Recovery of Lost Speech Segments Using Incremental Subspace Learning

Jianjun Huang,Xiongwei Zhang,Yafei Zhang 한국전자통신연구원 2012 ETRI Journal Vol.34 No.4

An incremental subspace learning scheme to recover lost speech segments online is presented. Our contributions in this work are twofold. First, the recovery problem is transformed into an interpolation problem of the time-varying gains via nonnegative matrix factorization. Second, incremental nonnegative matrix factorization is employed to allow online processing and track the evolution of speech statistics. The effectiveness of the proposed scheme is confirmed by the experiment results.

Speech Denoising via Low-Rank and Sparse Matrix Decomposition

Jianjun Huang,Xiongwei Zhang,Yafei Zhang,Xia Zou,Li Zeng 한국전자통신연구원 2014 ETRI Journal Vol.36 No.1

In this letter, we propose an unsupervised framework forspeech noise reduction based on the recent development oflow-rank and sparse matrix decomposition. The proposedframework directly separates the speech signal from noisyspeech by decomposing the noisy speech spectrogram intothree submatrices: the noise structure matrix, the clean speechstructure matrix, and the residual noise matrix. Evaluations onthe Noisex-92 dataset show that the proposed method achievesa signal-to-distortion ratio approximately 2.48 dB and 3.23 dBhigher than that of the robust principal component analysismethod and the non-negative matrix factorization method,respectively, when the input SNR is –5 dB.

circSPG21 protects against intervertebral disc disease by targeting miR-1197/ATP1B3

Huang Yizhen,Zhang Zhenlei,Wang Jianle,Shen Shuying,Yao Teng,Xu Yining,Chen Zizheng,Fang Bin,Ma Jianjun 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

The abnormal expression of circular RNAs (circRNAs) is associated with numerous human diseases. This study investigated the mechanism by which circRNA acts as competitive endogenous RNA in the regulation of degenerative intervertebral disc disease (IVDD). Decreased expression of circSPG21 was detected in degenerated nucleus pulposus cells (NPCs), the function of circSPG21 in NPCs was explored and verified, and the downstream target of circSPG21 was investigated. The interaction between circSPG21 and miR-1197 and its target gene ( ATP1B3 ) was studied by online database prediction and molecular biological verification. Finally, the circSPG21/miR-1197/ATP1B3 axis was verified in the mouse tail-looping model. The expression of circSPG21 in the nucleus pulposus in IVDD was directly related to an imbalance of anabolic and catabolic factors, which affected cell senescence. circSPG21 was found to play a role in human NPCs by acting as a sponge of miR-1197 and thereby affecting ATP1B3 . The regulation of circSPG21 provides a potentially effective therapeutic strategy for IVDD.

ON ASYMPTOTIC OF EXTREMES FROM GENERALIZED MAXWELL DISTRIBUTION

Huang, Jianwen,Wang, Jianjun Korean Mathematical Society 2018 대한수학회보 Vol.55 No.3

In this paper, with optimal normalized constants, the asymptotic expansions of the distribution and density of the normalized maxima from generalized Maxwell distribution are derived. For the distributional expansion, it shows that the convergence rate of the normalized maxima to the Gumbel extreme value distribution is proportional to 1/ log n. For the density expansion, on the one hand, the main result is applied to establish the convergence rate of the density of extreme to its limit. On the other hand, the main result is applied to obtain the asymptotic expansion of the moment of maximum.

Maintaining Drosha expression with Cdk5 inhibitors as a potential therapeutic strategy for early intervention after TBI

Huang Lu,Xia Li,Nie Tiejian,Cui Bozhou,Lu Jianjun,Lu Fangfang,Fan Feiyan,Ren Dongni,Lu Yuan,Gao Guodong,Yang Qian 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-

Traumatic brain injury (TBI) is a major cause of death and disability in adults. The pathological process of TBI involves a multifactorial cascade in which kinases have been proven contribute to interactions between relevant factors and amplification of signaling cascades. Cyclin-dependent kinase 5 (Cdk5) is a promising kinase that has been implicated in various brain disorders, including TBI. However, the mechanism by which Cdk5 induces neuronal damage remains unclear. Here, we show for the first time that Drosha, a key enzyme in microRNA biogenesis, is a pivotal substrate of abnormally activated Cdk5. Cdk5-mediated phosphorylation decreases Drosha expression and exacerbates nerve injury in TBI. We proved that maintaining Drosha expression via the administration of repurposed Cdk5 inhibitors that were previously studied in clinical trials is a promising approach for the early treatment of TBI. Together, our work identifies Drosha as a novel target for neuroprotective strategies after TBI and suggests Cdk5-mediated regulation of Drosha expression as a potential therapeutic strategy for early TBI intervention.

Effect of keratinase on ileal amino acid digestibility in five feedstuffs fed to growing pigs

Chengfei Huang,Dongli Ma,Jianjun Zang,Bo Zhang,Brian Sun,Ling Liu,Shuai Zhang 아세아·태평양축산학회 2018 Animal Bioscience Vol.31 No.12

Objective: This study was conducted to evaluate the effect of keratinase (KE) on the apparent ileal digestibility (AID) and standardized ileal digestibility (SID) of amino acids (AA) in rice bran, cottonseed meal (CSM), rapeseed meal (RSM), corn distillers dried grains with solubles (DDGS), and peanut meal (PNM). Methods: Twelve crossbred barrows (Duroc×Landrace×Yorkshire, 50.5±1.4 kg body weight [BW]) fitted with T-cannulas at the terminal ileum were allotted to a 12×6 Youden Square design with 12 diets and 6 periods. The treatment diets included rice bran, CSM, RSM, corn DDGS, PNM, or corn-soybean meal (cSBM) supplemented with 0.05% KE or not. Diets were given to pigs at a level of 3% BW in two equal meals. The endogenous AA losses were the mean results of three previously experiments determined by a same nitrogen-free diet fed to pigs. Pigs had free access to water during the experiment. Results: The KE supplementation improved (p<0.05) the AID and SID of Met, Thr, Val, Asp, Cys, and Tyr in rice bran. Inclusion of KE increased (p<0.05) the AID and SID of Met and Val in CSM. The KE supplementation decreased (p<0.05) the AID and SID of His in RSM and all measured AA except for Arg, Met, Trp, Val, Gly, and Pro in corn DDGS. There was an increase (p<0.05) in AID and SID of Leu, Ile, Met, Ala, Cys, Ser, and Tyr in PNM supplemented with KE compared with that without KE. Inclusion of KE increased (p<0.05) the AID and SID of crude protein, Leu, Ile, Phe, Thr, Asp, and Ser in cSBM. Conclusion: This study indicated that KE had different effects on ileal AA digestibility of feedstuffs for growing pigs, which can give some usage directions of KE in swine feed containing those detected feedstuffs.

Cloning and Distribution of Facilitative Glucose Transporter 2 (SLC2A2) in Pigs

Zuo, Jianjun,Huang, Zhiyi,Zhi, Aimin,Zou, Shigeng,Zhou, Xiangyan,Dai, Fawen,Ye, Hui,Feng, Dingyuan Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.9

Glucose is the main energy source for mammalian cells and its absorption is co-mediated by two different families of glucose transporters, sodium/glucose co-transporters (SGLTs) and facilitative glucose transporters (GLUTs). Here, we report the cloning and tissue distribution of porcine GLUT2. The GLUT2 was cloned by RACE and its cDNA was 2,051 bp long (GenBank accession no. EF140874). An AAATAA consensus sequence at nucleotide positions 1936-1941 was located upstream of the poly $(A)^+$ tail. Open reading frame analysis suggested that porcine GLUT2 contained 524 amino acids, with molecular weight of 57 kDa. The amino acid sequence of porcine GLUT2 was 87% and 79.4% identical with human and mouse GLUT2, respectively. GLUT2 mRNA was detected at highest level in porcine liver, at moderate levels in the small intestine and kidney, and at low levels in the brain, lung, muscle and heart. In the small intestine, the highest level was in the jejunum. In conclusion, the mRNA expression of GLUT2 was not only differentially regulated by age, but also differentially distributed along the small intestine of piglets, which may be related to availability of different intestinal luminal substrate concentrations resulting from different food sources and digestibility.

On asymptotic of extremes from generalized Maxwell distribution

Jianwen Huang,Jianjun Wang 대한수학회 2018 대한수학회보 Vol.55 No.3

In this paper, with optimal normalized constants, the asymptotic expansions of the distribution and density of the normalized maxima from generalized Maxwell distribution are derived. For the distributional expansion, it shows that the convergence rate of the normalized maxima to the Gumbel extreme value distribution is proportional to $1/\log n.$ For the density expansion, on the one hand, the main result is applied to establish the convergence rate of the density of extreme to its limit. On the other hand, the main result is applied to obtain the asymptotic expansion of the moment of maximum.

SOC ESTIMATION OF Li-ION BATTERY BASED ON IMPROVED EKF ALGORITHM

Zhengjun Huang,Yongshou Fang,Jianjun Xu 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.2

The state of charge (SOC) is one of the important performance indicators of battery, which provides an important basis for the management and control of Battery Management System (BMS). In view of the characteristics of lithium iron phosphate battery, considering the model accuracy and calculation amount, the equivalent circuit model of improved PNGV was selected. Based on that, an improved Extended Kalman Filter (EKF) algorithm was adopted to estimate the state of charge (SOC) of Li-ion battery, which covariance matrix was modified by the Levenberg-Marquardt method. At the end of this paper, the SOC estimation algorithm was verified by MATLAB simulations. The results show that compared with the standard EKF, the improved EKF has higher estimation accuracy and anti-interference ability, and has better convergence in the estimation process.

Effect of Glutinous Rice Slurry on the Unconfined Compressive Strength of Lime-Treated Seasonal Permafrost Subjected to Freeze-Thaw Cycles

Jie Deng,Jianjun Zhao,Xiao Zhao,Jianle Yu,Chun Lei,Minlee Lee,Runqiu Huang 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.4

It is important to account for the poor ecological environment of weak seasonal permafrost regions while developing a suitable ground improvement technique. As an organic non-polluting material, glutinous rice slurry improves the unconfined compressive strength of the soil through induction and synergy with lime. The Qinghai-Tibet Plateau has cold weather, large temperature differences between day and night, and a fragile ecological environment. Once damaged, it is extremely difficult to recover. This study investigates the effects of glutinous rice slurry on the unconfined compressive strength (UCS), failure mode, and microstructure of lime-treated seasonally frozen soil subjected to freeze–thaw cycles. Organic glutinous rice slurry with concentrations of 0, 2, 4, 6, and 8% was added to soil specimens that were treated with 10% lime and subjected to 0, 1, 3, 6, and 10 freeze–thaw cycles. In tests, the addition of glutinous rice pulp could increase the UCS of the soil by up to 40%. The first freeze-thaw cycle has the greatest impact on the UCS of the soil sample, with a decrease of 6 – 15%. Glutinous rice slurry can reduce the degradation effects of freeze-thaw cycles by increasing the contact area between soil particles. In a comprehensive evaluation under test conditions, a glutinous rice slurry concentration of 4% led to optimal results. It revealed the change characteristics of the microstructure under the action of freeze-thaw cycles, which has a good corresponding relationship with the macroscopic mechanical properties. The results can provide reference value for the application of glutinous rice slurry in the modification of subgrade soil in seasonal permafrost areas.