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Hyesu Jeon,Yujin Jin,Chang-Seon Myung,Kyung-Sun Heo 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.7
In this study, we investigated the anti-cancereffects of ginsenoside Rg2 (G-Rg2) and its underlyingsignaling pathways in breast cancer (BC) cells. G-Rg2 significantly induced cytotoxicity and reactive oxygen species(ROS) production in MCF-7 cells among various types ofBC cells including HCC1428, T47D, and BT-549. G-Rg2signifi cantly inhibited protein and mRNA expression ofcell cycle G1-S phase regulators, including p-Rb, cyclinD1, CDK4, and CDK6, whereas it enhanced the proteinand mRNA expression of cell cycle arrest and apoptoticmolecules including cleaved PARP, p21, p27, p53 and Bakthrough ROS production. These eff ects were abrogated bythe antioxidant N-acetyl-I-cysteine, or NADPH oxidaseinhibitors, such as diphenyleneiodonium chloride and apocynin. Interestingly, G-Rg2 induced mitochondrial damageby reducing the membrane potential. G-Rg2 further activatedthe ROS-sensor protein, AMPK and downstream targetsof AMPK activation, including PGC-1α, FOXO1, andIDH2, and downregulated mTOR activation and antioxidantresponse element-driven luciferase activity. Together, ourdata demonstrate that G-Rg2 mediates anti-cancer eff ectsby activating cell cycle arrest and signaling pathways relatedto mitochondrial damage-induced ROS production andapoptosis.
Yujin Jin,Hyesu Jeon,Thuy Le Lam Nguyen,Lila Kim,Kyung-Sun Heo 대한약학회 2023 Archives of Pharmacal Research Vol.46 No.12
Acute lung injury (ALI) is the leading cause of respiratory diseases induced by uncontrolled inflammation and cell death. Lipopolysaccharide (LPS) is a major trigger of ALI in the progression through macrophage differentiation and the accelerated release of pro-inflammatory cytokines. The present study aimed to investigate the protective effects of human milk oligosaccharides, specifically 3′-sialyllactose (3′-SL) and 6′-sialyllactose (6′-SL), on LPS-induced ALI and elucidate their underlying signaling pathways. The inhibitory effects of 3′-SL and 6′-SL on inflammation were evaluated using LPS-treated RAW 264.7 macrophages. To establish the ALI model, mice were treated with 10 mg/kg LPS for 24 h. Histological changes in the lung tissues were assessed using hematoxylin and eosin staining and immunofluorescence. LPS causes thickening of the alveolar wall infiltration of immune cells in lung tissues and increased serum levels of TNF-α, IL-1β, and GM-CSF. However, these effects were significantly alleviated by 100 mg/kg of 3′-SL and 6′-SL. Consistent with the inhibitory effects of 3′-SL and 6′-SL on LPS-induced pro-inflammatory cytokine secretion in serum, 3′-SL and 6′-SL suppressed mRNA expression of TNF-α, IL-1β, MCP-1, iNOS, and COX2 in LPS-induced RAW 264.7 cells. Mechanistically, 3′-SL and 6′-SL abolished LPS-mediated phosphorylation of NF-κB and STAT1. Interestingly, fludarabine treatment, a STAT1 inhibitor, did not affect LPS-mediated NF-κB phosphorylation. In summary, 3′-SL and 6′-SL protect LPS-induced macrophage activation and ALI through the STAT1 and NF-κB signaling pathways.
Therapeutic effects of ginsenosides on breast cancer growth and metastasis
Yujin Jin,Diem Thi Ngoc Huynh,Thuy Le Lam Nguyen,Hyesu Jeon,Kyung-Sun Heo 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.8
Breast cancer is the most common cause ofcancer-related deaths among women worldwide. Thus, thedevelopment of new and eff ective low-toxicity drugs is vital. The specifi c characteristics of breast cancer have allowed forthe development of targeted therapy towards each breast cancersubtype. Nevertheless, increasing drug resistance is displayedby the changing phenotype and microenvironmentsof the tumor through mutation or dysregulation of variousmechanisms. Recently, emerging data on the therapeuticpotential of biocompounds isolated from ginseng have beenreported. Therefore, in this review, various roles of ginsenosidesin the treatment of breast cancer, including apoptosis,autophagy, metastasis, epithelial-mesenchymal transition,epigenetic changes, combination therapy, and drug deliverysystem, have been discussed.
Thuy Le Lam Nguyen,Diem Thi Ngoc Huynh,Yujin Jin,Hyesu Jeon,Kyung-Sun Heo 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.2
Systemic or hepatic infl ammation is caused byintraperitoneal application of lipopolysaccharide (LPS). Inthis study, we investigated anti-infl ammatory and antioxidantproperties of combination of ginsenoside-Rg2 (G-Rg2) and-Rh1 (G-Rh1) on liver function under LPS challenging. Wefi rst confi rmed that G-Rg2 and -Rh1 at 100 μg/ml did notshow cytotoxicity in HepG2 cells. G-Rg2 and -Rh1 treatmentsignifi cantly inhibited activation of STAT3 and TAK1,and infl ammatory factors including iNOS, TNF-α, and IL-1βin peritoneal macrophages. In HepG2 cells, G-Rg2 and -Rh1treatment inhibited activation of STAT3 and TAK1/c-JunN-terminal kinase, and down-regulated nuclear translocationof NF-κB transcription factor. In addition, LPS-inducedmitochondrial dysfunction was restored by treatment withG-Rg2 and -Rh1. Interestingly, pretreatment with G-Rg2 and-Rh1 eff ectively inhibited mitochondrial damage-mediatedROS production induced by LPS stimulation, and alterationsof Nrf2 nuclear translocation and ARE promotor activitywere involved in G-Rg2 and -Rh1 eff ects on balancingROS levels. In liver tissues of LPS-treated mice, G-Rg2and -Rh1 treatment protected liver damages and increasedNrf2 expression while reducing CD45 expression. Takentogether, G-Rg2 and -Rh1 exerts a protective effect onliver function by increasing antioxidant through Nrf2 and anti-inflammatory activities through STAT3/TAK1 andNF-κB signaling pathways in liver cells and macrophages.
An Epidemiological Analysis of 28 Vivax Malaria Cases in Gimpo-si, Korea, 2020
Young Yil Bahk,Shin-Hyeong Cho,Kyoung-Nam Kim,Eun-Hee Shin,Byoung-Hak Jeon,Jeong-Hyun Kim,Sookkyung Park,Jeongran Kwon,Hyesu Kan,Miyoung Kim,Tong-Soo Kim 대한기생충학열대의학회 2021 The Korean Journal of Parasitology Vol.59 No.5
Since 1993, vivax malaria has been recognized as a public health burden in Korea. Despite of pan-governmental malaria-control efforts and the dramatic reduction in the burden of this disease over the last 10 years, vivax malaria has not been well controlled and has remained continuously endemic. We focused interviewed and examined the charts of 28 confirmed vivax malaria patients given malarial therapy for whom daily records were kept from Gimpo-si, Gyeonggi-do of Korea. Various epidemiological characteristics of vivax malaria, including the incubation period, medication used, and recurrence, and an evaluation of the parasitic characteristics from the focused interviews of patients from this region are described here. Most of the participants indicated the 3 most common symptoms of malaria (headache, chills and fever). Of the 28 cases, 2 experienced a second attack and there were 17 and 11 cases with short- and long-term incubation periods, respectively, yielding a short-term to long-term ratio of 1.5. Based on the parasitemia stages, most of the participants were tested at 5 to 7 days (11 cases) and 7 to 15 days (11 cases) after initial wave of asexual parasites. In conclusion, public health authorities should consider developing management measures to decrease the time lag for diagnosis and drafting unified and robust guidelines for drug use for malaria and drawing up unified and robust guidelines on the use of medication for malaria. It also suggests that routine monitoring, surveillance, and precise medical surveys in high-risk vivax malaria endemic areas are pivotal to controlling this persistent public disease and finally eliminating it from Korea.
베타/감마 동시 측정용 광섬유 이중 검출기의 개발을 위한 기초연구
홍승한(Seunghan Hong),신상훈(Sang Hun Shin),심혁인(Hyeok In Sim),김선근(Seon Geun Kim),전혜수(Hyesu Jeon),장재석(Jaeseok Jang),김재석(Jaeseok Kim),권구원(Guwon Kwon),장경원(Kyoung Won Jang),유욱재(Wook Jae Yoo),이봉수(Bongsoo Lee) 대한전기학회 2014 전기학회논문지 Vol.63 No.2
A fiber-optic beta/gamma dual detector system with two types of sensing probes was fabricated to detect the beta- and gamma-rays simultaneously. As scintillators of the sensing probe type 1, two different inorganic scintillators, CaF₂(Eu) and LYSO(Ce) crystals, were used to obtain the each scintillating efficiency with respect to betaand gamma-rays and the inherent energy spectra of radioactive isotopes. In the case of the sensing probe type 2, which is composed of two identical inorganic scintillators and a beta shielding material based on the lead, it could discriminate beta- and gamma-rays using a subtraction method. In conclusion, we demonstrated that the proposed fiber-optic beta/gamma dual detector could measure and discriminate beta- and gamma-rays using both energy spectroscopy and subtraction method.