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Efficient Activation of Dendritic Cells with Immuno-modulating Functional Nanoparticles in Hydrogel
Jaesung LIM,Hee Seung SEO,Jun-Hyeok HAN,Wooram PARK,Chun Gwon PARK 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.4
Modulation of the immunosuppressive tumor microenvironment (TME) is crucial for effective tumor treatment. Herein, we demonstrate an immune-modulating hydrogel containing functional nanoparticles. These nanoparticles were synthesized by a heat-up method and coated with CpG oligonucleotide capable of activating the dendritic cells. When the CpG-coated nanoparticles were treated to bone marrow-derived dendritic cells (BMDCs), it upregulated activation marker for DCs such as CD80, CD86, CD40, and MHC2 molecules, suggesting the nanoparticles-mediated maturation of BMDCs. For sustained and local delivery of the prepared CpG-coated nanoparticles to the tumor resection site, the functional nanoparticles were embedded in a hydrogel based on methacrylate-modified hyaluronic acid. Finally, the immune-modulating hydrogel was implanted in a fat pad after the surgical-resected breast tumor model in vivo. The implantation of the immune-modulating hydrogel could be able to effectively activate the DCs in the vicinity of the tumor resection site, resulting in the activation of cytotoxic T cells. We believe this strategy has great potential for effective prevention of tumor recurrence and metastasis.
Sepsis diagnosis and treatment using nanomaterials
Jaesung Lim,Yun Young Lee,Young Bin Choy,Wooram Park,Chun Gwon Park 대한의용생체공학회 2021 Biomedical Engineering Letters (BMEL) Vol.11 No.3
Sepsis is a life-threatening reaction that occurs when the body’s severe response to an infection damages the host’s owntissues. Sepsis has been globally recognized as a fatal disease. Rapid treatment of sepsis requires prompt identifi cation,administering antibiotics, careful hemodynamic support, and treating the cause of the infection. Clinical outcomes of sepsisdepend on early diagnosis and appropriate treatment. Unfortunately, current sepsis diagnosis and treatment, such as polymerasechain reaction-based assay, blood culture assay, and antibiotic therapy, are ineff ective; consequently, sepsis-relatedmortality remains high and increases antimicrobial resistance. To overcome this challenge, nanotechnology, which involvesengineering at a nanoscale, is used for diagnosing and treating sepsis. Preclinical models have shown protective eff ects andpotential utility in managing septic shock. Furthermore, nanotechnology treatments based on diverse materials result inthe eff ective treatment of sepsis, improving the survival rate. In this review, we present an overview of the recent researchadvancements in nanotechnology to diagnose and treat sepsis with a brief introduction to sepsis.
임병직(Byoungjik Lim),이준성(Junseong Lee),임성혁(Sung-Hyuck Lim),이기주(Keejoo Lee),박재성(Jaesung Park) 한국추진공학회 2021 한국추진공학회 학술대회논문집 Vol.2021 No.5
액체메탄엔진 핵심기술 선행연구를 목적으로 연소시험을 위한 시험장치를 구축하였다. 구축된 장치에 대한 기밀시험, 냉각시험, 센서 검증, 화재방지용 물 공급시험, 자동시퀀스 시험 및 액체질소를 활용한 극저온 수류시험 등의 검증시험을 성공적으로 수행하였다. 검증시험을 통해 설비 작동 안정성 및 사용 부품 적절성이 검증되었으며, 연소기를 장착한 수류시험 및 연소시험에도 활용되고 있다. For the purpose of supporting preceding research on the core technology for a liquid methane engine, a device for the hot firing test had been implemented. Subsequently, various tests including leak test, cool down test, sensor verification, fire preventing water supply test, auto sequence test, and cold flow test with liquid nitrogen were successfully conducted. These acceptance test results validated that the device is composed of appropriate components and safe for testing operation. In addition, a thrust chamber attached to the device was used for a cold flow test and a hot firing test.
임병직(Byoungjik Lim),임하영(Ha Young Lim),이기주(Keejoo Lee),박재성(Jaesung Park) 한국추진공학회 2021 한국추진공학회 학술대회논문집 Vol.2021 No.5
한국항공우주연구원 미래발사체연구단은 액체메탄엔진에 중점을 둔 소형발사체 상단의 선행기술을 개발하고 있다. 성능과 저비용을 검토하여 상단엔진은 메탄을 연료로 사용하는 팽창식 사이클로 결정되었으며, 최대한 많은 부품에 적층제작 기술을 적용할 계획이다. 본 논문에서는 1톤급 메탄엔진용 적층제작 연소기를 활용한 연소시험 준비 및 점화시험 과정에 대해서 소개하며, 향후 진행 방향에 대해서도 간단히 제시한다. The Future Launcher R&D Program Office of the Korea Aerospace Research Institute is developing preceding technologies for an upper stage of a small-satellite launch vehicle, with a focus on the liquid methane engine. An expander cycle has been chosen for the upper stage engine through a trade-off of performance and cost, and additive manufacturing technologies will be adopted to as many components as possible. In this work, we describe test preparation activities for hot firing and ignition tests of a thrust chamber for a 1-tonf class methane engine and briefly touch upon a near-term test plan.
Comparison of Solar Cells Interconnection with Metal Ribbons and Electrically Conductive Adhesives
Jaesung Bae(배재성),Juhwi Kim(김주휘),Jeongho Jeong(정정호),Jangwon Yoo(유장원),Chanyong Lee(이찬용),Hongsub Jee(지홍섭),Donggun Lim(임동건),Chaehwan Jeong(정채환),Jaehyeong Lee(이재형) 한국태양에너지학회 2021 한국태양에너지학회 학술대회논문집 Vol.2021 No.11