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Joon Myong SONG 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
For intratumoral uptake, the movement of nanoparticles(NPs) to tumor sites distant from the blood vessels is impaired by high interstitial fluid pressure (IFP), vessel density, limited interstitial space, dense networks of collagen fibers, and abundant tumor stromal cells (fibroblasts, immune cells, and tumor-associated macrophages). In addition, the tumor microenvironment can also create hypoxic and acidic conditions. To analyze the distribution of NPs and the existence of hypoxic cells in relation to blood vessels within a solid tumor, microscopic observation of tumor sections (<10 ㎛) is a well-established method. However, this provides far less information about the spatial distribution of NPs and fails to entirely characterize the quantitative relationship among the penetration depth of NPs, hypoxic regions, and blood vessels due to limited ability to observe tumor region. In this work, we use a tissue optical clearing technique to obtain transparent tissues without sectioning and three dimensional tissue reconstruction, subsequently achieving high-resolution information on tumor microenvironment. The aim of this study was to depict the spatial distribution of liposomal nanoparticles (Lip-Rus) in relation to tumor vasculature, hypoxic regions and clonogenic cells in intact transparent tumor tissues. The spatial distribution showed an apparent lack of Lip-Ru penetration into the tumor site. Quantitative verification indicated that the penetration depth of Lip-Ru was ~85 ㎛; however, the maximum distribution percentage was observed only within a 40 to 50 ㎛ distance from the nearest vessels. To validate the existence of viable cells deep inside the tumor, we examined the spatial distribution of hypoxic and clonogenic cells in intact transparent tumor tissues. Herein, for the first time, we present a direct demonstration of the spatial distribution of hypoxic and clonogenic cells in relation to blood vessels. HIF1α was selected as a marker to detect hypoxic regions, and CD44 was selected as a marker to identify clonogenic cells in the tumor microenvironment. Characteristic distance mapping illustrated that HIF1α expression in the tumor ranged from 62 to several hundred ㎛ (~460 ㎛), verifying that HIF1α is expressed far from blood vessels. By contrast, the distribution of CD44 decreased with the increasing distance from blood vessels; however, CD44 was still expressed in a significant area, ranging from approximately 70 ㎛ to 200 ㎛, and the maximum distribution of CD44 was observed until approximately 300 ㎛ from the nearest blood vessels. These findings reveal that hypoxic and clonogenic cells do not receive sufficient Lip-Ru and that beyond the maximum penetration of Lip-Ru, the tumor contains CD44- and HIF1α-positive cells that are viable.
Song Joon Myong,Lee Chul,Chung Koo Soon Korean Chemical Society 1994 Bulletin of the Korean Chemical Society Vol.15 No.1
Rare earth elements (REE) were individual separated by applying the gradient elution via HPLC using ${\alpha}-hydroxyisobutyric$ acid (HIBA) as an eluent. However, the overlap of Y and Dy peaks was too severe to obtain the resolution of these two peaks. The target transformation factor analysis (TTFA) was applied to resolve the elution peaks of Y and Dy. [A]$_{raw}$ formed from the absorbances of mixed solution was factor analyzed. The abstract factor analysis(AFA) was used to determine the number of components that contributed to the poorly resolved peaks. The error theory in the AFA showed that the number of components was 2. The test vectors which correspond to pure component were selected from the standard solutions of Y and Dy. TTFA was accomplished by target testing. The results showed that the resolution of two peaks as well as the determination of Y and Dy were possible by the factor analysis.
WiFi의 간섭을 평가하기 위한 IEEE 802.15.4 채널분석기의 구현
송명렬(Myong-Lyol Song),진현준(Hyun-Joon Jin) 대한전기학회 2014 전기학회논문지 P Vol.63 No.2
In this paper, an implementation of concurrent backoff delay process on a single chip with IEEE 802.15.4 hardware and 8051 processor core that can be used for analyzing the interference on IEEE 802.15.4 channels due to WiFi traffics is studied. The backoff delay process of IEEE 802.15.4 CSMA-CA algorithm is explained. The characteristics of random number generator, timer, and CCA register included in the single chip are described with their control procedure in order to implement the process. A concurrent backoff delay process to evaluate multiple IEEE 802.15.4 channels is proposed, and a method to service the associated tasks at sequentially ordered backoff delay events occurring on the channels is explained. For the implementation of the concurrent backoff delay process on a single chip IEEE 802.15.4 hardware, the elements for the single channel backoff delay process and their control procedure are used to be extended to multiple channels with little modification. The medium access delay on each channel, which is available after execution of the concurrent backoff delay process, is displayed on the LCD of an IEEE 802.15.4 channel analyzer. The experimental results show that we can easily identify the interference on IEEE 802.15.4 channels caused by WiFi traffics in comparison with the way displaying measured channel powers.
Arumugam, Parthasarathy,Song, Joon Myong Oxford University Press 2016 Integrative biology Vol.8 No.6
<P>Elevated expression of drug efflux pumps such as multidrug resistant protein-1 (MDR1/ABCB1) and multidrug resistance associated protein-1 (MRP1/ABCC1) in cancer stem cells (CSCs) among a bulky tumor cell population was attributed to drug resistance. For the first time, we have quantitatively evaluated the cytotoxic profile of camptothecin (CPT) against the CSC. In the present study, a Qdot based total internal reflection fluorescence (TIRF) detection system effectively interpreted that drug resistance to CPT was reduced in the CSC under ABCB1 inhibited conditions. This study revealed that quantitative finding of the EC50 value for apoptosis and necrosis in correlation with the ABC inhibitor and CSC population using TIRF could provide more details of the anti-cancer efficacy of chemotherapeutic agents.</P>
Shim, Yumi,Song, Joon Myong The Royal Society of Chemistry 2015 Chemical communications Vol.51 No.11
<P>In this study, it was found that breast cancer stem cells (CSCs) are formed from MCF-7 cells by benzo[<I>a</I>]pyrene (BP)-induced mutation. The breast CSCs were detected through simultaneous monitoring of CD44, CD24 and aldehyde dehydrogenase 1 (ALDH1) by hypermulticolor cellular imaging using an acousto-optical tunable filter (AOTF) and quantum dots (Q-dots).</P> <P>Graphic Abstract</P><P>In this study, it was found that breast cancer stem cells (CSCs) are formed from MCF-7 cells by benzo[<I>a</I>]pyrene (BP)-induced mutation. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cc08953g'> </P>
Efficacy and Tolerability of Generic Mirtazapine (Mirtax) for Major Depressive Disorder:
Hoo Rim Song,Won Myong Bahk,Young Sup Woo,Jong Hyun Jeong,Young Joon Kwon,Jeong Seok Seo,Won Kim,Moon Doo Kim,Young Chul Shin,Sang Yeol Lee,Kyung Joon Min 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.2
Objective: Mirtax is a generic mirtazapine widely used since 2003. We conducted an open-label, uncontrolled 6-week study to evaluate the efficacy and safety of Mirtax for major depressive disorder (MDD). Methods: Ninety three MDD patients with the diagnosis of MDD and 17-item Hamilton Depression Rating Scale (HDRS) score ≥14 were recruited. The HDRS, Montgomery-Åsberg Depression Rating Scale (MADRS), and the Clinical Global Impressions-Severity Scale (CGI-S) were administered at baseline, 1, 2, 4 and 6 weeks. Response (≥50% decrease in the HDRS or MADRS score), remission (absolute HDRS score ≤7 or MADRS score ≤10) and CGI-I score ≤2 were also calculated. Adverse event (AE) frequency and severity, weight, blood pressure, and pulse rate were checked to assess safety. Results: The starting dosage was 11.5±6.4 mg/day, and the maintenance dosage was 23.1±9.4 mg/day. During 6 weeks, HDRS, MADRS and CGI-S scores decreased from 25.1±5.6 to 11.9±8.6 (mean change –13.1±8.3, p<0.001), from 30.2±6.3 to 13.73±10.40 (mean change –16.5±9.8, p<0.001), and from 5.0±0.8 to 2.5±1.3 (mean change –2.5±1.3, p<0.001), respectively. The percentages of responders, remitters by HDRS and patients with a CGI-I score ≤2 were 64.6%, 35.4% and 52.7%, respectively. Significant decreases in HDRS, MADRS and CGI-S scores were confirmed at week 1. The total rate of AEs was 32.3%; the most frequently reported AEs were sedation (4.3%) and constipation (4.3%). Weight was increased from 58.8±10.6 to 60.3±9.3 kg (mean change 0.7±1.7 kg, p=0.004). Conclusion: This study, as the first clinical trial of generic mirtazapine, demonstrated the efficacy and tolerability of Mirtax for MDD using a single treatment design.