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FNC inhibits non-small cell lung cancer by activating the mitochondrial apoptosis pathway
Jing Xiang,Niu Shuai,Liang Yi,Chen Huiping,Wang Ning,Peng Youmei,Ma Fang,Yue Wanying,Wang Qingduan,Chang Junbiao,Zhang Yi,Zhang Yan 한국유전학회 2022 Genes & Genomics Vol.44 No.1
Background: Previously, we published that 4'-azid-2'-deoxy-2'-fluorarabinoside (FNC), a novel cytosine nucleoside analog, has good anti-viral and anti-tumor activity. Objective: This study aimed to further explore the role and molecular mechanism of FNC in non-small cell lung cancer (NSCLC). Methods: FNC was tested in the NSCLC H460 cell line, the Lewis mouse model, and the H460 cell xenograft model. The effects of FNC were assessed by cell viability, transwell migration, and wound scratch analyses of cell migration and invasion. Apoptosis was assessed by flow cytometry. Proteins expression was assessed by western blot and immunohistochemistry staining (IHC). Results: FNC inhibits the proliferation and metastasis of H460 cells in a time- and dose-dependent manner. FNC treatment showed efficacy and low toxicity in the Lewis mouse lung cancer model as well as in the H460 cell xenograft model. Further, FNC induced H460 cell apoptosis through the activation of the mitochondrial pathway. Notably, FNC inhibited invasion by increasing E-cadherin protein and reducing the protein expression of VEGF, MMP-2, MMP-9, and CD31. Conclusion: FNC inhibits NSCLC by activating the mitochondrial apoptosis pathway and regulating the expressions of multiple proteins related to cell adhesion and invasion, highlighting its potential as an NSCLC therapeutic.
Jing Yi-Yang,He Biao,Yang Xiang-Yu,Ma Zhi-Min 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.1
Based on the exact analytical method, this paper calculates the no-load back electromotive force, air gap fux density, cogging torque, and electromagnetic torque of outer rotor wheel-hub permanent magnet synchronous motor (PMSM); the calculation results are in good agreement with those of the fnite element method, which verifes the accuracy of the exact analytical method for solving the outer rotor PMSM. On this basis, the second-generation non-dominated sorting genetic algorithm (NSGA-II) is applied to optimize the multiple structural parameters and performance of the motor more quickly. Compared with the initial scheme of the motor, the torque ripple and permanent magnet mass of the optimized scheme is decreased by a quarter; the average electromagnetic torque, efciency is also improved. Finally, the simulation and experimental results show that the proposed method is reasonable and efective.
( Jing Yi ),( Bin Dong ),( Yong Gang Xue ),( Ning Li ),( Peng Gao ),( Yu Xin Zhao ),( Ling Ling Dai ),( Xiao Hu Dai ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.2
Microbial community shifts, associated with performance data, were investigated in an anaerobic batch digester treating high-solid food waste under mesophilic conditions using, a combination of molecular techniques and chemical analysis methods. The batch process was successfully operated with an organic removal efficiency of 44.5% associated with a biogas yield of 0.82 L/g VSremoval. Microbial community structures were examined by denaturing gel gradient electrophoresis. Clostridium and Symbiobacterium organisms were suggested to be mainly responsible for the organic matter catabolism in hydrolysis and acidogenesis reactions. The dynamics of archaeal and methanogenic populations were monitored using real-time PCR targeting 16S rRNA genes. Methanosarcina was the predominant methanogen, suggesting that the methanogenesis took place mainly via an aceticlastic pathway. Hydrogenotrophic methanogens were also supported in high-solid anaerobic digestion of food waste through syntrophism with syntrophic bacterium. Microbial community shifts showed good agreement with the performance parameters in anaerobic digestion, implying the possibility of diagnosing a high-solid anaerobic digestion process by monitoring microbial community shifts. On the other hand, the batch results could be relevant to the start-up period of a continuous system and could also provide useful information to set up a continuous operation.
Jing-Lei Zhao,Xu Chen,Gui-Lin She,Yan Jing,Ru-Qing Bai,Jin Yi,Hua-Yan Pu,Jun Luo 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.43 No.6
This paper presents an investigation on the free vibration characteristics of functionally graded nanocomposite double-beams reinforced by single-walled carbon nanotubes (SWCNTs). The double-beams coupled by an interlayer spring, resting on the elastic foundation with a linear layer and shear layer, and is simply supported in thermal environments. The SWCNTs gradient distributed in the thickness direction of the beam forms different reinforcement patterns. The materials properties of the functionally graded carbon nanotube-reinforced composites (FG-CNTRC) are estimated by rule of mixture. The first order shear deformation theory and Euler-Lagrange variational principle are employed to derive the motion equations incorporating the thermal effects. The vibration characteristics under several patterns of reinforcement are presented and discussed. We conducted a series of studies aimed at revealing the effects of the spring stiffness, environment temperature, thickness ratios and carbon nanotube volume fraction on the nature frequency.
Jing-yi Cheng,Lin Yang,Wei-kang Yuan,Xiang-li Long 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.5
The simultaneous scrubbing of NO and SO2 can be accomplished by hexamminecobalt(II) solution. Activated carbon acts as a catalyst to regenerate hexamminecobalt(II), Co(NH3)62+, to sustain the NO removal efficiency. In this paper, ZnCl2 solution has been used to ameliorate the catalytic performance of coconut activated carbon in the regeneration of Co(NH3)62+. The effects of the modification condition on the catalytic performance of activated carbon have been investigated in a batch stirred cell. The change of the surface chemical characteristics of the activated carbon caused by ZnCl2 treatment was measured by determining the concentrations of acidic and basic groups as well as their points of zero charge (pHpzc)with Boehm titration and mass titration. The alteration of the surface physical characteristics of the carbons was determined with an ASAP2000 Surface Analyzer using N2 as the adsorbate. The experiments demonstrate that the catalytic performance of the coconut activated carbon may be improved when the carbon is treated by ZnCl2 solution with concentration above 0.30 mol l1. The best ZnCl2 concentration may be 0.50 mol l1. The optimal impregnation duration is 9 h. High activation temperature is propitious for the amelioration of the catalytic capability of carbon. 4 h may be the best time for the activation of activated carbon. In our experiment, the NO removal efficiency is maintained at a level of 73% when the regeneration of Co(NH3)62+ is under the catalysis of modified carbon while that is 57% with the regeneration of Co(NH3)62+ catalyzed by original carbon. It can be concluded that such modification can improve the catalytic performance of coconut activated carbon in the simultaneous removal of SO2 and NO with Co(NH3)62+ ammonia solution.
Fault Detection Based on Graph Model for Dead Zone of Steam Turbine Control Valve
Yi-Jing Zhang,Ye Yuan,Li-Sheng Hu 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.8
The abnormal control valve dead zone in the steam turbine causes system oscillation severely, affecting the stable power generation of the power plant. In this study, a graph model is developed, and it can not only detect multiple faults at a time but also reduce the dependence on statistics. The graph topology of the steam turbine is built, including the process nodes and fault node indicating process variables and valve dead zone. Moreover, the graph convolution operation is conducted to classify the faulty and normal conditions. As a result, the simulation and experimental examples demonstrate that the accuracy of dead zone detection reaches 90% and 89% respectively, surpassing Multilayer Perceptron and Principal Component Analysis. The high-precision dead zone detection rate ensures that the method can be effectively applied to industry and improve economic benefits and operation safety.
Children`s Acquisition of Demonstrative Pronouns in Mandarin Chinese
( Yi Jing Zhao ) 한국언어정보학회 2007 학술대회 논문집 Vol.2007 No.-
This paper investigates children``s comprehension and production of demonstrative pronouns (DPs), ``zhege`` (this) and ``nage`` (that), in Mandarin Chinese. Subjects are children of ages three, four, five and six. Based on the results of the present experiment, children``s developmental stages and the corresponding age grading are provided. Also, the present study incorporates a physical clue into the experiment. The result suggests that in the acquisition of deixis children rely highly on physical context to work out the meaning distinction. In addition, Piaget``s egocentrism hypothesis and H. Clark``s marking hypothesis are examined in the study. The result seems to support the egocentrism hypothesis. Subjects under the age of six do fail to shift the deictic center when they and the experimenter have a different perspective. As for the marking hypothesis, the study seems to challenge the hypothesis. The result shows that children actually performed better on the marked term ``zhege`` than the unmarked member ``nage``.