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( Hi Young Kim ),( In Ho Yang ),( Shin Young Ryu ),( Dong Hwan Won ),( Awadut G. Giri ),( Wei Hong Wang ),( Hyuk Jae Choi ),( Jung Wook Chin ),( Dong Yup Hahn ),( Eun Hee Kim ),( Chul Kyeong Han ),( J 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
Two new benzophenones, acredinones A(1) and B(2), were isolated from a marine-sponge-associated Acre-monium sp. Fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 um, respectively.
( Jae Yik Lee ),( Sang Joon Park ),( Jae Hyuk Lee ),( Mi Kyung Kwak ),( Hye Jeong Kim ),( Dong Won Byun ),( Kyo Il Suh ),( Myung Hi Yoo ),( Hyun Sook Kim ),( Hyeong Kyu Park ) 대한내과학회 2016 대한내과학회 추계학술발표논문집 Vol.2016 No.1
Introduction: Several capillary changes detected by finger nailfold capillaroscopy have been shown to correlate with microvascular complications in type 1 diabetes. However, there are few reports on the relationship between nailfold capillary abnormalities and microvascular complications in type 2 diabetes (T2DM). Herein, we investigated whether nailfold capillary microscopic changes are associated with diabetic nephropathy in patients with T2DM. Methods: We conducted a cross-sectional study in patients with T2DM diagnosed within 20 years (duration of diabetes: 6.4±6.0 years). The nailfold capillaroscopy can visualize the capillary network in fingers and is a non-invasive test. The presence of morphological abnormalities, including avascular areas, giant capillaries, dilated, tortuous, or ramified capillaries, hemorrhages and capillary architectural derangements, in finger nailfold capillaroscopy image was assessed by a single rheumatology specialist. The severity of nailfold capillary change (0 : no change, 1 : capillary change/mm <33%, 2 : capillary change/mm between 33-66%, 3 : capillary change/mm >66%) was scored. Statistical analyses were performed using Pearson correlation or Spearman rank correlation as appropriate Results: A total of 63 patients with T2DM were enrolled. Both capillary architectural derangements and avascular areas in nailfold capillaroscopy showed significant correlations with albuminuria measured by spot urine or 24-hour urine collection after adjusting for sex, age, body mass index, duration of diabetes, hemoglobin, and HbA1C. Moreover, architectural derangements and avascular areas in nailfold capillaries were significantly associated with urinary albumin excretion rate in T2DM patients diagnosed within 10 years. Conclusions: These findings have shown that nailfold capillary abnormalities are independently associated with albuminuria in patients with T2DM of moderate duration, suggesting a role of capillary changes in the pathogenesis of diabetic nephropthy.
Kim, Kyoung-Ah,Lee, Ji-Suk,Park, Hi-Joon,Kim, Jin-Woo,Kim, Chang-Ju,Shim, In-Sop,Kim, Nam-Jae,Han, Seung-Moo,Lim, Sabina KYUNG HEE UNIVERSITY MEDICAL CENTER 2005 고황의학상 수상논문집 Vol.21-22 No.-
Oleanolic acid (OA) and ursolic acid (UA), triterpene acids having numerous pharmacological activities including anti-inflammatory, anti-cancer, and hepato-protective effects, were tested for their ability to modulate the activities of several cytochrome P450 (CYP) enzymes using human liver microsomes. OA competitively inhibited CYP1A2-catalyzed phenacetin O-deethylation and CYP3A4-catalyzed midazolam 1-hydroxylation, the major human drug metabolizing CYPs, with IC_(50) (K_(i)) values of 143.5 (74.2) μM and 78.9 (41.0) μM, respectively. UA competitively inhibited CYP2C19-catalyzed S-mephenytoin 4'-hydroxylation with an IC_(50) (K_(i)) value of 119.7 (80.3) μM. However, other CYPs tested showed no or weak inhibition by both OA and UA. The present study demonstrates that OA and UA have inhibitory effects on CYP isoforms using human liver microsomes. It is thus likely that consumption of herbal medicines containing OA or UA, or administration of OA or UA, can cause drug interactions in humans when used concomitantly with drugs that are metabolized primarily by CYP isoforms. In addition, it appears that the inhibitory effect of OA on CYP1A2 is, in part, related to its anti-inflammatory and anticancer activities.
Kim, Jiyoung,Kim, Jhoon,Cho, Hi-Ku,Herman, Jay,Park, Sang Seo,Lim, Hyun Kwang,Kim, Jae-Hwan,Miyagawa, Koji,Lee, Yun Gon Copernicus GmbH 2017 Atmospheric measurement techniques Vol.10 No.10
<P><p><strong>Abstract.</strong> Daily total column ozone (TCO) measured using the Pandora spectrophotometer (no. 19) was compared with data from the Dobson (no. 124) and Brewer (no. 148) spectrophotometers, as well as from the Ozone Monitoring Instrument (OMI) (with two different algorithms, Total Ozone Mapping Spectrometer (TOMS) TOMS and differential optical absorption spectroscopy (DOAS) methods), over the 2-year period between March 2012 and March 2014 at Yonsei University, Seoul, Korea. Based on the linear-regression method, the TCO from Pandora is closely correlated with those from other instruments with regression coefficients (slopes) of 0.95 (Dobson), 1.00 (Brewer), 0.98 (OMI-TOMS), and 0.97 (OMI-DOAS), and determination coefficients (R2) of 0.95 (Dobson), 0.97 (Brewer), 0.96 (OMI-TOMS), and 0.95 (OMI-DOAS). The daily averaged TCO from Pandora has within 3<span class='thinspace'></span>% differences compared to TCO values from other instruments. For the Dobson measurements in particular, the difference caused by the inconsistency in observation times when compared with the Pandora measurements was up to 12.5<span class='thinspace'></span>% because of diurnal variations in the TCO values. However, the comparison with Brewer after matching the observation time shows agreement with large <i>R</i><sup>2</sup> and small biases. The TCO ratio between Brewer and Pandora shows the 0.98<span class='thinspace'></span>±<span class='thinspace'></span>0.03, and the distributions for relative differences between two instruments are 89.2 and 57.1<span class='thinspace'></span>% of the total data within the error ranges of 3 and 5<span class='thinspace'></span>%, respectively. The TCO ratio between Brewer and Pandora also is partially dependent on solar zenith angle. The error dependence by the observation geometry is essential to the further analysis focusing on the sensitivity of aerosol and the stray-light effect in the instruments.</p> </P>
Lignan from Safflower Seeds Induces Apoptosis in Human Promyelocytic Leukemia Cells
Kim, Jae-Hi,Park, Youn-Hee,Park, Sang-Won,Yang, Eun-Kyoung,Lee, Won-Jung The Korean Society of Food Science and Nutrition 2003 Preventive Nutrition and Food Science Vol.8 No.2
We recently extracted lignans such as matairesinol and 2-hydroxyarctigenin from safflower seeds and found that they exhibit a potent cytotoxic effect on human promyleocytic leukemia HL-60 cells. In this study, we investigated whether mechanisms of the matairesinol-induced cell death are associated with the programmed cell death, apoptosis. Matairesinol dose-dependently reduced viability of HL-60 cells with an IC/sun 50/ value of 60 $\mu$M. Staining of cells with Hoechst 33342 revealed distinct morphological features of apoptosis, such as the nuclei broken into chromatin containing fragments of various sizes in the cells exposed to 100 $\mu$M matairesinol for 24 hr. Agarose gel electrophoresis of DNA from the cells treated with matairesinol showed internucleosomal DNA degradation into oligonucleosomal sizes. DNA ladder like patterns were easily detected after treatment with matairesinol concentrations ranging from 10 to 100 $\mu$M after 24 hr. In cells treated with 100 $\mu$M matairesinol for differing time periods, the DNA ladder was detectable from 6 hr onward. A time course histogram of the DNA content analyzed by flow cytometry revealed a rapid increase in subdiploid cells and a concomitant decrease in diploid cells exposed to 100 $\mu$M matairesinol. These results indicate that matairesinol-induced HL-60 cell death was due to the DNA damage and apoptosis.
Kim, Kyoung-Ah,Lee, Ji-Suk,Park, Hi-Joon,Kim, Jin-Woo,Kim, Chang-Ju,Shim, In-Sop,Kim, Nam-Jae,Han, Seung-Moo,Lim, Sabina WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-
Oleanolic acid (OA) and ursolic acid (UA), triterpene acids having numerous pharmacological activities including anti-inflammatory, anti-cancer, and hepato-protective effects, were tested for their ability to modulate the activities of several cytochrome P450 (CYP) enzymes using human liver microsomes. OA competitively inhibited CYP1A2-catalyzed phenacetin O-deethylation and CYP3A4-catalyzed midazolam 1-hydroxylation, the major human drug metabolizing CYPs, with IC_(50) (K_(i)) values of 143.5 (74.2) μM and 78.9 (41.0) μM, respectively. UA competitively inhibited CYP2C19-catalyzed S-mephenytoin 4'-hydroxylation with an IC_(50) (K_(i)) value of 119.7 (80.3) μM. However, other CYPs tested showed no or weak inhibition by both OA and UA. The present study demonstrates that OA and UA have inhibitory effects on CYP isoforms using human liver microsomes. It is thus likely that consumption of herbal medicines containing OA or UA, or administration of OA or UA, can cause drug interactions in humans when used concomitantly with drugs that are metabolized primarily by CYP isoforms. In addition, it appears that the inhibitory effect of OA on CYP1A2 is, in part, related to its anti-inflammatory and anticancer activities.
Lignan from Safflower Seeds Induces Apoptosis in Human Promyelocytic Leukemia Cells
Jae Hi Kim,Youn Hee Park,Sang Won Choi,Eun Kyoung Yang,Won Jung Lee 한국식품영양과학회 2003 Preventive Nutrition and Food Science Vol.8 No.2
We recently extracted lignans such as matairesinol and 2-hydroxyarctigenin from safflower seeds and found that they exhibit a potent cytotoxic effect on human promyleocytic leukemia HL-60 cells. In this study, we investigated whether mechanisms of the matairesinol-induced cell death are associated with the programmed cell death, apoptosis. Matairesinol dose-dependently reduced viability of HL-60 cells with an IC_(50) value of 60 μM. Staining of cells with Hoechst 33342 revealed distinct morphological features of apoptosis, such as the nuclei broken into chromatin containing fragments of various sizes in the cells exposed to 100 μM matairesinol for 24 hr. Agarose gel electrophoresis of DNA from the cells treated with matairesinol showed internucleosomal DNA degradation into oligonucleosomal sizes. DNA ladder like patterns were easily detected after treatment with matairesinol concentrations ranging from 10 to 100 μM after 24 hr. In cells treated with 100 μM matairesinol for differing time periods, the DNA ladder was detectable from 6 hr onward. A time course histogram of the DNA content analyzed by flow cytometry revealed a rapid increase in subdiploid cells and a concomitant decrease in diploid cells exposed to 100 μM matairesinol. These results indicate that matairesinol-induced HL-60 cell death was due to the DNA damage and apoptosis.