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알레르기 환자에서 한방 이외의 대체 요법의 사용 현황에 대한 다기관 조사
이현정 ( Hyun Jung Lee ),이재현 ( Jae Hyun Lee ),이용원 ( Yong Won Lee ),김철우 ( Cheol Woo Kim ),동헌종 ( Hun Jong Dhong ),박해심 ( Hae Sim Park ),조영주 ( Young Joo Cho ),조진희 ( Jin Hee Cho ),조상헌 ( Sang Heon Cho ),편복양 ( 대한내과학회 2011 대한내과학회지 Vol.80 No.1
Background/Aims: The use of unproven complementary/alternative medicine (CAM) to treat allergies is popular in Korea. We conducted a multicenter survey of the current use of CAM other than herbal medication in Korean allergy patients. Methods: This study enrolled 510 adults with allergic diseases, including asthma, allergic rhinitis, atopic dermatitis, and chronic urticaria, from ten hospitals. They underwent a structured questionnaire interview and clinical assessment of the prevalence, motivation, costs, and subjective assessment of CAM. Results: Of the patients, 16.7% used at least one type of CAM to treat their allergic diseases. Common types of CAM were diet (48.6%), aroma therapy (23.8%), massage (14.3%), breathing exercises (7.6%), baths (5.7%), and mind control (5.7%). The therapeutic effects of CAM included improved in patients using mind control (50%), diet (50%), breathing exercises (75%), and baths (33.3%), but worse in patients using aroma therapy (28%), and massage (26.7%). About 36.4% of the patients used CAM more than four times per year, and the average cost per CAM user was 370,000 won/year. The main reason for trying CAM was `hope to improve my constitution`. Conclusions: CAM is used widely for treating allergic diseases in Korea. Detailed knowledge of CAM and patient education are important. Further studies of the clinical efficacy of CAM are needed. (Korean J Med 2011;80:68-77)
( Hyun-woong Cho ),( Yung-taek Ouh ),( Kyu-min Lee ),( Sung Won Han ),( Jae Kwan Lee ),( Geum Jun Cho ),( Jin Hwa Hong ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: By identifying pregnancy-related risk factors for endometrial neoplasia, womens risk of developing this disease after childbirth can be predicted and high-risk women can be screened for early detection. Methods: Study data from women who gave birth in 2007 in Korea were collected from the Korea National Health Insurance (KNHI) claims database between 2007 and 2015. The adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the development of endometrial neoplasia were estimated by multivariate Cox proportional hazards models. Results: Data from 386,614 women were collected in this study. By 2015, of these, 3,370 were diagnosed with endometrial neoplasia from delivery. Multivariate Cox proportional hazards regression revealed that preeclampsia (HR 1.55, 95% CI 1.29-1.86), old age (HR 1.52, 95% CI 1.39-1.66), multiple pregnancy (HR 1.81, 95% CI 1.46-2.23), multiparity (HR 1.16, 95% CI 1.08-1.24), cesarean section (HR 1.15, 95% CI 1.07-1.23) and large for gestational age (HR 1.19, 95% CI 1.02-1.39) were independent risk factors for endometrial neoplasia. The risk for endometrial neoplasia increased as the number of risk factors increased (risk factors3: HR 2.11, 95% CI 1.86-2.40). Conclusion: This study showed that six pregnancy-related factorsold age, multiparity, multiple pregnancy, cesarean section, large for gestational age and preeclampsiaare positively correlated with future development of endometrial neoplasia including endometrial hyperplasia or cancer. Close observation and surveillance are warranted for the early diagnosis of endometrial diseases including endometrial cancer after pregnancy in high-risk women.
Jin, Hyun-Seok,Hong, Kyung-Won,Lim, Ji-Eun,Han, Hye-Ree,Lee, Jong-Young,Park, Hun-Kuk,Oh, Berm-Seok Korea Genome Organization 2008 Genomics & informatics Vol.6 No.3
Blood pressure refers to the force exerted by circulating blood on the walls of blood vessels, and chronical elevation of blood pressure is known as hypertension. Although hypertension is affected by genetic and environmental factors, the genetic background of hypertension is not fully understood. One of the candidate genetic factors, Prostaglandin-endoperoxide synthase 2 (PTGS2), is a membrane-bound enzyme, catalyzing the conversion of arachidonic acid to prostaglandin, and recently SNPs of PTGS2 gene was associated with hypertension in Japanese population. Therefore the association of PTGS2 polymorphisms was investigated with blood pressure in healthy Korean subjects, 470 unrelated individuals randomly selected from Ansung and Ansan cohorts. The 25 SNPs of PTGS2 gene were identified by the sequencing analysis of 24 Korean samples. Among identified polymorphisms, three SNPs (rs689466, -1329A>G; rs5275, +6365T>C; rs4648308, +8806G> A) were selected for further association analysis, and rs689466 located in promoter region was associated with blood pressure as well as triglyceride level in the blood. By in silico analysis, rs689466 locates in v-Myb transcription factor binding site, and the v-Myb site disappears when the SNP is changed from A to G nucleotide. Individuals with A/G and G/G genotype in rs689466 have higher blood pressure than those with A/A genotype, and the regression p-value is 0.008 for systolic and 0.004 for diastolic blood pressure. In summary, the PTGS2 polymorphism (rs689466) is associated with blood pressure in Asian populations based on this and Japanese studies, shedding light on it as a genetic risk marker of hypertension.
A case of malignant nodular hidradenoma on the scalp
( Hyun Ji Kang ),( Woo Jin Lee ),( Sungeun Chang ),( Mi Woo Lee ),( Jee Ho Choi ),( Chong Hyun Won ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Malignant nodular hidradenoma , also known as hidradenocarcinoma, is a rare, highly malignant tumor of the eccrine sweat glands. We report a case of a malignant nodular hidradenoma in a 53-year-old woman, who had a 3-year history of enlarging mass on the scalp. Histopathologically, tumor had irregular shape and asymmetrical architecture, showing high cellularity and marked cytologic atypia. We diagnosed malignant nodular hidradenoma based on histopathology. Before she came to our clinic, she had had a surgical excision at other clinic. However, 1 month after the surgery, we diagnosed a recurrence though punch skin biopsy. She had a second wide excision and remaining lesion was removed. There has been no evidence of recurrence or metastasis after the second excision.
( Jin-sung Yuk ),( Won I. Park ),( Jung Hun Lee ),( Hyeong Sik Ahn ),( Hyun Jung Kim ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: The purpose of this study was to compare treatment success rates, side effects rates and time to resolution between single-dose protocol and non-single-dose protocol (multi-dose protocol and two-dose protocol) of methotrexate (MTX) in treatment of ectopic pregnancy (EP) using randomized controlled trials (RCTs). 방법: We searched MEDLINE, EMBASE, SCOPUS, Web of Science, the Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, International Clinical Trials Registry Platform and EU Clinical Trials Register. The relative risk (RR) and 95% confidence intervals (CIs) were used for calculating dichotomous outcomes, while mean difference (MD) and 95% CIs were used for calculating continuous outcomes. 결과: We selected 9 RCTs among total 1521 articles. The success rate of single-dose protocol was similar to that of non-single-dose protocol in treating EP [RR (95% CI): 1.02 (0.98~1.06; 9 trials, 891 patients), I2=0%]. Although non-single-dose protocol tended to have a higher side effects compared to single-dose protocol, there was no significant difference in both group, [RR (95% CI): 0.76 (0.58~1.01; 7 trials, 704 patients), I2=12%]. However, in subgroup analysis about tubal pregnancy, non-single dose protocol appeared to have a higher side effects rate than single-dose protocol [RR (95% CI): 0.69 (0.51~0.93; 3 trials, 369 patients), I2=0%]. Single-dose protocol had longer resolution time than non-single-dose protocol [MD (95% CI): 4.5 (0.40~8.60; 5 trials, 528 patients), I2=83%]. 결론: Single-dose protocol has similar success rates to non-single-dose protocol in treating EP, and tends to lower side effects rate than non-single- dose protocol. Also, in treating tubal pregnancy, single-dose protocol has lower side effects rate than non-single-dose protocol. However, single- dose protocol has longer resolution time than non-single-dose protocol.