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Ziliang Li,Boyu Qin,Xiaoguang Qi,Jingtao Mao,Dan Wu 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.10
Isoalantolactone possessed various biological activities. However, whether it could treat breast cancer and its underlying mechanism remained largely unknown. This study was designed to evaluate the anticancer effects of isoalantolactoneonbreastcancerandexploredthemolecular mechanism.Twohumanbreastcancercelllines(MDA-MB231 and MCF-7) and one normal breast cellline (MCF-10A) were applied. Our data suggested that isoalantolactone decreased breast cancer cell viability in a dose-dependent manner, but showed almost no toxicity to MCF-10A cells. Theanticancereffectsofisoalantolactonewererelatedtothe overexpression of reactive oxygen species. Isoalantolactone significantly induced breast cancer cell apoptosis byactivating caspase cascade, cleaving poly (ADP-ribose) polymerase. Increase of Bax/Bcl-2 ratio, depolarization of mitochondrial membrane potential, release of cytochrome c from mitochondria to cytoplasm and cell cycle arrest at G2/ M phase were associated to the apoptosis induction. Additionally,isoalantolactoneincreasedtheproteinexpressionof p38 MAPK and JNK. The apoptosis-induction of isoalantolactone could be abrogated by co-treatment with SB203580 (inhibitor of p38 MAPK) or SP600125 (inhibitor of JNK). Furthermore, isoalantolactone induced breast cancer cells apoptosis in a caspase-independent pathway, which was downregulation of SIRT1. Therefore, isoalantolactone may serve as a chemotherapeutic agent for the treatment of human breast cancer.
Lu Jingtao,Zhu Chengkun,Li Xin 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.5
With the continuous increase of electric multiple unit (EMU) train service life, the train will be out of operation, but there are still some parts on the train can work normally. When EMU trains operate in regenerative braking state, a large amount of energy will be returned to the traction grid. In this paper, the decommissioned train equipment is selected, and the energy conversion method is considered, and a new regenerative braking energy recovery and utilization method is proposed, which is composed of decommissioned power converters, traction motors and vortex spring energy storage devices using mechanical elastic energy storage. And the energy storage system is constructed by feasibility analysis. This method provides a new idea for the reuse of retired equipment.
Simultaneous optimization of water and heat exchange networks
Zhiyou Chen,Jingtao Wang,Yanlong Hou,Xiaoduan Li 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.4
This paper focuses on the simultaneous optimization of the heat-integrated water allocation networks. Amathematic model is established to illustrate the modified state-space representation of this problem. An easy logicalmethod is employed to help identify the streams of hot or cold ones. In this model, the water exchange networks (WEN),heat exchange networks (HEN), and the interactions between the WEN and HEN combine together as one unity. Thus,the whole network can be solved at one time, which enhances the possibility to get a global optimal result. Examplesfrom the literature and a PVC plant are analyzed to illustrate the accuracy and applicability of this method.
Yu Fang,Yanqing Li,Xin Liao,Jie Deng,Qiannan Wang,Jingtao Liang,Bohua Yan 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.12
Depression, a prevalent psychiatric disorder, presents a serious health risk to humans. Increasing evidencesuggested that the gut microbiota and the 5-hydroxytryptamine (5-HT) pathway both contribute significantly to depression. This research aimed to investigate how Corydalis yanhusuo polysaccharides (CYP) could potentially alleviate depressioninduced by chronic unpredictable mild stress in mice, as well as its underlying mechanism. The sucrose preference test, tailsuspension test, and forced swimming test were employed to evaluate the behavior of mice. Enzyme-linked immunosorbentassay and PCR techniques were utilized to measure depression-related factors (dopamine [DA], 5-HT, norepinephrine [NE],brain-derived neurotrophic factor [BDNF], tryptophan hydroxylase 2 [TPH-2], 5-hydroxytryptophan [5-HTP], and tryptophanhydroxylase [TPH-1] levels). Hematoxylin and eosin staining and Nissl staining were conducted to observe histopathologicalchanges in the hippocampus, the differences in the diversity of gut flora between groups were analyzed using 16S rRNAsequencing, and gas chromatography–mass spectrometry metabolomics was utilized to evaluate short-chain fatty acid (SCFA)concentrations. The findings indicated that CYP treatment increased the sucrose preference index, decreased the immobilitytime, and improved neuropathological injury. In depressed mice, CYP improved the dysregulation of the gut microbiota, andincreased the SCFA levels. In addition, CYP enhanced the DA, 5-HT, NE, BDNF, and TPH-2 levels in the brain and theexpression of 5-HTP and TPH-1 in the colon, while SCFAs were positively correlated with these levels. In summary, ourstudy suggested that CYP may mitigate depression by ameliorating gut microbiota dysregulation, promoting the generation ofSCFAs, and activation of 5-HT signaling expression.
Study on the performance of different discharging devices of a continuous production system
Zhenya Duan,Jie Wang,Shujie Sun,Wenchen Li,Haodong Zhang,Guoyue Qiao,Junmei Zhang,Jingtao Wang 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.4
Based on the developed continuous production system of sodium phenol carboxylation reaction, severaltypes of discharging devices are proposed, which are suitable for the case where the transported particles are not easyto maintain a stable state in the transported fluid. Numerical simulations of the gas-solid two-phase flow characteristicsand particle distribution were performed with DPM, and the particle retention ratio and fluid loss degree were proposedto investigate the performance of the discharging devices. The results of simulations and industrial experimentsshowed that a guide plate installed in the “B” discharging device can solve the accumulation problem, realize the efficientand continuous delivery of the particles, and maintain a uniform distribution of particles. This study can providea reference for the design of a gas-solid two-phase discharging device, and guide the industrial experimental operationand modification of continuous production systems for sodium phenol carboxylation.
Single-Point Grinding of Alumina and Zirconia Ceramics Under Two-Dimensional Compressive Prestress
Gaofeng Zhang,Zhigang Wang,Wenxin Chen,Jingtao Li,Hao Sun,Kui Zhang 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.1
In this study, single-point grinding experiments were performed on alumina and zirconia ceramics to investigate the grinding processes under two-dimensional compressive prestress (TCP). Grinding forces and grooves were measured under different values of TCP to evaluate the grinding defects. The material removal rate and actual grinding depth were exploited to investigate the grinding-induced damage and material
Yu-Ying Liu,Wentao Yang,Shaohua Shi,Ya-Jie Li,Liang Zhao,Chunwei Shi,Fangyu Zhou,Yanlong Jiang,Jingtao Hu,Wei Gu,Gui-Lian Yang,Chun-feng Wang 대한수의학회 2017 Journal of Veterinary Science Vol.18 No.2
Goose parvovirus (GPV) continues to be a threat to goose farms and has significant economic effects on the production of geese. Current commercially available vaccines only rarely prevent GPV infection. In our study, Lactobacillus (L.) plantarum NC8 was selected as a vector to express the VP2 gene of GPV, and recombinant L. plantarum pSIP409-VP2/NC8 was successfully constructed. The molecular weight of the expressed recombinant protein was approximately 70 kDa. Mice were immunized with a 2 × 109 colony-forming unit/200 mL dose of the recombinant L. plantarum strain, and the ratios and numbers of CD11c+, CD3+CD4+, CD3+CD8+, and interferon gamma- and tumor necrosis factor alpha-expressing spleen lymphocytes in the pSIP409-VP2/NC8 group were higher than those in the control groups. In addition, we assessed the capacity of L. plantarum SIP409-VP2/NC8 to induce secretory IgA production. We conclude that administered pSIP409-VP2/NC8 leads to relatively extensive cellular responses. This study provides information on GPV infection and offers a clear framework of options available for GPV control strategies.
The role of CTNNB1 and LEF1 in feather follicles development of Anser cygnoides and Anser anser
Yue Sun,Yuxuan Zhou,Petunia Msuthwana,Jing Liu,Chang Liu,Cornelius Tlotliso Sello,Yupu Song,Ziqiang Feng,Shengyi Li,Wei Yang,Yunpeng Xu,Xiaomin Yan,Chuanghang Li,Yujian Sui,Jingtao Hu,Yongfeng Sun 한국유전학회 2020 Genes & Genomics Vol.42 No.7
Background Wingless-types/beta-catenin (Wnt/β-catenin) signaling pathway is one of the most extensively studied transcriptional cascades involved in various types of organogenesis including embryonic and postnatal development. Downy feather quantity is primarily affected by follicular development and gene regulations. Objective This research was aimed to investigate the role of catenin beta-1(CTNNB1) and lymphoid enhancerbinding factor-1 (LEF1) on feather follicles development at different developmental stages. Methods Fluorescence quantitative PCR, Western-blot and immunohistochemical methods were used in Anser cygnoides and Anser anser embryos (E12, E13 E18, and E28) and after birth gosling stages (G18, G48, G88) for gene expression analysis. Results CTNNB1 and LEF1 genes were expressed in Anser cygnoides and Anser anser at different embryonic and after-birth gosling developmental stages and the expression levels were significantly different in different stages (p < 0.05). The mRNA expression of CTNNB1 and LEF1 genes reached the highest level at D88 in Anser cygnoides, while the highest expression levels were at D18 and D88 in Anser anser, and the expression levels of CTNNB1 genes at D88 in all embryonic stages were significantly lower than after-birth stages. CTNNB1 and LEF1 protein expression were the highest at E12 and E28 for Anser cygnoides feather follicles development. While at a similar stage for Anser anser, the expression of CTNNB1 and LEF1 protein was the highest at D48 and D18. Protein expression at embryonic stages was in the epidermis (E) and the hair basal plate (P), the expression site for after-birth stages was in the dermal papilla (DP). Conclusion Our study illustrated that CTNNB1 and LEF1 has an impact on Anser cygnoides and Anser anser feather follicles growth and development.