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MUTYH Association with Esophageal Adenocarcinoma in a Han Chinese Population
Kong, Feng,Han, Xue-Ying,Luan, Yun,Qi, Tong-Gang,Sun, Chao,Wang, Jue,Hou, Hua-Ying,Jiang, Yu-Hua,Zhao, Jing-Jie,Cheng, Guang-Hui Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Adenocarcinoma of esophagus (AE) is a complex disease, affected by a variety of genetic and environmental factors. Much evidence has shown that the MutY glycosylase homologue (MUTYH) plays a key role in the pathogenesis of many cancers. However, there have been no reports on influence on AE in the Han Chinese population. The objective of this study was to investigate this issue. A gene-based association study was conducted using three single nucleotide polymorphisms(SNPs) reported in previous studies. The three SNPs (rs3219463, rs3219472, rs3219489) were genotyped in 207 unrelated AE patients and 249 healthy controls in a case-control study using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The results revealed that the genotype distribution of rs3219472 differed between the case and control groups (OR=1.66,95%CI=1.11-2.48, P=0.012), indicating that an association may exist between MUTYH and AE. These findings support a signifcant role for MUTYH in AE pathogenesis in the Han Chinese population.
Han Li,Hua Cao,Rong‑pei Yu,Zhen Miao,Ji‑hua Wang,Su‑Ping Qu,Qiang Yuan,Shenchong Li 한국원예학회 2018 Horticulture, Environment, and Biotechnology Vol.59 No.3
Paphiopedilum pacific shamrock is an orchid with high ornamental value. Understanding the mechanisms responsible for leaf color in albino mutants is important for ornamental development and breeding. In this study, we compared the leaf photosynthetic pigment content and transcriptome of albino mutants ppa01 and wild-type P. pacific shamrock. Photosynthetic pigment in mutants was less than 2% of the wild type and chl a/b was 60% less than the wild type. Transcriptome sequencing yielded 6.27 Gb and 5.67 Gb clean data from the mutant and wild-type leaves, respectively. De novo assembly yielded 104,763 unigenes with 15,400 greater than 1 kb in length. In unigene expression analysis, 3170 differentially expressed genes (DEGs) were identified with 2231 (70.38% of total DEGs) down-regulated. Results from GO and KEGG enrichment analysis, KEGG pathway analysis and qPCR suggest that the reduction of chloroplast biosynthesis and division in the mutant was due to low expression levels of ppGLK1 and ppFtsz. Mutants were associated with fewer chloroplasts in leaf cells, abnormal chloroplast structures, impaired chlorophyll biosynthesis, and thus reduced total chlorophyll and carotenoid contents. Furthermore, down-regulated expression of ppNYC1 reduced transformation of chlorophyll b into chlorophyll a, leading to a chl a/b decline. The research will guide future studies of leaf pigment mutations and the breeding of P. pacific shamrock.
A Single-Phase Current-Source Bidirectional Converter for V2G Applications
Han, Hua,Liu, Yonglu,Sun, Yao,Wang, Hui,Su, Mei The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.3
In this paper, a single-phase current-source bidirectional converter topology for V2G applications is proposed. The proposed converter consists of a single-phase current-source rectifier (SCSR) and an auxiliary switching network (ASN). It offers bidirectional power flow between the battery and the grid in the buck or boost mode and expands the output voltage range, so that it can be compatible with different voltage levels. The topology structure and operating principles of the proposed converter are analyzed in detail. An indirect control algorithm is used to realize the charging and discharging of the battery. Finally, the semiconductor losses and system efficiency are analyzed. Simulation and experimental results demonstrate the validity and effectiveness of the proposed topology.
Monoamine Oxidase Inhibitory Components from Cayratia japonica
Han, Xiang-Hua,Hong, Seong-Su,Hwang, Ji-Sang,Lee, Myung-Koo,Hwang, Bang-Yeon,Ro, Jai-Seup 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.1
Seven flavonoids were isolated from the whole plants and fruits of Cayratia japonica through the activity-guided isolation of a methanol extract using a monoamine oxidase (MAO) inhibition assay as a monitor. The chemical structures of the isolates were assigned as $apigenin-7-O-{\beta}-D-glucuronopyranoside$ (1), apigenin (2), luteolin (3), $luteolin-7-O-{\beta}-D-glucopyranoside$ (4), (+)-dihydroquercetin (taxifolin) (5), (+)-dihydrokaempferol (aromadendrin) (6) and quercetin (7). Among the isolated compounds, flavones such as apigenin (2) and luteolin (3), as well as the flavonol, quercetin (7) showed potent inhibitory effects against the MAO activity with $IC_{50}$ values of 6.5, 22.6, and $31.6{\mu}M$, respectively. However, the flavone glycosides, $apigenin-7-O-{\beta}-D-glucuronopyranoside$ (1) and $luteolin-7-O-{\beta}-D-glucopyranoside$ (4), showed mild MAO inhibition ($IC_{50}$ values: 81.7 and $118.6{\mu}M$, respectively). The flavanonol derivatives, taxifolin (5) and aromadendrin (6), also showed weak inhibition ($IC_{50}$ values: 154.7 and $153.1{\mu}M$, respectively). Furthermore, quercetin (7) had a more potent inhibitory effect on MAO-A ($IC_{50}$ value: $2.8{\mu}M$) than MAO-B ($IC_{50}$ value: $90.0{\mu}M$). Apigenin (2) and luteolin (3) also preferentially inhibited MAO-A ($IC_{50}$ values: 1.7 and $4.9{\mu}M$, respectively) compared with MAO-B ($IC_{50}$ values: 12.8 and $59.7{\mu}M$, respectively).
Monoamine Oxidase Inhibitory Constituents from the Fruits of Cudrania tricuspidata
Han Xiang Hua,Hong Seong Su,Hwang Ji Sang,Jeong Seon Hwa,Hwang Ji Hye,Lee Min Hee,Lee Myung Koo,Lee Dongho,Ro Jai Seup,Hwang Bang Yeon The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.12
A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4'-O-methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with $IC_{50}$ values of 19.4, 23.9, and 25.8 $\mu$M, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B ($IC_{50}$ 0.8 $\mu$M) than MAO-A ($IC_{50}$ >800 $\mu$M). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.
Han, Yue-Hua,Liu, Wen-Zhong,Shi, Yao-Zhou,Lu, Li-Qiong,Xiao, Shudong,Zhang, Qing-Hua,Zhao, Guo-Ping The Microbiological Society of Korea 2007 The journal of microbiology Vol.45 No.1
In order to search for specific genotypes related to this unique phenotype, we used whole genomic DNA microarray to characterize the genomic diversity of Helicobacter pylori (H. pylori) strains isolated from clinical patients in China. The open reading frame (ORF) fragments on our microarray were generated by PCR using gene-specific primers. Genomic DNA of H. pylori 26695 and J99 were used as templates. Thirty-four H. pylori isolates were obtained from patients in Shanghai. Results were judged based on In(x) transformed and normalized Cy3/Cy5 ratios. Our microarray included 1882 DNA fragments corresponding to 1636 ORFs of both sequenced H. pylori strains. Cluster analysis, revealed two diverse regions in the H. pylori genome that were not present in other isolates. Among the 1636 genes, 1091 (66.7%) were common to all H. pylori strains, representing the functional core of the genome. Most of the genes found in the H. pylori functional core were responsible for metabolism, cellular processes, transcription and biosynthesis of amino acids, functions that are essential to H. pylori's growth and colonization in its host. In contrast, 522 (31.9%) genes were strain-specific genes that were missing from at least one strain of H. pylori. Strain-specific genes primarily included restriction modification system components, transposase genes, hypothetical proteins and outer membrane proteins. These strain-specific genes may aid the bacteria under specific circumstances during their long-term infection in genetically diverse hosts. Our results suggest 34 H. pylori clinical strains have extensive genomic diversity. Core genes and strain-specific genes both play essential roles in H. pylori propagation and pathogenesis. Our microarray experiment may help select relatively significant genes for further research on the pathogenicity of H. pylori and development of a vaccine for H. pylori.
Han Ying-Hao,Chen Dong-Qin,Jin Mei-Hua,Jin Ying-Hua,Li Jing,Shen Gui-Nan,Li Wei-Long,Gong Yi-Xi,Mao Ying-Ying,Xie Dan-Ping,Lee Dong-Seok,Yu Li-Yun,Kim Sun-Uk,김지수,권태호,Cui Yu-Dong,Sun Hu-Nan 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-α productions. Excitingly, hispidin treatment retains the phagocytosis ability of macrophages which enabling them to perform the function of removing foreign invaders. Signaling studies showed, hispidin treatment dramatic suppressed the LPS induced mitogen activated protein kinases (MAPK) and JAK/STAT activations. In conclusion, our findings suggest that hispidin may be a new therapeutic target for clinical treatment of macrophages-mediated inflammatory responses.
Two New Iridoids from the Stem of <i>Catalpa ovata</i>
Han, Xiang Hua,Lee, Chul,Lee, Jin Woo,Jin, Qinghao,Jang, Hari,Lee, Ha Ju,Lee, Dongho,Lee, Sung‐,Joon,Hong, Jin Tae,Lee, Mi Kyeong,Hwang, Bang Yeon WILEY‐VCH Verlag 2015 Helvetica chimica acta Vol.98 No.3
<P><B>Abstract</B></P><P>Two new iridoids, 6‐<I>O</I>‐[(<I>E</I>)‐feruloyl]jioglutin D (<B>1</B>) and 6‐<I>O</I>‐(4‐hydroxybenzoyl)jioglutin D (<B>2</B>), and six known compounds, minecoside (<B>3</B>), specioside (<B>4</B>), picroside II (<B>5</B>), picroside III (<B>6</B>), 4‐hydroxybenzoic acid (<B>7</B>), and martynoside (<B>8</B>), were isolated from the stem of <I>Catalpa ovata.</I> The structures of the new compounds were established on the basis of spectroscopic techniques, including 1D‐ and 2D‐NMR.</P>
Intradural Transpetrosectomy for Petrous Apex Meningiomas
Han, Shuo,Zhang, Xiao-Hua,Han, Dong-Hua,Jin, Yi-Chao The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.5
Objective : This study aimed to assess the surgical results of the intradural transpetrosectomy for petrous apex meningiomas (PAMs). In addition, we describe the methods and techniques used to expose and manage superior petrous vein and greater superficial petrosal nerve. Methods : The authors conducted a retrospective study of 16 patients with PAMs operated by the senior author via the intradural transpetrosectomy between February 2012 to May 2017. We reviewed patient data regarding the general characteristics, surgical technique and surgery-related outcomes and adopted a combined follow-up strategy of clinic and telephone contacts to evaluate postoperative complications. Results : Simpson grade I and II resection was performed in 10 out of 16 cases (62.5%), and grade III resection were reported in the remaining six cases (37.5%) with no resultant mortality. The mean Karnofsky Performance Status score was 85.6 preoperatively and improved to 91.9 postoperatively, with a mean follow-up period of 34.4 months (range, 6-66 months). Tumor recurrence was found in two patients and they underwent the second surgical operation. Conclusion : PAMs could be completely resected by the intradural transpetrosectomy with an improved survival rate and postoperative life quality. Superior petrous vein and greater superficial petrosal nerve should be managed properly in avoidance of postoperative complications. Finally, most meningioma inside cavernous sinus or adhered to brainstem could be totally removed without postoperative complications.