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Joe, Eugene,Lee, Jeong Min,Kim, Kyung Won,Lee, Kyung Bun,Kim, Soo Jin,Baek, Jee Hyun,Shin, Cheong Il,Suh, Kyung Suk,Yi, Nam Joon,Han, Joon Koo,Choi, Byung Ihn Wiley Subscription Services, Inc., A Wiley Company 2012 JOURNAL OF MAGNETIC RESONANCE IMAGING Vol.36 No.5
<P><B>Abstract</B></P><P><B>Purpose:</B></P><P>To evaluate the diagnostic implications of the iterative decomposition of water and fat using echo‐asymmetry and the least‐squares estimation (IDEAL) technique to detect hepatic steatosis (HS) in potential liver donors using histopathology as the reference standard.</P><P><B>Materials and Methods:</B></P><P>Forty‐nine potential liver donors (32 male, 17 female; mean age, 31.7 years) were included. All patients were imaged using the in‐ and out‐of‐phase (IOP) gradient‐echo (GRE) and IDEAL techniques on a 1.5 T MR scanner. To estimate the hepatic fat fraction (FF), two reviewers performed regions‐of‐interest measurement in 15 areas of the liver seen on the IOP images and on the IDEAL‐FF images. The magnetic resonance imaging (MRI) and pathology values of macrosteatosis were correlated using the Pearson correlation coefficient. We analyzed the diagnostic performance of IOP imaging and IDEAL for detecting HS.</P><P><B>Results:</B></P><P>The results of the hepatic‐FF estimated on IDEAL were well correlated with the histologic degree of macrosteatosis (γ = 0.902, <I>P</I> < 0.001). IDEAL showed 100% sensitivity and 91% specificity for detecting HS, and IOP imaging showed 87.5% sensitivity and 97% specificity, respectively.</P><P><B>Conclusion:</B></P><P>IDEAL is a useful tool for the preoperative diagnosis of HS in potential living liver donors; it can also help to avoid unnecessary biopsies in these patients. J. Magn. Reson. Imaging 2012;36:1124–1130. © 2012 Wiley Periodicals, Inc.</P>
고지방 식이로 유발된 고지혈증 동물 모델에서 구기자가미방(枸杞子加味方)의 효과 연구
안가영,조재준,신민구,전상윤,An, Ga-Young,Joe, Jae-Joon,Shin, Min-Koo,Jeon, Sang-Yun 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.4
Objectives: This study was undertaken to investigate the effects of Gugijagami-bang (GGB) in a hyperlipidemic animal model induced by a high-fat diet using diverse biological methods. Methods: This study was to determine whether fractionated GGB extracts inhibit reactive oxygen species (ROS) and nitric oxide (NO) in RAW 264.7 cells. Hyperlipidemia was induced by a high-fat diet fed for 6 weeks. Total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride, liver function and histologic change of liver were measured after oral administration of GGB. Results: 1. DPPH scavenging bow performance was increased in a concentration-dependent manner by GGB. 2. Compared to the control group, NO production (%) and ROS production (%) were decreased significantly by GGB. 3. Total-cholesterol, LDL-cholesterol, triglyceride were decreased significantly by GGB. 4. HDL cholesterol increased more than the control group, but not significantly. 5. In histopathologic examination, fatty liver (hepatic steatosis) was inhibited, almost no rounds of fat were observed in the liver. Conclusions: GGB would appear effective in the prevention and treatment of atherosclerosis, ischemic heart disease, other cardiovascular diseases caused by hyperlipidemia.
Kim, Kyoung-Han,Kim, Yun Hye,Son, Joe Eun,Lee, Ju Hee,Kim, Sarah,Choe, Min Seon,Moon, Joon Ho,Zhong, Jian,Fu, Kiya,Lenglin, Florine,Yoo, Jeong-Ah,Bilan, Philip J,Klip, Amira,Nagy, Andras,Kim, Jae-Ryon Nature Publishing Group 2017 Cell research Vol.27 No.11
<P>Intermittent fasting (IF), a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction. However, our understanding of the underlying mechanisms of IF-mediated metabolic benefits is limited. Here we show that isocaloric IF improves metabolic homeostasis against diet-induced obesity and metabolic dysfunction primarily through adipose thermogenesis in mice. IF-induced metabolic benefits require fasting-mediated increases of vascular endothelial growth factor (VEGF) expression in white adipose tissue (WAT). Furthermore, periodic adipose-VEGF overexpression could recapitulate the metabolic improvement of IF in non-fasted animals. Importantly, fasting and adipose-VEGF induce alternative activation of adipose macrophage, which is critical for thermogenesis. Human adipose gene analysis further revealed a positive correlation of adipose VEGF-M2 macrophage-WAT browning axis. The present study uncovers the molecular mechanism of IF-mediated metabolic benefit and suggests that isocaloric IF can be a preventive and therapeutic approach against obesity and metabolic disorders.</P>
Intralymphatic Immunotherapy Alleviates Allergic Symptoms During Allergen Exposure in Daily Life
Lee, Sang Pyo,Jung, Joo Hyun,Lee, Sang Min,Joe, Eugene,Kang, Il Gyu,Kim, Seon Tae,Lee, Min Woo,Park, So Hyun,Choi, Seung Joon The Korean Academy of Asthma, Allergy and Clinical 2018 Allergy, Asthma & Immunology Research Vol.10 No.2