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J. Y. LIAO,H. LI,J. J. LIANG,Y. F. FENG,X. B. ZHANG,Y. Q. YIN,H. X. TAO 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2013 NANO Vol.8 No.1
Magnetic Ni micro/nanostructures with controlled morphology have drawn intensive attention due to their interesting physicochemical properties and potential applications in micro/nanodevices. In this study, one-dimensional Ni nanochains with an average diameter of about 140 nm were prepared by a magnetic-field-assisted chemical reduction of Ni2+ with hydrazine hydrate free of any template or surfactant. It was found that the morphology and the size of the Ni chains could be adjusted by changing the complexant used in the synthesis. The usage of surfactant in the synthesis would retard the firm connection of Ni nanoparticles and thus resulted in the formation of Ni nanochains consisting of loosely aggregated Ni nanoparticles. The magnetic measurement at room temperature indicated that the coercivity of the Ni sample reached 133.2 Oe, which was much higher than that of bulk Ni metal.
An, E.,Ock, C.-Y.,Kim, T.-Y.,Lee, K.-H.,Han, S.-W.,Im, S.-A.,Kim, T.-Y.,Liao, W.-L.,Cecchi, F.,Blackler, A.,Thyparambil, S.,Kim, W. H.,Burrows, J.,Hembrough, T.,Catenacci, D. V. T.,Oh, D.-Y.,Bang, Y.- KLUWER ACADEMIC PUBLISHERS GROUP 2017 Annals of Oncology Vol. No.
<P><B>Abstract</B></P><P><B>Background</B></P><P>A wide range of response rates have been reported in HER2-positive gastric cancer (GC) patients treated with trastuzumab. Other HER2-targeted therapies for GC have yet to show efficacy in clinical trials. These findings raise question about the ability of standard HER2 diagnostics to accurately distinguish between GC patients who would and would not benefit from anti-HER2 therapies.</P><P><B>Patients and methods</B></P><P>GC patients (<I>n </I>=<I> </I>237), including a subset from the Trastuzumab in GC (ToGA) trial were divided into three groups based on HER2 status and history of treatment with standard chemotherapy or chemotherapy plus trastuzumab. We applied mass spectrometry-based proteomic analysis to quantify HER2 protein expression in formalin-fixed tumor samples. Using HER2 expression as a continuous variable, we defined a predictive protein level cutoff to identify which patients would benefit from trastuzumab. We compared quantitated protein level with clinical outcome and HER2 status as determined by conventional HER2 diagnostics.</P><P><B>Results</B></P><P>Quantitative proteomics detected a 115-fold range of HER2 protein expression among patients diagnosed as HER2 positive by standard methods. A protein level of 1825 amol/µg was predicted to determine benefit from the addition of trastuzumab to chemotherapy. Trastuzumab treated patients with HER2 protein levels above this cutoff had twice the median overall survival (OS) of their counterparts below the cutoff (35.0 versus 17.5 months, <I>P </I>=<I> </I>0.011). Conversely, trastuzumab-treated patients with HER2 levels below the cutoff had outcomes similar to HER2-positive patients treated with chemotherapy. (Progression-free survival = 7.0 versus 6.5 months: <I>P </I>=<I> </I>0.504; OS = 17.5 versus 12.6 months: <I>P </I>=<I> </I>0.520). HER2 levels were not prognostic for response to chemotherapy.</P><P><B>Conclusions</B></P><P>Proteomic analysis of HER2 expression demonstrated a quantitative cutoff that improves selection of GC patients for trastuzumab as compared with current diagnostic methods.</P>
Matrix-based Chebyshev spectral approach to dynamic analysis of non-uniform Timoshenko beams
W.Y. Wang,J.Y. Liao,L.W. Hourng 국제구조공학회 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.39 No.5
A Chebyshev spectral method (CSM) for the dynamic analysis of non-uniform Timoshenko beams under various boundary conditions and concentrated masses at their ends is proposed. The matrixbased Chebyshev spectral approach was used to construct the spectral differentiation matrix of the governing differential operator and its boundary conditions. A matrix condensation approach is crucially presented to impose boundary conditions involving the homogeneous Cauchy conditions and boundary conditions containing eigenvalues. By taking advantage of the standard powerful algorithms for solving matrix eigenvalue and generalized eigenvalue problems that are embodied in the MATLAB commands, chebfun and eigs, the modal parameters of non-uniform Timoshenko beams under various boundary conditions can be obtained from the eigensolutions of the corresponding linear differential operators. Some numerical examples are presented to compare the results herein with those obtained elsewhere , and to illustrate the accuracy and effectiveness of this method.
Gong, Y.L.,Liao, X.D.,Liang, J.B.,Jahromi, M.F.,Wang, H.,Cao, Z.,Wu, Y.B. Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.6
An in vitro gas production technique was used in this study to elucidate the effect of two strains of active live yeast on methane ($CH_4$) production in the large intestinal content of pigs to provide an insight to whether active live yeast could suppress $CH_4$ production in the hindgut of pigs. Treatments used in this study include blank (no substrate and no live yeast cells), control (no live yeast cells) and yeast (YST) supplementation groups (supplemented with live yeast cells, YST1 or YST2). The yeast cultures contained $1.8{\times}10^{10}$ cells per g, which were added at the rates of 0.2 mg and 0.4 mg per ml of the fermented inoculum. Large intestinal contents were collected from 2 Duroc${\times}$Landrace${\times}$Yorkshire pigs, mixed with a phosphate buffer (1:2), and incubated anaerobically at $39^{\circ}C$ for 24 h using 500 mg substrate (dry matter (DM) basis). Total gas and $CH_4$ production decreased (p<0.05) with supplementation of yeast. The methane production reduction potential (MRP) was calculated by assuming net methane concentration for the control as 100%. The MRP of yeast 2 was more than 25%. Compared with the control group, in vitro DM digestibility (IVDMD) and total volatile fatty acids (VFA) concentration increased (p<0.05) in 0.4 mg/ml YST1 and 0.2 mg/ml YST2 supplementation groups. Proportion of propionate, butyrate and valerate increased (p<0.05), but that of acetate decreased (p<0.05), which led to a decreased (p<0.05) acetate: propionate (A: P) ratio in the both YST2 treatments and the 0.4 mg/ml YST 1 supplementation groups. Hydrogen recovery decreased (p<0.05) with yeast supplementation. Quantity of methanogenic archaea per milliliter of inoculum decreased (p<0.05) with yeast supplementation after 24 h of incubation. Our results suggest that live yeast cells suppressed in vitro $CH_4$ production when inoculated into the large intestinal contents of pigs and shifted the fermentation pattern to favor propionate production together with an increased population of acetogenic bacteria, both of which serve as a competitive pathway for the available H2 resulting in the reduction of methanogenic archaea.
Matrix-based Chebyshev spectral approach to dynamic analysis of non-uniform Timoshenko beams
Wang, W.Y.,Liao, J.Y.,Hourng, L.W. Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.39 No.5
A Chebyshev spectral method (CSM) for the dynamic analysis of non-uniform Timoshenko beams under various boundary conditions and concentrated masses at their ends is proposed. The matrix-based Chebyshev spectral approach was used to construct the spectral differentiation matrix of the governing differential operator and its boundary conditions. A matrix condensation approach is crucially presented to impose boundary conditions involving the homogeneous Cauchy conditions and boundary conditions containing eigenvalues. By taking advantage of the standard powerful algorithms for solving matrix eigenvalue and generalized eigenvalue problems that are embodied in the MATLAB commands, chebfun and eigs, the modal parameters of non-uniform Timoshenko beams under various boundary conditions can be obtained from the eigensolutions of the corresponding linear differential operators. Some numerical examples are presented to compare the results herein with those obtained elsewhere, and to illustrate the accuracy and effectiveness of this method.
Circulatory Antigen Processing by Mucosal Dendritic Cells Controls CD8<sup>+</sup> T Cell Activation
Chang, S.Y.,Song, J.H.,Guleng, B.,Cotoner, C.,Arihiro, S.,Zhao, Y.,Chiang, H.S.,O'Keeffe, M.,Liao, G.,Karp, Christopher L.,Kweon, M.N.,Sharpe, Arlene H.,Bhan, A.,Terhorst, C.,Reinecker, H.C. Cell Press 2013 Immunity Vol.38 No.1
Circulatory antigens transit through the small intestine via the fenestrated capillaries in the lamina propria prior to entering into the draining lymphatics. But whether or how this process controls mucosal immune responses remains unknown. Here we demonstrate that dendritic cells (DCs) of the lamina propria can sample and process both circulatory and luminal antigens. Surprisingly, antigen cross-presentation by resident CX3CR1<SUP>+</SUP> DCs induced differentiation of precursor cells into CD8<SUP>+</SUP> T cells that expressed interleukin-10 (IL-10), IL-13, and IL-9 and could migrate into adjacent compartments. We conclude that lamina propria CX3CR1<SUP>+</SUP> DCs facilitate the surveillance of circulatory antigens and act as a conduit for the processing of self- and intestinally absorbed antigens, leading to the induction of CD8<SUP>+</SUP> T cells, that partake in the control of T cell activation during mucosal immune responses.
X.F. Liao,L.Z. Zhao,J.S. Zhang,G. Ahmed,A.J. Khan,H.X. Zeng,H.Y. Yu,X.C. Zhong,Z.W. Liu,G.Q. Zhang 한국물리학회 2019 Current Applied Physics Vol.19 No.6
To improve the performance/cost ratio of NdFeB based permanent magnets, Ce or/and La substitutions for Nd have been suggested. To better understand the effects of these substitutions, the fundamental behavior of (Ce,La)-Fe-B alloys has to be clearly understood. Here, we reported a systematic investigation on the phase structure, microstructure, and magnetic properties of melt-spun (Ce,La)2Fe14B alloys. The results confirm that partial substitution of Ce by La can effectively enhance the hard magnetism and thermal stability of (Ce1- xLax)2Fe14B alloys, while over 80% La substitution leads to the decomposition of 2:14:1 phase. The lattice parameters a, c and the Curie temperature Tc of 2:14:1 phase increase linearly with the increasing La content. La substitution can effectively refine the grain, resulting in the enhancement of inter-grain exchange coupling. The (Ce0.7La0.3)2Fe14B alloy with a mean grain size of 25 nm exhibits high remanence, maximum energy product and intrinsic coercivity up to 0.69 T, 6.2 MGOe and 217 kA/m, respectively. The present work provides a good understanding on the melt-spun (Ce,La)-Fe-B system for further developing low cost rare earth permanent magnets.