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RISS 인기검색어
- 검색키워드
- 저자 : Hyunkyung Jung (검색결과 55 건)
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Jung, Hyunkyung,Park, Sungjo,Gunassekaran, Gowri Rangaswamy,Jeon, Mansik,Cho, Young-Eun,Baek, Moon-Chang,Park, Jae Yong,Shim, Gayong,Oh, Yu-Kyoung,Kim, In-San,Kim, Chulhong,Lee, Byungheon American Association for Cancer Research 2019 Cancer Research Vol.79 No.16
<P>These findings present a new tumor-targeting probe for photoacoustic-guided detection and drug delivery.</P><P><B></B></P><P>The lack of molecular targets and targeting probes remains a major drawback for targeted imaging and drug delivery in lung cancer. In this study, we exploited <I>in vivo</I> phage display to identify a novel targeting probe that homes to the tumor in a <I>K-ras<SUP>LA2</SUP></I> mutant mouse lung cancer model. Compared with other candidate peptides selected from 5 rounds of phage display, the CRQTKN peptide homed to tumor nodules in the lung of mutant mice at higher levels. Photoacoustic tomography of mutant mice detected lung tumors via tumor homing of the near-infrared fluorescence dye-labeled CRQTKN peptide. <I>Ex vivo</I> photoacoustic images of isolated organs further demonstrated tumor homing of the CRQTKN peptide, whereas minimal accumulation was observed in control organs, such as the liver. Compared with untargeted liposomes and doxorubicin, doxorubicin-loaded liposomes whose surface was modified with the CRQTKN peptide more efficiently delivered doxorubicin and reduced the number or size of tumor lesions in <I>K-ras<SUP>LA2</SUP></I> mutant mice. Analysis of hematologic parameters and liver and kidney function showed no significant systemic side effects by the treatments. Affinity-based identification was used to detect TNF receptor superfamily member 19L (TNFRSF19L), which was upregulated in lung tumors of mutant mice, as the receptor for the CRQTKN peptide. In conclusion, these results suggest that the CRQTKN peptide is a promising targeting probe for photoacoustic-guided detection and drug delivery to lung cancer, and acts by binding to TNFRSF19L.</P><P><B>Significance:</B></P><P>These findings present a new tumor-targeting probe for photoacoustic-guided detection and drug delivery.</P>
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( Jung Sun Kim ),( Tae Min Kim ),( Myoung Joo Kang ),( Sung Ae Koh ),( Hyunkyung Park ),( Seung-hyun Nam ),( Jae Joon Han ),( Gyeong-won Lee ),( Young Jin Yuh ),( Hee Jeong Lee ),( Jung Hye Choi ) 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.5
Background/Aims: Little attention is paid to chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Korea due to the rarity of the disease. With its rising incidence, we aimed to evaluate recent changes in treatment patterns and survival outcomes of patients with CLL/SLL. Methods: A total of 141 patients diagnosed with CLL/SLL between January 2010 and March 2020 who received systemic therapy were analyzed in this multicenter retrospective study. Results: The median patient age was 66 years at diagnosis, and 68.1% were male. The median interval from diagnosis to initial treatment was 0.9 months (range: 0-77.6 months), and the most common treatment indication was progressive marrow failure (50.4%). Regarding first-line therapy, 46.8% received fludarabine, cyclophosphamide, plus rituximab (FCR), followed by chlorambucil (19.9%), and obinutuzumab plus chlorambucil (GC) (12.1%). The median progression-free survival (PFS) was 49.3 months (95% confidence interval [CI], 32.7-61.4), and median overall survival was not reached (95% CI, 98.4 mo-not reached). Multivariable analysis revealed younger age (≤ 65 yr) (hazard ratio [HR], 0.46; p < 0.001) and first-line therapy with FCR (HR, 0.64; p = 0.019) were independently associated with improved PFS. TP53 aberrations were observed in 7.0% (4/57) of evaluable patients. Following reimbursement, GC became the most common therapy among patients over 65 years and second in the overall population after 2017. Conclusions: Age and reimbursement mainly influenced treatment strategies. Greater effort to apply risk stratifications into practice and clinical trials for novel agents could help improve treatment outcomes in Korean patients.
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중국인의 의료서비스 평가에 미치는 중요 영향 요인 분석 : 한국 병원의 중국 진출을 위한 시사점을 중심으로
정현경(Jung, Hyunkyung),배일현(Bae, Ilhyun),이희정(Lee, Heejung) 韓國商品學會 2015 商品學硏究 Vol.33 No.4
본 연구는 한국 보건의료산업의 해외진출이 활발해지는 상황에서 한국병원의 성공적 중국시장 진출을 위해 의료기관이 중요시해야할 의료서비스 품질과 이미지 관리의 중요성을 파악하고자 연구되었다. 이를 위해 현지 중국인을 대상으로 의료기관의 서비스 품질과 이미지 관리가 고객만족 및 재이용의도에 미치는 역할을 실증분석 하였다. 중국 현지인으로부터 수거된 설문지 200부 중 187부의 가용한 설문지를 최종 분석에 활용하였는데 연구결과와 시사점은 다음과 같다. 첫째, 의료서비스 품질의 하위차원으로 나타난 과정적 품질과 기술적 품질에서 기술적 품질이 고객만족 및 재이용의도에 더 큰 영향을 미치고 있는 것으로 나타났다. 둘째, 병원 이미지는 사회적 이미지와 의료진의 이미지로 구성되어 있으며 만족도와 재이용의도에 긍정적인 영향을 미치는 것으로 나타났다. 본 연구는 중국현지인이 인지하는 서비스품질과 이미지가 의료서비스 만족도에 미치는 직접적인 영향력을 파악함으로써, 현재 중국시장에 진출해 있거나 혹은 향후 중국진출을 계획하고 있는 우리나라 병원이 성공적으로 중국시장에서 정착할 수 있도록 유용한 시사점을 제공하고 있다. 또한, 중국인들로 하여금 중국 현지 의료기관 이용 경험에 대해 응답하도록 함으로써, 중국 소비자들의 니즈를 보다 더 정확하게 파악할 수 있고, 의료서비스와 병원이미지의 중요성을 실증적으로 보여주었다. 향후 연구에서는 보다 다양한 이론적 배경에서 신뢰도, 서비스 가치, 가격인지 및 국가 이미지 등 다양한 변수가 성공적인 병원 경영을 위해서 어떤 역할을 하는지 살펴본다면 보다 더 유용한 시사점을 줄 수 있을 것이다 Korea medical technology has been globally recognized, medical institution have very fine future of overseas expansion. In this situation, this paper is to investigate importance of medical service quality and image management of medical institution’s for overseas expansion and how influence to customer satisfaction and revisit intention. Out of 200 participants, 187 usable questionnaires were analyzed and collected by Chinese with their localmedical experiences. The findings of this study that process quality and technical quality were sub-factors of medical service quality and the technical quality was more effective on satisfaction and revisit intention. In addition hospital Image was consists of social image and medical team image, which were positively effective on satisfaction and revisit intention. This study was meaningful to give useful reference to the nation’s hospital for successful settlement in China market currently entered or planning of overseas expansion. And the service quality and image were perceived by local Chinese people, which were influence to medical service satisfaction. This study also figured out accurate Chinese needs and importance of medical service and medical image as answering with experienced localmedical hospital. This study also has a limitations. So, we expect that future study to figure out diverse variables’ roles for successful hospital management as studying a diverse theoretical background, trust, service value, cognitive price and national image
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Localization and persistence of hepatitis A virus in artificially contaminated oysters
Park, Hyunkyung,Jung, Soontag,Shin, Hansaem,Ha, Sang-Do,Park, Tae Jung,Park, Jong Pil,Seo, Dong Joo,Choi, Changsun Elsevier 2019 International journal of food microbiology Vol.299 No.-
<P><B>Abstract</B></P> <P>Bivalve molluscan shellfish, such as oysters, clams, and cockles, are well-recognized as vectors that concentrate foodborne pathogens by filter feeding. The objective of this study was to investigate the distribution and persistence of hepatitis A virus (HAV) in experimentally contaminated oysters that were either fed or not fed with algae. Oysters were experimentally contaminated with HAV and maintained in depuration conditions. qRT-PCR, immunohistochemistry (IHC), and <I>in situ</I> hybridization (ISH) were performed on oyster samples collected at 0, 1, 3, 5, and 7 days post-inoculation. When HAV-contaminated oysters were depurated for 7 days, HAV was detected in 91.1–97.8% of the digestive glands and gills. While the high viral load in the digestive glands in oysters did not change significantly regardless of algae-feeding, the viral load of the gills gradually decreased in both groups during the depuration. HAV antigen and RNA were detected in the digestive diverticula and connective tissues by both IHC and ISH. HAV was detected in the stomach, intestine, and gills by only ISH. The distribution of HAV in various oyster tissues may explain the persistence of contamination in oysters during the depuration process.</P> <P><B>Highlights</B></P> <P> <UL> <LI> High titer of HAV was accumulated in the digestive gland and gills of oysters. </LI> <LI> HAV capsid was localized in the hemocyte and digestive gland by immunohistochemistry. </LI> <LI> HAV RNA was visualized in the hemocytes and digestive gland by <I>in situ</I> hybridization. </LI> <LI> HAV was persistently detected in oysters for 7 days under depuration condition. </LI> </UL> </P>
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Hyunkyung Lee,Seungyeon Lee,Dawoon Jeong,Sun Jung Kim 고려인삼학회 2018 Journal of Ginseng Research Vol.42 No.4
Background: Ginsenoside Rh2 has been known to enhance the activity of immune cells, as well as to inhibit the growth of tumor cells. Although the repertoire of genes regulated by Rh2 is well-known in many cancer cells, the epigenetic regulation has yet to be determined, especially for comprehensive approaches to detect methylation changes. Methods: The effect of Rh2 on genome-wide DNA methylation changes in breast cancer cells was examined by treating cultured MCF-7 with Rh2. Pyrosequencing analysis was carried out to measure the methylation level of a global methylation marker, LINE1. Genome-wide methylation analysis was carried out to identify epigenetically regulated genes and to elucidate the most prominent signaling pathway affected by Rh2. Apoptosis and proliferation were monitored to examine the cellular effect of Rh2. Results: LINE1 showed induction of hypomethylation at specific CpGs by 1.6e9.1% (p < 0.05). Genomewide methylation analysis identified the “cell-mediated immune response”-related pathway as the top network. Cell proliferation of MCF-7 was retarded by Rh2 in a dose-dependent manner. Hypermethylated genes such as CASP1, INSL5, and OR52A1 showed downregulation in the Rh2-treated MCF-7, while hypomethylated genes such as CLINT1, ST3GAL4, and C1orf198 showed upregulation. Notably, a higher survival rate was associated with lower expression of INSL5 and OR52A1 in breast cancer patients, while with higher expression of CLINT1. Conclusion: The results indicate that Rh2 induces epigenetic methylation changes in genes involved in immune response and tumorigenesis, thereby contributing to enhanced immunogenicity and inhibiting the growth of cancer cells.
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Lee, Hyunkyung,Lee, Seungyeon,Jeong, Dawoon,Kim, Sun Jung The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.4
Background: Ginsenoside Rh2 has been known to enhance the activity of immune cells, as well as to inhibit the growth of tumor cells. Although the repertoire of genes regulated by Rh2 is well-known in many cancer cells, the epigenetic regulation has yet to be determined, especially for comprehensive approaches to detect methylation changes. Methods: The effect of Rh2 on genome-wide DNA methylation changes in breast cancer cells was examined by treating cultured MCF-7 with Rh2. Pyrosequencing analysis was carried out to measure the methylation level of a global methylation marker, LINE1. Genome-wide methylation analysis was carried out to identify epigenetically regulated genes and to elucidate the most prominent signaling pathway affected by Rh2. Apoptosis and proliferation were monitored to examine the cellular effect of Rh2. Results: LINE1 showed induction of hypomethylation at specific CpGs by 1.6-9.1% (p < 0.05). Genome-wide methylation analysis identified the "cell-mediated immune response"-related pathway as the top network. Cell proliferation of MCF-7 was retarded by Rh2 in a dose-dependent manner. Hypermethylated genes such as CASP1, INSL5, and OR52A1 showed downregulation in the Rh2-treated MCF-7, while hypomethylated genes such as CLINT1, ST3GAL4, and C1orf198 showed upregulation. Notably, a higher survival rate was associated with lower expression of INSL5 and OR52A1 in breast cancer patients, while with higher expression of CLINT1. Conclusion: The results indicate that Rh2 induces epigenetic methylation changes in genes involved in immune response and tumorigenesis, thereby contributing to enhanced immunogenicity and inhibiting the growth of cancer cells.
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