1-Kestose Blocks UVB-Induced Skin Inflammation and Promotes Type I Procollagen Synthesis via Regulating MAPK/AP-1, NF-κB and TGF-β/Smad Pathway

Jihye Baek,Jong-Hwa Kim,Jiwon Park,Do Hyun Kim,Soonok Sa,Jung-Sook Han,Wonyong Kim The Korean Society for Microbiology and Biotechnol 2024 Journal of microbiology and biotechnology Vol.34 No.4

Solar UVB irradiation cause skin photoaging by inducing the high expression of matrix metalloproteinase (MMPs) to inhibit the expression of Type1 procollagen synthesis. 1-Kestose, a natural trisaccharide, has been indicated to show a cytoprotective role in UVB radiation-induced-HaCaT cells. However, few studies have confirmed the anti-aging effects. In the present study, we evaluated the anti-photoaging and pathological mechanism of 1-kestose using Human keratinocytes (HaCaT) cells. The results found that 1-kestose pretreatment remarkably reduced UVB-generated reactive oxygen species (ROS) accumulation in HaCaT cells. 1-Kestose suppressed UVB radiation-induced MMPs expressions by blocking MAPK/AP-1 and NF-κB p65 translocation. 1-Kestose pretreatment increased Type 1 procollagen gene expression levels by activating TGF-β/Smad signaling pathway. Taken together, our results demonstrate that 1-kestose may serve as a potent natural trisaccharide for inflammation and photoaging prevention.

Potential Anti-Allergy and Immunomodulatory Properties of Lactococcus lactis LB 1022 Observed In Vitro and in an Atopic Dermatitis Mouse Model

Baek Jihye,Kim Jong-Hwa,Kim Wonyong 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.6

Lactococcus lactis is a lactic acid bacterium and used in the dairy food industry. The ameliorating effects of Lactobacillus species on atopic dermatitis (AD) have been extensively studied, but the specific effect of L. lactis strains has not yet been investigated. In this study, the efficacy of L. lactis LB 1022, isolated from natural cheese, was evaluated using RAW 264.7, HMC-1 and HaCaT cell lines and an ovalbumin-sensitized AD mouse model. L. lactis LB 1022 exhibited nitric oxide suppression and anti-allergy and anti-inflammatory activity in vitro. Oral administration of L. lactis LB 1022 to AD mice significantly reduced the levels of IgE, mast cells, and eosinophils, and a range of T cell-mediated T helper Th1, Th2, and Th17-type cytokines under interleukin (IL)-10, transforming growth factor-β (TGF-β), thymus and activation-regulated chemokine (TARC), and thymic stromal lymphopoietin (TSLP). In addition, L. lactis LB 1022 treatment increased the concentration of short-chain fatty acids. Overall, L. lactis LB 1022 significantly modulated AD-like symptoms by altering metabolites and the immune response, illustrating its potential as candidate for use in functional food supplements to alleviate AD.

Development of Reverse-transcription Loop-mediated Isothermal Amplification (RT–LAMP) Assay for Specific Detection of Foodborne Viruses

Jihye BAEK,Yunkyeong YEOM,Yeong-Hyeock KIM,Tae Jung PARK 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.10

노년기 사회적 고립과 외로움: 미국의 대응책과 시사점

백지혜 ( Baek Jihye ),류병주 ( Ryu Byeongju ) 한국보건사회연구원 2024 국제사회보장리뷰 Vol.28 No.-

사회적 고립과 외로움은 ‘새로운 전염병(new pandemic)’이라고 불릴 정도로 만연해졌으며, 개인의 건강 및 삶의 만족도 측면뿐 아니라 사회적으로도 중요한 문제로 떠오르고 있다. 특히 노년층의 경우 만성질환의 증가, 사회적 관계망 축소 등으로 인해 사회적 고립에 처하거나 외로움을 느낄 가능성이 상대적으로 높다. 이를 해결하기 위해 미국에서는 다양한 분야에서 노력을 기울이고 있다. 지역사회에서는 주민조직(빌리지) 활동을 통해 사회참여를 독려하고, 주거 측면에서는 코하우징과 같은 모델을 통해 외로움 완화와 소속감 증대를 돕는다. 기술 분야에서는 노인 친화적 플랫폼 개발이나 로봇을 활용한 사회적 연결 확대 등을 통해 고립을 방지하고, 보건 분야에서는 선제적 스크리닝 도입과 외로움 완화를 위한 다양한 서비스를 제공 및 연계한다. 이 글에서는 이러한 사례들을 통해 사회적 고립과 외로움 완화를 위한 정책적 시사점을 검토한다. Social isolation and loneliness, so widespread as to be called new pandemics, have emerged not only as individual health and life-satisfaction issues but also as social problems. Older adults, in particular, their chronic conditions deepening and their social networks thinning, are more likely to become socially isolated or lonely. The US has implemented multifaceted initiatives to address social isolation and loneliness among seniors. At the community level, older adults are encouraged to participate in “Village” social activities. When it comes to housing, the senior cohousing program is there to help older adults keep themselves from loneliness and foster a sense of belonging. Additionally, senior-friendly technology platforms and robotic systems are applied to assist older adults to connect with society and keep themselves from social isolation. The health sector has introduced an early screening system for older adults and provides and connects them with various services designed to alleviate their loneliness. This article examines some of the efforts ongoing in the US to reduce social isolation and loneliness among seniors and explores the implications they might have for Korea.

미국 보건 및 사회 서비스 연계 동향: 커뮤니티 케어 허브를 중심으로

백지혜 ( Baek Jihye ) 한국보건사회연구원 2023 국제사회보장리뷰 Vol.24 No.-

Autophagy-regulating small molecules and their therapeutic applications

Baek, Kyung-Hwa,Park, Jihye,Shin, Injae The Royal Society of Chemistry 2012 Chemical Society reviews Vol.41 No.8

<P>Autophagy or self-eating is a complicated cellular process that is involved in protein and organelle digestion occurring <I>via</I> a lysosome-dependent pathway. This process is of great importance in maintaining normal cellular homeostasis. However, disruption of autophagy is closely associated with various human diseases such as cancer, neurodegenerative disorders, heart disease and pathogen infection. Therefore, small molecules that modulate autophagy can be employed to dissect this complex process and ultimately could have high potential for the treatment of a variety of diseases. This <I>critical review</I> discusses general aspects of autophagy, autophagy-associated diseases and autophagy regulators for biological research and therapeutic applications (207 references).</P> <P>Graphic Abstract</P><P>This <I>critical review</I> discusses general aspects of autophagy, autophagy-associated diseases and autophagy regulators for biological research and therapeutic applications. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cs15328a'> </P>

The Excretion Study of 1,4,6-Androstatriene-3,17-dione(ATD) and its Metabolite in Human Urine

Jihye Lee,Sunyoung Baek,Jaeyeon Chung,Teawoo Yum,Yunje Kim,팽기정 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.12

인공지능 기반 자율주행 네트워크의 적대적 공격 방법

석지혜(Jihye Seok),정은수(Ensue Jeong),최소빈(Sobin Choi),백예진(Yejin Baek),이훈(Hoon Lee) 한국통신학회 2023 한국통신학회 학술대회논문집 Vol.2023 No.2

‘청년 안에서부터 바깥으로’

우지혜(Jihye Woo),백선기(Seon Gi Baek) 한국콘텐츠학회 2018 한국콘텐츠학회논문지 Vol.18 No.2

대중음악은 생산과 소비 과정에서 청년들의 내재된 욕망과 가치관이 잘 드러나는 공간이다. 그동안 한국의 청년세대 및 청년문화에 대한 논의는 주로 기성세대에 대한 저항이라는 정치적 논리 안에서 진행되어왔다. 그러나 이는 청년문화가 갖고 있는 고유한 미시적 특성들을 간과한다는 점에서 한계를 갖는다. 이에 본 연구는 미메시스 이론을 통해 대중음악 안에서 청년세대가 주체적으로 만들고 공유하는 기호 및 담론은 무엇이며, 그것이 사회적 맥락과 어떻게 연관되는 가를 살펴보았다. 그 결과, 1990년대 음악 〈교실 이데아〉와 〈We are the future〉에서는 기성세대에 대한 저항을 나타내는 이야기 구조 및 이항 대립이 두드러졌으며, 억압성 및 집합성을 나타내는 단어 표현들이 자주 등장한 반면, 2010년대 음악 〈Palette〉와 〈Tomboy〉에서는 파편화된 기호들이 다수 등장하며 그것들을 개별적인 문맥 안에서 재구성하는 담론 구조가 발견되었다. 이는 당시의 사회적 맥락 안에서 청년들이 경험하는 감성과 욕구를 가시화함으로써 그들로부터 많은 공감과 인기를 얻은 것으로 판단된다. 이를 통해 청년음악에 대한 고정된 시각적 접근에서 벗어나 시대적 맥락 안에서 음악에 담긴 청년들의 감성 및 욕망 등을 주목할 필요성을 제기한다. Popular music is a spce where intrinsic desires and values of young people are well exposed in its process of production and consumption. Previous discussions of Korean youth and youth culture have been proceeding mainly in the sense of their resistances to older generation. However, this is limited in that it neglects the inherent microscopic characteristics of youth culture. The purpose of this study is to investigate what the signs and discourses of youth generation make and share in popular music, and how it relates to social context through the ‘Mimesis’ theory. As a result, the songs of the 1990s remarkably showed the resistance to the old generation in its narrative structure and have signs which expresses repression and uniformity. On the other hand, the songs of the 2010s have many fragmented signs which has been reconstructed into individualized discourse structure. It is assumed that the songs have been able to gain a lot of empathy and popularity from the young generation by visualizing emotions and desires experienced by themselves in the social context. Through this study, it suggests to pay attention to the sensitivity, desire and creativity of young people in music in the social and cultural context of the time.

쪽방 거주 독거노인의 주거공간 분석 연구

강지혜 ( Jihye Kang ),강병길 ( Byungkil Kang ),백승현 ( Seunghyun Baek ),양영완 ( Youngwan Yang ) 한국공간디자인학회 2017 한국공간디자인학회논문집 Vol.12 No.1

(Background and Purpose)As the ratio of aged population has increased dramatically, the support and consideration for the elderly have become an important challenge for everyone of us. This study was conducted to create new value of housing space for the socially and economically isolated class, or the single elders at the age of 65 of older who are residing in slice rooms, which are the basic living units, to contribute to improving their quality of life. (Method)This study strictly limited the subjects to the `single elders` residing in the `slice room town` in Seoul. First, literature such as preceding studies and publications and the periodicals of research institutes were searched, collected, and studied under the keywords of slice rooms, small-sized houses, single elders, and aging society. Second, the major research area in Changsin-1-dong, Jongno-gu was visited for a spatial analysis to identify the problems to resolve first to secure the substantial findings and subjectivity of research. Third, the single elders residing at the slice room town were visited with the cooperation of Dongdaemun Slice Room Counseling Center to examine their living situations. Single elders in the target area were followed through their daily schedule to be observed and interviewed to identify their complaints. (Results)As a result of analyzing the living environment of slice room residers, they spent much of their time in the slice rooms due to financial hardships and were living in narrow spaces with the living goods piled and unorganized in the rooms. Living inside the slice rooms primarily requires solutions for the basic clothing, food, and housing needs. The living goods should be easy to store and the environment should be sanitary and safe. The living space should provide minimal square footage, but they were residing and cooking in 1.06 py rooms that do not meed the minimum housing standards(14㎡). Therefore, this study examined the ways to arrange the essential living goods owned by the single elders residing in slice rooms within the minimum living space. It studied the ways to store the small/medium goods efficiently for the single elders. (Conclusions) A solution with a design may have limitations, but the following design solutions were suggested to improve their quality of life: first, designs for the socially isolated class should be emotionally touching for the users before providing aesthetics or functionality. Second, the design should be attainable and realistic than a design with viable performance. Third, the design should be built using environmentally-friendly designs without any harm for the body or the environment rather than pursuing low cost for the economical value. Fourth, the findings should not be limited to this study, but consider possible development into a sustainable design.