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Nguyen Huu-Manh,Duong The-Khang,Nguyen Van-Khuyen,Nguyen Thi-Khanh-Ly,Dong Thi-Hoang-Yen,Nguyen Canh-Hung,Tung Nguyen-Thach 한국약제학회 2024 Journal of Pharmaceutical Investigation Vol.54 No.2
Purpose A two-step experimental design was used to develop a lornoxicam (LOR)-loaded topical hydrogel patch. We specifically focused on the simultaneous effect of the ion pair formation agent (triethanolamine [TEA]) and the chemical enhancer (cremophor RH40 [RH40]) on flux and conducted physicochemical studies and skin physiology assessments to obtain further information. Methods Drug-in-adhesive patches were fabricated using a micrometer-adjustable film applicator. The applied Design of Experiments (DoE) approach consisted of the Fractional Factorial Resolution V + design and the Central Composite Face design established by the MODDE® 12.0 software. Molecular-level drug-excipient interactions were investigated using infrared (IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy. The effects on skin physiological function was assessed using DermaLab Combo. Results DoE results revealed that TEA enhanced flux by 3.14-fold, whereas RH40 reduced it by 4.62-fold. The addition of RH40 resulted in the disappearance of the proton peak within the region of 12–13 ppm, suggesting competition for hydrogen bonding with LOR between TEA and RH40. The optimized formulation (4% TEA, 0% RH40, and 0.2% Al(OH)3) increased skin hydration by 6.20-fold. Opposing effects of TEA and RH40 on skin elasticity were observed. Conclusion Expected flux and adhesion strength for the optimized formulation were 7.18 μg·cm–2·h–1 and 11.79 mJ, respectively. Our understanding of the conflicting effects of TEA and RH40 has been advanced. The integrated use of the two-step DoE, physicochemical studies, and skin physiology assessments was proven to be effective in elucidating the simultaneous effects of different permeation-modifying strategies on patches, thus having substantial value for the successful execution of future research endeavors.
Nguyen Huu Tung,Chau Van Minh,Phan Van Kiem,Hoang Thanh Huong,Tran Thu Ha,Nguyen Tien Dat,Nguyen Xuan Nhiem,Nguyen Xuan Cuong,Jae-Hee Hyun,Hee-Kyoung Kang,김영호 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.12
One new C29 sterol with a cyclopropane ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC50 in the range of 12.8-27.8 μM.
Chemical Components from the Vietnamese Soft Coral Lobophytum sp.
Tung, Nguyen Huu,Minh, Chau Van,Kiem, Phan Van,Huong, Hoang Thanh,Nam, Nguyen Hoai,Cuong, Nguyen Xuan,Quang, Tran Hong,Nhiem, Nguyen Xuan,Hyun, Jae-Hee,Kang, Hee-Kyoung,Kim, Young-Ho 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.4
Chromatographic separation resulted in the identification of one new squalene derivative, named lobophytene (1), three cembranoid diterpenes (2-4), and two sterols (5 and 6) from the Vietnamese marine soft coral Lobophytum sp. Their structures were identified on the basis of extensive spectroscopic data and comparison of those with reported data. Compounds 1 and 2 showed significant cytotoxic activities against lung (A549) and colon (HT-29) cell lines with $IC_{50}$ values of 8.2 and $5.6\;{\mu}M$ for 1; 5.1 and $1.8\;{\mu}M$ for 2, respectively.
Nguyen Huu Tung,Seok Bean Song,Gyu Yong Song,김정아,구정은,강희경,Young-Sang Koh,김영호 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.4
Ginseng leaves and flowers have been known to be rich in various ginsenosides. The aim of present study is to screen the effect of 34 ginsenosides from ginseng leaves and flowers on interlukin (IL)-12 production in bone marrow-derived dendritic cells induced by lipopoly-saccharide (LPS). Noticeably, floralginsenoside Kc (5),floralginsenoside J (26), and ginsenoside I (33) exhibited particularly inhibitory effect on LPS-induced IL-12 production with IC50 values of 16.3, 25.8, and 6.7 μM, respectively. In addition, floralginsenoside Kc (5) suppressed significantly LPS-stimulated IL-6 and tumor necrosis factor-α (TNF-α)production. These results warrant further studies concerning potential of saponin extracts of Panax ginseng leaves and flowers for medicinal foods.
An Anti-influenza Component of the Bark of Alnus japonica
Nguyen Huu Tung,권혁준,김재홍,라정찬,김정아,김영호 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.3
This study to identify anti-influenza components of the bark of Alnus japonica resulted in the isolation of four lupane-type triterpenes (1-4) and one steroid (5). Their structures were characterized on the basis of physicochemical properties, NMR evidence, and ESI-MS data compared with reported data in the literature. Betulinic aldehyde (3) exhibited a particularly strong anti-influenza effect against KBNP-0028 relative to a positive control.
Steamed Ginseng-Leaf Components Enhance Cytotoxic Effects on Human Leukemia HL-60 Cells
Tung, Nguyen Huu,Song, Gyu Yong,Minh, Chau Van,Kiem, Phan Van,Jin, Long Guo,Boo, Hye-Jin,Kang, Hee-Kyoung,Kim, Young Ho The Pharmaceutical Society of Japan 2010 Chemical & pharmaceutical bulletin Vol.58 No.8
<P>Three new dammarane-type glycosides, named ginsenosides SL<SUB>1</SUB>—SL<SUB>3</SUB> (<B>1</B>—<B>3</B>), and eleven known compounds (<B>4</B>—<B>14</B>) were isolated from the heat-processed leaves of <I>Panax ginseng</I>. Their structures were elucidated on the basis of extensive chemical and spectroscopic methods. Cytotoxic-activity testing of compounds <B>1</B>—<B>14</B> against human leukemia HL-60 cells showed that ginsenosides Rh<SUB>3</SUB> (<B>11</B>) and Rk<SUB>2</SUB> (<B>12</B>) exhibited potent effects with IC<SUB>50</SUB> values of 0.8 and 0.9 μ<SMALL>M</SMALL>. In addition, ginsenosides SL<SUB>3</SUB> (<B>3</B>), 20<I>S</I>-Rg<SUB>2</SUB> (<B>7</B>), F<SUB>4</SUB> (<B>10</B>), 20<I>S</I>-Rh<SUB>2</SUB> (<B>13</B>) displayed strong activity with IC<SUB>50</SUB> values of 9.0, 9.0, 7.5, and 8.2 μ<SMALL>M</SMALL>, respectively. This is the first report on chemical components of the steamed ginseng leaves.</P>
Chemical Constituents from the Aerial Parts of Bupleurum falcatum L. and Biological Evidences
Nguyen Huu Tung,Takuhiro Uto,Osamu Morinaga,Yukihiro Shoyama 한국생약학회 2015 Natural Product Sciences Vol.21 No.2
In this study, phytochemical investigation on the aerial parts of Bupleurum falcatum resulted in the isolation of fourteen compounds including three quinic acid derivatives (1 - 3), five flavonoids (4 - 8), three monoterpene glycosides (9 - 11), and three saikosaponins (12 - 14). Compound 1 was first isolated from nature and unambiguously determined to be 3-O-feruloyl 5-O-caffeoylquinic acid on the basis of the extensive spectroscopic evidence. Biological testing revealed that saikosaponin A (12) and saikosaponin D (13) showed moderate anti-proliferative effects on HL-60 and HepG2 cancer cell lines.
Inhibitory Activity of Plantago major L. on Angiotensin I-converting Enzyme
Nguyen Xuan Nhiem,김영호,Bui Huu Tai,Phan Van Kiem,Chau Van Minh,Nguyen Xuan Cuong,Nguyen Huu Tung,Vu Kim Thu,Trinh Nam Trung,Hoang Le Tuan Anh,조성훈,장해동,권영인 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3
Eight compounds were isolated from methanol extract of Plantago major L. leaves and investigated for their ability to inhibit angiotensin I-converting enzyme activity. Among them, compound 1 showed the most potent inhibition with rate of 28.06 ± 0.21% at a concentration of 100 μM. Compounds 2 and 8 exhibited weak activities. These results suggest that compound 1 might contribute to the ability of P. major to inhibit the activity of angiotensin I- converting enzyme.
Nguyen Huu Tung,김영호,TRANHONG QUANG,Jeong-Hyun Son,구정은,Hye-Jin Hong,고영상,Gyu Yong Song 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.4
Interleukin-12, a heterodimeric cytokine comprising p40 and p35 subunits, plays an essential role in the regulating the differentiation of Th cells, which establish and maximize the capabilities of the immune system. The aim of present study is to screen the effect of 21 ginsenosides from steamed ginseng-leaves and flowers on IL-12 production in bone marrow-derived dendritic cells induced by lipopolysaccharide. Noticeably, ginsenoside Rg_6 (12) and ginsenoside F_4 (13) exhibited particularly inhibitory effect on LPS-induced IL-12 production with the inhibition values of 80 and 82%; and ginsenoside ST1 (4), ginsenoside SL_2 (8), ginsenoside SL_3 (9),ginsenoside Rh_3 (14), ginsenoside Rk_2 (15), and ginsenoside Rs_4 (18) showed moderate effects with inhibition rates of 63, 65, 67, 68, 71, 73, and 67%, respectively. These results warrant further studies concerning potential of saponin extracts of steamed ginseng-leaves and flowers for medicinal uses.