알레르기 ; 알레르기 환자에서 한방 이외의 대체 요법의 사용 현황에 대한 다기관 조사

이현정 ( Hyun Jung Lee ),이재현 ( Jae Hyun Lee ),이용원 ( Yong Won Lee ),김철우 ( Cheol Woo Kim ),동헌종 ( Hun Jong Dhong ),박해심 ( Hae Sim Park ),조영주 ( Young Joo Cho ),조진희 ( Jin Hee Cho ),조상헌 ( Sang Heon Cho ),편복양 ( 대한내과학회 2011 대한내과학회지 Vol.80 No.1

목적: 한국에서 알레르기 질환 치료를 위한 한방 치료뿐만 아니라 대체 요법이 많이 이용되고 있으며, 그 현황에 대하여 다기관 조사를 시행하였다. 방법: 10개의 대학병원 외래로 내원한 647명의 알레르기 환자를 대상으로 설문조사를 시행하였으며, 이 중 510명이 한방 이외의 대체 요법에 응답하였다. 이환되어 있는 알레르기 질환은 천식(50.0%), 알레르기 비염(36.0%), 아토피 피부염(36.0%), 그리고 두드러기(9.3%)였다. 각각 환자들에게 12 문항의 설문조사를 시행하였으며, 한방 이외의 대체 요법의 사용 빈도 및 종류, 대체 요법에 의지하게 된 이유, 비용, 그리고 치료효과에 대한 의견을 물어 보았다. 결과: 16.7%의 알레르기 환자에서 한방 이외의 다른 대체 요법을 받았으며, 평균 1.6종의 한방 이외의 대체 요법을 받았다. 가장 많이 의지하는 대체 요법은 민간 식이요법 (48.6%)이었고, 그 다음이 아로마 요법(23.8%), 지압(14.3%), 건강 호흡법(7.6%), 마인드 컨트롤(5.7%), 목욕요법(5.7%) 순이었다. 대체 요법을 받은 환자 중 마인드 컨트롤(50%), 식이요법(50%), 그리고 건강 호흡법(75%)의 경우 치료 효과가 만족스럽다는 응답이 높았으며, 목욕요법, 아로마 요법, 그리고 지압은 만족도가 각각 33.3%, 28.0%, 26.7%로 저조하였다. 대체 요법 사용자의 63.6%가 5회 미만의 대체 요법을 받았고, 91.8%가 1년 이내로 치료받았으며, 1인당 평균 연 37 만원을 지출하였다. 대체 요법을 선택한 가장 큰 이유는 체질이 개선될 수 있을까 해서(44.2%)였으며, 대체 요법이 몸에 부담이 없어서(31.4%), 면역기능이 강화되어서(22.9%) 순으로 나타났고, 15.7%는 양약치료가 도움이 되지 않아서 대체 요법을 선택하였다고 응답하였다. 결론: 한국에서 알레르기 환자의 상당수가 한방뿐만 아니라 여러 가지의 대체 요법을 사용하고 있음을 알 수 있었다. 대체 요법의 사용 빈도가 증가하고 그 종류가 다양함을 고려할 때, 의료진은 대체 요법의 현황에 대하여 정확히 인지하고 이에 대해 관심을 가지고 환자를 대하여야 하며 올바른 알레르기 질환 치료법에 대해 환자뿐만 아니라 의료인에게 교육하는 것이 필요하다. Background/Aims: The use of unproven complementary/alternative medicine (CAM) to treat allergies is popular in Korea. We conducted a multicenter survey of the current use of CAM other than herbal medication in Korean allergy patients. Methods: This study enrolled 510 adults with allergic diseases, including asthma, allergic rhinitis, atopic dermatitis, and chronic urticaria, from ten hospitals. They underwent a structured questionnaire interview and clinical assessment of the prevalence, motivation, costs, and subjective assessment of CAM. Results: Of the patients, 16.7% used at least one type of CAM to treat their allergic diseases. Common types of CAM were diet (48.6%), aroma therapy (23.8%), massage (14.3%), breathing exercises (7.6%), baths (5.7%), and mind control (5.7%). The therapeutic effects of CAM included improved in patients using mind control (50%), diet (50%), breathing exercises (75%), and baths (33.3%), but worse in patients using aroma therapy (28%), and massage (26.7%). About 36.4% of the patients used CAM more than four times per year, and the average cost per CAM user was 370,000 won/year. The main reason for trying CAM was `hope to improve my constitution`. Conclusions: CAM is used widely for treating allergic diseases in Korea. Detailed knowledge of CAM and patient education are important. Further studies of the clinical efficacy of CAM are needed. (Korean J Med 2011;80:68-77)

원-달러 선물계약과 NDF계약의 헤징효율성 비교

윤원철 ( Won Cheol Yun ),안현진 ( Hyun Jin An ) 한국파생상품학회 2004 선물연구 Vol.12 No.2

Inducement of Chondrogenic Differentiation in Injectable Hydrogels Embedded in Mouse Embryonic Stem Cells and Growth Factor for

( Won Woo Lee ),( Ji Sun Park ),( Hyun Jin Do ),( Dae Gyun Woo ),( Han Na Yang ),( Jae Hwan Kim ),( Keun Hong Park ) 한국조직공학과 재생의학회 2008 조직공학과 재생의학 Vol.5 No.1

Injectable hydrogel with growth factor was fabricated and investigated as a delivery vehicle of mouse embryonic stem cells(mES) for neocartilage formation. To determine the optimal growth factor in injectable hydrogel, we evaluated the GAG/DNA assay, RT-PCR analysis, and histology. GAG/DNA assay showed that TGF-β 3 enhanced the secretion of GAG content and proliferated well comparing to without TGF-β 3. RT-PCR results for the resultant cartilage tissue revealed that p(NiPAAm-co-AAc) hydrogels with TGF-β 3 was optimal for cartilage tissue formation in terms of collagen Type II and COMP gene expression and showed the results of histology and immunochemical histology.

Increased cell survival rate using attenuated baculovirus without virulence

Hyun Soo Kim,Won Seok Gwak,Jun Su Bae,Tae Hee Kim,Jin Yong Lee,Cheol June Choi,Young Kim,Soo Dong Woo 한국응용곤충학회 2019 한국응용곤충학회 학술대회논문집 Vol.2019 No.10

A Study of the Physical and Chemical Properties of Aerosols Generated by Laser Metal Cutting

Hyun Jin Boo,Hwa Jeong Han,Jonghyeon Kim,Su Hyeon Lee,Su Hyeon Kim,Byung Gi Park,Min-Ho Lee,Hee Kwon Ku,Dae-Won Cho 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.2

When decommissioning a nuclear power plant, the structure must be made to a disposable size. In general, the cutting process is essential when dismantling a nuclear power plant. Mainly, thermal cutting method is used to cutting metal structures. The aerosols generated during thermal cutting have a size distribution of less than 1 μm. The contaminated structures are able to generate radioactive aerosols in the decommissioning. Radioactive aerosols of 1 μm or less are deposited in the respiratory tract by workers’ breathing, causing the possibility of internal exposure. Therefore, workers must be protected from the risk of exposure to radioactive aerosols. Prior knowledge of aerosols generated during metal cutting is important to ensure worker safety. In this study, the physical and chemical properties of the aerosol were evaluated by measuring the number and mass concentrations of aerosols generated when cutting SUS304 and SA508 using the laser cutting method. High-resolution aerosol measuring equipment (HR-ELPI+, DEKATI) was used to measure the concentration of aerosols. The HR-ELPI+ is an impactor-type aerosol measuring equipment that measures the aerosol number concentration distribution in the aerodynamic diameter range of 6 nm to 10 um in real-time. And analyze the mass concentration of the aerosol according to the diameter range through the impactor. ICP-MS was used for elemental mass concentration analysis in the aerosol. Analytical elements were Fe, Cr, Ni and Mn. For the evaluation of physical and chemical properties, the MMAD of each element and CMAD were calculated in the aerosol distribution. Under the same cutting conditions, it was confirmed that the number concentration of aerosols generated from both materials had a uni-modal distribution with a peak around 0.1 um. CMAD was calculated to be 0.072 um for both SUS304 and SA508. The trend of the CMAD calculation results is the same even when the cutting conditions are changed. In the case of MMAD, it was confirmed that SUS304 had an MMAD of around 0.1 μm in size for only Fe, Cr and Mn. And SA508, Fe, Cr, Ni and Mn were all confirmed to have MMAD around 0.1 μm in size. The results of this study show that a lot of aerosols in the range of less than 1 μm, especially around 0.1 μm in size, are generated when metal is cut using laser cutting. Therefore, in order to protect the internal exposure of workers to laser metal cutting when decommissioning NPPs, it is necessary to protect from nano-sized aerosols beyond micron size.

Early Detection of Asymptomatic Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus

( Won Sang Yoo ),( Hee Jin Kim ),( Do Hee Kim ),( Myung Yong Lee ),( Hyun Kyung Chung ) 대한내과학회 2009 The Korean Journal of Internal Medicine Vol.24 No.3

Background/Aims: In type 2 diabetic patients, coronary artery disease (CAD) is usually detected at an advanced stage due to a lack of symptoms. The aim of this study was to define which clinical parameters or noninvasive tests predict CAD in asymptomatic type 2 diabetic patients. Methods: One hundred fourteen asymptomatic type 2 diabetic patients were divided into two groups based on the number of cardiovascular disease (CVD) risk factors (group A ≥2, group B ≤1). Treadmill exercise ECG tests (TMT) were conducted in all cases, and coronary artery angiography was performed on TMT-positive patients. Clinical parameters, diabetic status, and coronary angiographic findings were analyzed. Results: The prevalence of CAD was 41.0% in group A and 16.7% in group B. The number of risk factors was significantly correlated with the prevalence of CAD, but not with the severity of CAD. Multivariate analysis showed that family history of CAD (odds ratio [OR]=9.41; 95% confidence interval [CI], 1.60-55.49) and diabetes duration ≥10 years (OR=3.28; 95% CI, 1.29-8.84) were independent CAD risk factors in asymptomatic patients. Conclusions: We recommend a routine screening for CAD in type 2 diabetic patients who have a longer (≥10 years) diabetic duration or a family history of CAD, even if they are asymptomatic for CAD. (Korean J Intern Med 2009;24:183-189)

Diesel Engine Exhaust and Occupational Lung Cancer

Jin-Ha Yoon(윤진하),So-Young Park,Boowook Kim,Hyun-Seok Kwag,Won-Jeong Lee,Byung-Soon Choi 대한직업환경의학회 2012 대한직업환경의학회 학술대회 논문집 Vol.2012 No.11

TSE Amplification between Wild Type Mouse by PMCA

Hyun Joo Sohn,Yoon Hee Lee,Min Jeong Kim,Hyo Jin Kim,Won Young Lee,Kyung Je Park,In Soon Roh,In Soo Cho 대한수의학회 2013 대한수의학회 학술대회발표집 Vol.2013 No.-

Parkin Interacts with the PDZ Domain of Multi-PDZ Domain Protein MUPP1

Won Hee Jang(장원희),Young Joo Jeong(정영주),Sun Hee Choi(최선희),Won Hee Lee(이원희),Mooseong Kim(김무성),Sang-Jin Kim(김상진),Sang-Hwa Urm(엄상화),Il Soo Moon(문일수),Dae-Hyun Seog(석대현) 한국생명과학회 2014 생명과학회지 Vol.24 No.8

세포표면 수용체와 통로가 적절히 기능하려면 특정 세포 내 위치로 배치되고 조절되어야 한다. PSD95/Dlg/Zo-1 (PDZ) 도메인은 이러한 배치와 조절을 매개하는 다양한 단백질들을 인식하고 이 단백질들이 서로 결합하는데 관여한다. MUPP1은 13개의 PDZ domain을 가지는 단백질로서 여러 구조 단백질 및 신호전달 단백질과 상호결합하지만, MUPP1이 어떻게 안정화되며, 어떻게 신호전달과정에 관여하는지에 대해 아직 명확히 밝혀지지 않았다. 본 연구에서 MUPP1의 PDZ 도메인과 상호 작용하는 단백질을 규명하기 위하여 효모 two-hybrid 방법을 이용하였고, Parkin이 MUPP1과 결합하는 것을 확인하였다. Parkin은 E3 ubiquitin ligase로서, Parkin 유전자의 기능상실 돌연변이는 autosomal recessive juvenile parkinsonism을 일으키는 것으로 알려져 있다. Parkin은 MUPP1의 12번째 PDZ domain과 결합하지만, 다른 PDZ 도메인과는 결합하지 않았다. Parkin의 C-말단부위는 II 형 PDZ-결합모티프를 가지고 있는데, 이 모티프가 MUPP1과의 결합에 필수적임을 확인하였다. HEK-293T 세포에 MUPP1과 Parkin을 동시에 발현하여 발현위치를 확인한 결과 세포내의 같은 위치에서 발현하였다. 또한 Parkin은 MUPP1을 강하게 유비퀴틴화 하였다. 이러한 결과들은 MUPP1이 Parkin의 기질이며, Parkin에 의한 유비퀴틴화에 의해 MUPP1의 기능 혹은 안정성이 조절될 수 있음을 시사한다. The localization to specific subcellular sites and the regulation of cell surface receptors and channels are crucial for proper functioning. Postsynaptic density-95/Disks large/Zonula occludens-1 (PDZ)-domain is involved in recognition of and interaction between various proteins, by which the localization and the regulation are mediated. Multi-PDZ domain protein 1 (MUPP1) contains 13 PDZ domains. MUPP1 serves a scaffolding function for structure proteins and signaling proteins, but the mechanism how MUPP1 is stabilized and signalized has not yet been elucidated. We used the yeast two-hybrid system to identify proteins that interact with PDZ domains of MUPP1. We found an interaction between MUPP1 and Parkin. Parkin is an E3 ubiquitin ligase. Loss-of-function mutations of Parkin gene are known to cause an autosomal recessive juvenile parkinsonism. Parkin bound to the 12th PDZ domain, but not to other PDZ domains of MUPP1. The C-terminal end of Parkin has a type II PDZ-association motif, which was essential for the interaction with MUPP1 in the yeast two-hybrid assay. When co-expressed in HEK-293T cells, Parkin co-localized with MUPP1. When co-expressed with ubiquitin in HEK-293T cells, MUPP1 has been strongly ubiquitinated by Parkin. These findings collectively suggest that MUPP1 is a novel substrate of Parkin and its function or stability could be modulated by Parkin-mediated ubiquitination.

Iridium Complexes Containing Bis(imidazoline thione) and Bis(imidazoline selone) Ligands for Visible-Light-Induced Oxidative Coupling of Benzylamines to Imines

Jin, Jaewon,Shin, Hee-Won,Park, Joon Hyun,Park, Ji Hoon,Kim, Eunchul,Ahn, Tae Kyu,Ryu, Do Hyun,Son, Seung Uk American Chemical Society 2013 Organometallics Vol.32 No.14

<P>Novel iridium(III) complexes containing bis(N-heterocyclic carbene), bis(imidazoline thione) <B>L2</B>, and bis(imidazoline selone) <B>L3</B> were prepared. The iridium complexes bearing <B>L2</B> and <B>L3</B> showed the significant absorption of visible light with maximum intensity at ∼460 nm. Bis(2-(2′-benzothienyl)pyridinato)iridium(III) complexes (<B>Ir-6</B>) with <B>L3</B> showed excellent ability as a photosensitizer of visible light. Under blue LED irradiation with maximum emission at 460 nm, 0.25 mol % <B>Ir-6</B> showed 94% conversion of benzylamine for 5 h at room temperature. Through mechanistic studies, it was suggested that the photoinduced oxidative coupling of benzylamine by <B>Ir-6</B> follows a singlet oxygen pathway. The excellent performance of <B>Ir-6</B> originated from the efficient visible light absorption at 460 nm and the enhanced triplet state due to the heavy-atom effect of <B>L3</B>. This work shows that bis(imidazoline thione) and bis(imidazoline selone) can be efficient ligands for tuning the optical properties of iridium(III) complexes.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orgnd7/2013/orgnd7.2013.32.issue-14/om4004412/production/images/medium/om-2013-004412_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/om4004412'>ACS Electronic Supporting Info</A></P>