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( Jeong Hoon Kim ),( Jin Sun Choi ),( Sunhong Kim ),( Kidae Kim ),( Pyung Keun Myung ),( Sung Goo Park ),( Yeon Soo Seo ),( Byoung Chul Park ) 생화학분자생물학회 2015 BMB Reports Vol.48 No.1
Ubiquitination is a post translational modification which mostly links with proteasome dependent protein degradation. This process has been known to play pivotal roles in the number of biological events including apoptosis, cell signaling, transcription and translation. Although the process of ubiquitination has been studied extensively, the mechanism of polyubiquitination by multi protein E3 ubiquitin ligase, SCF complex remains elusive. In the present study, we identified UbcH5a as a novel stimulating factor for poly-ubiquitination catalyzed by SCFhFBH1 using biochemical fractionations and MALDI-TOF. Moreover, we showed that recombinant UbcH5a and Cdc34 synergistically stimulate SCFhFBH1 catalyzed polyubiquitination in vitro. These data may provide an important cue to understand the mechanism how the SCF complex efficiently polyubiquitinates target substrates. [BMB Reports 2015; 48(1): 25-29]
황선홍(Sunhong Hwang),김진형(Jinhyung Kim),정동원(Dongwon Jeong),김희석(Heuiseog Kim),백두권(Doo-Kwon Baik) 한국정보과학회 2008 한국정보과학회 학술발표논문집 Vol.35 No.1
다양한 분야에서 ISO/IEC 11179를 기반으로 MDR(Metadata Registry)시스템들이 개발되었다. 그러나 현재 구축된 메타데이타 관리 시스템들은 표준을 따라서 생성되지 않아 메타데이타 간 불일치가 발생하는 문제가 있다. 그리고 메타데이타를 공유하고 교환할 수 있는 표준화된 접근방법을 제공하지 않아 MDR 시스템마다 상이한 방법을 이용하여 개발되는 문제점을 야기한다. 이러한 문제점들을 해결하기 위해 SQL/MDR이 제안되었다. SQL/MDR은 MDR에 대한 사용하기 쉬운 표준 인터페이스를 제공함으로써 반복적인 메타데이터 레지스트리 접근연산 개발 시 메타데이터 레지스트리 간 데이터 불일치를 개선할 수 있게 한다. 그러나 SQL/MDR은 검색을 위한 연산만을 지원할 뿐, MDR 구축 시 접근제어를 위한 연산은 제공하지 않아 정확하고 표준화된 MDR 구축 및 안전한 접근제어를 보장하지 못한다. 이 논문에서는 앞서 언급한 SQL/MDR문제점 중에서 안전한 접근제어를 보장할 수 있는 방법으로 MCL(Metadata Control Language)을 제안한다. MCL은 ISO/IEC 11179 Part 6에서 제안하는 사용자 그룹의 역할과 권한을 미리 정의하여 사용자를 사용자 그룹으로 할당하는 간단한 연산자를 사용함으로써 사용상의 편이성과 보안성을 증대시킨다. 또한 시스템 관리자가 쉽고 정확하게 MDR에 대한 접근제어 규칙을 쉽게 정의할 수 있게 하여 시스템 관리 시간 및 비용을 감소시킨다.
Chromatin Changes Associated with Neuronal Maintenance and Their Pharmacological Application
Lee, Jang Ho,Kim, Jeong-Hoon,Kim, Sunhong,Cho, Kyoung Sang,Lee, Sung Bae Bentham Science Publishers 2018 Current neuropharmacology Vol.16 No.2
<P><B>Background:</B></P><P> The transcriptional control of neuronal specification and early development has been intensively stud-ied over the past few decades. However, relatively little is known about transcriptional programs associated with the mainte-nance of terminally differentiated neuronal cells with respect to their functions, structures, and cell type-specific identity features.</P><P><B>Methods:</B></P><P> Notably, largely because of the recent advances in related techniques such as next generation sequencing and chromatin immunoprecipitation sequencing, the physiological implications of system-wide regulation of gene expression through changes in chromatin states have begun to be extensively studied in various contexts and systems, including the nervous system.</P><P><B>Results:</B></P><P> Here, we attempt to review our current understanding of the link between chromatin changes and neuronal mainte-nance in the period of life after the completion of neuronal development. Perturbations involving chromatin changes in the system-wide transcriptional control are believed to be closely associated with diverse aspects of neuronal aging and neuro-degenerative conditions.</P><P><B>Conclusion:</B></P><P> In this review, we focused on heterochromatin and epigenetic dysregulation in neurodegenerative conditions as well as neuronal aging, the most important risk factor leading to neuronal degeneration, in order to highlight the close association between chromatin changes and neuronal maintenance. Lastly, we reviewed the cur-rently available and potential future applications of pharmacological control of the chromatin states associated with neuronal maintenance.</P>
김지원 ( Ji Won Kim ),이선홍 ( Sunhong Lee ),임현이 ( Hyun Ee Yim ),정종철 ( Jong Cheol Jeong ),신규태 ( Gyu-tae Shin ),김흥수 ( Heungsoo Kim ),박인휘 ( Inwhee Park ) 대한내과학회 2018 대한내과학회지 Vol.93 No.4
Branchio-oto-renal (BOR) syndrome is a rare autosomal dominant disorder that is characterized by preauricular pits, branchial fistula, branchial cyst, hearing impairment, and kidney anomalies. Hearing impairment is the single most common feature of BOR syndrome, affecting 89% of patients. Preauricular pits (77%), kidney anomalies (66%), branchial fistula (63%), external auditory canal anomalies (41%) are also common. For most patients, BOR syndrome does not affect life expectancy. The major life-threatening feature of this condition is kidney dysfunction, which occurs with about 6% of kidney anomalies. Therefore, once BOR syndrome is recognized in a patient, careful evaluation to detect renal anomalies and treatment of any kidney involvement are necessary. No case reports of BOR syndrome involving adult-onset end-stage kidney disease have been published in the Korean medical literature. We report a case of end-stage kidney disease in a 19-year-old male patient with BOR syndrome, together with a review of the pertinent literature. (Korean J Med 2018;93:398-403)
Identification of Novel Binding Partners for Caspase-6 Using a Proteomic Approach
( Ju Yeon Jung ),( Su Rim Lee ),( Sunhong Kim ),( Seung Wook Chi ),( Kwang Hee Bae ),( Byoung Chul Park ),( Jeong Hoon Kim ),( Sung Goo Park ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.5
Apoptosis is the process of programmed cell death executed by specific proteases, the caspases, which mediate the cleavage of various vital proteins. Elucidating the consequences of this endoproteolytic cleavage is crucial to understanding cell death and other related biological processes. Although a number of possible roles for caspase-6 have been proposed, the identities and functions of proteins that interact with caspase-6 remain uncertain. In this study, we established a cell line expressing tandem affinity purification (TAP)-tagged caspase-6 and then used LC-MS/MS proteomic analysis to analyze the caspase-6 interactome. Eight candidate caspase-6-interacting proteins were identified. Of these, five proteins (hnRNP-M, DHX38, ASPP2, MTA2, and UACA) were subsequently examined by co-immunoprecipitation for interactions with caspase-6. Thus, we identified two novel members of the caspase-6 interactome: hnRNP-M and MTA2.
Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells
( Phil Young Lee ),( Byoung Chul Park ),( Seung Wook Chi ),( Kwang-hee Bae ),( Sunhong Kim ),( Sayeon Cho ),( Seongman Kang ),( Jeong-hoon Kim ),( Sung Goo Park ) 생화학분자생물학회 2016 BMB Reports Vol.49 No.10
Granzyme A (GzmA) was first identified as a cytotoxic T lymphocyte protease protein with limited tissue expression. A number of cellular proteins are known to be cleaved by GzmA, and its function is to induce apoptosis. Histones H1, H2B, and H3 were identified as GzmA substrates during apoptotic cell death. Here, we demonstrated that histone H4 was cleaved by GzmA during staurosporine-induced cell death; however, in the presence of caspase inhibitors, staurosporine-treated Raji cells underwent necroptosis instead of apoptosis. Furthermore, histone H4 cleavage was blocked by the GzmA inhibitor nafamostat mesylate and by GzmA knockdown using siRNA. These results suggest that histone H4 is a novel substrate for GzmA in staurosporine-induced cells. [BMB Reports 2016; 49(10): 560-565]
Yang Jee Myung,Yun KyungA,Jeon Jehwi,Yang Hae Young,Kim Bora,Jeong Sunhong,Lee Junyeop,Oh Wang-Yuhl,Uemura Akiyoshi,Song Joon Seon,Kim Pilhan,Lee Joo Yong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
We aimed to characterize the vascular phenotypes of an experimental autoimmune retinal uveitis (EAU) model induced by interphotoreceptor retinoid-binding protein (IRBP) using multimodal imaging techniques. We systemically administered IRBP or vehicle to adult C57BL/6 mice. Fundus photography, optical coherence tomography (OCT), in vivo live confocal imaging using different tracers, OCT angiography (OCTA), and electroretinography (ERG) were performed after IRBP immunization. Hematoxylin and eosin and immunofluorescence staining were performed to characterize the immune response and vascular permeability. Mice with EAU exhibited perivascular inflammation, vitritis, and superficial retinal inflammation on fundus photography and OCT. H&E revealed immune cell infiltration in the perivascular area of the retina and choroid accompanied by a significant degree of perivasculitis that subsequently damaged photoreceptors 3 weeks postimmunization. Immunofluorescence staining showed subsequent transcytosis induction after local microglial activation followed by neutrophil recruitment in the perivascular area. Transcytosis in the superficial and deep vascular areas was improved by immune cell suppression. Intravital in vivo confocal imaging showed signs of neutrophil infiltration and obstructive vasculitis with perivascular leakage 3 weeks postimmunization. OCTA revealed a significant decrease in vascular flow in the deep capillary layer of the retina. Functional analysis showed that scotopic responses were intact at 2 weeks; however, normal photopic and scotopic responses were hardly detected in mice with EAU mice at 3 weeks postimmunization. Our data suggest that inflammatory cell activation and subsequent transcytosis induction in endothelial cells might be a major pathogenic factor for vascular leakage in uveitis, providing new insights into the pathophysiology of retinal vasculitis in noninfectious uveitis.