http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
전래동화에 기초한 장단-말놀이 활동이 유아의 언어능력, 국악능력, 그리기표상능력에 미치는 효과
장효지(Hyo-Ji Jang),김성희(Sung-Hee Kim) 중앙대학교 한국교육문제연구소 2016 한국교육문제연구 Vol.34 No.2
본 연구의 목적은 만 5세 유아를 대상으로 전래동화에 기초한 장단-말놀이 활동을 개발하고 유아의 언어능력, 국악능력, 그리기표상능력에 미치는 효과를 분석하여 유아교육 현장 적용 및 타당성을 검증하는데 있다. 연구대상은 K시에 소재한 실험집단 C유치원 만 5세 유아 20명과 비교집단 R유치원 만 5세 유아 20명을 연구 대상으로 선정하였으며 연구대상의 평균연령은 실험집단 72.05개월, 비교집단 72.40개월로 동질 집단인 것으로 나타났다. 연구도구는 ‘구문의미 이해력 검사’(서울장애인종합복지관, 2009), 유아국악능력 검사 도구(박형신, 2006), 그리기표상능력(지성애, 2001)을 사용하였다. 연구결과는 SPSS 18.0 프로그램을 사용하여 공변량분석(ANCOVA)를 실시하였다. 본 연구 결과는 ‘전래동화에 기초한 장단-말놀이 활동’은 유아의 언어능력, 국악능력 증진에 효과적인 것으로 밝혀졌다. The purpose of this study is to analyze the effects of a Korean folktale based rhythm-word play activity on children’s language, drawing representation, and traditional Korean music ability in an early childhood education. ‘The Construction Meaning Comprehension Test’ is used to measure children’s language ability and it was developed and standardized by Seoul Community Rehabilitation Center(2009), ‘Traditional Korean Music Ability Test’ developed by Park Hyung-Shin(2006), ‘The Drawing Representation Inventory’ developed by Chi Sung-Ae(2001). In conclusion, a ‘Korean folktale based rhythm-word play activity’ has positive effects on language and traditional Korean music ability development. This study proves the validity of applying ‘ a Korean folktale based rhythm-word play activity’ in young children's education. Therefore, children’s language ability and traditional Korean music ability can be effectively increased by actively applying ‘a Korean folktale based rhythm-word play activity’ teaching-learning method in young children's education.
Sang-Hee Lee,In-Ju Jung,Hyesook Jang 대한의생명과학회 2018 Biomedical Science Letters Vol.24 No.4
Manganese (Mn) is used as main materials in various chemical processes of industry, but it suggested that Mn brings about its toxicant by fume or dust through respiratory system and skin barrier. Mn toxicant induces the loss of mental health and life quality by cerebrovascular and skin diseases. Nevertheless, it lefts much unknown on the mechanism and the effectively therapeutic methods about Mn toxicant. Therefore, this study was evaluated the cytotoxicity induced by manganese dioxide (MnO₂) in cultured NIH3T3 fibroblasts, and also, the correlation between MnO₂-induced cytotoxicity and oxidative stress was examined. While, the effect of Eclipta prostrata L. (EP) extract belong to Compositae was assessed against MnO₂-induced cytotoxicity in the view of antioxidative effect for searching the natural resources mitigating or preventing the MnO₂-induced cytotoxicity. In this study, MnO₂-induced cytotoxicity was revealed as mid-toxic by Borenfreud and Puerner`s toxic criteria, and catalase (CAT), an antioxidant prevented MnO₂-induced cytotoxicity by the remarkable increase of cell viability in these cultures. While, in the protective effect of EP extract on MnO₂-induced cytotoxicity, EP extract effectively prevented the cytotoxicity induced by MnO₂ via antioxidative effects such as xanthine oxidase (XO) inhibitory ability and DPPH-radical scavenging ability. From the above results, EP extract showed the effective prevention against MnO₂-induced cytotoxicity correlated with oxidative stress by antioxidative effects. Conclusively, this study may be useful to research or development the alternatively therapeutic agent from natural resources like EP extract for the treatment of diseases resulted in oxidative stress.
Sung, Eun-Sil,Park, Kyung-Jin,Lee, Seung-Hyun,Jang, Yoon-Seon,Park, Sang-Koo,Park, Yoo-Hoi,Kwag, Won-Jae,Kwon, Myung-Hee,Kim, Yong-Sung American Association for Cancer Research, Inc 2009 Molecular Cancer Therapeutics Vol.8 No.8
<P>The proapoptotic tumor necrosis factor-related apoptosis inducing ligand (TRAIL) receptors death receptor (DR) 4 and DR5 are attractive targets to develop the receptor-specific agonistic monoclonal antibodies (mAb) as anticancer agents because of their tumor-selective cell death-inducing activity. Here, we report a novel agonistic mAb, AY4, raised against human DR4 in mice. ELISA analysis revealed that AY4 specifically bound to DR4 without competition with TRAIL for the binding. Despite distinct binding regions of AY4 on DR4 from those of TRAIL, AY4 as a single agent induced caspase-dependent apoptotic cell death of several tumor types through the extrinsic and/or intrinsic pathways without substantial cytotoxicity to normal human hepatocytes. Further, the AY4-sensitive cells followed the same cell death characteristics classified as type I and type II cells by the response to TRAIL, suggesting that the cell death profiles in responses to DR4 and/or DR5 stimulation are determined by the downstream signaling of the receptor rather than the kind of receptor. Noticeably, AY4 efficiently induced cell death of Jurkat cells, which have been reported to be resistant to other anti-DR4 agonistic mAbs, most likely due to the unique epitope property of AY4. In vivo administration of AY4 significantly inhibited tumor growth of human non-small cell lung carcinoma preestablished in athymic nude mice. Conclusively, our results provide further insight into the DR4-mediated cell death signaling and potential use of AY4 mAb as an anticancer therapeutic agent, particularly for DR4-responsive tumor types.</P>
[PE-0005] A White Waxy Hybrid Corn, ?Dodamchal? with Good Eating Quality
Sang-Woo Kim(Sang-Woo Kim),Jong Hyeong Lee(Jong Hyeong Lee),Byoung Rourl Choi(Byoung Rourl Choi),Eun Kyu Jang(Eun Kyu Jang),Young Rok Kim(Young Rok Kim),Hae Chan Jung(Hae Chan Jung),Jung-Hee Jang(Jung 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Jang, Moon Hee,Piao, Xiang Lan,Kim, Hyun Young,Cho, Eun Jung,Baek, Seung Hoon,Kwon, Sung Won,Park, Jeong Hill Pharmaceutical Society of Japan 2007 Biological & pharmaceutical bulletin Vol.30 No.6
<P>Oxidative damage induced by β-amyloid (Aβ) is closely associated with the hallmark pathologies of Alzheimer's disease (AD) and may play a critical role in the development of AD. In this study, the protective effects of vitisin A and heyneanol A, resveratrol oligomers isolated from <I>Vitis amurensis</I> R<SMALL>UPR</SMALL>. (Vitaceae), against Aβ-induced oxidative cell death were investigated using rat pheochromocytoma (PC12) cells. Exposure of PC12 cells to the Aβ (20 μ<SMALL>M</SMALL>) for 24 h resulted in neuronal cell death, whereas pretreatment with vitisin A or heyneanol A at the concentration range of 5—50 μ<SMALL>M</SMALL> reduced Aβ-induced cell death. In addition, Aβ-induced elevation of reactive oxygen species generation, the primary cause of Aβ-induced oxidative stress, was attenuated by treatment of vitisin A or heyneanol A (10, 25, 50 μ<SMALL>M</SMALL>). Aβ-treated cells also displayed characteristic features of apoptosis such as induction of DNA fragmentation and caspase-3 activation, but vitisin A and heyneanol A (10, 50 μ<SMALL>M</SMALL>) significantly suppressed these events. These results suggest that vitisin A and heyneanol A prevent Aβ-induced neurotoxicity through attenuating oxidative stress induced by Aβ, and may be useful as potential preventive or therapeutic agents for AD.</P>
Jang, Moon Hee,Piao, Xiang Lan,Kim, Jong Moon,Kwon, Sung Won,Park, Jeong Hill John Wiley Sons, Ltd. 2008 Phytotherapy research Vol.22 No.4
<P>In the course of screening for acetylcholinesterase and butyrylcholinesterase inhibitors from natural products by an in vitro Ellman method, the extract of the roots of Vitis amurensis Rupr. (Vitaceae) showed significant cholinesterase inhibitory activity. Employing a bioassay-linked HPLC method, followed by a semi-preparative HPLC method, two compounds of interest were isolated and characterized as vitisin A and heyneanol A. They inhibited effectively both acetylcholinesterase and butyrylcholinesterase in a dose-dependent manner and exhibited higher activity against butyrylcholinesterase compared with that of galantamine, a positive control. Furthermore, the aggregation of &bgr;-amyloid was evaluated in vitro based on a thioflavine T fluorescence assay to expand their activity profile, with the result that both compounds showed the ability to block &bgr;-amyloid aggregation. Copyright © 2008 John Wiley & Sons, Ltd.</P>