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마진열,이남헌,황대선,하혜경,유영법,신현규,Ma, Jin-Yeul,Lee, Nam-Hun,Huang, Dae-Sun,Ha, Hye-Kyung,Yu, Young-Beob,Shin, Hyun-Kyoo 대한한의학방제학회 2008 大韓韓醫學方劑學會誌 Vol.16 No.1
Objectives : This study was to assessment the toxicity of Sipjeondaebo-tang(Shiquan dabu-decoction) by micronucleus test. Methods : Sipjeondaebo-tang(Shiquan dabu-decoction) water-extract in vivo micronucleus test was performed using 7 weeks ICR mice. At 24 hours after with Sipjeondaebo-tang extract at the doses of 0, 500, 1000 and 2000 mg/kg/day by peritoneal route mice were sacrificed and bone marrow cells were prepared for smear slides. Results : As a result of counting the micronucleus polychromate erythrocyte of 2000 polychromate erythrocyte, all treatment groups did not show statistically significant increase than negative control group. and there was no clinical sign and body weight connected with injection of Sipjeondaebo-tang(Shiquan dabu-decoction) extract. Conclusions: It was concluded that Sipjeondaebo-tang extract did not induce micronucleus in the bone marrow cells of ICR mice
양격산화탕(凉膈散火湯) 추출액이 ICR mouse에서의경구 투여 급성독성에 미치는 영향
마진열,황대선,서창섭,이시우,김종열,신현규,Ma, Jin-Yeul,Huang, Dae-Sun,Seo, Chang-Seob,Lee, Si-Woo,Kim, Jong-Yeol,Shin, Hyeun-Kyoo 사상체질의학회 2009 사상체질의학회지 Vol.21 No.3
1. Objectives: The aim of this study is data analysis for acute toxicity and safety of Yangkyuksanhwa-tang. 2. Methods: We investigated the acute toxicity for water-extracted Yangkyuksanhwa-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Yangkyuksanhwa-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg. 3. Results: We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions: The data confirmed that Yangkyuksanhwa-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 mg/kg). In conclusion, LD50 of Yangkyuksanhwa-tang was over 5000 mg/kg and it is very safe to mice.
Mouse(ICR)에 있어서 시험물질 열다한소탕(熱多寒少湯) 추출액의 급성독성 시험
마진열,황대선,이시우,김종열,신현규,Ma, Jin-Yeul,Huang, Dae-Sun,Lee, Si-Woo,Kim, Jong-Yeol,Shin, Hyeun-Kyoo 사상체질의학회 2009 사상체질의학회지 Vol.21 No.1
1. Objectives This study was designed to andyze the acute toxicity and safety of Yeoldahanso-tang 2. Methods We investigated the acute toxicity for water-extracted Yeoldahanso-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Yeoldahanso-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg. 3. Results We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions The data confirmed that Yeoldahanso-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 mg/kg). In conclusion, LD50 of Yeoldahanso-tang was over 5000 mg/kg and it is very safe to mice.
태음조위탕(太陰調胃湯) 추출액이 ICR mouse에서의 경구 투여 급성독성에 미치는 영향
마진열,황대선,서창섭,이시우,김종열,신현규,Ma, Jin-Yeul,Huang, Dae-Sun,Seo, Chang-Seob,Lee, Si-Woo,Kim, Jong-Yeol,Shin, Hyeun-Kyoo 사상체질의학회 2010 사상체질의학회지 Vol.22 No.2
1. Objectives: The aim of this study is to investigate the acute toxicity and safety of Taeeumjowi-tang. 2. Methods: We investigated the acute toxicity for water-extracted Taeeumjowi-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Taeeumjowi-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg. 3. Results: We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions: The data confirmed that Taeeumjowi-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 mg/kg). In conclusion, LD50 of Taeeumjowi-tang was over 5000 mg/kg and it is very safe to mice.
SD 랫트를 이용하여 四君子湯의 아급성 독성에 관한 연구
마진열(Ma Jin-Yeul),유영법(Yu Young-Beob),하혜경(Ha Hye-Kyung),황대선(Huang Dae-Sun),신현규(Shin Hyun-Kyoo) 한국한의학연구원 2007 한국한의학연구원논문집 Vol.13 No.3
Sagunja-tang(Sijunzi-tang) has been traditionally prescribed as a restorative. The present study was undertaken to determine the possible toxic effects of Sagunja-tang on SD rats. In this study, we investigated the subacute toxicity of water-extracted Sagunja-tang(Sijunzi-tang) on SD rats. Twenty rats were orally adiministered Sagunja-tang for 28 days at a dose of 0 ㎎/㎏(control group) or 1500㎎/㎏(treated group), respectively. All of subjects was survived. No significant difference in abnormal clinical signs, related to hematological values, serum biochemical values, water and feed intake, coagulation time, autopsy analysis, organ weight, tissue microscopically, funduscopy, urine intake and urinalysis, was detected. Compared with the control group, we could not find any subacute toxic alteration in treated group (l500㎎/㎏) for 28 days. This result suggests that Sagunja-tang(Sijunzi-tang), a herbal medicine prescription, is a safe prescription to body.