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Hyeong Ho Jo,Eun Young Kim,Jin Tae Jung,Joong Goo Kwon,Eun Soo Kim,Hyun Seok Lee,Yoo Jin Lee,Kyeong Ok Kim,Byung Ik Jang 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.2
Background/Aims: The diagnosis of intestinal tuberculosis (ITB) is often challenging. Therapeutic anti-tubercular trial (TATT) issometimes used for the diagnosis of ITB. We aimed to evaluate the changing pattern of fecal calprotectin (FC) levels during TATT inpatients with ITB. Methods: A retrospective review was performed on the data of 39 patients who underwent TATT between September 2015 andNovember 2018 in five university hospitals in Daegu, South Korea. The analysis was performed for 33 patients with serial FCmeasurement reports. Results: The mean age of the participants was 48.8 years. The final diagnosis of ITB was confirmed in 30 patients based on completemucosal healing on follow-up colonoscopy performed after 2 months of TATT. Before starting TATT, the mean FC level of the ITBpatients was 170.2 μg/g (range, 11.5-646.5). It dropped to 25.4 μg/g (range, 11.5-75.3) and then 23.3 μg/g (range, 11.5-172.2) afterone and two months of TATT, respectively. The difference in mean FC before and one month after TATT was statistically significant(p<0.001), and FC levels decreased to below 100 μg/g in all patients after one month of TATT. Conclusions: All ITB patients showed FC decline after only 1 month of TATT, and this finding correlated with complete mucosalhealing in the follow-up colonoscopy after 2 months of TATT.
Jo Hyeong Ho,Kim Nayoung,Oh Hyeon Jeong,Song Du Hyun,Choi Yonghoon,Park Jaehyung,Lee Jongchan,Yoon Hyuk,Shin Cheol Min,Park Young Soo,Lee Dong Ho,Lee Hye Seung,Park Young Suk,Ahn Sang-Hoon,Suh Yun-Suh 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.5
Background/Aims: There are few reports regarding mixed carcinoma, defined as a mixture of glandular and poorly cohesive components, in patients with gastric cancer (GC). The aim of this study was to evaluate the proportion and characteristics of mixed carcinoma in GC patients. Methods: A total of 7,215 patients diagnosed with GC at Seoul National University Bundang Hospital were enrolled from March 2011 to February 2020. GC was divided into four groups (wellmoderately differentiated GC, poorly differentiated GC, poorly cohesive carcinoma, and mixed carcinoma). The proportion of each GC type and the clinicopathological features were analyzed and divided into early GC and advanced GC. Results: The proportion of mixed carcinoma was 10.9% (n=787). In early GC, submucosal invasion was the most common in poorly differentiated (53.7%), and mixed carcinoma ranked second (41.1%). Mixed carcinoma showed the highest proportion of lymph node metastasis in early GC (23.0%) and advanced GC (78.3%). In advanced GC, the rate of distant metastasis was 3.6% and 3.9% in well-moderately differentiated GC and mixed carcinoma, respectively, lower than that in poorly differentiated GC (6.4%) and poorly cohesive carcinoma (5.7%), without statistical significance. Conclusions: Mixed carcinoma was associated with lymph node metastasis compared to other histological GC subtypes. And it showed relatively common submucosal invasion in early GC, but the rates of venous invasion and distant metastasis were lower in advanced GC. Further research is needed to uncover the mechanism underlying these characteristics of mixed carcinoma (Trial registration number: NCT04973631).
Jo Hyeong Ho,Kim Nayoung,Jang Jieun,Choi Yonghoon,Park Jaehyung,Park Young Mi,Ahn Soyeon,Yoon Hyuk,Shin Cheol Min,Park Young Soo,Lee Dong Ho,Oh Hyeon Jeong,Lee Hye Seung,Park Young Suk,Ahn Sang-Hoon,S 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2
Background/Aims: The incidence and prognosis of gastric cancer (GC) shows sex difference. This study aimed to evaluate the effect of body mass index (BMI) on GC survival depending on sex. Methods: The sex, age, location, histology, TNM stages, BMI, and survival were analyzed in GC patients from May 2003 to February 2020 at the Seoul National University Bundang Hospital. Results: Among 14,688 patients, there were twice as many males (66.6%) as females (33.4%). However, under age 40 years, females (8.6%) were more prevalent than males (3.1%). Cardia GC in males showed a U-shaped distribution for underweight (9.6%), normal (6.4%), overweight (6.1%), obesity (5.6%), and severe obesity (9.3%) but not in females (p=0.003). Females showed decreased proportion of diffuse-type GC regarding BMI (underweight [59.9%], normal [56.8%], overweight [49.5%], obesity [44.8%], and severe obesity [41.7%]), but males did not (p<0.001). Both sexes had the worst prognosis in the underweight group (p<0.001), and the higher BMI, the better prognosis in males, but not females. Sex differences in prognosis according to BMI tended to be more prominent in males than in females in subgroup analysis of TNM stages I, II, and III and the operative treatment group. Conclusions: GC-specific survival was affected by BMI in a sex-dependent manner. These differences may be related to genetic, and environmental, hormonal factors; body composition; and muscle mass (Trial registration number: NCT04973631).
조지형 ( Jo Ji Hyeong ),장민화 ( Jang Min Hwa ),조영준 ( Jo Yeong Jun ),박선희 ( Park Seon Hui ),조동규 ( Jo Dong Gyu ),김성호 ( Kim Seong Ho ),황중하 ( Hwang Jung Ha ),조규향 ( Jo Gyu Hyang ),도준영 ( Do Jun Yeong ),윤경우 ( Yun 대한내과학회 2003 대한내과학회지 Vol.65 No.4
목적: 학교, 군, 직장 등에서 집단 신체검사가 의무적으로 행해지면서 우리 나라에서 무증상 요 이상은 임상에서 흔히 접할 수 있는 질환임에도 아직 이에 대한 임상 및 조직 병리학적 소견에 관한 연구는 부족한 상태이다. 저자들은 무증상 요 이상을 주소로 내원한 환자들의 임상양상 및 신 생검을 통한 병리학적 소견을 조사하여 이전의 보고들과 비교 분석하고자 하였다. 방법: 1998년 1월부터 2002년 7월까지 대구지역 3개 종합병원에 무증상 요 이상을 주소 Background: Asymptomatic urinary abnormalities are one of the most frequent abnormalities in clinical nephrology. However, there are few large-scaled studies about the clinical manifestations and the pathologic findings of the disease. The aim of present
조형호 ( Hyeong Ho Jo ),강선미 ( Sun Mi Kang ),김시혜 ( Si Hye Kim ),라모니 ( Moni Ra ),박병규 ( Byeong Kyu Park ),권중구 ( Joong Goo Kwon ),김은영 ( Eun Young Kim ),정진태 ( Jin Tae Jung ),김호각 ( Ho Gak Kim ),류헌모 ( Hun Mo Ry 대한소화기학회 2016 대한소화기학회지 Vol.68 No.1
In adults, most intussusceptions develop from a lesion, usually a benign or malignant neoplasm, and can occur at any site in the gastrointestinal tract. Intussusception in the proximal gastrointestinal tract is uncommon, and gastro-gastric intussusception is extremely rare. We present a case of gastro-gastric intussusception secondary to a primary gastric lymphoma. An 82-year-old female patient presented with acute onset chest pain and vomiting. Abdominal CT revealed a gastro-gastric intussusception. We performed upper gastrointestinal endoscopy, revealing a large gastric mass invaginated into the gastric lumen and distorting the distal stomach. Uncomplicated gastric reposition was achieved with endoscopy of the distal stomach. Histological evaluation of the gastric mass revealed a diffuse large B cell lymphoma that was treated with chemotherapy. (Korean J Gastroenterol 2016;68:40-44)
임신과 동반된 급성백혈병과 골수이형성증후군 증례보고 4예
김조영 ( Kim Jo Yeong ),조진호 ( Jo Jin Ho ),장성운 ( Jang Seong Un ),김현철 ( Kim Hyeon Cheol ),강석호 ( Kang Seog Ho ),조형준 ( Jo Hyeong Jun ),이경미 ( Lee Gyeong Mi ),은미나 ( Eun Mi Na ),정상근 ( Jeong Sang Geun ),김윤아 ( Ki 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.5
We have reviewed the medical records of 4 pregnant patients with concomitant acute leukemia at our institution in conjunction with determining the delivery process in order to reduce complications associated with the delivery. Of the 4 patients, three cases were diagnosed as acute leukemia and the other as myelodysplastic syndrome. One experienced an incomplete abortion at gestational age of 10 weeks, after remission induction chemotherapy. The remaining three patients made delivery at full term by Cesarean section. Our observation indicated that Cesarean delivery was advisable for these three patients. Most of the patients had thrombocytopenia or anemia. Before the Cesarean section or dilatation or evacuation, transfusion was undertaken to prevent hemorrhage or severe anemia. In the cases of refractoriness to blood transfusion, a greater amount was transfused. After Cesarean section, some complications were reported such as fever, delayed wound repair, and vaginal bleeding. Based on the our observations, we are of the opinion that pregnant women with acute leukemia or myelodysplastic syndrome can be managed even in those cases where the state of leukemia is not in complete remission or chemotherapy-induced cytopenia is. And the proper measures are timely undertaken to prevent complications associated with delivery.