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A Poly(β-Amino Ester) of Spermine and Poly(ethylene Glycol) Diacrylate as a Gene Carrier
Jere, Dhananjay,Kim, Tae Hee,Arote, Rohidas B.,Jiang, Hu Lin,Cho, Myung Haing,Nah, Jae Woon,Cho, Chong Su Trans Tech Publications, Ltd. 2007 Key Engineering Materials Vol.342 No.-
<P>Vectors are vital aspect of gene delivery system which decides the success of gene therapy. Efficient transfection with minimum or no toxicity, are two principal aims of any gene delivery system. In this our study, we rationally developed biodegradable water soluble poly(ßamino ester) (PAE) based on spermine (SPR) and poly (ethylene glycol) (PEG), by Michael-type addition reaction and further studied for its potential as a gene carrier. Confirmation of synthesized PAE was done by proton NMR spectroscopy. In gel retardation assay, the PAEs have shown good DNA binding ability over wide range of polyplexes. The addition of PEG over SPR resulted in a novel PAE with higher degree of safety and transfection efficiency as compared with polyethylenimine 25K (PEI) when studied in 293T human kidney carcinoma cells.</P>
Xu, Cheng-Xiong,Jere, Dhananjay,Jin, Hua,Chang, Seung-Hee,Chung, Youn-Sun,Shin, Ji-Young,Kim, Ji-Eun,Park, Sung-Jin,Lee, Yong-Hoon,Chae, Chan-Hee,Lee, Kee Ho,Beck, George R,Cho, Chong-Su,Cho, Myung-Ha American Lung Association 2008 American journal of respiratory and critical care Vol.178 No.1
<P>RATIONALE: The low efficiency of conventional therapies in achieving long-term survival of patients with lung cancer calls for the development of novel therapeutic options. Recent advances in aerosol-mediated gene delivery have provided the possibility of an alternative for the safe and effective treatment of lung cancer. OBJECTIVES: To demonstrate the feasibility and emphasize the importance of noninvasive aerosol delivery of Akt1 small interfering RNA (siRNA) as an effective and selective option for lung cancer treatment. METHODS: Nanosized poly(ester amine) polymer was synthesized and used as a gene carrier. An aerosol of poly(ester amine)/Akt1 siRNA complex was delivered into K-ras(LA1) and urethane-induced lung cancer models through a nose-only inhalation system. The effects of Akt1 siRNA on lung cancer progression and Akt-related signals were evaluated. MEASUREMENTS AND MAIN RESULTS: The aerosol-delivered Akt1 siRNA suppressed lung tumor progression significantly through inhibiting Akt-related signals and cell cycle. CONCLUSIONS: The use of poly(ester amine) serves as an effective carrier, and aerosol delivery of Akt1 siRNA may be a promising approach for lung cancer treatment and prevention.</P>
Quantifying and controlling bond multivalency for advanced nanoparticle targeting to cells
Makhani Elliot Y.,Zhang Ailin,Haun Jered B. 나노기술연구협의회 2021 Nano Convergence Vol.8 No.38
Nanoparticles have drawn intense interest as delivery agents for diagnosing and treating various cancers. Much of the early success was driven by passive targeting mechanisms such as the enhanced permeability and retention (EPR) effect, but this has failed to lead to the expected clinical successes. Active targeting involves binding interactions between the nanoparticle and cancer cells, which promotes tumor cell-specific accumulation and internalization. Furthermore, nanoparticles are large enough to facilitate multiple bond formation, which can improve adhesive properties substantially in comparison to the single bond case. While multivalent binding is universally believed to be an attribute of nanoparticles, it is a complex process that is still poorly understood and difficult to control. In this review, we will first discuss experimental studies that have elucidated roles for parameters such as nanoparticle size and shape, targeting ligand and target receptor densities, and monovalent binding kinetics on multivalent nanoparticle adhesion efficiency and cellular internalization. Although such experimental studies are very insightful, information is limited and confounded by numerous differences across experimental systems. Thus, we focus the second part of the review on theoretical aspects of binding, including kinetics, biomechanics, and transport physics. Finally, we discuss various computational and simulation studies of nanoparticle adhesion, including advanced treatments that compare directly to experimental results. Future work will ideally continue to combine experimental data and advanced computational studies to extend our knowledge of multivalent adhesion, as well as design the most powerful nanoparticle-based agents to treat cancer.
Hybrid of baculovirus and galactosylated PEI for efficient gene carrier
Kim, You-Kyoung,Choi, Jae Young,Jiang, Hu-Lin,Arote, Rohidas,Jere, Dhananjay,Cho, Myung-Haing,Je, Yeon Ho,Cho, Chong-Su Elsevier 2009 Virology Vol.387 No.1
<P><B>Abstract</B></P><P>Baculovirus, containing an appropriate eukaryotic promoter, is considered an attractive approach for an efficient and safe gene delivery vehicle. However, the drawbacks of baculovirus, such as the lack of specificity and the inactivation of baculovirus by the complement system in human serum, negatively affect efficient gene delivery. Therefore, a hybrid system utilizing the positive aspects of both viral and non-viral vector systems would be useful to overcome the obstacles of either system alone. In this study, we constructed a hybrid system composed of baculovirus (B) and galactosylated polyethylenimine (GP)/DNA complexes through electrostatic interaction. The resulting GP/B hybrid had suitable physicochemical properties and low cytotoxicity for use in gene therapy. Furthermore, the GP/B significantly enhanced transduction efficiency and showed good cell-specificity compared to either viral or non-viral vector systems. These results suggest that the GP/B hybrid system can be used in gene therapy to enhance transduction efficiency and hepatocyte specificity.</P>
Carter Steven J.,Wong Ka Lun,Bradshaw Emily,Falevai Zoia,Borup Jered 한국다문화교육학회 2023 Multicultural Education Review Vol.15 No.4
This research used three scales to explore ethnicity and other variables’ effects on university students’ self-assessed academic help-seeking. The scores from each respective scale were regressed onto academic and demographic variables. In two of the three regression models, Age was the only significant factor, older students self-assessing as less avoidant and more persuaded of the benefits of help-seeking. However, investigating an interaction in one model revealed that older Pacific Islanders followed an opposite pattern, self-assessing as more avoidant of help-seeking with increased age, and significantly more avoidant than same-age peers of other ethnicities. Pacific Islanders also self-assessed significantly higher in instrumental help-seeking. In summary, except for Pacific Islanders, ethnic background had surprisingly little effect on academic help-seeking, a finding which may be attributable to the highly multicultural research setting. These findings suggest that younger students and older Pacific Islanders may benefit from focused efforts to facilitate their receiving academic help.
Folate conjugated poly(ester amine) for lung cancer therapy.
Arote, Rohidas B,Yoon, Mi-Kyong,Kim, Tae-Hee,Jere, Dhananjay,Jiang, Hu-Lin,Kim, You-Kyoung,Park, In-Kyu,Cho, Chong-Su American Scientific Publishers 2010 Journal of Nanoscience and Nanotechnology Vol.10 No.5
<P>Folate conjugated poly(ester amine) (PEA) was prepared by reaction of folic acid with PEAs based on polycaprolactone (PCL) and low molecular weight polyethylenimine (LMW-PEI) with PEG as a linker. This novel gene carrier showed excellent physicochemical properties and relatively low cytotoxicity compared with PEI 25K. It showed excellent transfection efficiency through folate receptor mediated endocytosis.</P>
Some physical properties and oxidative stability of biodiesel produced from oil seed crops
Fatai Abiola Lateef,Okechukwu Dominic Onukwuli,Uche Chukwu Okoro,Paul Madus Ejikeme,Paul Jere 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.5
Biodiesel is a cleaner burning fuel than petrodiesel and a suitable replacement in diesel engine. It is producedfrom renewable sources such as vegetable oils or animal fats. Biodiesel fuel was prepared from castor (CSO), palmkernel (PKO) and groundnut (GNO) oils through alkali transesterification reaction. The biodiesel produced was characterizedas alternative diesel fuel. Fuel properties such as specific gravity, viscosity, calorific (combustion) value, TheCSO, PKO and GNO were measured to evaluate the storage/oxidative stability of the oils to compare them with commercialpetrodiesel. The biodiesel produced had good fuel properties with respect to ASTM D 6751 and EN 14214specification standards, except that the kinematic viscosity of castor oil biodiesel was too low. The viscosity of castoroil biodiesel at different temperatures was in the range of 4.12-7.21mm2/s. However, promising results which conformedto the above specification standards were realized when castor oil biodiesel was blended with commercial petrodiesel. At 28 oC the specific gravity recorded for CSO, PKO and GNO biodiesel was higher than the values obtained forpetrodiesel. Commercial petrodiesel had the highest oxidative stability than biodiesel produced from CSO, PKO andGNO oils.