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( Takamasa Ishii ),( Masaki Miyazawa ),( Phil S. Hartman ),( Naoaki Ishii ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.5
Most intracellular reactive oxygen species (ROS), especially superoxide anion (O2·-) that is converted from oxygen, are overproduced by excessive electron leakage from the mitochondrial respiratory chain. Intracellular oxidative stress that damages cellular components can contribute to lifestyle-related diseases such as diabetes and arteriosclerosis, and age-related diseases such as cancer and neuronal degenerative diseases. We have previously demonstrated that the excessive mitochondrial O2·- production caused by SDHC mutations (G71E in C. elegans, I71E in Drosophila and V69E in mouse) results in premature death in C. elegans and Drosophila, cancer in mouse embryonic fibroblast cells and infertility in transgenic mice. SDHC is a subunit of mitochondrial complex II. In humans, it has been reported that mutations in SDHB, SDHC or SDHD often result in inherited head and neck paragangliomas (PGLs). Recently, we established Tet-mev-1 conditional transgenic mice using our uniquely developed Tet-On/Off system, which equilibrates transgene expression to endogenous levels. These mice experienced mitochondrial respiratory chain dysfunction that resulted in O2·- overproduction. The mitochondrial oxidative stress caused excessive apoptosis leading to low birth weight and growth retardation in the neonatal developmental phase in Tet-mev-1 mice. Here, we briefly describe the relationships between mitochondrial O2·- and aging phenomena in mev-1 animal models. [BMB reports 2011; 44(5): 298-305]
Taeko Ishii,Masaru Ishii,Yutaka Shimazu,Junichi Kikuta 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.5
Sphingosine-1-phosphate (S1P), a biologically active lysophospholipid that is enriched in blood, controls the trafficking of osteoclast precursors between the circula-tion and bone marrow cavities via G protein-coupled receptors, S1PRs. While S1PR1 mediates chemoattraction toward S1P in bone marrow, where S1P concentration is low, S1PR2 mediates chemorepulsion in blood, where the S1P concentration is high. The regulation of precursor recruitment may represent a novel therapeutic strategy for controlling osteoclast-dependent bone remodeling. Through intravital multiphoton imaging of bone tissues, we reveal that the bidirectional function of S1P temporospatially regulates the migration of osteoclast precursors within intact bone tissues. Imaging technologies have enabled in situ visualization of the behaviors of several players in intact tissues. In addition, intravital microscopy has the potential to be more widely applied to functional analysis and intervention.
Changes in species diversity of ground beetle assemblages in riverbanks of the Yamato River, Japan
Cheol-min Lee,Ishii Minoru 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.10
We investigated ground beetles in riverbank of the Yamato River in Nara and Osaka Prefectures,to elucidate changes in the species diversity and assemblage structure.Ground beetles were collected with unbaited pitfall traps once a week from April to December 2006 at five sites; sandy and grassy riverbanks in Ikaruga (Site 1) and Sangoh Towns, Nara Prefecture (Site 2),a gravelly riverbed in a valley in Kashiwara City (Site 3),and sandy and grassy riverbanks with willow trees in Fujiidera (Site 4) and Matsubara Cities,Osaka Prefecture (Site 5). A total of 4,319 individuals belonging to 53 species from two families were captured at the 5 sites. Species richness was the highest at Site 4 (40 spp.), higher at Sites 2, 5 and 1 (31, 30 and 29 spp. respectively), and the lowest at Site 3 (19 spp.). Compared with results in 1988 (Ishii etal., 1996), species richness of both small-and middle-sized specie sand both temperate and northern species increased, and 2 southern species and 2 species endemic to Japan were newly recorded. It should be noted that large numbers of Bembidion lissonotum and Nobria lewisi, "gravel riverspecialists", were caught at Site3. Our results demonstrate that ground-beetle fauna was well maintained in riverbank of the Yamato River in last 18 years.
Inhaled Corticosteroid and Secondary Glaucoma: A Meta-analysis of 18 Studies
Ishii Mai,Horita Nobuyuki,Takeuchi Masaki,Matsumoto Hiromi,Ebina-Shibuya Risa,Hara Yu,Kobayashi Nobuaki,Mizuki Nobuhisa,Kaneko Takeshi 대한천식알레르기학회 2021 Allergy, Asthma & Immunology Research Vol.13 No.3
Purpose Guidelines and systematic reviews frequently warn of inhaled corticosteroid (ICS)-induced glaucoma. However, most of the published studies deny it. Methods We performed a systematic review of randomized, cohort, nested-case control, cross-sectional studies by using Meta-analyses of Observational Studies in Epidemiology statement. Four major databases, PubMed, EMBASE, Cochrane Search Manager, and the Web of Science Core Collection as well as meta-analysis were used. Studies comparing incidence, prevalence and intraocular pressure (IOP) between patients who were treated with and without ICSs were included. A random-model meta-analysis was performed using the inverse variance method. Results Out of 623 studies screened, 18 with 31,665 subjects were finally included. No significant difference between the 2 groups was observed for crude glaucoma incidence (odds ratio [OR], 0.95; 95% confidence interval [CI], 0.86–1.04; P = 0.26; I 2 = 0%; P for heterogeneity = 0.57) as a primary endpoint, adjusted glaucoma incidence (OR, 0.90; 95% CI, 0.65–1.24; P = 0.64), crude prevalence (OR, 1.82; 95% CI, 0.23–14.19; P = 0.57), adjusted prevalence (OR, 1.22; 95% CI, 0.50–2.96; P = 0.66), IOP change during ICS treatment (mean difference [MD] +0.01 mmHg; 95% CI, −0.19–0.20; P = 0.95), and single measurement IOP (MD +0.37 mmHg; 95% CI, −0.24–0.97; P = 0.23). Time-to-event analysis for glaucoma development as one of the secondary endpoints (adjusted hazard ratio, 0.52; 95% CI, 0.28–0.96) suggested a reverse association between ICS and glaucoma. Conclusions The ophthalmological side effects of ICSs, such as glaucoma and intraocular hypertension, should not be exaggerated.
Ishii, Naohiro,Fukazawa, Emi,Aoki, Tomoko,Kishi, Kazuo Korean Cleft Palate-Craniofacial Association 2019 Archives of Craniofacial Surgery Vol.20 No.2
Frontotemporal dermoid cysts with a cutaneous sinus tract in the sphenoid bone are rarely found, and furthermore, the spreading of these cysts across the frontal branch of the facial nerve has not been reported. Herein, we present a 5-year-old case of a dermoid cyst successfully resected with preservation of this nerve using a combined extracranial and intracranial approach. This approach is recommended for a safe and radical resection of the lesion and for securing an aesthetic outcome.
Determination of Nutritious Calcium in Some Vegetables
Ishii, Yuuko,Takiyama, Kazuyoshi 한국분석과학회 1995 분석과학 Vol.8 No.4
Vegetables contain more or less calcium. By the traditional method the total calcium in the vegetable was analyzed. A part or calcium in the vegetable is fixed as calcium oxalate and the calcium does not utilize for nutrition. In this investigation the free calcium was determined by extraction in boiling water, the combined calcium with oxalic acid was determined by extraction in 0.1 M hydrochloric aci and the other calcium combined with protein, amino acid etc. was estimated. The amount of calcium obtained from the difference between the total calcium and calcium exmtaining in calcium oxalate was estimated to be nutritious.