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L-Asparaginase가 Mouse의 肝細胞에 미치는 影響
鄭鎬三,李圭植,尹康默 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.1
L-asparaginase hydrolysis L-asparagine which is essential amino acid for tumor cells to produce an antitumorous effect. On the other hand, it was reported that this drug provoked cytotoxic effect following the inhibition of protein synthesis and that this was a consequence of the exhaustion of L-asparagine in the normal cell. Therefore, the authors have demonstrated the toxicity of L-asparaginase on the hepatic parenchymal cell observing with light and electron microscope: Male mice of ICR strain were used in this experiment and the weight of experimental animals was around 20gm. The animals were divided into two groups, the control and the L-asparaginase treated groups and subdivided into the 6th, 12th and 24th hours groups. L-asparaginase 2,500 I.U./kg, in the water for injection was injected intraperitoneally for the animals of L-asparaginase treatment group. The animals of control group were given water for injection only. The experimental animals were sacrificed at the 6,12 and 24 hours after an administration of L-asparaginase or water for injection. The liver specimens were stained with hematoxylin oesin, methyl green-pyronin and oil red 0 method and observed them under the light microscope. And the ultrathin sectioned specimens were stained with uranyl acetate and lead citrate and observed with the JEM 100B electron microscope. The results obtained were as follows: 1. Cellular swelling accompanied with the vesicular or vacuolar formation, reduction or disappearance of the pyroninophilic granules and fat infiltration were observed in the hepatic parenchymal cells of the L-asparaginase treated mouse. 2. Dilatation, sacculation and fragmentation of the cisternae of RER were accompanied with dissociation of membrane bound ribosomes, and proliferation of SER associated with depletion of glycogen particles were observed. And formation of numerous primary lysosomes, secondary lysosomes, autophagic vacuoles, multivesicular bodies and irregular sized lipid droplets were recognized in the hepatic parenchymal cells of the L-asparaginase treated mouse. Consequently, it is suggested that intraperitoreal injection of L-asparaginase would include the cellular degeneration of the hepatic parenchymal cells in the mouse.
함현식,강삼룡 明知大學校 産業技術硏究所 1984 産業技術硏究所論文集 Vol.3 No.-
The aims of this paper are : (1) to review the techniques to measure the metal dispersion of the supported metal catalysts, (2) to review the experimental results of sintering of supported metal catalysts, (3) to present the methods used to correlate the sintering data, and (4) to discuss the mechanistic models proposed for the sintering process. The experimental results presented will be restricted to supported Group Ⅷ metals ; the majority of the data being for platinum supported on alumina or silica.
Flavonoids from the Leaves of Polygonum Sachalinense Fr. Schm.(Ⅰ)
Sam-Sik Kang(강삼식) 한국생약학회 1981 생약학회지 Vol.12 No.4
From the leaves of Polygonum sachalinense Fr. Schm. (Polygonaceae) quercetin, mp 316∼8°, and avicularin, mp 216∼6°, [α]^D_(20)-152°, were isolated and characterized by spectral data. Both are first isolation from this plant.
Flavonols Inhibit Sortases and Sortase-Mediated <i>Staphylococcus aureus</i> Clumping to Fibrinogen
Kang, Sam Sik,Kim, Jae-Gyu,Lee, Tae-Hoon,Oh, Ki-Bong Pharmaceutical Society of Japan 2006 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.29 No.8
<P>Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. In <I>Staphylococcus aureus</I>, deletion of the sortase isoforms results in marked reduction in virulence and infection potential, making it an important antivirulence target. We examined the effects of naturally occurring flavonols on recombinant sortase A (SrtA) and B (SrtB) prepared from <I>S. aureus</I> ATCC6538p and found that these compounds inhibited the activity of sortases, without exhibiting antibacterial activities. Among the flavonols tested, morin, myricetin, and quercetin exhibited strong sortase inhibitory activities (SrtA IC<SUB>50</SUB>: 37.39—52.70 μ<SMALL>M</SMALL>, SrtB IC<SUB>50</SUB>: 8.54—36.89 μ<SMALL>M</SMALL>). The fibrinogen cell-clumping activity data highlight the potential of flavonols for the treatment of <I>S. aureus</I> infections <I>via</I> inhibition of sortase.</P>
Lathyrus Saponin, a New Trisaccharide Glycoside from Lathyrus japonicus
Kang, Sam Sik,Ahn, Byung Tae,Kim, Ju Sun,Bae, KiHwan 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-
A new triterpenoid saponin, named Lathyrus saponin (3), was isolated from the whole plant of Lathyrus japonicus Willd, together with two known saponins, azukisaponins Ⅱ (1) and Ⅴ (2), as their methyl esters. The structure of 3 was determined to be soyasapogenol B 3-O-β-D-glucopyranosyl(1-2)-β-D-glucopyranosyl(1-2)-β-D-glucuronopyranoside on the basis of physicochemical and spectroscopic methods.
Anthraquinones from the Leaves of Polygonum sachalinense
Sam-Sik Kang(강삼식),Won-Sick Woo(우원식) 한국생약학회 1982 생약학회지 Vol.13 No.1
From the leaves of Polygonum sachalinense Fr. Schm. (Polygonaceae) physcion (I) mp 205∼6°, emodin (II) mp 248∼50°, physcion-8-0-β-glycoside (III) mp 245∼6°and emodin-8-0-β-glucoside (IV) mp 186∼8°were isolated.