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Lee, Jennifer,Lee, Seon-Young,Lee, Jaeseon,Lee, Juhyun,Baek, Seungye,Lee, Dong-Gun,Kim, Eun-Kyung,Lee, Sung Hak,Cho, Mi-La,Kwok, Seung-Ki,Ju, Ji Hyeon,Park, Sung-Hwan Oxford University Press 2016 Rheumatology Vol.55 No.1
<P>Objective. Triggering receptor expressed on myeloid cells 1 (TREM-1), which amplifies the inflammation elicited by the Toll-like receptor pathway, was originally implicated in sepsis and bacterial infection. However, it has been suggested that TREM-1 may also play an important role in non-infectious inflammation. The present study was conducted to investigate whether TREM-1 is involved in human acute gouty inflammation. Methods. A total of 37 gout patients were recruited between March 2011 and January 2014 from Seoul St Mary's Hospital. The expression of TREM-1 on mononuclear cells was assessed using FACS analysis, immunostaining and real-time RT-PCR. To block the TREM-1 signal, soluble TREM-1 (sTREM-1) or the synthetic blocking peptide LP17 was used. The concentration of sTREM-1 was assessed by ELISA. Results. FACS analysis and real-time RT-PCR demonstrated that TREM-1 expression was higher in the SF mononuclear cells of acute gouty arthritis patients than in peripheral blood mononuclear cells (PBMCs). Immunohistochemical staining of tophi tissues revealed TREM-1 expression, with confocal microscopy demonstrating TREM-1 expression on tophi tissue macrophages. We also demonstrated that MSU treatment induced TREM-1 expression on the PBMCs of acute gout patients in vitro. Although blockade of TREM-1 did not directly suppress MSU-induced IL-1 beta production of PBMCs in vitro, the concentration of soluble TREM-1 was higher in the SF of gout vs OA patients and was positively correlated with serum CRP. Conclusion. TREM-1 is induced by MSU and is associated with the inflammation of human acute gouty arthritis.</P>
Component Characteristics of Xanthoceras sorbifolium Seeds for Bioenergy Plant Utilization
Lee, Hyunseok,Yi, Jaeseon,An, Chanhoon,Kim, Minsu,Lee, Jeonghoon Institute of Forest Science 2015 Journal of Forest Science Vol.31 No.4
Xanthoceras sorbifolium is considered as bio-energy crops owing to the high oil content from kernel. This study was performed to analyze calorific value, crude ash content, ultimate ratio, crude lipid and fatty acid composition among seed sources. Calorific values ranged from $4,526.0\;cal\;g^{-1}$ to $7,377.2\;cal\;g^{-1}$ in seeds and kernels showed the highest value. Calorific values and crude ash contents were observed as significant difference among plantations and/or individuals (p>0.05). Kernel from SD-F plantation showed the highest calorific value and lower crude ash content. C content comprised 63.4%, the highest levels was detected from SD-F (64.8%). Crude lipid content in kernel observed as 54.5 g $100\;g^{-1}$ from SD-F. In contrast it was determined the lowest value from LN-JARS as 46.5 g $100\;g^{-1}$. The fatty acid composition of kernel was determined to those of oleic acid (31.3%) and linoleic acid (38.1%) from SD-F and LN-JARS. These results will be offered to useful information for breeding materials selection.
Lee Jaeseon,Yoon Jinsoo,Jeon Jaesung,Hong Yohan,오성근,Huh Hoon 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.8
Battery reliability is emerging as a new challenge due to the thermal stability and electrolyte wettability of polyolefin separators used in lithium-ion batteries. In this study, a method to improve the thermal stability and electrolyte wettability of a polyolefin separator is proposed. Bicomponent nanofibers were successfully fabricated by electro-spinning poly (vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) with high ionic conductivity and polyacrylonitrile (PAN) with excellent thermal stability. The nanofiber-based separator of PVDF-HFP/PAN exhibited high porosity (60–76%), electrolyte uptake (≅2,000%), and thermal stability (5%<shrinkage, at 200 °C) than conventional polyolefin separator. The battery using the bicomponent nanofiber separator composed of PVDF-HFP and PAN showed better cycle performance (421 mAh/g, after 80 cycle), efficiency (≅99.6%), and c-rate performance (418 mAh/g, 3C) than the battery using polyolefin separator.
THERMAL FRICTION TORQUE CHARACTERISTICS OF STAINLESS BALL BEARINGS
JaeSeon Lee,JiHo Kim,JongIn Kim 한국트라이볼로지학회 2002 한국트라이볼로지학회 학술대회 Vol.2002 No.10
Stainless steel ball bearings are used in the control element drive mechanism and driving mechanisms such as step motor and gear boxes for the integral nuclear reactor, SMART. The bearings operate in pressurized pure water (primary coolant) at high temperature and should be lubricated with only this water because it is impossible to supply greases or any additional lubricant since the whole nuclear rector system should be perfectly sealed and the coolant cannot contain ingredients for bearing lubrication. Temperature of water changes from room temperature to about 120 degree Celsius and pressure rises up to 15㎫ in the nuclear reactor. It can be anticipated that the frictional characteristics of the ball bearings changes according to the operating conditions, however little data are available in the literature. It is found that friction coefficient of 440C stainless steel itself does not change sharply according to temperature variation from the former research, and the friction coefficient is about 0.45 at low speed range. In this research frictional characteristics of the assembled ball bearings are investigated. A special tribometer is used to simulate the axial loading and the bearing operating conditions, temperature and pressure in the driving mechanism in the nuclear reactor. Highly purified water is used as lubricant, and the water is heated up to 120 degree Celsius and pressurized to 15㎫. Friction force is monitored by the torque transducer.
Synergistic effects of oxygen on phosphine for the control of 6 major agricultural pests
Jaeseon Lee,Hyun Kyung Kim,Hyunna Koo,Gil-Hah Kim,Byung Ho Lee 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.04
Phosphine(PH3) is very effective fumigant and is widely used to control pests. Oxygen treatment was found to enhance phosphine toxicity and reduce fumigation time. We researched the insecticidal activities and synergistic effects of oxygen with phosphine(PH3) against on adult stage of 6 agricultural pests as Frankliniella occidentalis, F. intonsa, Pseudococcus comstocki, Planococcus citri, Myzus persicae and Tetranychus urticae. Adults F. occidentalis, F. intonsa, P. comstocki and P. citri was highly susceptible to PH3 at 2mg/L for 2h treatment. However, M. persicae and T. urticae were showed very low fumigation effects at 2mg/L for 2h treatment. These 2 pests were treated with PH3 to increase the times (16h and 20h). And we also researched the synergistic effects of PH3 under controlled atmospheres of 50% and 80% oxygen(O2). Increase of the time and atmospheric oxygen showed improving activities of the PH3 in the 2 agricultural pests. Therefore, PH3 is an effective fumigant against F. occidentalis, F. intonsa, P. comstocki and P. citri, and its synergistic effect with oxygen is effective to control M. persicae and T. urticae. PH3 with oxygen could be useful for managing the agricultural and quarantine pests.
복부 컴퓨터 단층촬영영상에서 다중 확률 아틀라스 기반 형상제한 그래프-컷을 사용한 신실질 자동 분할
이재선(Jaeseon Lee),홍헬렌(Helen Hong),나군호(Koon Ho Rha) 한국컴퓨터그래픽스학회 2016 컴퓨터그래픽스학회논문지 Vol.22 No.4
본 논문에서는 복부 CT 영상에서 다중 확률 아틀라스 기반 형상제한 그래프-컷을 사용한 신실질 자동 분할 방법을 제안한다. 제안 방법은 다음의 세 단계로 구성된다. 첫째 신실질의 다양한 형상정보를 이용하기 위해 피질기반 유사정합을 통한 다중 확률 아틀라스를 생성한다. 둘째, 최대사후확률 추정을 통해 그래프-컷의 초기 씨앗을 추출하고, 형상제한 그래프-컷을 통해 신실질을 분할한다. 셋째, 확률 아틀라스의 정합 오차를 줄이고 분할 정확도를 높이기 위해, 정합 및 분할을 반복적으로 수행한다. 제안방법의 성능을 평가하기 위해 정성적 평가 및 정량적 평가를 수행하였다. 실험결과 제안방법이 신실질과 유사한 밝기값을 갖는 주변 영역으로의 누출을 방지하여 개선된 분할 정확도를 보여준다. In this paper, we propose an automatic segmentation method of renal parenchyma on abdominal CT image using graph-cuts with shape constraint based on multi-probabilistic atlas. The proposed method consists of following three steps. First, to use the various shape information of renal parenchyma, multi-probabilistic atlas is generated by cortex-based similarity registration. Second, initial seeds for graph-cuts are extracted by maximum a posteriori (MAP) estimation and renal parenchyma is segmented by graph-cuts with shape constraint. Third, to reduce alignment error of probabilistic atlas and increase segmentation accuracy, registration and segmentation are iteratively performed. To evaluate the performance of proposed method, qualitative and quantitative evaluation are performed. Experimental results show that the proposed method avoids a leakage into neighbor regions with similar intensity of renal parenchyma and shows improved segmentation accuracy.