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창면 불쾌글레어 평가실험의 조건설정 및 타당성 검토를 위한 기초실험
김선화,김병수,이진숙 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1
The purpose of the study is to found the base experimental data by testing the adaptable time of eyes with administrating experimental conditions including source luminance, background illuminance and the position of subjects, by examining the appropriation of evaluating discomfort glare caused by actual window and simulated window. The process of the study is as follows: 1) In terms of the previous experiment, the large of Mock-up, evaluation values and subjective positions were administrated. 2) The experiment on the adaptable time of eyes is conducted with source luminance, background illuminance and the subjective position. 3) At the same Mock-up condition, the experiments for evaluating discomfort glare caused by actual window and by simulated window were conducted and contrasted. The adaptable time of eyes is rationally tested as 120 seconds with source luminance, background illuminance and the subjective position. And the difference on the boundary of evaluating values caused by actual window and simulated window ranges from 13% to 5%. On the basis of the result, the applicability of evaluating discomfort glare caused by simulated window is presented
창면불쾌글레어 평가를 위한 인공창 실험의 타당성 검토 연구
이진숙,김병수,김선화 대한건축학회 2003 대한건축학회논문집 Vol.19 No.12
The purpose of this study is to find the base experimental data by testing the recovery time of human eye with administrating experimental conditions, source luminance, background illuminance and the position of subjects, by examining the appropriateness of evaluating discomfort glare caused by actual window and by simulated window. The process of this study is as follows: 1) In terms of the previous experiment, the large of Mock-up, evaluation values and subjective positions were administrated. 2) The experiment on the recovery time of human eye is conducted by source luminance, background illuminance and the subjective position. 3) At the same Mock-up condition, the experiments for evaluating discomfort glare caused by actual window and by simulated window were conducted and contrasted. Rationally tested recovery time of human eye is 120 seconds with source luminance, background illuminance and the subjective position. And the difference on the boundary of evaluating values caused by actual window and by simulated window ranges from 13% to 5%. On the basis of the result, the validity of discomfort glare evaluation caused by simulated window is presented.
Synergistic Effects of Leflunomide and Benazepril in Streptozotocin-Induced Diabetic Nephropathy
Jin, Hua,Piao, Shang Guo,Jin, Ji Zhe,Jin, Ying Shun,Cui, Zhen Hua,Jin, Hai Feng,Zheng, Hai Lan,Li, Jin Ji,Jiang, Yu Ji,Yang, Chul Woo,Li, Can S.Karger 2014 The Nephron Journals Vol.126 No.3
<P>Abstract</P><P><B><I>Background:</I></B> Leflunomide (LEF) and benazepril have renoprotective effects on diabetic nephropathy (DN) through their anti-inflammatory and anti-fibrotic activities. This study investigated whether combined treatment using LEF and benazepril affords superior protection compared with the respective monotherapies. <B><I>Methods:</I></B> Diabetes was induced with streptozotocin (STZ, 65 mg/kg) by intraperitoneal injection in male Wistar rats. Two weeks after STZ injection, diabetic rats were treated daily for 12 weeks with LEF (10 mg/kg), benazepril (10 mg/kg), or a combination of both. Basic parameters (body weight, fasting blood glucose level, and 24 h urinary protein excretion), histopathology, inflammatory [inflammatory cell infiltration (ED-1), monocyte chemoattractant protein-1 (MCP-1), and Toll-like receptor-2 (TLR-2)] and glomerulosclerotic factors [transforming growth factor-β<SUB>1</SUB> (TGF-β<SUB>1</SUB>) and connective tissue growth factor (CTGF)], and oxidative stress (8-hydroxy-2'-deoxyguanosine, 8-OHdG) were studied. <B><I>Results:</I></B> Benazepril or LEF treatment significantly prevented body weight loss and 24 h urinary protein excretion induced by diabetes; combined treatment with LEF and benazepril further improved these parameters compared with giving each drug alone (all p < 0.01). Increased expression of inflammatory (MCP-1 and TLR-2) and glomerulosclerotic (TGF-β<SUB>1</SUB> and CTGF) factors in diabetic rat kidney was reduced by treatment with either LEF or benazepril and was further reduced by the combined administration of the two drugs (p < 0.01). These effects were accompanied by suppression of urinary 8-OHdG excretion. There was no significant between-group difference in blood glucose level. <B><I>Conclusions:</I></B> LEF treatment lessens DN, and combined treatment with LEF and benazepril provides synergistic effects in preventing DN.</P><P>© 2014 S. Karger AG, Basel</P>
Jin, Mei Hua,Hong, Chang Hee,Lee, Hye Young,Kang, Hyo Jin,Han, Sang Won Wiley Subscription Services, Inc., A Wiley Company 2010 Environmental toxicology Vol.25 No.1
<P>2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent endocrine disruptor compound and induces multiple organ dysfunctions. The effect of TCDD exposure both in adults and in utero has been well established. However, little is known about the effects of TCDD acquired through mother's milk on the development of the male reproductive system. The aim of this study was to investigate the effects and mechanisms of TCDD from lactational exposure. TCDD (1 μg/kg) was administered to C57BL/6 mouse mothers for 4 days from the day of delivery. On postnatal day 30 (PND 30) and postnatal day 60 (PND 60), body weight, body length, and anogenital distance (AGD) of male offspring were measured. The weights of the testes and epididymides were also measured. Epididymides were used for sperm counts, and testes were used to measure the activity of antioxidant enzymes (SOD, CAT, GPX, GR), the parameters of oxidative stress (hydrogen peroxide, MDA), and testosterone. In addition, expression of p53 and the proapoptotic protein, Bax, were analyzed by Western blot. TCDD exposure decreased body weight, body length, and AGD in both PND 30 and PND 60 groups compared with the control group. The activity of all antioxidant enzymes at PND 60 was decreased after TCDD treatment. TCDD treatment decreased testicular testosterone levels in both the PND 30 and PND 60 groups. The expression of p53 and Bax were also upregulated by TCDD and did not return to normal levels by PND 60. These data suggest that TCDD affects development of male offspring when the mother is exposed to TCDD during lactation. In addition, oxidative stress is a major mediator of TCDD-induced adverse effects, and p53 may play an important role in this mechanism. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2010.</P>
Jin, Cheng Hua,Krishnaiah, Maddeboina,Sreenu, Domalapally,Subrahmanyam, Vura B.,Rao, Kota S.,Lee, Hwa Jeong,Park, So-Jung,Park, Hyun-Ju,Lee, Kiho,Sheen, Yhun Yhong,Kim, Dae-Kee American Chemical Society 2014 Journal of medicinal chemistry Vol.57 No.10
<P>A series of 2-substituted-4-([1,2,4]triazolo[1,5-<I>a</I>]pyridin-6-yl)-5-(6-methylpyridin-2-yl)imidazoles was synthesized and evaluated to optimize a prototype inhibitor of TGF-β type I receptor kinase (ALK5), <B>6</B>. Combination of replacement of a quinoxalin-6-yl moiety of <B>6</B> with a [1,2,4]triazolo[1,5-<I>a</I>]pyridin-6-yl moiety, insertion of a methyleneamino linker, and a <I>o</I>-F substituent in the phenyl ring markedly increased ALK5 inhibitory activity, kinase selectivity, and oral bioavailability. The <B>12b</B> (EW-7197) inhibited ALK5 with IC<SUB>50</SUB> value of 0.013 μM in a kinase assay and with IC<SUB>50</SUB> values of 0.0165 and 0.0121 μM in HaCaT (3TP-luc) stable cells and 4T1 (3TP-luc) stable cells, respectively, in a luciferase assay. Selectivity profiling of <B>12b</B> using a panel of 320 protein kinases revealed that it is a highly selective ALK5/ALK4 inhibitor. Pharmacokinetic study with <B>12b</B>·HCl in rats showed an oral bioavailability of 51% with high systemic exposure (AUC) of 1426 ng × h/mL and maximum plasma concentration (<I>C</I><SUB>max</SUB>) of 1620 ng/mL. Rational optimization of <B>6</B> has led to the identification of a highly potent, selective, and orally bioavailable ALK5 inhibitor <B>12b</B>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2014/jmcmar.2014.57.issue-10/jm500115w/production/images/medium/jm-2014-00115w_0012.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm500115w'>ACS Electronic Supporting Info</A></P>
Jin, Li-Hua,Han, Chang-Soo American Chemical Society 2014 ANALYTICAL CHEMISTRY - Vol.86 No.15
<P>A simple and effective quantum dots (QDs)-based sensing method for copper ion (Cu<SUP>2+</SUP>) in water is developed with improved selectivity and ultrahigh sensitivity in the presence of thiosulfate. For this, hexadecyl trimethylammonium bromide (CTAB) modified CdSe/ZnS QDs is used as a fluorescent probe. In the absence of thiosulfate, mercury and silver ions show strong interference with Cu<SUP>2+</SUP> ions even though the sensitivity can be obtained within a few nanomolar. By using our method, the lowest detected concentration for Cu<SUP>2+</SUP> is 0.15 nM in the presence of thiosulfate in DI water. Also, it is successfully demonstrated for Cu<SUP>2+</SUP> ion detection in practical application (tap water) down to lowest detection limit, 0.14 nM. This method provides a good potential for copper ions detection with simplicity, rapidity, ultrahigh sensitivity, and excellent selectivity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2014/ancham.2014.86.issue-15/ac501515f/production/images/medium/ac-2014-01515f_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac501515f'>ACS Electronic Supporting Info</A></P>
Hua, Serenus,Hu, Chloe Y.,Kim, Bum Jin,Totten, Sarah M.,Oh, Myung Jin,Yun, Nayoung,Nwosu, Charles C.,Yoo, Jong Shin,Lebrilla, Carlito B.,An, Hyun Joo American Chemical Society 2013 Journal of proteome research Vol.12 No.10
<P>Despite recent advances, site-specific profiling of protein glycosylation remains a significant analytical challenge for conventional proteomic methodology. To alleviate the issue, we propose glyco-analytical multispecific proteolysis (Glyco-AMP) as a strategy for glycoproteomic characterization. Glyco-AMP consists of rapid, in-solution digestion of an analyte glycoprotein (or glycoprotein mixture) by a multispecific protease (or protease cocktail). Resulting glycopeptides are chromatographically separated by isomer-specific porous graphitized carbon nano-LC, quantified by high-resolution MS, and structurally elucidated by MS/MS. To demonstrate the consistency and customizability of Glyco-AMP methodology, the glyco-analytical performances of multispecific proteases subtilisin, pronase, and proteinase K were characterized in terms of quantitative accuracy, sensitivity, and digestion kinetics. Glyco-AMP was shown be effective on glycoprotein mixtures as well as glycoproteins with multiple glycosylation sites, providing detailed, quantitative, site- and structure-specific information about protein glycosylation.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2013/jprobs.2013.12.issue-10/pr400442y/production/images/medium/pr-2013-00442y_0010.gif'></P>