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Association between C16orf47 Gene and Serum Liver Enzyme Levels in the Korean Population
Hyo?Jun Ahn,Yong?Bin Eom 대한의생명과학회 2013 Biomedical Science Letters Vol.19 No.3
Serum liver enzyme levels are widely used in the clinical diagnosis of liver diseases and the assessment of liver status. They also have epidemiological significance to be prospective risk factors for type 2 diabetes, cardiovascular disease. In the previous study, single nucleotide polymorphisms (SNPs) in several genes have been reported to be associated with serum liver enzyme levels in American population. We aimed to confirm whether the genetic variation of C16orf47 (chromosome 16 open reading frame 47) gene also influence the serum liver enzyme levels in Korean population. We genotyped variants in or near C16orf47 in a population?based sample including 994 unrelated Korean adult. Here, we performed association analysis to elucidate the possible relations of genetic polymorphisms in C16orf47 gene with serum liver enzyme levels. By examining genotype data of a total of 944 subjects in 5 hospital health promotion center, we discovered the C16orf47 gene polymorphisms are associated with serum liver enzyme levels. The common and highest significant polymorphism was rs7203412 (β=3.68, P=3.66E?06) with glutamic oxaloacetic transferase (GOT) and rs7203412 (β=6.2, P=7.06E?05) with glutamic pyruvate transaminase (GPT) in all group. Furthermore, the SNP rs7203412 was consistently associated with GOT (β=6.41, P=6.78E?08) and GPT (β=11.53, P=2.81E?06) in men group. Consequently, we found statistically significant SNP in C16orf47 gene that are associated with serum levels of GOT and GPT. In addition, these results suggest that the individuals with the minor alleles of the SNP in the C16orf47 gene may be more elevated serum liver enzyme levels in the Korean population.
Hyo-Jun Ahn,Yong-Bin Eom 대한의생명과학회 2013 Biomedical Science Letters Vol.19 No.4
Serum levels of alkaline phosphatase (ALP) are widely used in the clinical diagnosis of hepatic diseases and the assessment of liver status. They also have epidemiological significance to be prospective risk factors for bone diseases, such as osteitis deformans, rickets, osteomalacia, hyperparathyroidism, healing fractures, and osteoblastic bone tumors. In the previous study, single nucleotide polymorphisms (SNPs) in several genes have been reported to be associated with serum levels of liver enzyme in American population. We aimed to confirm whether the genetic variation of RETNLB (resistin like beta) gene also influence the serum levels of liver enzyme in Korean population. We genotyped variants in or near RETNLB in a population-based sample including 994 Korean adults. Here, we performed association analysis to elucidate the possible relations of genetic polymorphisms in RETNLB gene with serum levels of liver enzyme. By examining genotype data of a total of 944 subjects in 5 hospital health promotion centers, we discovered the RETNLB gene polymorphisms are associated with serum levels of ALP. The common and highest significant polymorphism was rs736327 (β=8.66, P=2.37E-05), rs7639070 (β=8.56, P=3.24E-05) with ALP in all groups. Furthermore, the ALP was consistently associated with rs736327 (β=10.40, P=5.23E-05), rs7639070 (β=10.32, P=6.74E-05) in the male population. Consequently, we found statistically significant SNPs in RETNLB gene that are associated with serum levels of ALP. In addition, these results suggest that the individuals with the minor alleles of the SNP in the RETNLB gene may have elevated serum levels of ALP in the Korean population.
P42 Ebp1 functions as a tumor suppressor in non-small cell lung cancer
( Hyo Rim Ko ),( Truong Lx Nguyen ),( Chung Kwon Kim ),( Young Bin Park ),( Kyung Hoon Lee ),( Jee Yin Ahn ) 생화학분자생물학회 2015 BMB Reports Vol.48 No.3
Although the short isoform of ErbB3-binding protein 1 (Ebp1), p42 has been considered to be a potent tumor suppressor in a number of human cancers, whether p42 suppresses tumorigenesis of lung cancer cells has never been clarified. In the current study we investigated the tumor suppressor role of p42 in non-small cell lung cancer cells. Our data suggest that the expression level of p42 is inversely correlated with the cancerous properties of NSCLC cells and that ectopic expression of p42 is sufficient to inhibit cell proliferation, anchorage-independent growth, and invasion as well as tumor growth in vivo. Interestingly, p42 suppresses Akt activation and overexpression of a constitutively active form of Akt restores the tumorigenic activity of A549 cells that is ablated by exogenous p42 expression. Thus, we propose that p42 Ebp1 functions as a potent tumor suppressor of NSCLC through interruption of Akt signaling.[BMB Reports 2015; 48(3): 159-165]
Association between SMAD2 Gene and Serum Liver Enzyme Levels in the Korean Population
Hyo-Jun Ahn,Jae Woong Sull,Yong-Bin Eom 대한의생명과학회 2013 Biomedical Science Letters Vol.19 No.2
Genome-wide association studies (GWAS) have identified a number of common variants associated with serum liver enzyme homeostasis in population. In the previous study, single nucleotide polymorphisms (SNPs) in several genes have been reported to be associated with serum liver enzyme levels in European population. We aimed to confirm whether the genetic variation of SMAD2 (SMAD family member 2) gene influence the serum liver enzyme levels in Korean population. We genotyped variants in or near SMAD2 in a population-based sample including 994 unrelated Korean adult. Here, we performed association analysis to elucidate the possible relations of genetic polymorphisms in SMAD2 gene with serum liver enzyme levels. By examining genotype data of a total of 944 subjects in 5 hospital health promotion center, we discovered the SMAD2 gene polymorphisms are associated with serum liver enzyme levels. The common and highest significant polymorphism was rs17736760 (β=3.51, P=5.31E-07) with glutamic oxaloacetic transferase (GOT), rs17736760 (β=5.99, P=1.25E-05) with glutamic pyruvate transaminase (GPT), and rs17736760 (β=15.68, P=9.93E-07) with gamma glutamyl transferase (GGT) in all group. Furthermore, the SNP rs17736760 was consistently associated with GOT (β=5.25, P=1.72E-06), GPT (β=9.97, P=1.16E-05), GGT (β=26.13, P=3.43E-06) in men group. Consequently, we found statistically significant SNP in SMAD2 gene that are associated with serum levels of GOT, GPT, and GGT. In addition, these results suggest that the individuals with the minor alleles of the SNP in the SMAD2 gene may be more elevated serum liver enzyme levels in the Korean population.
( Hyo Sang Jo ),( Duk-soo Kim ),( Eun Hee Ahn ),( Dae Won Kim ),( Min Jea Shin ),( Su Bin Cho ),( Jung Hwan Park ),( Chi Hern Lee ),( Eun Ji Yeo ),( Yeon Joo Choi ),( Hyeon Ji Yeo ),( Christine Seok Y 생화학분자생물학회 2016 BMB Reports Vol.49 No.11
Oxidative stress is closely associated with various diseases and is considered to be a major factor in ischemia. NAD(P)H: quinone oxidoreductase 1 (NQO1) protein is a known antioxidant protein that plays a protective role in various cells against oxidative stress. We therefore investigated the effects of cell permeable Tat-NQO1 protein on hippocampal HT-22 cells, and in an animal ischemia model. The Tat-NQO1 protein transduced into HT-22 cells, and significantly inhibited against hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced cell death and cellular toxicities. Tat-NQO1 protein inhibited the Akt and mitogen activated protein kinases (MAPK) activation as well as caspase-3 expression levels, in H<sub>2</sub>O<sub>2</sub> exposed HT-22 cells. Moreover, Tat-NQO1 protein transduced into the CA1 region of the hippocampus of the animal brain and drastically protected against ischemic injury. Our results indicate that Tat-NQO1 protein exerts protection against neuronal cell death induced by oxidative stress, suggesting that Tat-NQO1 protein may potentially provide a therapeutic agent for neuronal diseases. [BMB Reports 2016; 49(11): 617-622]
안효진 ( Hyo Jin Ahn ),서덕원 ( Deok Won Seo ),류호선 ( Ho Sun Ryu ),고인성 ( In Sung Ko ),이수빈 ( Su Bin Lee ),박세진 ( Se Jin Park ) 대한한방신경정신과학회 2011 동의신경정신과학회지 Vol.22 No.2
Objectives: The purpose of this study was to investigate the clinical application of Korean Traditional treatment to psychogenic torticollis patient who has panic disorder as underlying disease. Methods: Herb medicine used in this study are Heosu-san(Huishou-san) which is previously used for torticollis in several studies, Guibi-tang(Guipi-tang) and Gamiondam-tang(Jiaweiwendan-tang) which are frequently used for phychological disease. Also, physical therapy and aroma therapy were practiced which basically stretches and relaxes muscles around cervical muscles. Self exercise of cervical muscles was carried out during acupuncture. Results: After the comprehensive treatment, the clinical symptoms of the patient were improved. Conclusions: It is suggested that oriental medical treatment are effective in psychogenic torticollis.
원저(原著) : 소아 수혈용 소단위 적혈구 농축액 제조 및 사용경험
엄용빈 ( Yong Bin Eom ),배인철 ( In Cheol Bse ),안효준 ( Hyo Jun Ahn ),이정신 ( Jung Sin Lee ),김현옥 ( Hyun Ok Kim ) 대한임상병리사협회 1996 임상수혈검사학회 발표자료집 Vol.3 No.1
For pediatric and neonatal transfusions, it is important to supply the volume needed. Newborns, compared to adult, require transfusion more frequently, which increases donor exposure and donor-related risks such as hepatitis. The unique small-volume requirements of transfusion to neonates may give rise to a large amount of wastage. Thus, a single donor unit for adult transfusion is not adequate for the pediatric and neonatal transfusion. Our technical approaches for pediatric units are available to supply the small volume needed and decrease blood wastage associated with requests for small volume transfusion and reduce donor exposure for those infants who are maintained with transfusion from the same unit for several days (14 days). Small-volume bags is attached to tubing from the outlet port of the main bag using the Sterile Connective Device. The repeated manipulation needed to make small-volume aliquots of packed RBCs did not result in contamination. This method for pediatric transfusion was simple for preparation and easy to adjust the volume. The outcome of the transfused patients was successful. In Korea, transfusion services providing blood for pediatrics and neonates need to develop the methods of preparing 70~120 ml pediatric units of whole blood or red blood cells to realize above advantages and to minimize wastage.