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Shuku, Yoshiaki,Mizuno, Asato,Ushiroguchi, Ryo,Hyun, Chang Seok,Ryu, Young Jun,An, Byeong-Kwan,Kwon, Ji Eon,Park, Soo Young,Tsuchiizu, Masahisa,Awaga, Kunio The Royal Society of Chemistry 2018 Chemical communications Vol.54 No.31
<P>A supramolecular honeycomb lattice was successfully formed by using triradical trianion species of triptycene tribenzoquinone (TT) which forms strong intermolecular π-π pancake bonds toward three directions. The crystal structure of Rb3TT·2H2O belongs to the hexagonal <I>P</I>6/<I>m</I> space group, the tight-binding band calculation of which reveals Dirac cones and flat bands.</P>
Yasunori Nakamura,Jun Sano,Kohji Ohki,Toshimasa Higuchi,Kotaro Aihara,Seiichi Mizuno,Osami Kajimoto,Satoshi Nakagawa,Yoshitaka Kajimoto 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.4
Casein hydrolysate, prepared with Aspergillus oryzaeprotease, contains angiotensin I-converting enzyme in-hibitory peptides, such as Val-Pro-Pro and Ile-Pro-Pro. We conducted a randomized, double-blind, placebo-controlled studyto evaluate the effect of casein hydrolysate on the blood pressure of 144 subjects with high-normal blood pressure (n . 104)and mild hypertension (n . 40). Subjects were randomly assigned to two groups for a 12-week intake period. In the test group,both systolic (SBP) and diastolic (DBP) blood pressure decreased significantly compared with the placebo group: SBP/DBPsignificantly decreased from 138.2. 6.5/84.4. 5.3 mm Hg at week 0 to 132.3. 7.3 (P. .001)/81.2. 4.8 mm Hg (P..001) at week 12. In the stratified analysis, the test product showed an antihypertensive effect in both the subject group withhigh-normal blood pressure and that with mild hypertension. No side effect was observed in any subjects in this study. Theseresults demonstrate that the casein hydrolysate, prepared with A. oryzaeprotease, produced a significant reduction in bloodpressure in a population of subjects with high-normal blood pressure or mild hypertension without an adverse event.
Ryo Kanematsu,Masaki Mizuno,Tomoo Inoue,Toshiyuki Takahashi,Toshiki Endo,Seiji Shigekawa,Jun Muto,Daisuke Umebayashi,Takafumi Mitsuhara,Kazutoshi Hida,Junya Hanakita 대한척추신경외과학회 2023 Neurospine Vol.20 No.3
Objective: The impact of adjuvant radiotherapy on overall survival (OS) and progressionfree survival (PFS) of patients with grade II spinal cord astrocytomas remains controversial. Additionally, the relationship between progression and clinical deterioration after radiotherapy has not been well investigated. Methods: This study included 53 patients with grade II intramedullary spinal cord astrocytomas treated by either subtotal, partial resection or open biopsy. Their clinical performance status was assessed immediately before operation and 1, 6, 12, 24, and 60 months after surgery by Karnofsky Performance Scale (KPS). Patients with and without adjuvant radiotherapy were compared. Results: The groups with and without radiation comprised 23 and 30 patients with a mean age of 50.3 ± 22.6 years (range, 2–88 years). The mean overall disease progression rate was 47.1% during a mean follow-up period of 48.4 ± 39.8 months (range, 2.5–144.5 months). In the radiation group, 11 patients (47.8%) presented with progressive disease, whereas 14 patients (46.7%) presented with progressive disease in the group without radiation. There were no significant differences in OS or PFS among patients with or without adjuvant radiotherapy. KPS in both groups, especially radiation group, gradually decreased after operation and deteriorated before the confirmation of disease progression. Conclusion: Adjuvant radiotherapy did not show effectiveness regarding PFS or OS in patients with grade II spinal cord astrocytoma according to classical classification based on pathohistological findings.
Ken Takagi,Nobuyuki Tanahashi,Nozomi Amagasu,Kaito Mizuno,Jun Kawanokuchi,Guo Yi,Torao Ishida 사단법인약침학회 2017 Journal of Acupuncture & Meridian Studies Vol.10 No.1
A previous study on rats showed that simultaneous acupuncture stimulation at the “Bai-Hui” (GV 20) and the “Yintáng” (Ex-HN3) acupoints alleviated the state of depression to an extent similar to that achieved by pharmacotherapy. This study investigated whether the alleviation of the depressed state required simultaneous acupuncture at these two acupuncture points. For the purposes of testing the effect of acupuncture on depressive symptoms, we treated a depression model rat, where depression had been induced by using a mild water-immersion stress technique, with either acupuncture stimulation at only one acupuncture point (GV 20 or Ex-HN3) or an antidepressant, and we measured the immobile time for evaluating the state of depression. Anxiety, as a symptom commonly associated with depression, was also evaluated by measuring the number of head dips. Neither the immobile time nor the number of head dips decreased upon acupuncture stimulation. From this study, single acupuncture stimulation at either “GV 20” or “Ex-HN3” alleviated neither the state of depression nor the anxiety. The water-immersion stress used to make the depression model rats was shown not to induce anxiety; however, the stress induced by immobilizing the rats for acupuncture stimulation did lead to anxiety.
Tomihiko Edura,Hiromasa Takahashi,Masashi Nakata,Ken Tsutsui,Kenji Itaka,고이누마히데오미,Jun Mizuno,Yasuo Wada 한국물리학회 2006 Current Applied Physics Vol.6 No.1
Organic thin lm transistors (O-TFTs) are attracting attentions recently for their possible application to exible eld eect tran-sistor (FET) devices and even for candidate devices in post-silicon information systems. However, the organic thin lms usuallygrow in a polycrystalline state, and the electrical properties are very dicult to set at an appropriate value because orientationand size of the polycrystalline grains are almost uncontrollable. Thus, it should be necessary to clarify the conduction characteristicsorganic thin lms. This paper reports on a nano-scale electrode array, which provides a method to characterize single organic semi-conductor grain, as well as to determine the single grain boundary eect on the electrical conduction. The fabrication method of thenano-scale electrode array and evaluation results are described. Single grain and single grain boundary in MBE grown pentacenethin lm were detected and were measured for the rst time using FET structures. The resistance of single grain was estimatedof the resistance of single grain pentacene thin lm and single pentacene grain boundary.
MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis
Lee Dong-Joon,Kim Pyunggang,Kim Hyun-Yi,Park Jinah,Lee Seung-Jun,An Haein,Heo Jin Sun,Lee Min-Jung,Ohshima Hayato,Mizuno Seiya,Takahashi Satoru,Jung Han-Sung,Kim Seong-Jin 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
The asymmetric division of stem cells permits the maintenance of the cell population and differentiation for harmonious progress. Developing mouse incisors allows inspection of the role of the stem cell niche to provide specific insights into essential developmental phases. Microtubule-associated serine/threonine kinase family member 4 (Mast4) knockout (KO) mice showed abnormal incisor development with low hardness, as the size of the apical bud was decreased and preameloblasts were shifted to the apical side, resulting in amelogenesis imperfecta. In addition, Mast4 KO incisors showed abnormal enamel maturation, and stem cell maintenance was inhibited as amelogenesis was accelerated with Wnt signal downregulation. Distal-Less Homeobox 3 (DLX3), a critical factor in tooth amelogenesis, is considered to be responsible for the development of amelogenesis imperfecta in humans. MAST4 directly binds to DLX3 and induces phosphorylation at three residues within the nuclear localization site (NLS) that promotes the nuclear translocation of DLX3. MAST4-mediated phosphorylation of DLX3 ultimately controls the transcription of DLX3 target genes, which are carbonic anhydrase and ion transporter genes involved in the pH regulation process during ameloblast maturation. Taken together, our data reveal a novel role for MAST4 as a critical regulator of the entire amelogenesis process through its control of Wnt signaling and DLX3 transcriptional activity.