초고속 치과용 핸드피스 개발

한명철,김정관,최명욱,이왕근,김헌주 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

The dental high-speed handpiece is one of the most popular and important devices that has been widely used as the main means of cutting tooth structure and restorative materials in dentistry, In consideration of usage and marketability of the dental handpiece, it is obviously worthy of investigating it. In this paper, a high speed dendal handpiece is developed through reverse engineering with 3D X-Ray CT equipment and wire cutter for the Mark II model in NSK. The demension of the handpiece parts is obtained through this process, and 3D modeling is performed with CATIA V5. The interference between parts can be examined through the part assembly in CATIA, and the performance is finally compared with Mark II model in NSK.

Abdominal hysterectomy: can we decrease the number?

김주명 ( Joo Myung Kim ),( Mi La Kim ),( Ho Won Han ),( Jong Young Jun ),( Kwan Young Joo ) 대한산부인과학회 2008 대한산부인과학회 학술대회 Vol.94 No.-

자궁 탈출-자궁 적출술이 필요한가?

김주명 ( Joo Myung Kim ),조준형 ( Jun Hyung Cho ),김태진 ( Tae Jin Kim ),주관영 ( Kwan Young Joo ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.7

A Random Probe-based DNA Microarray Chip for Specific Pathogen Detection

Kwan Jong CHANG,Joo-Myung AHN,Jin Yong LEE,Ee Tack HWANG,Byoung Chan KIM,Man Bock GU 한국생물공학회 2010 한국생물공학회 학술대회 Vol.2010 No.4

골반 종양 환자의 수술전 CA-125치의 진단적 의의

이명재,이병주,권혁,김용봉,이응수,박성관 인제대학교 1995 仁濟醫學 Vol.16 No.3

상피성 난소암에서 주로 관찰되는 종양 표지물질인 CA-125는 종양의 악성여부와 수술 후 경과 관찰에 매우 유용하다고 알려져 있다. 이에 저자들은 1987년 7월부터 1995년 6월까지 인제대학교 부속 서울백병원 산부인과에 골반종양으로 진단되어 개복수술을 시행한 253명의 혈청 CA-125치를 분석하여 혈청 CA-125치가 수술 전 종양의 악성 여부를 구별할 수 있는 지를 알아보고자 이 연구를 시행하였다. To evaluate the diagnostic significance of tumor marker CA-125 in patients with pelvic masses, we measured preoperative serum CA-125 level in patients who underwent operations due to pelvic masses from July 1987 to June 1995. Serum CA-125 level of 35u/ml was determined as cut-off levels. The following results were obtained 1.The histology of pelvic masses in 253 study patients consisted of 216 benign(85%) and malignant masses 37(15%) 2.CA-125 levels of the benign pelvic masses and malignant pelvic masses were 63.8u/ml and 231.2u/ml respectively. These differences were statistically significant. (p<0.05) 3.Using 35u/m1 as a cutoff, the false positivity of malignant ovarian tumor was 81.1%. 4.In contrast to the mean CA-125 concentration of mucinous adenocarcinoma of 154.8u/ml, the mean CA-125 concentration of non-mutinous adenocarcinoma was 266.5u/ml. There was a statistically significant difference between these two groups. 5.Using 35u/ml as a cutoff, the positivity according to FIGO staging was 9 out of 15cases (60%) in stage I, 4 out of 4 cases(100%) in stage II, 14 out of 16cases (87.5%) in stage III, and 2 out of 2 cases (100%) at stage IV. 6.When the cut off point of CA-125 concentration was decided as 35u/ml, sensitivity, specificity, positive predictive value, and diagnostic efficiency of CA-125 concentration for malignant ovarian tumor were 81.08%, 58.33%, 27.27%, 94.12%, and 56.13% respectively. Our results suggest that CA-125 assay can be used only as a diagnostic adjunct for discriminating benign from malignant ovarian tumors.

The Anti-oxidative and Anti-inflammatory Effects of Caffeoyl Derivatives from the Roots of <i>Aconitum koreanum</i> R. R<small>AYMOND</small>

Park, Kwan Hee,Park, Min,Choi, Sun Eun,Jeong, Mi Sook,Kwon, Joo Hee,Oh, Myung Hwan,Choi, Hyung Kyun,Seo, Seong Jun,Lee, Min Won Pharmaceutical Society of Japan 2009 Biological & pharmaceutical bulletin Vol.32 No.12

<P>Activity guided fractionation of <I>Aconitum koreanum</I> root extract (RAK), a traditional medicine in Korea, afforded four caffeoyl derivatives, caffeic acid (1), 4,5-dicaffeoylquinic acid (2), 3,5-dicaffeoylquinic acid (3) and 3,5-dicaffeoylquinic acid methyl ester (4). In order to evaluate the anti-oxidative and anti-inflammatory effects of these compounds, their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities and abilities to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 were examined. And the protein and mRNA levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-stimulated HaCaT cells were also quantified by Western blotting and reverse transcription-polymerase chain reaction (RT-PCR). Compounds (1—4) showed potent DPPH radical scavenging and NO inhibitory activities as compared with positive controls (<SMALL>L</SMALL>-ascorbic acid and <I>N</I>(G)-monomethyl-<SMALL>L</SMALL>-arginine (<SMALL>L</SMALL>-NMMA), respectively). Also, these compounds dose-dependently inhibited the expressions of iNOS and COX-2 as well as their mRNA levels.</P>

Th1 and Th2 Cytokine Profiles of Xenograft Porcine Kidney-15 Cells by Recombinant Human IL-32α,β

Young Kwan Kim,Eun Joo Lee,Pyung Keun Myung 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

The mechanism involved in rejection of porcine islets transplanted intraportally in mice was investigated Th1 and Th2 cytokine profiles of xenograft porcine kidney-15 cells by recombinant human IL-32α,β. Reults showed that xenotransplantation of porcine islets upregulated chemokines that are involved in T-cell recruitment, and T-cell and macrophage infiltration. IL-32 is a recently described cytokine produced mainly by T, natural killer, and epitherial cells that has the properties of a classical proinflammatory mediator. In this study, Th1 and Th2 cytokine profiles were examined in recombinant human IL-32α,β (rhIL-32α,β) treated mice after porcine kidney 15 (PK15) cells transfer. In vitro and in vivo experiments, the treatment of rhIL-32α,β after PK15 cells transfer regulated xenograft cellular rejection by escaping recognition of host immune cells of xenotransplantation during the early phases of xenograft rejection via modulation of CD8+ T cells.

Immune Regulation of Xenograft Rejection by Recombinant Human IL-32α,β

Young Kwan Kim,Eun Joo Lee,Pyung Keun Myung 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

The type of tissue or organ transplanted and the phylogenetic distance between the donor and the recipient have profound importance for the immune response to xenotransplantation. IL-32 is a recently described cytokine produced mainly by T cells, natural killer, and epitherial cells that has the properties of a classical proinflammatory mediator. In this study, the influence of recombinant human IL-32α or β (rhIL-32α,β) cells on the growth of C57BL/6 mouse spleen cells was investigated and its effect on immune regulation of xenografts was examined in mice transferred with porcine kidney 15 (PK15) cells. These results suggest that the treatment of rhIL-32 after PK15 cells transfer regulated xenograft cellular rejection by escaping recognition of host immune cells of xenotransplantation during the early phases of xenograft rejection via modulation of CD8+ T cells.

간경변증 환자에서 거대 식도 정맥류에 대한 비내시경 예측인자

장명희 ( Myung Hee Chang ),손주현 ( Joo Hyun Sohn ),김태엽 ( Tae Yeob Kim ),손병관 ( Byoung Kwan Son ),김종표 ( Jong Pyo Kim ),전용철 ( Yong Cheol Jeon ),한동수 ( Dong Soo Han ) 대한소화기학회 2007 대한소화기학회지 Vol.49 No.6

목적: 간경변증 환자에서 식도 정맥류 출혈은 중요 사인중의 하나로 간경변 진단 시 정맥류 존재 여부와 출혈 위험도를 평가하기 위해서 상부위장관내시경 검사가 권장된다. 그러나 비용-효과에서 모든 간경변증 환자를 대상으로 내시경 검사를 시행해야 하는지에 대한 논란이 있다. 이번 연구는 간경변증 환자에서 정맥류 출혈의 고위험군인 거대 식도정맥류에 대한 비내시경 예측인자를 찾고자 시행하였다. 대상 및 방법: 의무 기록을 후향 조사하여 처음 간경변증으로 진단된 총 736명 환자 중 상부위장관 출혈로 내원하였거나 출혈의 과거력이 있는 경우, 상부위장관내시경 검사를 이전 시행했던 경우, 베타 차단제 복용력, 간문맥 혈전증, 간암이 있는 환자 등을 제외하고 진단 당시 상부위장관내시경 검사를 시행한 환자 245명(남자 171명, 여자 74명)을 대상으로 조사하여 15개의 변수를 통해 거대 식도 정맥류의 비내시경 예측인자를 분석하였다. 간경변증 진단은 임상 소견 및 검사실 소견에서 간경변증에 합당하며 동시에 방사선 검사에서 간경변증 소견을 보이는 경우 혹은 간 조직 검사에서 확진된 경우로 하였다. 결과: 간경변증 환자 245명 중 186명(75.9%)에서 식도 정맥류가 관찰되었고, 55명(22.4%)에서 거대 식도 정맥류가 존재하였다. 간경변증 원인은 바이러스101명(41.2%), 알코올 104명(42.4%), 바이러스/알코올 모두있는 경우 24명(9.8%), 기타 16명(6.6%)이었다. 전체 환자에서 51%, 35.1%, 13.9%가 Child-Pugh A, B, C 등급에 각각 속하였다. 단변량 분석에서 나타난 거대 식도 정맥류 예측인자는 알코올과의 연관성, Child-Pugh 점수, 복수, 비장 비대 및 크기, 혈소판 감소증, 알부민, 프로트롬빈 활성도 등이었고, 다변량 분석에서는 알코올과의 연관성(p=0.017), 12 cm 이상의 비장 비대(p=0.003) 및 복수의 존재(p<0.001)만이 거대 식도 정맥류에 대한 독립 예측인자였다. 독립 예측인자 중 2개 이상을 가진 경우 진단 민감도는 80%, 특이도는 64.2%, 음성 예측도는 91.7%였으며, 한 개의 예측인자도 없을 경우 거대 정맥류는 존재하지 않았다. 결론: 이번 연구에서 거대 식도 정맥류에 대한 비내시경 예측인자는 복수의 존재, 비장 비대, 알코올과의 연관성이었고, 이 중 2가지 이상을 가진 환자는 거대 식도 정맥류가 존재할 가능성이 높으므로 선별검사 목적으로 상부위장관내시경 검사를 반드시 시행해야 할 것으로 생각한다. Background/Aims: The aim of this study was to identify non-endoscopic predictors for the presence of large esophageal varices in Korean patients with liver cirrhosis. Methods: Among 736 patients with liver cirrhosis newly diagnosed between the year 2001 and 2005, 245 patients (171 men and 74 women, mean age of 51.9 years) fulfilled the inclusion criteria and underwent EGD as screening tests for esophageal varices. Fifteen variables were analysed to identify the presence of large esophageal varices. Results: Esophageal varices were noted in 186 patients (75.9%) and large varices in 55 patients (22.4%), while 59 patients (24.1%) had no varices at the time of initial diagnosis of cirrhosis. The causes of liver cirrhosis were viral hepatitis (41.2%), chronic alcoholism (42.4%), viral hepatitis/alcoholism (9.8%), and others (6.6%). Fifty-one percent, 35.1% and 13.9% of the patients belonged to Child-Pugh class A, B, and C, respectively. Variables associated with the presence of large esophageal varices on univariate analysis were the presence of ascites, splenomegaly (long-axis ≥12 cm by ultrasound measure), alcoholism, Child-Pugh class, platelet count, prothrombin time, and albumin. On multivariate analysis, alcohol, splenomegaly, and ascites were significantly associated with the presence of large esophageal varices. If the patients have two of them, sensitivity and negative predictive value were 80% and 91.7%, respectively. Patients without all three factors had no large esophageal varices. Conclusions: These results suggest that patients who have at least two among ascites, splenomegaly, and alcoholism would have an increased risk of having large esophageal varices. (Korean J Gastroenterol 2007;49:376-383)

항공기 부품용 Ti-6Al-4V Laser 가열 고속밀링 가공 시 모재온도와 절삭속도의 상관관계

안명관(Myung-Kwan Ahn),김정한(Jeoung-Han Kim),주영석(Young-Seok Joo) 한국항공우주학회 2021 한국항공우주학회 학술발표회 논문집 Vol.2021 No.11