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Han, Sang Hoon,Kim, Saegun,De, Umasankar,Mishra, Neeraj Kumar,Park, Jihye,Sharma, Satyasheel,Kwak, Jong Hwan,Han, Sangil,Kim, Hyung Sik,Kim, In Su American Chemical Society 2016 Journal of organic chemistry Vol.81 No.24
<P>The weakly coordinating ketone group directed C-H functionalizations of chromones, 1,4-naphthoquinones, and xanthones with various maleimides under rhodium(III) catalysis are described. These protocols efficiently provide a range of succinimide-containing chromones, naphthoquinones, and xanthones with excellent site selectivity and functional group compatibility. All synthetic compounds were screened for in vitro anticancer activity against human breast adenocarcinoma cell lines (MCF-7). In particular, compounds 7aa and 7ca with a naphthoquinone scaffold were found to be highly cytotoxic, with an activity competitive with anticancer agent doxorubicin.</P>
A newborn girl with harlequin ichthyosis genetically confirmed by ABCA12 analysis
Jihye Kim,Jung Min Ko,Seung Han Shin,Ee-Kyung Kim,Han-Suk Kim 대한의학유전학회 2019 대한의학유전학회지 Vol.16 No.2
Harlequin ichthyosis (HI, OMIM #242500) is one of the most severe skin diseases among the autosomal recessive congenital ichthyoses, with high morbidity and mortality, particularly in newborns. Clinically, it is characterized by a typical appearance of generalized, thick, yellowish, hyperkeratotic plates with deep erythematous ἀssures on the skin. Herein, we present the case of a newborn girl with HI that was genetically conἀrmed by targeted gene panel analysis. The premature baby was en-cased in an opaque white membrane with erosion covering the skin of the entire body except the lips, with her hands and feet restricted by the membrane. Humidiἀcation, emollient, and retinoic acid treatment were started; the thick ichthyosis gradually peeled off and the underlying skin was only covered with thin scales. Targeted gene panel analysis using next-generation se-quencing and validation with Sanger sequencing and quantitative polymerase chain reaction analyses conἀrmed compound heterozygous mutations of the ABCA12 gene (p.N1380S and a partial gene deletion encompassing exon 9). The parents were carriers for each of the identiἀed mutations. Early recognition of the genetic etiology of congenital ichthyosis can, thus, facili-tate genetic counseling for patients and their families.
Han, Jihye,Bae, Joonbeom,Choi, Chang-Yong,Choi, Sang-Pil,Kang, Hyung-Sik,Jo, Eun-Kyeong,Park, Jongsun,Lee, Young Sik,Moon, Hyun-Seuk,Park, Chung-Gyu,Lee, Myung-Shik,Chun, Taehoon Informa UK (TaylorFrancis) 2016 AUTOPHAGY Vol.12 No.12
<P>Severe hepatic inflammation is a common cause of acute or chronic liver disease. Macrophages are one of the key mediators which regulate the progress of hepatic inflammation. Increasing evidence shows that the TAM (TYRO3, AXL and MERTK) family of RTKs (receptor tyrosine kinases), which is expressed in macrophages, alleviates inflammatory responses through a negative feedback loop. However, the functional contribution of each TAM family member to the progression of hepatic inflammation remains elusive. In this study, we explore the role of individual TAM family proteins during autophagy induction and evaluate their contribution to hepatic inflammation. Among the TAM family of RTKs, AXL (AXL receptor tyrosine kinase) only induces autophagy in macrophages after interaction with its ligand, GAS6 (growth arrest specific 6). Based on our results, autophosphorylation of 2 tyrosine residues (Tyr815 and Tyr860) in the cytoplasmic domain of AXL in mice is required for autophagy induction and AXL-mediated autophagy induction is dependent on MAPK (mitogen-activated protein kinase)14 activity. Furthermore, induction of AXL-mediated autophagy prevents CASP1 (caspase 1)-dependent IL1B (interleukin 1, ) and IL18 (interleukin 18) maturation by inhibiting NLRP3 (NLR family, pyrin domain containing 3) inflammasome activation. In agreement with these observations, axl(-/-) mice show more severe symptoms than do wild-type (Axl(+/+)) mice following acute hepatic injury induced by administration of lipopolysaccharide (LPS) or carbon tetrachloride (CCl4). Hence, GAS6-AXL signaling-mediated autophagy induction in murine macrophages ameliorates hepatic inflammatory responses by inhibiting NLRP3 inflammasome activation.</P>
JiHye Han,Hyung Joo Kim,Leeyong Song,김한성,김봉주,Dohyung Lim 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.7
The main aim of this study was to identify whether braking force applied to a stationary lead vehicle in low-speed, rear-end collisions should be considered for whiplash injury mechanism assessment and safety system development. A three-dimensional motion capture system with eight infrared cameras and a wireless surface electromyogram were used to quantify the kinematic, moment, and muscle activation characteristics of the neck joint during low-speed, rear-end collision tests. The maximum angles of the neck joint did not differ significantly during the tests with and without the applied braking force during low-speed, rear-end collisions (p > 0.05). However, the angular velocity of the neck joint with the braking force applied was higher than without the applied braking force (p < 0.05). The maximum moments of the neck joint when the braking force was applied were generally 1.4 ± 0.2 times higher than those without the braking force (p < 0.05). The muscle activations of the sternocleidomastoid and splenius capitis under braked conditions were 1.2 ± 0.1 and 1.5 ± 0.2 times higher than those without braking, respectively (p < 0.05). The results indicate that braking force applied to the stationary lead vehicle during a low-speed, rear-end collision should be considered for whiplash injury mechanism assessment and safety system development.
시각적 인터페이스 내 색상과 단어, 감정 연결을 고려한 프레임워크 연구
한지혜(Jihye Han),이상원(Sangwon Lee) 한국HCI학회 2018 한국HCI학회 학술대회 Vol.2018 No.1
시각적 인터페이스를 통한 커뮤니케이션이 일상생활에서 활발하게 이루어짐에 따라 시각적 채널을 이용한 언어적, 비언어적 정보의 처리에도 관심이 모아지고 있으며, 효과적인 메세지 전달을 위해 사용자의 감정을 목표로 한 인터페이스 구성 또한 중요성이 강조되고 있다. 이러한 사용자의 감정과 인터페이스의 구성에 관하여 그동안의 연구들은 이미지와 감정 혹은 텍스트와 감정과 같이 이차원적으로 접근되어 왔지만, 본 연구는 시각적 채널을 통해 들어오는 언어적, 비언어적 정보를 단어와 색상으로 구체화하여 단어와 색상, 감정을 함께 고려했다. 세 가지 요소의 연결에 대한 연구를 발전시키기 위해 관련된 이전 연구들을 메타분석하여 시각적 인터페이스 내의 단어와 색상, 감정에 대한 리서치 프레임 워크를 만들어 제시했다.
유아교사 대상 유튜브 동영상에 대한 유치원 교사의 인식과 요구
한지혜(Jihye Han),이승연(Seung Yeon Lee) 한국교원교육학회 2023 한국교원교육연구 Vol.40 No.2
The purpose of this study was to investigate kindergarten teachers' perceptions and demands on YouTube videos for early childhood teachers. 257 kindergarten teachers who had experience of watching YouTube videos for early childhood teachers completed a survey. The results of this study were as follows. First, compared to online teacher education programs, a key advantage of YouTube videos in terms of platform characteristics was its accessibility, while a key disadvantage was the difficulty of asking questions to the creator; a key advantage of YouTube videos in terms of content characteristics was that it could be applied directly to the practice, while a key disadvantage was that the quality of the content might not be guaranteed. Compared to off-line teacher education programs, a key advantage of YouTube videos was that the time and place could be determined freely, while a key disadvantage was the difficulty of asking questions to the creator. Second, as the demands of kindergarten teachers on YouTube videos for early childhood teachers, they preferred ‘understanding and practicing the curriculum’ as topic, kindergarten teachers as creator, and between 5 and 20 minutes as length per video. As for the support necessary for efficient watching, providing keywords to figure out the contents of the video was the most preferred. The teachers were mostly in favor of regarding YouTube videos for early childhood teachers as teacher education programs and preferred partial reflection of those. These results reveal that YouTube videos for early childhood teachers are in its early stages of sharing practical knowledge of teachers on a new platform, and suggest that active self-regulation and feedback should be preceded to improve the quality of content, prior to regarding those as part of teacher education programs.
부모 방임이 다문화청소년의 비행경험에 미치는 영향 : 우울의 매개효과를 중심으로
한지혜(Jihye Han),김경희(Kyunghee Kim) 한국교정복지학회 2020 교정복지연구 Vol.0 No.64
본 연구는 부모의 방임과 다문화청소년의 비행경험의 관계에서 우울의 매개효과를 검증하는데 목적이 있다. 이를 위해 2015년도에 실시된 다문화청소년 종단조사를 통해 수집된 중학교 2학년 1,348명의 자료를 분석하였다. 연구결과 부모방임이 다문화청소년의 우울과 비행 모두 영향을 미치는 것으로 나타났고, 다문화청소년의 우울이 높을수록 비행 확률을 높이는 것으로 나타났다. 부모의 방임이 다문화청소년의 비행에 미치는 영향에 있어서 우울은 매개역할을 하였다. 본 연구 결과는 다문화청소년의 비행을 낮추기 위해 필요한 접근방법에서 부모의 방임 뿐만 아니라 우울에 대한 관심을 가지는 것이 필요함을 시사한다. The purpose of this study is to examine the mediating effect of depression between neglect of parents and delinquency experience of multicultural adolescents. A cross-sectional data from the study of Multicultural Adolescents, which is conducted by National Youth Policy Institute in 2015, were used. The study examined a nationally representative sample of 1,348 multicultural adolescents including middle school students(2 grade). The results showed that parents neglect affects both depression and delinquency of multicultural adolescents, and the higher the depression of multicultural adolescents, the higher the probability of delinquency. Furthermore, depression mediated the parents neglect and delinquency among multicultural adolescents. This study suggests that it is necessary to pay attention to depression as well as parents neglect in the approach necessary to reduce delinquency of multicultural adolescents.