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Jun Wang,Li Jiang,Sheng Ding,Si-Yi He,Shun-Bi Liu,Zhong-Jie Lu,Yuan-Zhang Liu,Li-Wen Hou,Bin-Su Wang,Jin-Bao Zhang 연세대학교의과대학 2023 Yonsei medical journal Vol.64 No.4
Purpose: We aimed to analyze the optimal timing of enteral nutrition (EN) in the treatment of sepsis and its effect on sepsis-asso ciated acute kidney injury (SA-AKI.)Materials and Methods: The MIMIC-III database was employed to identify patients with sepsis who had received EN. With AKI as the primary outcome variable, receiver operating characteristic (ROC) curves were utilized to calculate the optimal cut-off time of early EN (EEN). Propensity score matching (PSM) was employed to control confounding effects. Logistic regressions and propen sity score-based inverse probability of treatment weighting were utilized to assess the robustness of our findings. Comparisons within the EEN group were performed. Results: 2364 patients were included in our study. With 53 hours after intensive care units (ICU) admission as the cut-off time of EEN according to the ROC curve, 1212 patients were assigned to the EEN group and the other 1152 to the delayed EN group. The risk of SA-AKI was reduced in the EEN group (odds ratio 0.319, 95% confidence interval 0.245–0.413, p<0.001). The EEN patients re ceived fewer volumes (mL) of intravenous fluid (IVF) during their ICU stay (3750 mL vs. 5513.23 mL, p<0.001). The mediating ef fect of IVF was significant (p<0.001 for the average causal mediation effect). No significant differences were found within the EEN group (0–48 hours vs. 48–53 hours), except that patients initiating EN within 48 hours spent fewer days in ICU and hospital. Conclusion: EEN is associated with decreased risk of SA-AKI, and this beneficial effect may be proportionally mediated by IVF volume.
Association of microRNA-3144 variant with the susceptibility to hepatocellular carcinoma
Jun Zhang,Yi Liu,Jie Liu,Rui Wang,Min Cai,Shunji Yu,Yanyun Ma,Weihong Xu,Chunfang Gao,Jiucun Wang,Lifang Hou 한국유전학회 2014 Genes & Genomics Vol.36 No.6
Increasing studies suggest that microRNAs, anew group of small non-coding molecules, regulate theexpression of their target genes and play some roles in cancers. Thus, it is hypothesized that the genetic variants ofmicroRNAs could contribute to the susceptibility to cancers. In this study, the association between rs67106263 in microRNA-3144 and the risk of hepatocellular carcinoma (HCC)was explored in a large-scaled case–control population basedon MassARRAY technology. It was discovered that comparedwith the carriers of wide-type GG genotype and heterozygoteGA genotype of microRNA-3144, thesignificantly increased risk of HCC was observed in thesubjects with the homozygote variant AA (adjusted oddsratio = 1.285, 95 % confidence interval = 1.004–1.643,P = 0.046). Additionally, the variant was also associatedwith the expression of alpha fetoprotein (AFP), which is thediagnostic marker for HCC. Our findings suggest for the firsttime that rs67106263 may play some roles in the risk of HCC,expecting future molecular researches to elucidate the possiblemechanisms behind these results.
A Coumarin-based Fluorescent Sensor for Selective Detection of Copper (II)
Wang, Jian-Hong,Guo, Xin-Ling,Hou, Xu-Feng,Zhao, Hui-Jun,Luo, Zhao-Yang,Zhao, Jin Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.8
Cu (II) detection is of great importance owing to its significant function in various biological processes. In this report, we developed a novel coumarin-based chemosensor bearing the salicylaldimine unit (2) for $Cu^{2+}$ selective detection. The results from fluorescence spectra demonstrated that the sensor could selectively recognize $Cu^{2+}$ over other metal cations and the detection limit is as low as $0.2{\mu}M$. Moreover, the confocal fluorescence imaging in HepG2 cells illustrated its potential for biological applications.
Wang, Feng,Fang, Ping,Hou, Dan-Yang,Leng, Zai-Jun,Cao, Le-Jie Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Background: Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) can predict the clinical response to tyrosine kinase inhibitor (TKI) therapy. However, EGFR mutations may be different in primary tumors (PT) and metastatic lymph nodes (MLN). The aim of this study was to compare EGFR mutations between PT and the corresponding MLN in NSCLC patients, and provide some guidelines for clinical treatment using TKI therapy. Materials and Methods: A systematic review and meta-analysis was performed with several research databases. Relative risk (RR) with the 95% confidence interval (CI) were used to investigate the EGFR mutation status between PT and the corresponding MLN. A random-effects model was used. Results: 9 publications involving 707 patients were included in the analysis. It was found that activation of EGFR mutations identified in PT and the corresponding MLN was 26.4% (187/707) and 19.9% (141/707), respectively. The overall discordance rate in our meta-analysis was 12.2% (86/707). The relative risk (RR) for EGFR mutation in PT relative to MLN was 1.33 (95%CI: 1.10-1.60; random-effects model). There was no significant heterogeneity between the studies ($I^2$=5%, p=0.003). Conclusions: There exists a considerable degree of EGFR mutation discrepancy in NSCLC between PT and corresponding MLN, suggesting that tumor heterogeneity might arise at the molecular level during the process of metastasis.
Wang, Xiao-bo,Gao, Hui-Yuan,Hou, Bai-ling,Huangi, Jian,Xi, Rong-gang,Wu, Li-Jun 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.5
School of Traditional Chinese Medicines, Shenyang Pharmaceutical University , Department of Pharmacy, Department of traditional Chinese MeNanoparticle realqar powders (NRP) inhibited U937 cell growth in a time and dose-dependent manner. U937 cells treated with NRP showed typical characteristics of apoptosis including the morphological changes and DNA fragmentation. Caspase family inhibitor (z-VAD-fmk), caspase-8, -9 inhibitor (z-IETD-fmk, Ac-LEHD-CHO, respectively) and caspase-3 inhibiter (z-DEVD-fmk) partially prevented NRP -induced apoptosis. Moreover, the classical substrates of caspase-3 poly-ADP ribose polymerase (PARP) was degraded after U937 cells treatment with NRP. In audition, NRP Increased the ratio of Bax/Bcl-2 protein expression. Although p38 inhibitor (SB203580) and ERK inhibitor (PD98059) failed to block cell death, JNK inhibitor(SP600125) had marked inhibitory effects on NRP -induced apoptosis. Furthermore, the phosphorylation of JNK was up-regulated, suggesting that JNK was responsible for NRP -induced apoptosis in U937 cells. These results suggested that the caspase, mitochondria and MAPK signal pathways were involved in NRP-induced U937 apoptosis.
Delong Hou,Songhang Wang,Jinming Chang,Zhou Xu,Qi Zeng,Zhonghui Wang,Yongcheng Yang,Jun Yan,Yi Chen 한국섬유공학회 2020 Fibers and polymers Vol.21 No.8
Plasticizers that enable flexible polyvinyl chloride (PVC) are usually combustible, restricting the application ofPVC in fire-prone scenarios. In this context, intrinsically flame-retardant plasticizers displaying dual function continue to bethe focus of intensive research. Despite their efficiency, the majority of these dual-functional plasticizers previously reportedcontain halogen elements, which, once ignited, emanate toxic and potentially carcinogenic substances, along with toxic gasesand smoke, polluting the environment, damaging the biota, and threatening human health. Here, we report a strategy to obtaina halogen-free, intrinsically flame-retardant PVC bio-plasticizer that harnesses the phenolic hydroxyl of naturally occurringcardanol and covalent attachment of an organophosphate moiety. When combined with di-(2-ethylhexyl) phthalate (DOP),the organophosphate-containing cardanol is qualified as a co-plasticizer, while endowing the PVC materials with flameretardancy. Unlike inorganic flame-retardants, the engineered cardanol is compatible with PVC such that the mechanicalproperties of the PVC materials are not compromised. The rationale underlying the present effort may provide guidance fordeveloping sustainable alternatives to halogen-containing plasticizers to address the sustainability challenge now confrontingPVC industry.
Device-to-Device Relay Cooperative Transmission Based on Network Coding
( Jing Wang ),( Mingsheng Ouyang ),( Wei Liang ),( Jun Hou ),( Xiangyang Liu ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.7
Due to the advantages of low transmit power consumption, high spectral efficiency and extended system coverage, Device-to-Device (D2D) communication has drawn explosive attention in wireless communication field. Considering that intra-cell interference caused between cellular signals and D2D signals, in this paper, a network coding-based D2D relay cooperative transmission algorithm is proposed. Under D2D single-hop relay transmission mode, cellular interfering signals can be regarded as useful signals to code with D2D signals at D2D relay node. Using cellular interfering signals and network coded signals, D2D receiver restores the D2D signals to achieve the effect of interference suppression. Theoretical analysis shows that, compared with Amplify-and-forward (AF) mode and Decode-and-forward (DF) mode, the proposed algorithm can dramatically increase the link achievable rate. Furthermore, simulation experiment verifies that by employing the proposed algorithm, the interference signals in D2D communication can be eliminated effectively, and meanwhile the symbol error rate (SER) performance can be improved.
Environmental fatigue correction factor model for domestic nuclear-grade low-alloy steel
Gao, Jun,Liu, Chang,Tan, Jibo,Zhang, Ziyu,Wu, Xinqiang,Han, En-Hou,Shen, Rui,Wang, Bingxi,Ke, Wei Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.8
Low cycle fatigue behaviors of SA508-3 low-alloy steel were investigated in room-temperature air, high-temperature air and in light water reactor (LWR) water environments. The fatigue mean curve and design curve for the low-alloy steel are developed based on the fatigue data in room-temperature and high-temperature air. The environmental fatigue model for low-alloy steel is developed by the environmental fatigue correction factor (F<sub>en</sub>) methodology based on the fatigue data in LWR water environments with the consideration of effects of strain rate, temperature, and dissolved oxygen concentration on the fatigue life.