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Jiang, Heng Bo,Wu, Guosong,Lee, Sang-Bae,Kim, Kwang-Mahn Elsevier 2017 Surface & coatings technology Vol.313 No.-
<P><B>Abstract</B></P> <P>Magnesium (Mg) and its alloys as biodegradable metallic materials have attracted fundamental research in the field of orthopedics and cardiovascular materials. However, magnesium implants exhibit poor corrosion resistance, especially in the physiological environment, which limits medical applications. To improve the corrosion resistance of the Mg, anodization was applied to an ultra-high concentration of fluoride electrolyte. Then, surface morphology, coating thickness and composition were determined, and the corrosion behavior of anodized Mg alloys was evaluated. The results of coating by anodization showed that a porosity structure with a pore size of 600–900nm and thickness of 1–14μm is generated on the Mg alloy substrate, and this coating component is magnesium fluoride. In electrochemical corrosion tests and immersion corrosion tests, the anodized Mg alloy was tested, and the anodized Mg alloy shows significantly improved corrosion resistance compared with untreated Mg alloy in simulated body fluid (SBF).</P> <P><B>Highlights</B></P> <P> <UL> <LI> A porous MgF<SUB>2</SUB> coating is created on Mg alloy by anodization in molten fluoride salt. </LI> <LI> The anodizing time is <30s. </LI> <LI> Corrosion resistance of the anodized Mg alloy is obviously improved. </LI> </UL> </P>
Expression of Ki67 in Papillary Thyroid Microcarcinoma and its Clinical Significance
Zhou, Yuan,Jiang, Hong-Gang,Lu, Ning,Lu, Bo-Hao,Chen, Zhi-Heng Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
Purpose: To investigate the expression of Ki67 protein in papillary thyroid microcarcinoma(PTMC), and to analyze its clinical significance. Materials and Methods: Ki67 protein expression was evaluated in the tissues of 108 human PTMC and 50 other benign papillary hyperplasia of thyroid specimens using immunohistochemistry. Results: The expression intensity of Ki67 in PTMC and benign papillary hyperplasia of thyroid specimens were $1.45{\pm}1.83%$ and $0.46{\pm}0.46%$.The positive expression rates were 46.3% and 14%. There were significant differences between these two groups (p<0.01). There was no significant variation of the expression intensity and positive expression rates of Ki67 in PTMC with gender, age, position of the tumor and the level of TSH pre-operation (p>0.05), but these parameters varied with tumor size, invasion by membrane and cervical lymph node metastasis (p<0.05 or p<0.01). Conclusions: The expression of Ki67 in PTMC was related to tumor size, invasion by membrane and cervical lymph node metastasis, and could be the important indicator for judging clinical progress and estimating prognosis.
An Efficient Parallel Infilling Strategy and Its Application in Sheet Metal Forming
Yan-Min Xie,Yuan-Heng Guo,Fei Zhang,Yue-Peng Yue,Mei-Qiang Feng,Jiang-Bo Zhao 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.8
Infilling strategies play an important role in kriging based optimization, especially when computationally expensive simulations are involved. In order to improve the efficiency of constructing a high-precision kriging model, an improved expected improvement criterion (IEI) and a parallel infilling strategy are proposed based on the maximum expected improvement (EI) criterion. In the proposed parallel infilling strategy, new sample points are generated by employing IEI criterion coupled with EI criterion. During the improved sampling process, redundant and pseudo sample are deleted in order to avoid failure of constructing a kriging model. An improved weighted particle swarm optimization (WPSO) algorithm is proposed to improve optimization efficiency. The proposed parallel infilling strategy is applied to nonlinear function optimization and variable blank holder force (VBHF) optimization in a double-c stamped part. Based on the LHD and software DYNAFORM, kriging models between the VBHF and forming quality are constructed. Compared with the initial kriging models, the meat relative error of kriging models with the proposed parallel infilling strategy for the wrinkling and average thinning rate are reduced by 95% and 55%, respectively. The optimal VBHF is obtained by the WPSO. The results show that, cracking has been completely eliminated and wrinkling has been decreased, greatly improving the forming quality of the double-c stamped part.
Gui-Yue Huang,Heng Bo Jiang,Jung-Yul Cha,Kwang-Mahn Kim,Chung-Ju Hwang 대한치과교정학회 2017 대한치과교정학회지 Vol.47 No.5
Objective: The purpose of this study was to examine the effect of commercially available fluoride-containing oral rinses on the corrosion behavior of titanium alloys, which are the main components of orthodontic miniscrews. Methods: Four commercially available oral rinses (solution A, pH 4.46/260 ppm fluoride; solution B, pH 4.41/178 ppm fluoride; solution C, pH 6.30/117 ppm fluoride; and solution D, pH 4.17/3.92 ppm fluoride) were tested on titanium alloy (Ti- 6Al-4V) circular plates, and saline was used as the control. The open-circuit potential and potentiodynamic polarization of these materials were measured. Thereafter, all samples were evaluated under a field-emission scanning electron microscope. Results: Among the tested oral rinses, except solution D, the more the fluoride content was, the greater was the corrosion potential downtrend; the corrosion resistance of the titanium alloy sample was also lowered significantly (p < 0.05). Field-emission scanning electron microscopic analysis of the surface morphology of the titanium alloy samples revealed that all samples had some defects, crevices, or pitting after exposure to the oral rinses than before treatment. In particular, the samples in solution A showed the most changes. Conclusions: Commercially available oral rinses having a high fluoride concentration and a low pH may reduce the corrosion resistance of titanium alloys used in dental appliances such as orthodontic titanium miniscrews and brackets.
Jeong-Hyun Ryu,Jae-Sung Kwon,Heng Bo Jiang,Jung-Yul Cha,Kwang-Mahn Kim 대한치과교정학회 2018 대한치과교정학회지 Vol.48 No.5
Objective: The aim of this systematic multiscale analysis was to evaluate the effects of thermoforming on the physical and mechanical properties of thermoplastic materials used to fabricate transparent orthodontic aligners (TOAs). Methods: Specimens were fabricated using four types of thermoplastic materials with different thicknesses under a thermal vacuum. Transparency, water absorption and solubility, surface hardness, and the results of three-point bending and tensile tests were evaluated before and after thermoforming. Data were analyzed using one-way analysis of variance and Student’s t -test. Results: After thermoforming, the transparency of Duran and Essix A+ decreased, while the water absorption ability of all materials; the water solubility of Duran, Essix A+, and Essix ACE; and the surface hardness of Duran and Essix A+ increased. The flexure modulus for the 0.5-mm-thick Duran, Essix A+, and eCligner specimens increased, whereas that for the 0.75-/1.0-mm-thick Duran and eClginer specimens decreased. In addition, the elastic modulus increased for the 0.5-mm-thick Essix A+ specimens and decreased for the 0.75-mm-thick Duran and Essix ACE and the 1.0-mm-thick Essix ACE specimens. Conclusions: Our findings suggest that the physical and mechanical properties of thermoplastic materials used for the fabrication of TOAs should be evaluated after thermoforming in order to characterize their properties for clinical application.