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Lee, Sung-Sik,Park, Soojin,Kim, Ju-Young,Kim, Hye-Rim,Lee, Sungyul,Oh, Han Bin The Royal Society of Chemistry 2014 Physical chemistry chemical physics Vol.16 No.18
<P>We present infrared multiple photon dissociation (IRMPD) spectroscopy and quantum chemical calculation results for the protonated permethylated β-cyclodextrin (CD)–water non-covalent complex, the simplest β-CD non-covalent complex, in the gas-phase. The IRMPD spectrum in the region 2700–3750 cm<SUP>−1</SUP> consisted of three strong peaks at 3096, 3315, and 3490 cm<SUP>−1</SUP>. These spectral features in the experimental IRMPD spectrum were compared with a large set of infrared absorption spectra predicted using density functional theory (DFT) calculations for the protonated β-CD–water complex. Complex III (see Fig. 4c), in which the water molecule (at the primary rim) and the proton (at the secondary rim) were separated, was found to suitably reflect the main spectral characteristics found in the experimental IRMPD spectrum. The absence of the homodromic hydrogen bond ring, due to replacement of hydroxyl groups with methoxy groups in permethylated β-CD, rendered the primary rim open compared with the unmodified β-CD ‘one-gate-closed’ lowest energy conformer. This study demonstrates that IRMPD studies combined with DFT theoretical calculations can be a good method for studying molecular interactions of large host–guest pairs.</P> <P>Graphic Abstract</P><P>Water was found to interact with permethylated β-CD through multiple hydrogen bondings with methoxy groups of the rim. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cp54841d'> </P>
Oh, Hye Rim,An, Chang Hyeok,Yoo, Nam Jin,Lee, Sug Hyung Science Press ; W.B. Saunders 2015 PATHOLOGY ONCOLOGY RESEARCH Vol.21 No.3
<P>Mucins are important in tumorigenesis and expressional alterations of mucins are common in human cancers. A membrane-bound mucin MUC15 and secreted mucins MUC4 and MUC7 are known to involve in tumorigenesis, but their mutation status in cancers remains unknown. Aim of this study was to explore whether MUC4, MUC7 and MUC15 genes are mutated and expressionally altered in gastric (GC) and colorectal cancers (CRC). In a public database, we found that MUC15 and MUC7 genes had mononucleotide repeats in the coding sequences that might be mutation targets in the cancers with microsatellite instability (MSI). We analyzed the mutations in 90 GC and 141 CRC (high MSI (MSI-H) or stable MSI/low MSI (MSS/MSI-L)) by single-strand conformation polymorphism analysis and DNA sequencing. In the present study, we found MUC15 frameshift mutations (14.7% of GC and 15.2% of CRC with MSI-H), MUC 7 frameshift mutations (2.9% of GC with MSI-H) and MUC4 frameshift mutations (8.8% of GC and 3.8% of CRC with MSI-H). These mutations were not found in in MSS/MSI-L (0/118). Additionally, we analyzed intratumoral heterogeneity (ITH) of MUC15 mutation in 16 CRC and found that seven CRC (43.8%) harbored regional ITH of MUC15. We also analyzed MUC15 expression in GC and CRC by immunohistochemistry. Negative MUC15 expression was identified in 15-41% of the GC and CRC irrespective of MSI status. Of note, the negative expression was more common in those with MUC15 mutations. We identified alterations of MUC genes at various levels (frameshift mutations, genetic ITH and expression loss), which together might play a role in tumorigenesis of GC and CRC with MSI-H. Our data suggest that mutation analysis in multiple regions is needed for a better evaluation of mutation status in CRC with MSI-H.</P>
Oh, Hye Rim,An, Chang Hyeok,Yoo, Nam Jin,Lee, Sug Hyung Modern Medicine, etc.] 2015 Pathology Vol.47 No.2
<P>Initiation of transcription for ribosomal RNA (rRNA) by RNA polymerase I requires TATA-binding protein (TBP) and TBP-associated factors (TAF1A, TAF1B and TAF1C). p53 tumour suppressor inhibits rRNA transcription by blocking TAF1C-UBF interaction, but alterations of TAF1C itself in tumorigenesis remain unknown. The aim of this study was to explore whether TAF1C gene was mutated in gastric (GC) and colorectal cancers (CRC).In a public database, we found that TAF1C gene had a mononucleotide repeat (C8) in the coding sequences that might be a mutation target in the cancers with microsatellite instability (MSI). We analysed 79 GC and 124 CRC by single-strand conformation polymorphism and DNA sequencing analyses. In this study, we found TAF1C frameshift mutations (8.8% of GC and 10.1% of CRC with MSI-H), which were not found in stable MSI/low MSI (MSS/MSI-L) (0/90). In addition, we analysed intratumoural heterogeneity (ITH) of TAF1C frameshift mutations in 16 CRC and found that three CRC (18.8%) harboured regional ITH of the TAF1C frameshift mutations. Our results indicate that TAF1C gene harboured not only somatic frameshift mutations but also the mutational ITH, which together might play a role in tumourigenesis of GC and CRC. Our data also suggest that multi-regional mutation analysis is needed for a better evaluation of the mutation status in CRC.</P>
광학 문자 인식(OCR)을 활용한 저시력자 및 시각장애인 등 사회적 약자를 위한 비건 판독 시스템 개발
오혜림 ( Hye-rim Oh ),공예나 ( Ye-na Kong ),김정민 ( Jeong-min Kim ),최재준 ( Jea-jun Choi ) 한국정보처리학회 2023 한국정보처리학회 학술대회논문집 Vol.30 No.2
커져만 가는 비건 시장에 비해서 비건 제품의 가격은 높고, 한정되어 있다. 성분표만을 보고 비건 여부를 파악하기에는 어렵고, 저시력자 및 시각장애인에게는 더욱 어려운 일이다. 치주 질환이나 당뇨를 포함한 크고 작은 다양한 질병으로 인해 육식 섭취 대신 불가피하게 채식을 실천해야 하는 경우 또는 가격 부담이 크고 찾기 어렵다. 그래서 비건 인증을 받은 제품 대신 일반 제품들 사이에서 비건에 적합한 제품을 찾는 데 도움이 되는 시스템을 개발하고자 한다. 본 논문에서는 저시력자 및 시각장애인을 위한 큰 글씨 화면, 음성 입출력 시스템 제공과 성분표 촬영을 통해 비건 적합 여부 및 알레르기 정보 제공, 사용자 특성 분석을 통한 UI 구성의 서비스를 제공한다. 성분표 촬영에 어려움을 겪는 저시력자 및 시각장애인에게 편리를 제공하기 위해 소프트웨어 뿐만 아니라 하드웨어를 구성한다.
A novel antibacterial peptide in Apis mellifera against the enteric pathogenic Escherichia coli
Hyun Rim Oh,Hye-Kyung Kim,Mi Ra Lee,Man-young Lee,Ah Rang Kang,Soo Eun Kang,Tae Ho Oh,Seong Hee Kim,Yong-Soo Choi 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10
Insect peptides have been extensively studied due to beneficial effects in the treatment of infectious diseases. Melittin, a fundamental component of honeybee venom produced by European honeybee Apis mellifera, has applied to prevent various inflammatory disease and bacterial infections in human. However, the therapeutic application of melittin is limited due to its low stability, hemolytic activity and expensive manufacturing costs. In this study, we aimed to discovery unknown peptides from the Apis mellifera and evaluate its antibacterial activity against Escherichia coli KACC 10005. A total 15,853 peptide sequences were diciphered using Illumina HiSeq 2500 next-generation sequencing (NGS) platform and analyzed based on the Apis mellifera official Gene Set Version 3.2 (amel_OGSv3.2) and the Collection of Anti-Microbial Peptides (CAMPR3) database. All the peptide sequences and annotation data sets were combined and sorted by physicochemical features of antimicrobial peptides (AMPs), such as short peptide length <=50, positive charge, isoelectric point (8.0<=pl<=12), and aggregation propensity (in-vitro: <=500, in-vivo: –40<= Na4vSS <=60). Among the screened peptides, four unknown peptide candidates, named AMP1-4, were chemically synthesized and tested for antimicrobial activity in comparison with a reference peptide, melittin. Inhibition of bacterial growth was observed in the AMP4 treated group from 6 hours to 48 hours post-treatment against E. coli. These results suggest that honeybee-derived peptide sequences can be applied as natural resources to acquire novel AMPs and the peptide sequences derived parameters are enough to recognize antibacterial peptides. In addition, the selected novel peptide candidate, AMP4, has antibacterial activity.