stroke Vol.22 No.1
Background and purpose Whether pharmacologically altered high-density lipoprotein cholesterol (HDL-C) affects the risk of cardiovascular events is unknown. Recently, we have reported the Prevention of Cardiovascular Events in Asian Patients with Ischaemic Stroke at High Risk of Cerebral Haemorrhage (PICASSO) trial that demonstrated the non-inferiority of cilostazol to aspirin and superiority of probucol to non-probucol for cardiovascular prevention in ischemic stroke patients (clinicaltrials.gov: NCT01013532). We aimed to determine whether on-treatment HDL-C changes by cilostazol and probucol influence the treatment effect of each study medication during the PICASSO study. Methods Of the 1,534 randomized patients, 1,373 (89.5%) with baseline cholesterol parameters were analyzed. Efficacy endpoint was the composite of stroke, myocardial infarction, and cardiovascular death. Cox proportional hazards regression analysis examined an interaction between the treatment effect and changes in HDL-C levels from randomization to 1 month for each study arm. Results One-month post-randomization mean HDL-C level was significantly higher in the cilostazol group than in the aspirin group (1.08 mmol/L vs. 1.00 mmol/L, P<0.001). The mean HDL-C level was significantly lower in the probucol group than in the non-probucol group (0.86 mmol/L vs. 1.22 mmol/L, P<0.001). These trends persisted throughout the study. In both study arms, no significant interaction was observed between HDL-C changes and the assigned treatment regarding the risk of the efficacy endpoint. Conclusions Despite significant HDL-C changes, the effects of cilostazol and probucol treatment on the risk of cardiovascular events were insignificant. Pharmacologically altered HDL-C levels may not be reliable prognostic markers for cardiovascular risk.
Acute Stroke Care in Korea in 2013–2014: National Averages and Disparities
Jun Yup Kim,Keon-Joo Lee,Jihoon Kang,Beom Joon Kim,김성은,Hyunji Oh,Hong-Kyun Park,Yong Jin Cho,Jong-Moo Park,Kwang-Yeol Park,Kyung Bok Lee,Soo Joo Lee,Tackeun Kim,Ji Sung Lee,Juneyoung Lee,Ki Hwa Yang,A 대한의학회 2020 Journal of Korean medical science Vol.35 No.20
Background: This study aimed to describe the current status of acute stroke care in Korea and explore disparities among hospitals and regions. Methods: The 2013 and 2014 national stroke audit data and the national health insurance claims data were linked and used for this study. Stroke patients hospitalized via emergency rooms within 7 days of stroke onset were selected. Results: A total of 19,608 patients treated in 216 hospitals were analyzed. Among them 76% had ischemic stroke; 15%, intracerebral hemorrhage (ICH); and 9%, subarachnoid hemorrhage (SAH). Of the hospitals, 31% provided inpatient stroke unit care. Ambulances were used in 56% of cases, and the median interval from onset to arrival was 4.5 hours. One-quarter of patients were referred from other hospitals. Intravenous thrombolysis (IVT) and endovascular treatment (EVT) rates were 11% and 4%, respectively. Three-quarters of the analyzed hospitals provided IVT and/or EVT, whereas 47% of hospitals providing IVT and 67% of hospitals providing EVT had less than one case per month. Decompressive surgery was performed on 28% of ICH patients, and clipping and coiling were performed in 17.2% and 14.3% of SAH patients, respectively. There were noticeable regional disparities between the various interventions, ambulance use, arrival time, and stroke unit availability. Conclusion: This study describes the current status of acute stroke care in Korea. Despite quite acceptable quality of stroke care, it suggests regional and hospital disparities. Expansion of stroke units, stroke center certification or accreditation, and connections between stroke centers and emergency medical services are highly recommended.
Park, Jong-Moo,Cho, Yong-Jin,Lee, Kyung Bok,Park, Tai Hwan,Lee, Soo Joo,Han, Moon-Ku,Ko, Youngchai,Lee, Jun,Cha, Jae-Kwan,Lee, Byung-Chul,Yu, Kyung-Ho,Oh, Mi-Sun,Lee, Ji Sung,Lee, Juneyoung,Bae, Hee-J Elsevier 2014 Journal of stroke and cerebrovascular diseases Vol.23 No.10
<P><B>Background</B></P> <P>This study aimed to estimate the population-attributable risks (PARs) of 9 major risk factors for stroke in Korea through a case–control study and to test the feasibility and validity of internet-based control recruitment.</P> <P><B>Methods</B></P> <P>From April 2008 to September 2009, controls were enrolled via internet after providing consent for participation through a web-based survey. The cases included patients who were admitted to the participating centers due to acute stroke or transient ischemic attack within 7 days of onset during the study period. Each control was age- and sex-matched with 2 cases. Adjusted odd ratios, age-standardized prevalence, and PARs were estimated for the 9 major risk factors using the prevalence of risk factors in the control group and the age and sex characteristics from Korea's national census data.</P> <P><B>Results</B></P> <P>In total, 1041 controls were matched to 2082 stroke cases. Because of a shortage of elderly controls in the internet-based recruitment, 248 controls were recruited off-line. The PARs were 23.44%, 10.95%, 51.32%, and 6.35% for hypertension, diabetes, smoking, and stroke history, respectively. Hypercholesterolemia, atrial fibrillation, obesity, coronary heart disease, and a family history of stroke were not associated with stroke. Comparison with education and religion of the control group with that mentioned in the national census data showed a notable difference.</P> <P><B>Conclusions</B></P> <P>The study results imply that internet-based control recruitment for a case–control study requires careful selection of risk factors with high self-awareness and effective strategies to facilitate the recruitment of elderly participants.</P>
On the size of the F-test for the one-way random model with heterogeneous error variances
Lee, Juneyoung,Khuri, André,I.,Kim, Kee Whan,Lee, Sangkon Taylor Francis 2007 JOURNAL OF STATISTICAL COMPUTATION AND SIMULATION Vol.77 No.6
<P> Traditional analysis of variance tests are based on the assumption of homogeneous error variances, which often fails in real experimental situations. Violation of this assumption affects not only the power of the standard F-test, but also its size. When a design is unbalanced, the effect of unequal error variances is even more complex. In this paper, we study the effect of heterogeneous error variances on the size of the F-test concerning the among-group variance component in an unbalanced random one-way model. We also provide a method for computing the true critical value of the F-test for a given level of significance.</P>
Lee, Juneyoung,Lee, Dong Gun Published by Elsevier/North Holland on behalf of t 2014 FEMS microbiology letters Vol.355 No.1
<P>Melittin is one of the best-studied antimicrobial peptides, and many studies have focused on the membrane underlying its membrane-disruptive activity. We previously showed that melittin could cause some hallmarks of apoptosis in Candida albicans. Here, we first report the exact mechanism of melittin-induced fungal apoptosis. We first characterized the reactive oxygen species generated by melittin. The results showed that melittin strongly produced highly reactive hydroxyl radicals (OH), which contribute to cell death. Next, we showed that melittin also disrupted the mitochondrial membrane potential (δψm) and induced the Ca(2+) release from the endoplasmic reticulum and its remarkable accumulation in mitochondria. Finally, we investigated the role of caspase in the apoptotic pathway. The results showed that melittin activated metacaspase, which was mediated by cytochrome c release. To summarize, melittin is involved in the mitochondria- and caspase-dependent apoptotic pathway in C.?albicans. Our findings suggest that melittin possesses a dual antimicrobial mechanism, including membrane-disruptive and apoptotic actions.</P>
A Novel Antifungal Analog Peptide Derived from Protaetiamycine
Juneyoung Lee,Hyun Joo Hong,Jin-Kyoung Kim,Jae-Sam Hwang,김양미,이동건 한국분자세포생물학회 2009 Molecules and cells Vol.28 No.5
Previously, the 9-mer analog peptides, 9Pbw2 and 9Pbw4, were designed based on a defensin-like peptide, protaetia-mycine isolated from Protaetia brevitarsis. In this study, antifungal effects of the analog peptides were investigated. The antifungal susceptibility testing exhibited that 9Pbw4 contained more potent antifungal activities than 9Pbw2. A PI influx assay confirmed the effects of the analog peptides and demonstrated that the peptides exerted their activity by a membrane-active mechanism, in an energy-independent manner. As the noteworthy potency of 9Pbw4, the mecha-nism(s) of 9Pbw4 were further investigated. The membrane studies, using rhodamine-labeled giant unilamellar vesicle (GUV) and fluorescein isothiocyanate (FITC)-dextran loaded liposome, suggested that the membrane-active mechanism of 9Pbw4 could have originated from the pore-forming ac-tion and the radii of pores was presumed to be anywhere from 1.8 nm to 3.3 nm. These results were confirmed by 3D-flow cytometric contour-plot analysis. The present study suggests a potential of 9Pbw4 as a novel antifungal pep-tide.
Lee, Juneyoung,Park, Cana,Park, Seong-Cheol,Woo, Eun-Rhan,Park, Yoonkyung,Hahm, Kyung-Soo,Lee, Dong Gun John Wiley Sons, Ltd. 2009 Journal of Peptide Science Vol.15 No.9
<P>Previously, we investigated the antimicrobial properties of pleurocidin (Ple) enantiomers. Our studies showed that the L-enantiomer exhibited about a 2–16 fold more potent activity against bacterial strains as compared to that of the D–enantiomer. However, fungal strains were about two–fold more susceptible to the D–enantiomer than to the L-enantiomer. In this study, confocal laser scanning microscopy indicates that the Ple enantiomers internalize into the cell surface. The present results also suggest that they could be characterized by a membrane–active mechanism. To further elucidate their selective membranolytic activities, we conducted a fluorescence analysis. A study with 1,6–diphenyl–1,3,5–hexatriene, a hydrophobic molecule, showed that the L–and the D–enantiomer exert more potent antibacterial or antifungal activity than their opposite enantiomer, respectively. Furthermore, we synthesized liposomes by using representative phospholipids consisting of bacterial or fungal membranes. Our results show that the L-enantiomer causes significant dye leakage from negatively charged liposomes (PG/CL; 58:42, PC/PG; 1:1, w/w) which mimic bacterial membranes such as Staphylococcus aureus. Conversely, the D–enantiomer has more potent leakage effects against fungal liposomes (PC/PE/PI/ergosterol; 5:4:1:2, w/w/w/w, PC/ergosterol; 10:1, w/w). In summary, these results suggest that the selective antimicrobial effects of the Ple enantiomers against bacterial and fungal cells may be due to the different lipid compositions of prokaryotes and eukaryotes. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.</P>