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임현수 ( Lim¸ Hyunsu ),조규만 ( Cho¸ Kyuman ),김태훈 ( Kim¸ Taehoon ) 한국건축시공학회 2021 한국건축시공학회지 Vol.21 No.5
건축공사에서 먹매김 공정은 건물의 구성요소를 계획된 위치에 정확히 형성하기 위한 기준이 되므로 높은 정밀도가 요구 된다. 최근의 건축물 규모 증가 및 숙련공 부족 추세에서 먹매김 공사는 로봇 기반의 자동화 기술 도입을 통한 생산성 및 품질 향상 요구가 크게 나타나고 있으며, 특히 가장 선행되는 골조공사 먹매김 작업의 중요도 및 자동화 필요성은 더욱 크다고 할 수 있다. 이러한 배경에서 본 연구는 건축물 골조공사용 먹매김에 적합한 시공 자동화 시스템 개발 방향을 제시하고자 한다. 기존 유사 기술 고찰을 토대로 하여 5가지 구성기술과 17개의 세부 기술요소를 도출하였으며, 전문가 설문을 통한 중요도 평가를 수행하였다. 설문 결과, 열악한 주행 및 작업 환경에 대응하기 위한 주행부 및 마킹부 기술이 가장 중요한 구성기술로 파악되었으며, 이러한 환경에서 정밀도를 확보하기 위한 제어기술과 전반적인 프로세스의 자동화기술의 중요성이 높게 나타났다. 본 연구 결과는 향후 보다 실용적이고 효율적인 자동화 시스템 개발에 기여할 것이다. In building construction, the layout operation is performed to accurately construct the building components in their planned locations, and requires a high level of accuracy and precision. With increases in building size and a lack of skilled laborers, this work has seen an increasing demand for productivity and quality improvements through robot-based construction automation. In particular, the layout work for building structures has a higher need for automation. On this background, this study suggests a direction for the development of an automated layout system of building structures. 5 technical factors and 17 sub-factors were derived based on reviews of existing similar systems, and an evaluation of their importance was carried out through an expert survey. As a result, it was found that the most important factors were driving and marking systems for coping with poor driving and working conditions. In terms of sub-factors, control techniques to secure precision and technologies to automate the overall layout process showed high importance. These findings will contribute to the development of more practical and efficient automation systems.
Hyunsu Kim,Kyung‑Wan Baek,고은지,Nguyen Thanh Luan,Yunjin Lim,Heyong Jin Roh,Nameun Kim,Do‑Hyung Kim,Ahran Kim,Yung Hyun Choi,Suhkmann Kim,Heui‑Soo Kim,Mee Sun Ock,차희재 한국유전학회 2020 Genes & Genomics Vol.42 No.7
Background Viral hemorrhagic septicemia (VHS) is a serious viral disease that infects the olive flounder in South Korea. The Korean aquaculture industry experienced an economic loss caused by the high infectivity and mortality. Objective This study aimed to evaluate the infection density of VHSV in various organs of the olive flounder including spleen, liver, kidney, stomach, esophagus, intestine, gill, muscle, heart, and brain. Olive flounders were collected from a local fish farm and injected subcutaneously with 106 PFU/fish. Methods Each 15 fish were sampled at 0, 3, and 7 days post challenge (dpc), respectively, to perform quantitative analysis of VHSV using SYBR-green based real-time PCR in various tissues including spleen, liver, head-kidney, body-kidney, muscle, esophagus, stomach, intestine, gill, and brain. Results Organs infected with VHSV were obtained after 3 and 7 days. Each organs were examined for viral infection using real-time PCR. The data obtained from this experiment revealed copy numbers higher than 10 copies per 100 ng cDNA in the spleen (15.26 ± 3.11 copies/100 ng of cDNA), muscle (11.24 ± 2.25 copies), and gill (14.23 ± 6.26 copies), but lower in liver, head-kidney, body-kidney, esophagus, brain and stomach. Conclusion The present study, together with previous data, demonstrated that the gill, spleen, and muscle are the major target organs of VHSV in olive flounder. Therefore, central monitoring of spleen, gill and muscle should be considered and might be necessary if anti-VHSV treatment is to be successful in infected olive flounder.
EGFR Inhibitors Enhanced the Susceptibility to NK Cell-mediated Lysis of Lung Cancer Cells
Kim, Hyunsu,Kim, Sun-Hee,Kim, Mi-Ju,Kim, So-Jung,Park, Soo-Jung,Chung, Joo-Seop,Bae, Jae-Ho,Kang, Chi-Dug Lippincott Williams Wilkins, Inc. 2011 Journal of immunotherapy Vol.34 No.4
As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D (NKG2D) ligands on cancer cells and made the cells sensitive to NK –cell-mediated killing; inhibition of epidermal growth factor receptor (EGFR) pathway might lead to induction of NKG2D ligands. In this study, it was investigated whether EGFR inhibitors, including erlotinib or gefitinib, could regulate expression of NKG2D ligands in various lung cancer cells including A549, NCI-H23, and SW-900. The EGFR inhibitors predominantly increased transcription and surface expression of ULBP1, and subsequently increased susceptibility of the cancer cells to NK-92 cells. When the selective inhibitors of nuclear factor-kappa B, phosphatidylinositol 3-kinase, mitogen-activated protein kinases, and PKC were treated to discriminate downstream signaling of EGFR pathway, expression of ULBP1 in the cancer cells was induced by inhibition of PKC. Treatment with phorbol 12-myristate 13-acetate restored the EGFR inhibitor-induced ULBP1 transcription. Binding activity to ULBP1 promoter region of AP-2α, which suggested as suppressor of expression of ULBP1, was decreased by treatment with EGFR inhibitors, and restored by pretreatment with phorbol 12-myristate 13-acetate in A549 and SW-900. Rottlerin, a PKC&dgr; inhibitor, also decreased the binding activity of AP-2α in dose-dependent manner. This study suggests that EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells by induction of ULBP1 by inhibition of PKC pathway and therapeutic efficacy of EGFR inhibitors in lung cancer may be mediated in part by increased susceptibility to NK cell-mediated cytotoxicity.
Kim, Jong-Hoon,Chung, Hwan-Suck,Kang, Moonkyu,Kim, Yong,Kim, Byung-Su,Kim, Youn-Sub,Bae, Hyunsu Elsevier 2011 Diabetes research and clinical practice Vol.93 No.2
<P><B>Abstract</B></P> <P>PM021, which consists of two herbal components, Mori Folium and Aurantii Fructus, is routinely used to treat diabetes in Korea. In this study, the anti-diabetic effect of PM021 on an animal model of developing type 2 diabetes of Otsuka Long–Evans Tokushima Fatty (OLETF) rats was investigated. Eight weeks of age male OLETF rats were treated daily with PM021 or vehicle for five months. Specifically, changes in body weight, blood glucose, urine volume, food intake and oral glucose tolerance were measured in rats for five months. The rats in this study were divided into four groups: a Long–Evans Tokushima Otsuka (LETO) rat group, which is a genetic control group for OLETF, that received no treatment; a PM021 treatment group of LETO rats; OLETF rats that received no treatment; and OLETF rats that received PM021 treatment. The results showed that PM021 significantly prevented increases in body weight, blood glucose, and urine and food intake that resulted from the induction of obesity and diabetes. PM021 also improved glucose tolerance in OLETO rats. However, PM021 had no effect on LETO rats, a control group of OLETF rats. Taken together, these findings indicate that PM021 has distinct anti-diabetic effects without any adverse effects or toxicities.</P>
연구논문 : 2007년 3월 31일 서해에서 발생한 기상해일에 대한 기상학적 분석
김현수 ( Hyunsu Kim ),김유근 ( Yoo Keun Kim ),우승범 ( Seung Buhm Woo ),김명석 ( Myung Seok Kim ) 한국환경과학회 2014 한국환경과학회지 Vol.23 No.12
A meteo-tsunami occurred along the coastline of South Korea on 31 March 2007, with an estimated maximum amplitude of 240 cm in Yeonggwang (YG). In this study, we investigated the synoptic weather systems around the Yellow sea including the Bohai Bay and Shandong Peninsula using a weather research and forecast model and weather charts of the surface pressure level, upper pressure level and auxiliary analysis. We found that 4-lows passed through the Yellow sea from the Shandung Peninsula to Korea during 5 days. Moreover, the passage of the cold front and the locally heavy rain with a sudden pressure change may make the resonance response in the near-shore and ocean with a regular time-lag. The sea-level pressure disturbance and absolute vorticity in 500 hPa projected over the Yellow sea was propagated with a similar velocity to the coastline of South Korea at the time that meteo-tsunami occurred.
기상민감질환과 기상요소의 상관관계에 대한 의료진의 기초인식파악을 위한 설문조사기반 연구
김현수 ( Hyunsu Kim ),김유근 ( Yoo-keun Kim ),정주희 ( Ju-hee Jeong ),안혜연 ( Hye Yeon An ),김태희 ( Taehee Kim ),윤진아 ( Jina Yun ),원경미 ( Kyung-mi Won ),이지호 ( Jiho Lee ),오인보 ( Inbo Oh ),이영미 ( Young-mi Lee ),임연주 ( Ye 한국환경과학회 2017 한국환경과학회지 Vol.26 No.5
Provider-oriented weather information has been rapidly changing to become more customer-oriented and personalized. Given the increasing interest in wellness and health topics, the demand for health weather information, and biometeorology, also increased. However, research on changes in the human body according to weather conditions is still insufficient due to various constraints, and interdisciplinary research is also lacking. As part of an effort to change that, this study surveyed medical practitioners at an actual treatment site, using questionnaires, to investigate what kind of weather information they could utilize. Although there was a limit to the empirical awareness that medical staff had about weather information, most respondents noted that there is a correlation between disease and weather, with cardiovascular diseases (coronary artery disease (98.5%) and hypertension (95.9% ), skin diseases (atopic dermatitis (100%), sunburn (93.8%)) being the most common weather-sensitive ailments. Although there are subject-specific differences, most weather-sensitive diseases tend to be affected by temperature and humidity in general. Respiratory and skin diseases are affected by wind and solar radiation, respectively.