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조용훈,이정희,Hamisi Tindwa,Hongray Howerelia PATNAIK,성정환,김수곤,Bharat Bhusan Patnaik,오승한,이용석,한연수 한국곤충학회 2016 Entomological Research Vol.46 No.2
Target of rapamycin (TOR) is an evolutionarily conserved serine–threonine kinase that affects various cellular functions including growth, development, ageing, immunity and autophagy. Inhibition in TOR activity stimulates autophagy, a self‐eating process that ensures survival by maintaining metabolic homeostasis and energy retention at both cellular and organismal levels. To understand the interplay between TOR and autophagy during development and immunity, we screened and identified a TOR homologue from the coleopteran insect, Tenebrio molitor (TmTOR). The full‐length cDNA of TmTOR contained an open reading frame (ORF) of 7,197 bp encoding a protein of 2,398 amino acids, and a 5′‐ and 3′‐ untranslated region (UTR) of 156 and 457 bp, respectively. Deduced amino acid sequence of TmTOR shows characteristic Huntington, EF3A, ATM, TOR (HEAT) repeat, focal adhesion kinase targeting (FAT), rapamycin‐binding, phosphatidylinositol 3‐/4‐kinase and FRAP, ATM and TRRAP C‐terminal (FATC) domains known to be conserved among TOR orthologs. TmTOR showed high sequence identity (92%) with Tribolium castaneum TOR (TcTOR) and the two were placed in the same cluster of the phylogenetic tree. TmTOR shows high mRNA expression level in the fat body and integument of T. molitor larvae. Significantly, a reduced expression of TmTOR mRNA during pupation correlated to an increase in the area of autolysosomes. Intriguingly, T. molitor larvae showed an increase in TmTOR transcripts upon a challenge with various bacterial pathogens. This suggests a negative role of TmTOR in the regulation of autophagy during development.
PANM 데이터베이스 업데이트 (Version 5.1) : 연체동물 전사체 서열 분석의 정확도 증진을 위한 오염되어진 곰팡이 유전자 서열 검색기능 추가
송대권,이용석,상민규,박지은,정준양,홍찬의,김용태,신현준,류자미,이혁,Hongray Howerelia PATNAIK,Bharat Bhusan Patnaik,조용훈,박소영,강세원 한국패류학회 2023 The Korean Journal of Malacology Vol.39 No.1
The PANM database (Protostome DB) is a public repository of protein sequences available from the Protostomia group (includes Arthropoda, Mollusca, and Nematoda). The latest version of PANM DB v5.0 (released in 2022) contained 21,276,123 protein sequences that comprised 4% of the total NCBInr protein data. In this study, an update of PANM DB, i.e., version 5.1, is presented that could accurately analyze the large-scale transcriptome data of molluscs for the contaminating fungal gene sequences. This version can filter out the fungal genes, thereby restricting the annotation to molluscs-only sequences. Using the database, we confirmed 1,589,546 amino acid sequences from 32 fungal species, which can be essentially filtered from the unigenes of 20 species of endangered molluscs. In general, the updated version of PANM DB is expected to enhance the accuracy of bioinformatics analyses of invertebrate NGS data, providing a valuable resource for researchers. PANM version 5.1 can be downloaded for free at https://panm.sch.ac.kr/ for local BLAST analysis.