Inhibition of brain tumor cell proliferation by alternating electric fields

Jeong, Hyesun,Sung, Jiwon,Oh, Seung-ick,Jeong, Seonghoon,Koh, Eui Kwan,Hong, Sunghoi,Yoon, Myonggeun American Institute of Physics 2014 APPLIED PHYSICS LETTERS Vol.105 No.20

Influence of Illness Uncertainty on Health Behavior in Individuals with Coronary Artery Disease: A Path Analysis

Jeong Hyesun,Lee Yesul,Lee Yoonju 한국간호과학회 2024 Journal of Korean Academy of Nursing Vol.54 No.2

Purpose: This study aimed to investigate the influence of uncertainty-related factors on the health behavior of individuals with coronary artery disease (CAD) based on Mishel’s uncertainty in illness theory (UIT). Methods: We conducted a cross-sectional study and path analysis to investigate uncertainty and factors related to health behavior. The study participants were 228 CAD patients who visited the outpatient cardiology department between September 2020 and June 2021. We used SPSS 25.0 and AMOS 25.0 software to analyze the data. Results: The final model demonstrated a good fit with the data. Eleven of the twelve paths were significant. Uncertainty positively affected danger and negatively affected self-efficacy and opportunity. Danger had a positive effect on perceived risk. Opportunity positively affected social support, self-efficacy, perceived benefit and intention, whereas it negatively affected perceived risk. Social support, self-efficacy, perceived benefit and intention had a positive effect on health behavior. We found that perceived benefit and intention had the most significant direct effects, whereas self-efficacy indirectly affected the relationship between uncertainty and health behavior. Conclusion: The path model is suitable for predicting the health behavior of CAD patients who experience uncertainty. When patients experience uncertainty, interventions to increase their self-efficacy are required first. Additionally, we need to develop programs that quickly shift to appraisal uncertainty as an opportunity, increase perceived benefits of health behavior, and improve intentions.

Changes in Empathy of Nursing College Students: A Cohort Longitudinal Study

Jeong, Hyesun,Lee, Keelyong 기본간호학회 2021 기본간호학회지 Vol.28 No.4

Purpose: This study aimed to identify changes in sub-areas of empathy over the 4 years from admission to graduation of nursing college students. Methods: This descriptive survey study was conducted using a longitudinal cohort design. The participants in this study were 158 South Korean nursing students attending a university in Chungcheongbuk Province or Gyeonggi Province, all of whom passed the certification evaluation for the 4-year nursing educational institute. Data from 126 participants were analyzed. The level of empathy was measured five times from March 2012 to December 2015. Empathy was identified using a multi-dimensional measurement tool consisting of four sub-constructs of cognitive and emotional aspects: (1) perspective taking, (2) fantasy, (3) empathic concern, and (4) personal distress. Data were analyzed using SPSS version 25 to provide descriptive statistics of the participants’ general characteristics and empathy level and to perform repeated-measures analysis of variance for the sub-constructs empathy. Results: Perspective taking (F=13.08, p<.001) and personal distress (F=5.24, p=.001), but not fantasy or empathic concern, showed significant differences over time. Conclusion: Cognitive empathy (perspective taking) and emotional empathy (personal distress) improved. Intervention programs should be developed to maintain and strengthen changes in empathy in nursing education.

The mimicking agent of postconditioning has neuroprotective effect through activation of NF-κB on cerebral ischemia

JEONG Jaewon,YANG Jiwon,Kim Soojin,JEONG Hyesun,KIM Bokyung,JUNG Siyun,SONG Yun Seon 大韓藥學會 2012 大韓藥學會 總會 및 學術大會 Vol.2012 No.1

Thymidine decreases the DNA damage and apoptosis caused by tumor‐treating fields in cancer cell lines

Jeong Hyesun,Jo Yunhui,윤명근,홍성회 한국유전학회 2021 Genes & Genomics Vol.43 No.9

Background Tumor-treating felds (TTFields) is an emerging non-invasive cancer-treatment modality using alternating electric felds with low intensities and an intermediate range of frequency. TTFields afects an extensive range of charged and polarizable cellular factors known to be involved in cell division. However, it causes side-efects, such as DNA damage and apoptosis, in healthy cells. Objective To investigate whether thymidine can have an efect on the DNA damage and apoptosis, we arrested the cell cycle of human glioblastoma cells (U373) at G1/S phase by using thymidine and then exposed these cells to TTFields. Methods Cancer cell lines and normal cell (HaCaT) were arrested by thymidine double block method. Cells were seeded into the gap of between the insulated wires. The exposed in alternative electric felds at 120 kHz, 1.2 V/cm. They were counted the cell numbers and analyzed for cancer malignant such as colony formation, Annexin V/PI staining, γH2AX and RT-PCR. Results The colony-forming ability and DNA damage of the control cells without thymidine treatment were signifcantly decreased, and the expression levels of BRCA1, PCNA, CDC25C, and MAD2 were distinctly increased. Interestingly, however, cells treated with thymidine did not change the colony formation, apoptosis, DNA damage, or gene expression pattern. Conclusions These results demonstrated that thymidine can inhibit the TTFields-caused DNA damage and apoptosis, suggesting that combining TTFields and conventional treatments, such as chemotherapy, may enhance prognosis and decrease side efects compared with those of TTFields or conventional treatments alone.

간호대학생의 노인체험복 착용경험에 관한 연구

정혜선(Hyesun Jeong),김응종(Eungjong Kim),김정희(Junghee Kim) 한국노년학회 2010 한국노년학 Vol.30 No.1

본 연구는 간호대학생에게 적용한 노인체험복 착용경험을 파악하고 노인에 대한 태도 및 부양의식에 대한 효과를 규명하는 유사실험연구이다. 연구대상자는 노인간호 강의 및 노인체험복 경험이 없는 간호과 학생으로서 실험집단 44명, 비교집단 41명이었다. 실헙집단 학생들은 노인체험복을 착용한 후 시력과 청력기능, 척추 및 관절기능, 손가락기능에 어떤 변화가 나타나는지를 체험하는 활동을 하였다. 집단 간의 동질성 검정은 t-test, X² test, Fisher's exact test를 이용하였으며, 태도와 부양의식의 집단간 비교에는 t-test와 paired t-test를 적용하였다. 체험소감문은 내용분석을 하였다. 노인체험복 착용경험 후 노인에 대한 태도와 노인부양의식은 유의한 변화가 없었으나 체험소감문의 내용분석에서는 노인의 모습과 행동에 대한 공감적 이해와 노인을 공경하고 배려하겠다는 다짐 등을 보였다. 또한 자신의 노후생활에 대해 슬프고 두려운 느낌을 표현하면서 노후를 위한 자가관리를 생각하였다. 본 연구를 통하여, 노인체험복 착용경험이 실험집단의 노인에 대한 이해, 노인을 대하는 행동, 노인에 대한 간호방법 및 자신의 노후에 대한 준비 등에 대하여 긍정적 사고와 의지를 고취시켰음을 확인하였다. 따라서 이는 노인간호학 교과목에 필요한 의미 있는 학습경험으로 사료된다. 이러한 효과의 양적 검정을 위해서는 첫째, 학습경험을 체계적으로 조직화하고 공유하는 방안, 둘째, 체험의 질을 높일 수 있는 전략의 도입, 셋째, 작은 효과에 민감한 도구를 활용한 반복 연구 등이 필요하며 아울러 체험과정에서의 안전을 위한 철저한 사전교육과 감독이 함께 이루어져야 할 것이다. This quasi-experimental study examined the experience of simulation clothes and its effects among undergraduate nursing students. Method: The experimental group consisted of 44 sophomore students in a diploma nursing program, while 41 students comprised the comparison group. Only the experimental group experienced the functional decline of aging after taking on simulation clothes. Homogeneity between the groups was analyzed using t-test, and Fisher's exact test. Paired t-test and t-test were adopted for testing changes of attitudes and awareness of supporting elders. In addition, contents of students' reports of the aging simulation experience were analyzed. Results: No significant quantitative effect was observed in attitudes toward elders and awareness of supporting elders. However, the simulation experience seemed to have enhanced students' understanding of elders and of basic elder care as well. Furthermore, the students could think of preparing for their later lives. Conclusion: The experience of simulation clothes is a meaningful learning opportunity in gerontological nursing curriculum. Students' experiences need to be shared and reinforced in a discussion session. Safety should be secured in the process of the experience. The simulation experience can be further developed to raise its quality.

근골격계 만성통증 노인의 삶의 질 영향요인

정혜선(Jeong, Hyesun),이윤주(Lee, Yoonju) 대한근관절건강학회 2018 근관절건강학회지 Vol.25 No.2

Selective Fe2+ Ion Recognition Using a Fluorescent Pyridinyl-benzoimidazole-derived Ionophore

Jeong Ah Lee,Geun Hee Eom,Hyun Min Park,Ju Hoon Lee,Hyesun Song,홍창섭,윤성호,Cheal Kim 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.11

Fluorescent organic molecules that respond to changes in the Fe2+ concentration with selectivity to other abundant di-valent metal ions will offer the ability to understand the dynamic fluctuations of the Fe2+ ion in interesting media. The use of 6-Br-ppmbi, derived from 2-pyridin-2-yl-benzimidazole, for metal ion-selective fluorescence recognition was investigated. Screening of the main group and transition metal ions showed exclusive selectivity for Fe2+ ions even in the presence of competing metal ions. In addition, the requirement for low concentrations of probe molecules to detect certain amounts of Fe2+ ions make this sensor unique compared to previously reported Fe2+ ion sensors.

Selective Fe²⁺ Ion Recognition Using a Fluorescent Pyridinyl-benzoimidazole-derived Ionophore

Lee, Jeong Ah,Eom, Geun Hee,Park, Hyun Min,Lee, Ju Hoon,Song, Hyesun,Hong, Chang Seop,Yoon, Sungho,Kim, Cheal Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.11

Fluorescent organic molecules that respond to changes in the $Fe^{2+}$ concentration with selectivity to other abundant di-valent metal ions will offer the ability to understand the dynamic fluctuations of the $Fe^{2+}$ ion in interesting media. The use of 6-Br-ppmbi, derived from 2-pyridin-2-yl-benzimidazole, for metal ion-selective fluorescence recognition was investigated. Screening of the main group and transition metal ions showed exclusive selectivity for $Fe^{2+}$ ions even in the presence of competing metal ions. In addition, the requirement for low concentrations of probe molecules to detect certain amounts of $Fe^{2+}$ ions make this sensor unique compared to previously reported $Fe^{2+}$ ion sensors.

Domain-oriented variability modeling for reuse of simulation models

Lee, Hyesun,Yang, Jin-Seok,Kang, Kyo Chul,Pyun, Jai-Jeong SAGE Publications 2014 Simulation Vol.90 No.4

<P>Reusability is an important quality attribute for defense modeling and simulation (MS) due to the ever-changing combat simulations and new requirements. There has been research conducted worldwide for reusing simulation models. The methods proposed in these studies (including One Semi-Automated Forces (OneSAF)) support reuse of simulation components in the development of new models. As the reuse units in the existing methods are at the simulation component level, when existing components do not satisfy new simulation requirements, new components have to be developed and maintained separately from the existing ones. However, simulation components in the same domain tend to have common parts; behavior models for tactical missions and battlefield functions in the same domain are derived from the same tactical doctrine/manual, and thus they tend to have a common structure. There is a need for a new method to maximize reusability by providing “fine-grained” reuse, i.e. composing simulation components from reusable fine-grained modules (i.e. behaviors/functions). We address the problem by applying the product line engineering concept to the development of simulation components. Commonalities and variabilities (CVs) of domain-specific simulation requirements and CVs of tactical behaviors and battlefield functions are identified in domain-oriented variability modeling. Then, the CVs are used to design and implement domain-specific simulation component assets with domain-specific tactical behaviors and battlefield functions while embedding the identified variabilities. These domain-specific component assets are instantiated based on selections of variabilities and then integrated to develop a simulation model. Feasibility of the method was demonstrated in an infantry squad combat domain of the Republic of Korea armed forces.</P>