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21세기 대구 · 경북의 성장 동력으로서 『문화자본』의 의미
권찬태,권기정,김진수,이영기 慶北大學校出版部 2005 經商論集 Vol.32 No.2
본 연구에서는 문화자본의 의미를 바탕으로 대구 · 경북이 본래 가지고 있지만, 활용하지 못하고 있던 문화자본을 대구 · 경북 지역의 성장동력 산업으로 이끌기 위한 전체적인 방향을 제시하고자 하였다. 첫째, 대구 · 경북은 문화의 21세기에서 창조적이고 차별화된 문화자본을 축적하기 위해 지역 내 숨겨진 자원을 발굴하고, 개발해야 한다. 둘째, 사회 · 문화 주동적 성향을 토대로 창의적이고 미래지향적인 문화상품을 개발해 나가야 하고, 세계 속에 대구 · 경북을 알릴 수 있는 대표 브랜드 상품 개발에 주력해야 한다. 셋째, 풍부한 문화유산, 자연환경 등의 유 · 무형의 자원을 최대한 활용하여야 한다. 본 연구에서는 이러한 세 가지 방안의 실천을 위한 행정기관, 기업, 언론 및 교육기관에 따른 방법 또한 제시하였다. 먼저, 지역정부는 문화인프라 구축의 중요성을 인식해야한다. 다음으로, 기업은 문화자본 축적을 비용으로 생각하기보다는 투자로 생각할 수 있는 인식의 전환이 필요하다. 마지막으로, 언론 및 교육기관에서는 선진문화지역으로 도약하기 위한 지역 주민들의 자긍심과 인식이 확대될 수 있도록 도와주어야한다. This paper suggested that the role of cultural capital to be economic growth engine in Daegu and Kyungpook region. Daegu and Kyungpook's role is as followed ; The first, Daegu and Kyungpook should develop and unearth hidden cultural resources, and the second, should develop creative cultural goods based on social and cultural propensity, the third should use the tangible and intangible resources such as cultural inheritance and nature. Besides this, this paper also suggested the roles of local government, local business, local press and local educational institution in Dageu and Kyungpook region. At first, local government should recognize the importance of cultural infrasturcture, the local business needs the concept of cultural capital, and the local press and educational institution should help local citizens have the pride of local culture.
Eun Jung Lee,Zuly Jiménez,Kwang‑Hoon Seo,Gi Baeg Nam,Young‑Gyu Kang,Tae Ryong Lee,Donghyun Kim,양덕춘 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.1
Coumestrol (CMS), one of the soybean isoflavonoids which contains several benefits for maintaining skin function including antiageing properties. In this study, we evaluated various explant sources and plant genotypes to determine competent soybean adventitious root materials for the mass production of CMS, and investigated their skin care efficacies to be used as a novel cosmetic ingredient. Adventitious roots were directly induced from in vitro seedling derived from the mature seeds, extracts were prepared and refluxed for enzymatic deglycosylation. In vitro cell cytotoxicity was evaluated using normal human dermal fibroblast and murine B16 melanoma cells after treatment with increasing concentrations of methanol soybean adventitious roots extracts for 72 h. Finally, in vitro cell assays on HDF cells were performed to evaluate the effect of the soybean adventitious roots extracts in collagen production. The root induction frequency and biomass productivity were significantly affected by plant genotypes, explant sources, the type of auxin used and its concentration. The total CMS production (per 1 L medium) after 4 weeks of culture in a bulb-type bubble bioreactor (3 L capacity) was the highest in the adventitious roots induced from the radicles of Glycine max, ‘Sinhwakong’. Different strengths of Murashige and Skoog (MS) medium were tested to develop culture protocols and the highest total CMS production (per 1 L medium) was observed at 1/2 MS. The content of coumestrin, the glycoside form of CMS, was higher than that of CMS in the roots cultured in 1/2 MS medium for 4 weeks in a bioreactor. The final content of CMS in the ethanol extract after enzymatic deglycosylation was 81.3-fold higher than non-enzymatic deglycosylation. Almost all the coumestrin in the roots were converted to CMS. Further, the enriched CMS root did not exhibit any cell cytotoxicity in normal human dermal fibroblast (HDF) and murine B16 melanoma cells (B16) for 72 h. In addition, in vitro collagen production assay on HDF cells showed that the enriched CMS root increased the collagen production compared to the coumestrol, daidzein, and non-enzyme-treated sample. Thus, enriched CMS root could be potential ingredient for the cosmetic applications
Yoon, Wan-Hee,Jung, Yeon-Joo,Kim, Tae-Dong,Li, Ge,Park, Byoung-Jeon,Kim, Ji-Yeon,Lee, Young-Chul,Kim, Jim-Man,Park, Jong-Il,Park, Hae-Duck,No, Zae-Sung,Lim, Kyu,Hwang, Byung-Doo,Kim, Young-S 충남대학교 암공동연구소 2005 암공동연구소 업적집 Vol.4 No.
Gabexate mesilate (GM), a synthetic protease inhibitor, has an antiproteinase activity on various types of plasma serine proteases. However, its role on matrix metalloproteinases (MMPs) has not been identified. In this study, we investigated the effect of GM on MMPs and on the invasion and metastasis of human colon cancer cell lines and neoangiogenesis. The activities of MMPs secreted from these cells were significantly reduced by GM but unaffected by the serine protease inhibitor aprotinin. GM directly inhibited purified progelatinase A derived from T98G human glioblastoma cells. In vitro, GM significantly reduced the invasive ability of colon cancer cells but not cellular motility, whereas aprotinin affected neither. Liver metastatic ability and tumorigenic potential in nude mice were remarkably reduced on treatment with GM. Immunohistochemical analysis of GM-treated tumors in mice showed a marked increase in apoptosis and a significant reduction in tumor angiogenesis. Human umbilical vein endothelial cell proliferation, tube formation, and neoangiogenesis in the rabbit cornea and Matrigel implanted in mice were significantly inhibited by GM. These results suggest that GM is a novel inhibitor of MMPs and that it may inhibit the invasion and metastasis of human colon cancer cells by blocking MMPs and neoangiogenesis.
Yoon, Wan-Hee,Jung, Yeon-Joo,Kim, Tae-Dong,Li, Ge,Park, Byoung-Jeon,Kim, Ji-Yeon,Lee, Young-Chul,Kim, Jim-Man,Park, Jong-Il,Park, Hae-Duck,No, Zae-Sung,Lim, Kyu,Hwang, Byung-Doo,Kim, Young-S 충남대학교 암연구소 2005 암연구소 업적집 Vol.4 No.-
Gabexate mesilate (GM), a synthetic protease inhibitor, has an antiproteinase activity on various types of plasma serine proteases. However, its role on matrix metalloproteinases (MMPs) has not been identified. In this study, we investigated the effect of GM on MMPs and on the invasion and metastasis of human colon cancer cell lines and neoangiogenesis. The activities of MMPs secreted from these cells were significantly reduced by GM but unaffected by the serine protease inhibitor aprotinin. GM directly inhibited purified progelatinase A derived from T98G human glioblastoma cells. In vitro, GM significantly reduced the invasive ability of colon cancer cells but not cellular motility, whereas aprotinin affected neither. Liver metastatic ability and tumorigenic potential in nude mice were remarkably reduced on treatment with GM. Immunohistochemical analysis of GM-treated tumors in mice showed a marked increase in apoptosis and a significant reduction in tumor angiogenesis. Human umbilical vein endothelial cell proliferation, tube formation, and neoangiogenesis in the rabbit cornea and Matrigel implanted in mice were significantly inhibited by GM. These results suggest that GM is a novel inhibitor of MMPs and that it may inhibit the invasion and metastasis of human colon cancer cells by blocking MMPs and neoangiogenesis.