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김진호,김재선,연종은,변관수,이창홍,김종극,임형준,박영태 대한소화기학회 1999 대한소화기학회지 Vol.32 No.6
Background/Aims: Esophageal segmental dysmotility has been extensively studied, while reports regarding segmental hypotonic peristalsis are rare. This study was carried out to elucidate the possible relationship between segmental hypotonic peristalsis and midesophageal diverticulum. Methods: Fifteen patients with midesophageal diverticulum and 15 age- and sex-matched controls were evaluated with conventional and mapping esophageal manometry. Results: Conventional manometric parameters were similer in the patients and controls. The conventional manometry identified motility disorders in 5 patients (33%) (4 nonspecific esophageal motility disorders and 1 nutcracker esophagus). The mapping manometry showed that segmental hypotonic peristalsis was noted in 6 patients (40%), but it was not found among the controls. Five patients (33%) showed no abnormality from either manometric method. Conclusions: This observation suggests that segmental hypotonic peristalsis is frequently found in patients with idesophageal diverticulum, although its clinical significance and role in the pathogenesis of diverticulum remain to be investigated. Mapping manometry may be a useful tool in the cases with suspected segmental esophageal dysmotility including diverticulum, even though the conventional manometry shows normal finding.
Ji Soon Sin,Su Youn Yim,Yeon Kyung Lee,Chul Kyu Kim,Byung Guk Kim,Sun Bo Shim,Seung Wan Jee,Su Hae Lee,Chang Jun Bae,Jong-Min Woo,Sang Seop Kim,Mi Kyong Jang,Jung Sik Cho,Sung Man Kim,Chung Yeol Lee,K 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.3
Selenium and selenoprotein are tightly associated with the protective and antioxidant effects against damage induced by various metal ions in the kidney. Many effects of these kidney damage and stress are mediated by the mitogen-activated protein kinase signaling pathways. To investigate whether selenium treatment and selenoprotein M overexpression would impact on the mitogen-activated protein kinase pathway in the kidney, we detected the phosphorylation level of major components involving p38 kinase, c-jun N-terminal kinase and extracellular signaling-regulated kinase in the transgenic rat overexpressing human selenoprotein M gene. At first, western blot analysis showed that transgenic rats used in this study had the highly expression level of selenoprotein M in the kidney tissue, respectively. The phosphorylation level of p38 kinase was slightly increased in the wild-type rats of selenium-treated group, while did not change in the transgenic rats. Also, the phosphorylation level of c-jun N-terminal kinase was very similar with the change patterns of p38 kinase. Especially, extracellular signaling-regulated kinase was significantly inhibited in the selenium-treatment group. Furthermore, this inhibition rate of extracellular signaling-regulated kinase was stimulated by selenium M overexpression in the transgenic rats. These results suggest that the overexpression of selenoprotein M could effectively influenced the kidney cell proliferation, differentiation and apoptosis through the inhibition of extracellular signaling-regulated kinase in the kidney tissue of transgenic rat.