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- 저자 : Yasunori Nakamura (검색결과 3 건)
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Yasunori Nakamura,Jun Sano,Kohji Ohki,Toshimasa Higuchi,Kotaro Aihara,Seiichi Mizuno,Osami Kajimoto,Satoshi Nakagawa,Yoshitaka Kajimoto 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.4
Casein hydrolysate, prepared with Aspergillus oryzaeprotease, contains angiotensin I-converting enzyme in-hibitory peptides, such as Val-Pro-Pro and Ile-Pro-Pro. We conducted a randomized, double-blind, placebo-controlled studyto evaluate the effect of casein hydrolysate on the blood pressure of 144 subjects with high-normal blood pressure (n . 104)and mild hypertension (n . 40). Subjects were randomly assigned to two groups for a 12-week intake period. In the test group,both systolic (SBP) and diastolic (DBP) blood pressure decreased significantly compared with the placebo group: SBP/DBPsignificantly decreased from 138.2. 6.5/84.4. 5.3 mm Hg at week 0 to 132.3. 7.3 (P. .001)/81.2. 4.8 mm Hg (P..001) at week 12. In the stratified analysis, the test product showed an antihypertensive effect in both the subject group withhigh-normal blood pressure and that with mild hypertension. No side effect was observed in any subjects in this study. Theseresults demonstrate that the casein hydrolysate, prepared with A. oryzaeprotease, produced a significant reduction in bloodpressure in a population of subjects with high-normal blood pressure or mild hypertension without an adverse event.
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Effect of Several Adsorbents on The Gastrointestinal Absorption of Paraquat
Machijima, Hiraku,Nakamura, Hiroyuki,Hatanaka, Tomomi,Sugibayashi, Kenji,Morimoto, Yasunori The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.5
The effect of several adsorbents on paraquat poisohing was investigated (1) by measuring the saturatd amount of the poison adhered on the adsorbents in vitro and (2) by assaying the blood level of paraquat in the rat in in situ intestinal absorption experiments. Activated charcoal powder, natural aluminum silifonate) were used as adorbents. The steady-state blood level of paraquat in its absorption experiment with the cationic exchange resins was markedly lower than those without the resins or with other adsorbents. A good relationship was achieved between the calculated AUC or adsorptioin rate (in situ) and the saturated adsorption amount (in vitro). The rank order of the effect was sodium polystyene sulfonate > calcium polystyene sulfonate>natural aluminum silicate>activated charcoal powder. The effect of sodium polystyrene sulfonate after intestinal washing with physiological saline ws also measured, and a synergistic effect (marked decrease in blood paraquat level0 was found as compared with the intestinal washing alone. The simultaneous use of G.I. weshing and powerful adsorbent was scientifically proven to be most benefical.
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Effects of Val-Pro-Pro and Ile-Pro-Pro on Nondipper Patients: A Preliminary Study
Mari Takahashi Kurosawa,Yasunori Nakamura,Naoyuki Yamamoto,Kazuhisa Yamada,Toshiro Iketani 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.5
Much clinical evidence on the antihypertensive effects of the milk-derived antihypertensive peptides Val-Pro-Pro and Ile-Pro-Pro (lactotripeptides) has been reported. However, circadian rhythm effects determined by ambulatory blood pressure monitoring (ABPM) to eliminate the confounding influence of the white-coat effect have not been fully studied. Twelve hypertensive patients not receiving antihypertensive medication (2 men, 10 women; mean age±standard deviation, 63.5±8.3 years) who had been visiting our clinic for more than 1 year participated in this study. Mean (±standard deviation) systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 142.4±2.6 and 83.5±6.4 mm Hg, respectively, at the first office visit. After patients ingested a fermented milk product containing antihypertensive peptides (2.53 mg Val-Pro-Pro; 1.52 mg Ile-Pro-Pro) for more than 4 weeks, both office SBP and DBP were significantly reduced to a mean (±standard deviation) of 133.3±7.0 mm Hg and 76.5±8.4 mm Hg (P<.001 and P<.005 by paired t-test), respectively. The 24-hour SBP and DBP determined by ABPM were reduced from 127.3±2.4 and 78.7±2.3 mm Hg to 120.2±2.4 and 75.0±2.2 mm Hg (P<.001 and P<.05), respectively. Awake-time SBP (08:00–21:00), night-time SBP (0:00–05:00), and early-morning SBP (06:00–07:00) were reduced from 130.9±2.4 to 123.3±2.3 mm Hg, 118.7±2.9 to 113.2±3.4 mm Hg, and 132.8±4.3 to 122.4±3.9 mm Hg (by paired t-test: P<.001, P<.05, and P<.05), respectively. As seen with DBP measured by ABPM, 24-hour DBP and awake-time DBP were significantly reduced from 78.7±2.3 to 75.0±2.2 mm Hg and 82.1±2.5 to 77.3±2.2 mm Hg (P<.05 and P<.01), respectively. Office BP and 24-hour blood pressure did not significantly differ between the dipper and nondipper groups at baseline. However, after treatment, night-time and early-morning blood pressure were significantly reduced from baseline in the nondipper group (−8.5±2.5 and −15.6±3.7 mm Hg; P<.05 and P<.01, respectively) but not in the dipper group (−2.5±3.6 and −1.2±4.7 mm Hg; P not significant), and the reduction in early-morning blood pressure significantly differed between the groups (P<.05). These results suggest that Val-Pro-Pro and Ile-Pro-Pro decrease blood pressure in patients with stage I hypertension and result not only in lower blood pressure at night-time but also in lower early-morning SBP in nondipper patients.
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