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Triterpenoids and Diarylheptanoids from Alnus hirsuta Inhibit HIF-1 in AGS Cells
WenYi Jin,Xing Fu Cai,나민균,이정준,배기환 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.4
Bioassay-guided fractionation and purification of the EtOAc soluble fraction from the MeOH extract of the stem bark of Alnus hirsuta (Betulaceae), using an in vitro HIF-1 assay, led to the isolation of four triterpenoids (1-4) and six diarylheptanoids (5-10). Their structures were determined by comparison with the physicochemical and spectroscopic data in the literature. These compounds were investigated for their effects on the hypoxia-induced HIF-1 activation using an HIF-1a mediated reporter gene assay in AGS cells. Among them, two diarylheptanoids, 2- oxatrycyclo[13.2.2.13,7]eicosa-3,5,7(20),15,17,18-hexaen-10-16-diol (6) and 2-oxatrycyclo [13.2.2.13,7]eicosa-3,5,7-(20),15,17,18-hexaen-10-one (7), inhibited HIF-1 activation dosedependently with IC50 values of 11.2 µM and 12.3 µM, respectively. These two compounds had no significant cytotoxicity to the AGS cells at the effective concentration for the inhibition of HIF-1 activation.
Isolation of Constituents and Anti-complement Activity from Acer okamotoanum
WenYi Jin,JongPill Lee,Phuong Thien Thuong,이형규,송경식,성연희,배기환,민병선 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.2
A novel acylated sterol glucoside (1) along with four known compounds, β-amyrin acetate (2), 3β,24-dihydroxytaraxer-14-ene (3), cleomiscosin A (4), and cleomiscosin C (5), were isolated from the leaf and twig of Acer okamotoanum Nakai (Aceraceae). The structure of the new compound was determined to be β-sitosterol glucoside-3'-O-hexacosanoicate based on chemical and spectroscopic analyses. In addition, the novel compound was found to exhibit a significant inhibitory effect (IC50 value of 0.2 µM) on the complement system activated by the classical pathway.
Cytotoxic Anthraquinones and Stilbenes from Reynoutria sachalinensis (Fr. Schm.) Nakai
Jin, Wenyi,Na, Min-Kyun,Song, Gyu-Yong,Lee, Young-Mi,Bae, Ki-Hwan The Korean Society of Medicinal Crop Science 2005 한국약용작물학회지 Vol.13 No.2
Five known anthraquinones, physcion (1), I-O-methylemodin (2), emodin (3), $physcion-8-O-{\beta},-D-glucopyranoside$ (5), $emodin-8-O-{\beta},-D-glucopyranoside$ (6) and two known stilbenes, trans-resveratrol (4), $trans-resveratrol-3-O-{\beta},-D-glucopyranoside$ (7) were isolated from MeOH extract of Reynoutria sachalinensis (Polygonaceae). All structures were unambiguously established by 1D and 2D NMR and MS data and the compounds were evaluated for their cytotoxicity against L1210, HL-60, BI6F10 tumor cell lines in MTT assay. Among the compounds, trans-resveratrol (4) exhibited significant cytotoxic activity with $IC_{50}$ values of 9.2, 6.7 and $9.8\;{\mu}g/ml$, against the test cell lines respectively, but compounds 1-3 exhibited the moderate cytotoxic activity.
Antioxidant Activity of Cleomiscosins A and C Isolated from Acer okamotoanum
Jin, Wenyi,Thuong, Phuong Thien,Su, Nguyen Duy,Min, Byung-Sun,Son, Kun-Ho,Chang, Hyeun-Wook,Kim, Hyun-Pyo,Kang, Sam-Sik,Sok, Sok,Bae, Ki-Hwan 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.3
Phytochemical investigation of Acer okamotoanum leaf and twig led to the isolation of two coumarinolignans, cleomiscosin A (1) and cleomiscosin C (2). Here, we found that 2 dose-dependently inhibits LDL oxidation mediated by either catalytic copper ions (Cu$^{2+}$) or free radicals generated with the azo compound 2,2'-azobis-(2-amidinopropane)dihydro-chloride (AAPH)with IC$_{50}$s of 29.5 and 11.9 ${\mu}$M, respectively. By electrophoretic analysis, we also observed that 2 protects apolipoprotein B-100 (apoB-100) against Cu$^{2+}$-induced fragmentation (65.3% inhibition at 5 ${\mu}$M). Furthermore, fluorescence analyses clearly indicated that both 4 and 2 protect against the oxidative modification of apoB-100 induced by either Cu$^{2+}$or HOCI (1, IC$_{50}$s of 13.4and 8.1 ${\mu}$M, respectively; 2, IC$_{50}$s of 23.6 and 3.9 ${\mu}$M, respectively). These findings suggest that 1 and 2 could be beneficial in preventing LDL oxidation in atherosclerotic lesions.
Cytotoxic Anthraquinones and Stilbenes from Reynoutria sachalinensis (Fr. Schm.) Nakai
Wenyi Jin,Min-Kyun Na,Gyu-Yong Song,Young-Mi Lee,Ki-Hwan Bae 한국약용작물학회 2005 한국약용작물학회지 Vol.13 No.2
Five known anthraquinones, physcion (1), I-O-methylemodin (2), emodin (3), physcion-8-O-β,-D-glucopyranoside (5), emodin-8-O-β,-D-glucopyranoside (6) and two known stilbenes, trans-resveratrol (4), trans-resveratrol-3-O-β,-D-glucopyranoside (7) were isolated from MeOH extract of Reynoutria sachalinensis (Polygonaceae). All structures were unambiguously established by 1D and 2D NMR and MS data and the compounds were evaluated for their cytotoxicity against L1210, HL-60, BI6F10 tumor cell lines in MTT assay. Among the compounds, trans-resveratrol (4) exhibited significant cytotoxic activity with IC50 values of 9.2, 6.7 and 9.8 μg/ml, against the test cell lines respectively, but compounds 1-3 exhibited the moderate cytotoxic activity.
Cytotoxic and COX-2 Inhibitory Constituents from the Aerial Parts of Aralia cordata
이익수,WenYi Jin,Xinfeng Zhang,Tran Manh Hung,송경식,성연희,배기환 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.7
Three diterpenes (1, 8, and 9), three triterpenes (3, 4, and 7), one saponin (11), four sterols (2, 5, 6, and 12), and one cerebroside (10) were isolated from the EtOH extract of the aerial parts of Aralia cordata by repeated silica gel column chromatography. Their chemical structures were identified by comparing their physicochemical and spectral data with those published in literatures. All isolated compounds were evaluated for their cytotoxicity against L1210, K562, and LLC tumor cell lines using MTT assay. Of which, 3β,5α-dihydroxy-6β-methoxyergosta- 7,22-diene (6) showed a potent cytotoxicity against all cell lines with IC50 values of 11.7, 11.9, and 15.1 µM, respectively, while compounds 1, 5, and 11 showed a moderate or weak cytotoxicity. These isolates were also examined for their inhibitory activity against COX-1 and COX-2. Although most compounds, except for 2, 10, and 12, showed a strong inhibitory activity against COX-1, they exhibited a moderate or weak inhibitory activity against COX-2.
Bo Li,Wenyi Lv,Chunde Li,Jiongxian Yang,Jiajia Chen,Jin Feng,Li Chen,Zhenyu Ma,Youqi Li,Jiayi Wang,Yanwei Liu,Yanong Li,Shuai Liu,Shiqi Luo,Xiaoguang Qiu 대한암학회 2020 Cancer Research and Treatment Vol.52 No.4
Purpose Whether craniospinal irradiation (CSI) could be replaced by limited-field radiation in non-metastatic bifocal germinoma remains controversial. We addressed the issue based on the data from our series and the literature. Materials and Methods Data from 49 patients diagnosed with non-metastatic bifocal germinoma at our hospital during the last 10 years were collected. The Pediatric Quality of Life Inventory 4.0 was used to evaluate health-related quality of life (HRQOL). Additionally, 81 patients identified from the literature were also analyzed independently. Results In our cohort, 34 patients had tumors in the sellar/suprasellar (S/SS) plus pineal gland (PG) regions and 15 in the S/SS plus basal ganglia/thalamus (BG/T) regions. The median follow-up period was 52 months (range, 10 to 134 months). Our survival analysis showed that patients treated with CSI (n=12) or whole-brain radiotherapy (WBRT; n=34) had comparable disease-free survival (DFS; p=0.540), but better DFS than those treated with focal radiotherapy (FR; n=3, p=0.016). All 81 patients from the literature had tumors in the S/SS+PG regions. Relapses were documented in 4/45 patients treated with FR, 2/17 treated with whole-ventricle irradiation, 0/4 treated with WBRT, and 1/15 treated with CSI. Survival analysis did not reveal DFS differences between the types of radiation field (p=0.785). HRQOL analysis (n=44) in our cohort found that, compared with S/SS+PG germinoma, patients with BG/T involvement had significantly lower scores in social and school domains. However, HRQOL difference between patients treated with CSI and those not treated with CSI was not significant. Conclusion In patients with non-metastatic bifocal germinoma, it is rational that CSI could be replaced by limited-field radiation. HRQOL in patients with BG/T involvement was poorer.
Zheng, Mingshan,Jin, Wenyi,Son, Kun-Ho,Chang, Hyeun-Wook,Kim, Hyun-Pyo,Bae, Ki-Hwan,Kang, Sam-Sik The Korean Society of Medicinal Crop Science 2005 한국약용작물학회지 Vol.13 No.2
Five coumarins, psoralen (1), scopoletin (2), isoimperatorin (4), (+)-marmesin (5) and xanthotoxin (6), three chromones, cimifugin (3), hamaudol (7) and sec-O-glucosylhamaudol (10), one sterol, daucosterol (8) and one aliphatic alcohol, galactitol (9) were isolated from the root of Peucedanum japonicum. Their chemical structures were identified by the physicochemical and spectroscopic data by comparing literature values. Among them, compounds 9 and 10 were isolated for the first time from this plant. The anti-inflammatory effects of isolated compounds were examined on cyclooxygenase (COX), compounds 1, 2 and 7 showed inhibitory activity on COX-1 with $IC_{50}$ values of 0.88, 0.27 and 0.30 mM, respectively. In the test for COX-2 activity, only compound 7 showed significant inhibitory activity with the $IC_{50}$ value of 0.57 mM. The other compounds exhibited weak inhibitory or no inhibitory activity.
Mingshan Zheng,Wenyi Jin,Kun-Ho Son,Hyeun-Wook Chang,Hyun-Pyo Kim,Ki-Hwan Bae,Sam-Sik Kang 한국약용작물학회 2005 한국약용작물학회지 Vol.13 No.2
Five coumarins, psoralen (1), scopoletin (2), isoimperatorin (4), (+)-marmesin (5) and xanthotoxin (6), three chromones, cimifugin (3), hamaudol (7) and sec-O-glucosylhamaudol (10), one sterol, daucosterol (8) and one aliphatic alcohol, galactitol (9) were isolated from the root of Peucedanum japonicum. Their chemical structures were identified by the physicochemical and spectroscopic data by comparing literature values. Among them, compounds 9 and 10 were isolated for the first time from this plant. The anti-inflammatory effects of isolated compounds were examined on cyclooxygenase (COX), compounds 1, 2 and 7 showed inhibitory activity on COX-1 with IC50 values of 0.88, 0.27 and 0.30 mM, respectively. In the test for COX-2 activity, only compound 7 showed significant inhibitory activity with the IC50 value of 0.57 mM. The other compounds exhibited weak inhibitory or no inhibitory activity.