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Inhibitory Lignans against NFAT Transcription Factor from Acanthopanax koreanum
Xing Fu Cai,Im Seon Lee,Nguyen Tien Dat,Guanghai Shen,강종성,Dong Hyun Kim,Young Ho Kim 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.7
Three lignans isolated from the roots of A. koreanum (Araliaceae), namely eleutheroside E (1), tortoside A (2), and hemiariensin (4), were evaluated for their ability to inhibit NFAT transcription factor. Of these compounds, compound 4, possessing a diarylbutane skeleton, exhibited potent inhibitory activity against NFAT transcription factor (IC50: 36.3 ± 2.5 mM). However, the activities of 1 (IC50: > 500 mM) and 2 (IC50: 136.1 ± 9.4 mM), which possess bisaryldioxabicyclooctane skeletons, were lower. As the lignan derivatives of the same skeletons, hinokinin (5) and (-)-yatein (6) with diarylbutane skeletons and (+)-syringaresinol (3) with a bisaryldioxabicyclooctane skeleton were also studied for their inhibitory effects on NFAT transcription factor.
Phytochemical Constituents from Acanthopanax divaricatus var. albeofructus
Cai, Xing Fu,Shen, Guanghai,Dat, Nguyen Tien,Lee, Eun Joo,Kim, Young Ho 충남대학교 약학대학 의약품개발연구소 2005 藥學論文集 Vol.20 No.-
Five known compounds were isolated from the methanolic extract of the roots of Acanthopanax divaricatus var. albeofructus through repeated silica gel and YMC gel column chromatography. Their chemical structures were elucidated as farnesol (1), linoleic acid (2), stigmasterol (3), (-)-sesamin (4), and falcarindiol (5) by spectroscopic analysis.
Cai, Xing-Fu,Shen, Guanghai,Dat, Nguyen-Tien,Kang, Ok-Hwa,Lee, Young-Mi,Lee, Jung-Joon,Kim, Young-Ho The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.9
Five known kaurane type diterpenoids, 16$\alpha$H, 17-isovaleryloxy-ent-kauran-19-oic acid (1), 16$\alpha$-hydroxy-17-isovaleryloxy-ent-kauran-19-oic acid (2), paniculoside-IV (3), 16$\alpha$-hydroxy-ent-kauran-19-oic acid (4), and ent-kaur-16-en-19-oic acid (5) were isolated from the root of Acanthopanax koreanum by repeated column chromatography and reversed phase preparative HPLC. The structures of these compounds were established from physicochemical and spectral data. Among the isolated compounds 16$\alpha$H, 17-isovaleryloxy-ent-kauran-19-oic acid (1) showed potent inhibitory activity ($IC_50$ value, 16.2 $\mu$ M) on TNF-$\alpha$ secretion from HMC-1, a trypsin-stimulated human leukemic mast cell line.
Triterpenoids from Acanthopanax koreanum Root and Their Inhibitory Activities on NFAT Transcription
Cai, Xing-Fu,Lee, Im-Seon,Shen, Guanghai,Dat, Nguyen-Tien,Lee, Jung-Joon,Kim, Young-Ho The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.8
Two triterpenoids (1,4) and two triterpenoid glycosides (2,3) were isolated from the root of Acanthopanax koreanum (Araliaceae). Their structures were identified as impressic acid (1), acankoreoside A (2), 3-epi-betulinic acid 28-O-[(${\alpha}-L-rhamnopyranosyl(1{\rightarrow}4)-{\beta}-D-glucopyrano-syl(1{\rightarrow}6)]-{\beta}-D-glucopyranosyl]$ ester (3), and ursolic acid (4) by physicochemical and spectro-scopic methods. Of these compounds, impressic acid (1) exhibited a potent inhibitory activity against NFAT transcription factor ($IC_{50}:{\;}12.65{\;}{\mu\textrm{m}}$).
Allergic Identification for Ginkgo Kernel Protein in Guinea Pigs
Cai-e Wu,Jian-Ting Yang,Gong-Jian Fan,Ting-Ting Li,Zhen-Xing Tang,Fu-Liang Cao 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.3
Ginkgo biloba L. can cause allergic reactions when consumed. In this paper, an allergy test to guinea pig was investigated. Guinea pigs were sensitized with 50 mg/mL of ginkgo kernel protein orally on days 1, 3, and 5, and intraperitoneally challenged with 100mg/mL of the protein on day 7 after the last sensitization. The volume of sensitization and challenge was 0.20mL/100 g weight. The results showed the average allergy grade for guinea pigs reached four and the allergy rate was 100%. The immunoglobulin G and E levels in sera were significantly higher than those in the controls. Footpads swelled distinctly, and the passive cutaneous allergy test manifested a positive response. There were inflammatory changes in the lungs and intestines. In conclusion, the present results may indicate that gingko kernel protein has an allergenic capacity.
Cytotoxic Terpenoids from the Methanolic Extract of Bridelia cambodiana
Khiev, Piseth,Cai, Xing-Fu,Chin, Young-Won,Ahn, Kyung-Seop,Lee, Hyeong-Kyu,Oh, Sei-Ryang The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.6
Bioactivity-guided isolation of Bridelia cambodiana, with a cytotoxicity assay using a small panel of cancer cell lines, led to the isolation and identification of five active compounds, 24-methyllanosta-9(11),25-dien-3${\beta}$-ol, 3-epi-glutinol, betulinic acid, ursolic acid, and maslinic acid, along with eight triterpenoids and three steroids.
Nan, Ji-Xing,Jin, Xue-Jun,Lian, Li-Hua,Cai, Xing Fu,Jiang, Ying-Zi,Jin, Hong Ri,Lee, Jung Joon Pharmaceutical Society of Japan 2008 Biological & pharmaceutical bulletin Vol.31 No.4
<P>The hepatoprotective effects of a diterpenoid acanthoic acid isolated from <I>Acanthopanax koreanum</I> N<SMALL>AKAI </SMALL>were evaluated in a <SMALL>D</SMALL>-galactosamine/lipopolysaccharide-induced fulminant hepatic failure mouse model. Mice were pretreated orally with acanthoic acid 12 and 1 h before intraperitoneal injection of <SMALL>D</SMALL>-galactosamine and lipopolysaccharide. Pretreatment with the compound markedly reduced lethal liver injury in experimental animals. The effects were likely associated with a significant decrease in serum tumor necrosis factor (TNF)-α levels, which are correlated not only with those of alanine aminotransferase and aspartate aminotransferase but also with the reduced number of apoptotic hepatocytes in the liver as confirmed using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling method and DNA fragmentation assay. These results suggest that acanthoic acid protects against <SMALL>D</SMALL>-galactosamine/lipopolysaccharide-induced fulminant liver failure at least in part by a mechanism associated with the down-regulation of TNF-α secretion.</P>