Sarcopenia is associated with severe erectile dysfunction in older adults: a population-based cohort study

Hyungchul Park,Il-Young Jang,Minkyu Han,Heayon Lee,정희원,Eunju Lee,Dae Hyun Kim 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.5

Background/Aims: Sarcopenia and erectile dysfunction (ED) are associated with poor health and quality of life in older men. We investigate the association between sarcopenia and severe ED in community-dwelling older men. Methods: We prospectively assessed sarcopenia and ED in 519, community-dwelling, older men (mean age, 74.0) in Pyeongchang, Korea, in 2016 to 2017. Sarcopenia was based on muscle mass, grip strength, and gait speed according to the Asian Working Group consensus algorithm. Severe ED was defined as 5-item International Index of Erectile Function questionnaire score under 8. Logistic regressions were used to study associations between incident severe ED and sarcopenia, after adjusting age, cardiovascular risk factors, depression, and polypharmacy. Results: The prevalence of severe ED was 52.4% and that of sarcopenia was 31.6%. At baseline, the prevalence of severe ED was higher in men with sarcopenia than in those without (73.2% vs. 42.8%; adjusted odds ratio [aOR], 1.89; 95% confidence interval [CI], 1.18 to 3.03; p = 0.008). Slow gait speed (aOR, 2.80; 95% CI, 1.18 to 6.62; p = 0.019) and decreased muscle mass (aOR, 2.54; 95% CI, 1.11 to 5.81; p = 0.027) were associated with the incidence of severe ED, while decreased grip strength (aOR, 0.76; 95% CI, 0.30 to 1.91; p = 0.564) was not. Conclusions: Sarcopenia was associated with severe ED. Slow gait speed, and decreased muscle mass was independently associated with incident severe ED at 1 year. Further research is warranted to examine whether an intervention targeting these components can prevent severe ED.

철도 급전시스템 신뢰도 평가 연구

김형철(Hyungchul Kim),차준민(Jun-Min Cha),김진오(Jin-O Kim),한문섭(Moonseob Han) 한국철도학회 2005 한국철도학회 학술발표대회논문집 Vol.- No.-

This paper proposes a new reliability evaluation for traction power system. The electric railway consists of traction power systems, various vehicles, operating equipment, track, overhead line and electric equipment, It is a fundamental function of traction power systems that supply customers with reasonable price, acceptable reliability and high quality power. In a general way, the power system reliability deals with the ability to satisfy load demands in supply capability or rating of every factor. On the other hand, the reliability of traction power systems has been focused on train time delay caused by power outage. In this paper, we make a selection optimum reliability indices for the reliability evaluation of electric traction power systems. The reliability study not only applies a plan for traction supply system after detecting the vulnerable point of existing traction supply systems but also makes a role in stable operating railway.

반능동형 머플러의 배압분포 특성에 관한 연구

노형철(Hyungchul Noh),박경석(Kyoungsuk Park),박세종(Sejong Park),변영호(Youngho Byun),한창평(Changpyung Han),손성만(Sungman Son) 한국자동차공학회 2005 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2005 No.11_1

In design of muffler, Noise reduction is most important point in the past. By reason of this factor, study of muffler mainly used acoustic analysis for predictive modeling. but, recently muffler design factor, back pressure reduction and enhanced engine performance is more important than noise reduction. and developing process uses FEM and fluid analysis. but these process is not clearly defined the value for effective pressure.<br/> In this study, make experiment in muffler and semi-active muffler and analysis back pressure. This has made it possible to optimize muffler design, and defined design variable.

자동차 주행조건을 고려한 노면마찰계수에 관한 연구

노형철(Hyungchul Noh),박경석(Kyoungsuk Park),최명진(Myungjin Choi),한창평(Changpyoung Han),변영호(Youngho Byun) 한국자동차공학회 2005 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2005 No.11_3

While a great deal of automobile accidents are caused by the carelessness of drivers, a more careful study illustrates that another major cause for these accidents can be found in improper road conditions and poor transportation facilities. Visual distances is one of the important factors in the geometric design of roads. In particular, the visual distance for stopping is very important in the design of vertical and surface alignments. It is also vital in establishing control and operational methods for intersections which tack roads or traffic lights. Deceleration and the friction coefficients of tire and surface play an important role in calculating the visual distance. In other words, when the friction coefficient is smaller, the safety stop visual distance must be longer. In contrast, when the friction coefficient is larger, the design standard for visual distance becomes shorter. The road traffic safety authority has recently studied the stop friction coefficient and the results has highly different from the prices set by American Association of State Highway and Transportation Officials(AASHTO). In this research various various test automobiles are used separately to study speed, roads, and road surfaces. Then the results are analyzed and compared with similar tests and related tests conducted in the past.

Association of polymorphisms in microRNA machinery genes (DROSHA, DICER1, RAN, and XPO5) with risk of idiopathic primary ovarian insufficiency in Korean women

Rah, HyungChul,Jeon, Young Joo,Lee, Bo Eun,Kim, Jung O,Shim, Sung Han,Lee, Woo Sik,Choi, Dong Hee,Kim, Ji Hyang,Kim, Nam Keun by The North American Menopause Society. 2013 Menopause Vol.20 No.10

OBJECTIVE: The aim of our study was to investigate whether polymorphisms in microRNA machinery genes are associated with the risk of primary ovarian insufficiency (POI). METHODS: We genotyped 136 POI patients and 236 controls among Korean women for nine single nucleotide polymorphisms (SNPs; DROSHA rs6877842 and rs10719; DICER1 rs13078 and rs3742330; RAN rs14035; and XPO5 rs34324334, rs2257082, rs11544382, and rs11077) by polymerase chain reaction–restriction fragment length polymorphism analysis. Differences in genotype frequencies between patients and controls were compared, and odds ratios (ORs) and 95% CIs were determined as measures of the strength of the association between genotype and POI. RESULTS: Of the nine SNPs, XPO5 rs34324334 and rs11544382 were monomorphic and were not analyzed further. The XPO5 rs2257082 CT and CT + TT variant genotypes were more frequent in patients (OR, 2.097; 95% CI, 1.207-3.645) than in controls (OR, 2.030; 95% CI, 1.196-3.445). The combined frequencies of XPO5 rs2257082 CT + TT and rs11077 AC + CC genotypes were higher in patients than in controls (OR, 2.526; 95% CI, 1.088-5.865). An association of POI risk with other polymorphisms was not found. A haplotype-based analysis of seven polymorphisms of the microRNA machinery genes for gene-gene interactions suggests that ***ACTA, ***GCCA, ***G*C*, *T*ATTA, and ***ACT* haplotypes (asterisk indicates SNP locus not included; DROSHA rs6877842 and rs10719, DICER1 rs13078 and rs3742330, RAN rs14035, and XPO5 rs2257082 and rs11077 polymorphisms) are associated with higher POI prevalence, and that ***GCTA, ***ACCA, *C*ATTA, and *C*ATT* haplotypes are associated with lower POI prevalence. CONCLUSIONS: Our data demonstrate that the XPO5 rs2257082 T variant allele occurs more frequently in POI patients than in controls, suggesting that this allele may be associated with increased POI risk.

Association between kinase insert domain-containing receptor polymorphisms (−604T>C, 1192G>A, 1719A>T) and premature ovarian failure in Korean women

Rah, HyungChul,Jeon, Young Joo,Choi, Youngsok,Shim, Sung Han,Ko, Jung Jae,Yoon, Tae Ki,Cha, Sun Hee,Kim, Nam Keun The North American Menopause Society 2012 Menopause Vol.19 No.9

OBJECTIVE: The aim of the study was to investigate whether the −604T>C, 1192G>A, and 1719A>T polymorphisms in the kinase insert domain-containing receptor (KDR) gene confer risk for premature ovarian failure (POF) in Korean women. METHODS: DNA samples from 133 POF patients and 230 controls were genotyped for the three KDR single nucleotide polymorphisms by polymerase chain reaction–restriction fragment length polymorphism analysis. RESULTS: The POF patients had significantly increased frequencies of the KDR −604TC and −604TC + CC genotypes (odds ratio [OR], 1.975; 95% CI, 1.219-3.201 and OR, 1.948; 95% CI, 1.221-3.109, respectively) and of the −604TC + CC/1192GG combined genotype (OR, 2.271; 95% CI, 1.359-3.795) and a decreased frequency of the 1192GA genotype (OR, 0.457; 95% CI, 0.231-0.905) compared with the controls. The genotype frequency of the 1719A>T polymorphism was not significantly different between the two groups. The frequencies of the KDR −604C/1192G/1719T, −604C/1192G, and −604C/1719T haplotypes (OR, 3.319; 95% CI, 1.564-7.041; OR, 2.083; 95% CI, 1.351-3.212; and OR, 1.979; 95% CI, 1.073-3.649, respectively) were significantly higher among POF patients than controls, whereas the −604T/1719T haplotype frequency (OR, 0.657; 95% CI, 0.472-0.915) was lower among POF patients. CONCLUSIONS: Carriers of the KDR −604C variant allele (−604TC and −604TC + CC genotypes; −604TC + CC/1192GG combined genotype; −604C/1192G/1719T haplotype, −604C/1192G haplotype, −604C/1719T haplotype) are consistently more prevalent among POF patients than among controls, suggesting that the KDR −604C allele may increase the risk of POF development in Korean women.

진동대 시험을 활용한 구조물의 모드 형상에 따른 동적 p-y 곡선 특성 분석

한재혁(Han, Jae-hyeok),안성노(Ahn, Seongnoh),윤형철(Yoon, Hyungchul),정종원(Jung, Jongwon) 한국방재학회 2021 한국방재학회논문집 Vol.21 No.5

말뚝기초의 내진설계 시, 지진의 동적 하중을 고려한 지반의 비선형적 거동을 나타내는 p-y 곡선이 필요하다. 최근 지반-구조물 상호작용을 고려한 p-y 곡선 분석이 이루어지고 있으나, 다층 구조물을 활용한 연구는 부족한 실정이다. 이에 본 연구에서는 진동대 실험을 통해 구조물 모드형상(구조물이 부재, 단층 구조물, 3층 구조물)에 따른 지반-구조물 상호작용 영향을 고려한 p-y 곡선 특성을 분석하였다. 그 결과, (1) 입력가속도의 증가에 따른 휨모멘트 및 말뚝 변위의 증가, (2) 각 구조물의 고유진동수에서 최대 지반 반력 및 말뚝 변위 발생을 관찰하였다. 또한, 본 연구에서 사용된 3층 구조물에 비해 단층 구조물의 경우 휨모멘트, 지반 반력 및 p-y 곡성의 기울기가 크게 나타났다. 이는, 단층 구조물로 모사한 내진설계가 보수적인 설계임을 나타낸다. In the seismic design of pile foundations, a p-y curve representing the nonlinear behavior of the ground considering the dynamic load of the earthquake is required. Recently, p-y curve analyses reflecting the soil-structure interaction have been conducted, but studies on multilayer structures have not been investigated extensively. In this study, the p-y curve characteristics were analyzed, considering the influence of the ground-structure interaction based on the mode shape of the structure (no structure, single-story structure, and three-story structure) through shake table tests. It was found that (1) the bending moment and pile displacement increased with input acceleration, and (2) the maximum soil resistance and pile displacement occurred at the natural frequencies of each structure were observed. In addition, the bending moment, soil resistance, and p-y curve slope were higher in the single-story structure than in the three-story structure. The findings indicate that the seismic design simulated for a single-story structure is conservative.

Solute Carrier Family 19, Member 1 (<i>SLC19A1</i>) Polymorphisms (−43T>C, 80G>A, and 696C>T), and Haplotypes in Idiopathic Recurrent Spontaneous Abortion in a Korean Population

Rah, HyungChul,Choi, Yi Seul,Jeon, Young Joo,Choi, Youngsok,Cha, Sun Hee,Choi, Dong Hee,Ko, Jung Jae,Shim, Sung Han,Kim, Nam Keun Springer-Verlag 2012 Reproductive sciences Vol.19 No.5

<P>The objective was to investigate the association between idiopathic recurrent spontaneous abortion (RSA) and 3 SLC19A1 polymorphisms (-43T>C, 80G>A, and 696C>T). DNA from 269 patients with RSA and 125 controls were genotyped for the 3 SLC19A1 single nucleotide polymorphisms (SNPs) by polymerase chain reaction-restriction fragment length polymorphism. Homocysteine and folate levels of 100 patients with RSA were available for analysis. The combination genotypes of SLC19A1 -43TC/80GG, -43TC/80AA, and -43CC/80GA; 80GA/696TT, 80AA/696CC; and -43TC/696CC were less frequent in patients with RSA compared to controls (P < .05 for each). The -43C/80A/696??T and -43T/80G/696C haplotypes were more frequent in patients than controls, whereas -43T/80A/696C, -43C/80A/696C, -43C/80G/696C, -43C/80G/696T, and -43T/80G/696T haplotypes were less frequent in patients (P < .05 for each). The -43T/80G and 80A/696T haplotypes were more frequent in patients, while -43T/80A, -43C/80G, 80A/696C, 80G/696T, and -43C/696C haplotypes occurred less frequently in patients (P < .05 for each). The associations between idiopathic RSA occurrence and SLC19A1 -43T>C/80G>A/696C>T polymorphisms were identified and can be developed as biomarkers for RSA risk.</P>

직류철도에서의 접지 유지보수 방안

한문섭(Han Moonseob),김형철(Kim hyungchul),나재두(Na Jae-Du) 한국철도학회 2008 한국철도학회 학술발표대회논문집 Vol.- No.-

D.C. traction systems can cause stray currents which could adversely affect both the railway concerned and outside installations, when the return circuit is not sufficiently insulated versus earth. As experience for several decades has not shown evident corrosion effects from a.c. traction systems and actual investigations are not completed, stary currents flowing from a d.c. traction system is issued. D.C. traction systems can cause stray currents can be corrosion and subsequent damage of metallic structures, where stray currents leave the metallic structures. There is also the risk of overheating, arcing and fire and subsequent danger to persons and equipment. Any provision employed to control the effects of stray currents be checked, verified and validated. Direct measurement of stray current is difficult and a provision employed to control the effects of stray currents is proposed.

Association of methylenetetrahydrofolate reductase (MTHFR 677C>T) and thymidylate synthase (TSER and TS 1494del6) polymorphisms with premature ovarian failure in Korean women

Rah, HyungChul,Jeon, Young Joo,Choi, Youngsok,Shim, Sung Han,Yoon, Tae Ki,Choi, Dong Hee,Cha, Sun Hee,Kim, Nam Keun The North American Menopause Society 2012 Menopause Vol.19 No.11

OBJECTIVE: The aim of our study was to investigate whether methylenetetrahydrofolate reductase (MTHFR) gene variant (MTHFR 677C>T) and thymidylate synthase (TS) gene variants (TS enhancer region [TSER] and TS 1494del6) confer a risk for premature ovarian failure (POF). METHODS: We genotyped 136 POF patients and 236 controls among Korean women for the three single nucleotide polymorphism sites using polymerase chain reaction restriction fragment length polymorphism analysis. Differences in the MTHFR 677C>T, TSER, and TS 1494del6 genotype frequencies between POF patients and controls were compared, and odds ratios (ORs) and 95% CIs were determined as a measure of the strength of the association between genotypes and POF. RESULTS: The MTHFR 677CT and CT + TT variant genotypes were more frequent in POF patients than in controls (OR, 2.249; 95% CI, 1.317-3.843; and OR, 2.132; 95% CI, 1.268-3.585, respectively). The combined genotype frequencies of MTHFR 677CT + TT/TSER 3R3R and 677CT + TT/TS 1494del6 del6/del6 were higher in patients than in controls (OR, 2.300; 95% CI, 1.219-4.337; and OR, 3.314; 95% CI, 1.623-6.767, respectively). The T-3R-del6 and T-2R-del6 (MTHFR 677C>T/TSER/TS 1494del6) haplotypes were more frequent in patients (OR, 1.450; 95% CI, 1.050-2.002; and OR, 2.911; 95% CI, 1.191-7.117, respectively), whereas the C-2R-del6 haplotype was less frequent in patients (OR, 0.372; 95% CI, 0.152-0.912). The T-del6 (MTHFR 677/TS 1494del6) haplotype frequency was higher among patients (OR, 1.653; 95% CI, 1.206-2.266), whereas the C-del6 haplotype frequency was lower among patients (OR, 0.700; 95% CI, 0.516-0.950). We did not find an association between TSER or TS 1494del6 polymorphisms and POF. CONCLUSIONS: Our data suggest that the MTHFR 677T allele may increase the risk for POF, which could lead to the development of novel genetic markers for predicting the risk of POF in patients.