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Jhoo, Jin Hyeong,Park, Woong Yang,Kim, Ki Woong,Lee, Kwang Hyuk,Lee, Dong Young,Youn, Jong Chul,Suh, Young Ju,Seo, Jeong-Sun,Woo, Jong Inn Korea Genome Organization 2004 Genomics & informatics Vol.2 No.2
To examine whether the IL-1A (-889) polymorphism associates with a risk for Alzheimer's disease (AD) and acts interactively with the apolipoprotein (APOE) $\epsilon$4 in the development of AD, we performed genotype analyses of the IL-1A and the APOE of the 102 Korean AD patients and 200 Korean non-demented controls. We failed to detect a significant difference in genotypic and allelic frequencies of IL-1A between the AD group and control group. No overexpression of the IL-1A C/T genotype and IL-1A T allele was found when we analyzed the late-onset and early-onset patients, separately. There was no significant genetic interaction between IL-1A polymorphism and the APOE polymorphism. I n conclusion, the IL-1A polymorphism did not contribute to the development of AD independently or interactively with the APOE $\epsilon$4 allele in Koreans.
유기수은 유발 뇌손상에 미치는 셀레늄의 작용기전 및 전자현미경적 관찰
Jhoo, Wnag-Kee,Kim, Hyoung-Chun,Song, Ke-Yong 한국독성학회 1991 Toxicological Research Vol.7 No.1
The present study was performed to explore the antioxidant effect of selenium on damaged brain induced by organic mercury. Male ICR mice were given consecutively 7 injections for 7 days of : (I) sodium selenite 1 mg/kg s.c. alone, (2) methylmercuric chloride 10mg/kg s.c. alone, (3) methylmercuric chloride simultaneously in combination with sodium selenite, and (4) saline alone as control respectively. Based on the above protocol, we monitored various oxyradical scavenging system as well as the finding of electron microscopy. The results from brain tissues were as follows` 1. Selenium inhibited the rate of generation of superoxide radical.
Availability of brain serotonin transporters in patients with restless legs syndrome
Jhoo, J. H.,Yoon, I. -Y.,Kim, Y. K.,Chung, S.,Kim, J. -M.,Lee, S. B.,Kim, T. H.,Moon, S. H.,Kim, S. E.,Kim, K. W. Ovid Technologies (Wolters Kluwer) - American Acad 2010 Neurology Vol.74 No.6
<P>BACKGROUND: Selective serotonin reuptake inhibitors have been associated with the risk of restless legs syndrome (RLS), suggesting that dysregulation of serotonergic neurotransmission may provoke or exacerbate RLS. METHODS: We compared the availability of serotonin transporter (SERT) between 16 drug-naïve patients with RLS and 16 healthy controls. SERT was measured in the pons and medulla via [(123)I]-2beta-carbomethoxy-3beta-(4-iodophenyl) tropane (beta-CIT) SPECT. A ratio of specific to nonspecific brain uptake (V(3)'') was used for all comparisons. RLS was diagnosed according to the criteria proposed by the National Institute of Health, and its severity was measured using the International RLS Study Group (IRLSSG) Severity Scale. RESULTS: The availability of SERT was similar in the RLS group and the control group with regards to the pons (1.24 +/- 0.31 vs 1.24 +/- 0.25, p > 0.1) and the medulla (0.99 +/- 0.25 vs 1.00 +/- 0.23, p > 0.1). However, IRLSSG Severity Scale scores increased with decrease of SERT availability in both the pons (beta = -0.50, t = -3.19, p = 0.009) and the medulla (beta = -0.42, t = -2.44, p = 0.03). CONCLUSIONS: Although serotonin transporter (SERT) availability in pons and medulla was similar in the restless legs syndrome (RLS) group and the control group, the severity of RLS symptoms increased as the availability of SERT decreased. These data partially support the hypothesis that an increase of serotonergic neurotransmission in the brainstem may exacerbate RLS, possibly via dual modulations on striatal dopaminergic neurotransmission and on the activities of spinal motor and sensory neurons.</P>
A Normative Study of the Disability Assessment for Dementia in Community-Dwelling Elderly Koreans
JinHyeong Jhoo,YeonKyung Chi,HyoJung Choi,JiWon Han,TaeHui Kim,JungJae Lee,SeokBum Lee,JoonHyuk Park,JongChul Youn,JeongLan Kim,SeungHo Ryu,DongYoung Lee,Ki Woong Kim 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.4
Objective-We investigated demographic influences on Korean version of Disability Assessment for Dementia (DAD-K) performance and developed normative data for DAD-K. Methods-The DAD-K was administered to 2362 normal controls (NCs), 296 patients with mild cognitive impairment (MCI) and 293 patients with Alzheimer’s disease (AD). MANOVA and ROC curve analysis were used to compare DAD-K performance and the diagnostic accuracy of DAD-K, respectively. The demographic influence on DAD-K scores was analyzed by multiple linear regression and ANOVA. Normative DAD-K data were calculated using natural logarithmic transformation. Results-All DAD-K scores were significantly different among groups (p<0.001). Post hoc analysis showed that instrumental activities of daily living (IADL), executive function and DAD-K total scores began to decline significantly in the very mild stage of AD, whereas the basic activities of daily living (BADL) scores began to decline in the mild stage of AD. The area under the ROC curve differentiating MCI or AD from NC was 0.737 and that differentiating AD from MCI or NC was 0.911. IADL and planning and organization scores were influenced by age and education and performance and DAD-K total scores were influenced by education. Conclusion-The demographic influences on DAD-K scores are not conspicuous and are mainly limited to the IADL and planning and organization scores. Unitary or minimally stratified norms for a specific population were developed for DAD-K application. Our results suggest that the DAD-K is useful for differentiating NC or MCI from AD but not as powerful for differentiating NC from MCI.
JinHyeong Jhoo,KiWoong Kim,YoungJu Suh,DongYoung Lee,JongChul Youn,JungHie Lee,JongInn Woo 대한신경정신의학회 2004 PSYCHIATRY INVESTIGATION Vol.1 No.1
Objectives-The aim of this study is to examine the impact of the apolipoprotein E (APOE) polymorphism on the risk of Alzheimer s disease (AD) in Koreans. Materials and Methods-We determined the APOE genotype of 303 probable AD patients and 1,052 non-demented normal controls, and compared their genotypic and allelic frequencies. Then, we determined the odds ratios for AD of the APOE polymorphism in the subjects, stratified by age and gender. Results-The APOE 4 allele was more prevalent in the AD patients than in the controls (P<0.0001). The APOE 4 allele increased the risk of AD in a dose-dependent manner; the odds ratios for AD of the APOE 4-heterozygous and the APOE 4-homozygous subjects were 3.9 (95% CI=2.8-5.3) and 15.6 (95% CI=6.6-36.7), respectively. The APOE 4-conferred AD risk was also dependent on the age and gender of the subjects; the odds ratios for AD were highest in the subjects aged 75-79 years and higher in the women than in the men. Conclusions-The APOE 4 allele is a significant genetic risk factor for AD and confers the AD risk in a dose-, age- and genderdependent manner in Koreans.
주진형(JinHyeong Jhoo) 대한노인정신의학회 2007 노인정신의학 Vol.11 No.1
The rapid increase of the elderly and dementia patients has motivated psychiatrists and government officials in Korea to participate in dementia research, programs and projects more actively since the nineties. Korean association for geriatric psychiatry and Korean association for dementia were founded in 1994 and the ministry of health and welfare pronounced the 10 year project for dementia in 1995 and the dementia service program at the public health center was established by law in 1997. Several leading groups of psychiatrists have started the dementia registry and service programs with the public health centers based on local communities and their endeavor made the foundation for nationwide projects for early detection of dementia. The pilot project of registry and service for dementia has been performed with the participation of 16 hospitals and 21 public health centers in 2006. And in 2007 nationwide project for early detection of dementia has started with 60 hospitals and 85 public health centers throughout the country. This project might contribute to delay the development and progression of dementia and help to promote the quality of life in dementia patients and their families in Korea.