Risk Assessment of Secondary Primary Malignancies in Nasopharyngeal Carcinoma: A Big-Data Intelligence Platform-Based Analysis of 6,377 Long-term Survivors from an Endemic Area Treated with Intensity-Modulated Radiation Therapy during 2003-2013

Lu-Lu Zhang,Guo-Hong Li,Yi-Yang Li,Zhen-Yu Qi,Ai-Hua Lin,Ying Sun 대한암학회 2019 Cancer Research and Treatment Vol.51 No.3

Purpose The incidence, risk factors and survival impact of secondary primary malignancies (SPMs) among survivors of nasopharyngeal carcinoma (NPC) treated with definitive intensity-modulated radiation therapy (IMRT) with or without chemotherapy are poorly characterized. Materials and Methods Consecutive patients (n=6,377) from the big-data intelligence platform at Sun Yat-sen University Cancer Center, China (in a high-incidence area) with newly diagnosed non-metastatic pathologically proven non-keratinizing undifferentiated NPC treated with IMRT±chemotherapy between January 2003 and June 2013 were retrospectively analyzed. Cumulative incidence of SPMs was calculated using the Kaplan-Meier method. Cox proportional hazards model was used to identify potential risk factors for SPMs and assess whether SPMs affect overall survival. Results Of the 6,377 patients, 189 (3.0%) suffered SPMs (median follow-up, 62 months). One-, 2-, 3-, 4-, and 5-cumulative risks of SPMs were 0.4%, 0.9%, 1.6%, 2.2%, and 2.6%, respectively. Latency from start of IMRT to SPMs diagnosis was 37 months (range, 6 to 102 months). In patients with SPMs, 14.3% suffered SPMs within 1 year post-IMRT: 1-3 years, 38.1%; 3-5 years, 33.9%; and > 5 years, 13.7%. Lung cancer was the most common SPM (50/6,377, 0.78%). Multivariate analysis demonstrated sex (male, 64% increase), age (! 50 years, 68% increase), and smoking history (41% increase) were significant risk factors for SPMs, and SPMs were associated with poorer overall survival. Conclusion This large cohort study confirms SPMs a dreadful complication for long-term survivors of NPC treated with IMRT. SPMs negatively impact overall survival in NPC. Close follow-up is recommended for older male survivors with a smoking history.

Colonic Transit Disorder Mediated by Downregulation of Interstitial Cells of Cajal/Anoctamin-1 in Dextran Sodium Sulfate-induced Colitis Mice

Chen Lu,Hongli Lu,Xu Huang,Shaohua Liu,Jingyu Zang,Yujia Li,Jie Chen,Wenxie Xu 대한소화기 기능성질환∙운동학회 2019 Journal of Neurogastroenterology and Motility (JNM Vol.25 No.2

Background/Aims Interstitial cells of Cajal (ICC) and their special calcium-activated chloride channel, anoctamin-1 (ANO1) play pivotal roles in regulating colonic transit. This study is designed to investigate the role of ICC and the ANO1 channel in colonic transit disorder in dextran sodium sulfate (DSS)-treated colitis mice. Methods Colonic transit experiment, colonic migrating motor complexes (CMMCs), smooth muscle spontaneous contractile experiments, intracellular electrical recordings, western blotting analysis, and quantitative polymerase chain reaction were applied in this study. Results The mRNA and protein expressions of c-KIT and ANO1 channels were significantly decreased in the colons of DSS-colitis mice. The colonic artificial fecal-pellet transit experiment in vitro was significantly delayed in DSS-colitis mice. The CMMCs and smooth muscle spontaneous contractions were significantly decreased by 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB), an ANO1 channel blocker, and NG-Nitro-L-arginine methyl ester hydrochloride (L-NAME), an inhibitor of nitric oxide synthase activity, in DSS-colitis mice compared with that of control mice. Intracellular electrical recordings showed that the amplitude of NPPB-induced hyperpolarization was more positive in DSS-colitis mice. The electric field stimulation-elicited nitric-dependent slow inhibitory junctional potentials were also more positive in DSS-colitis mice than those of control mice. Conclusion The results suggest that colonic transit disorder is mediated via downregulation of the nitric oxide/ICC/ANO1 signalling pathway in DSS-colitis mice.

Laser Ablation Synthesis, Structure, and Exchange Bias of Mn4C/MnO Powders

Yao, Lu-Lu,Si, Ping-Zhan,Ge, Hong-Liang,Qian, Hui-Dong,Choi, Chul-Jin Springer-Verlag 2019 Journal of electronic materials Vol.48 No.3

Dynamics of Yeast-like Symbiote and Its Relationship with the Virulence of Brown Planthopper, Nilaparvata lugens Stal, to Resistant Rice Varieties

Lu, Zhong-Xian,Yu, Xiao-Ping,Chen, Jian-Ming,Zheng, Xu-Song,Xu, Hong-Xing,Zhang, Jue-Feng,Chen, Lie-Zhong Korean Society of Applied Entomology 2004 Journal of Asia-Pacific Entomology Vol.7 No.3

Abundance of the yeast-like symbiote (YLS) in brown planthopper (BPH), Nilaparvata lugens Stal, collected from rice fields in China and obtained from International Rice Research Institute (IRRI), was monitored. The role of YLS in nymph survival rate, development and adult reproduction, and activities of transaminases in BPH on different resistant rice varieties were examined. Also, the relationship between YLS and virulence shifts of BPH to resistant rice varieties was discussed. The results indicated that the virulence of BPH populations to resistant rice varieties was strongly related to the abundance of YLS in 5th instar nymphs and brachypterous females of BPH field populations at Nanning in South China and Hangzhou m East China, showing the more abundance of YLS in BPH, the higher virulence of BPH to resistant rice varieties, while no obvious differences in YLS abundance were monitored between three BPH biotypes. Numbers of YLS reduced significantly in female adult of BPH biotype 1 fed on resistant rice varieties IR26, Mudgo and ASD7, compared with that fed on susceptible rice variety TN1. The lowest YLS abundance of BPH from field population was found in 2nd generation successively fed on resistant varieties, and the number of YLS was resumed at 4th generation when the BPH has adapted the resistant varieties. The markedly lower nymphal survival rate, adult fecundity and activities of alanine and aspartic transminase, and significantly longer nymph duration in the three aposymbiotic biotypes than in the symbiotic ones were recorded on both susceptible and resistant rice varieties. However, the much greater differences between aposymbiotic and symbiotic BPH were found on the inadaptable resistant rice varieties than that on the fitness resistant rice varieties. Those results implied that YLS in BPH should playa crucial role in the virulent shift of BPH populations to resistant rice varieties.

The Clinicopathological Significance of Bmi-1 Expression in Pathogenesis and Progression of Gastric Carcinomas

Lu, Hang,Sun, Hong-Zhi,Li, Hua,Cong, Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

Background: Oncogenic Bmi-1 (B-lymphoma Moloney murine leukemia virus insertion region-1) belongs to the Polycomb-group (PcG) family of proteins and plays an important role in the regulation of proliferation, senescence, cell cycle and apoptosis, chromosome stability, activation of gene transcription. Methods: To clarify the roles of Bmi-1 in tumourigenesis and progression of gastric carcinomas, it was examined by immunohistochemistry (IHC) and real-time RT-PCR in gastric carcinomas, dysplasia, intestinal metaplasia (IM), and gastritis with a comparison of its expression with clinicopathological parameters of carcinomas. Results: There was gradually increased Bmi-1 protein expression from gastritis, IM, dyplasia to carcinoma (p<0.001). Bmi-1 expression was positively linked to tumor size, depth of invasion, lymph node metastasis and worse prognosis of carcinomas (p<0.001), but not to age or sex of carcinoma patients (p>0.05). There was higher Bmi-1 protein expression in intestinal-type carcinomas than diffuse-type ones (p<0.001). At mRNA level, Bmi-1 protein expression was increased from gastritis, IM, dysplasia and carcinoma (p<0.001). Bmi-1 overexpression was observed in gastric carcinoma with larger diameter, deeper invasion, lymph node metastasis, and intestinal-type carcinoma (p<0.05). Conclusion: These findings indicate that up-regulated Bmi-1 expression is positively linked to pathogenesis, growth, invasion, metastasis and differentiation of gastric carcinomas. It was considered as a promising marker to indicate the aggressive behaviors and prognosis of gastric carcinomas.

Body water percentage from childhood to old age

( Hong Lu ),( Eric Ayers ),( Pragnesh Patel ),( Tej K. Mattoo ) 대한신장학회 2023 Kidney Research and Clinical Practice Vol.42 No.3

Background: Total body water (TBW) increases with growth, but the body water percentage (TBW%) decreases with aging. The objective of our study was to delineate TBW% in males and females by bioelectrical impedance analysis (BIA) from early childhood to old age. Methods: We enrolled 545 participants aged 3 to 98 years (258 male, 287 female). Among the participants, 256 had a normal weight and 289 were overweight. The TBW was measured by BIA, and TBW% was derived by dividing the TBW (L) value by body weight (kg). For analysis, we divided participants into the four age groups of 3-10, 11-20, 21-60, and ≥61 years. Results: In normal-weight subjects, the TBW% was similar at 62% between males and females in the 3-10-year group. It remained unchanged in males until and through adult life, then decreased to 57% in the ≥61-year group. In normal-weight female subjects, the TBW% decreased to 55% in the 11-20-year group, remained relatively unaltered in the 21-60-year group, then decreased to 50% in the ≥61-year group. In overweight subjects, the TBW% values in males, as well as females, were significantly lower as compared to those with normal weight. Conclusion: Our study showed that the TBW% in normal-weight males changes very little from early childhood to adult life compared to that of females, who showed a decrease in TBW% during the pubertal years. In normal-weight subjects of both sexes, the TBW% decreased after the age of 60 years. Overweight subjects had significantly lower TBW% as compared to those with normal weight.

Expression and Localization of the spermatogenesis-related gene, Znf230, in mouse testis and spermatozoa during postnatal development

( Hong Xia Song ),( Dan Su Pan Lu ),( Ji Yun Yang ),( Wei Zhang ),( Yuan Yang ),( Yun Qiang Liu ),( Si Zhong Zhang ) 생화학분자생물학회 2008 BMB Reports Vol.41 No.9

Photo-multicomponent reactions leading to the construction of isocoumarins and large ring lactone precursors

Lu, Zhi-Feng,Yue, Jia-Jun,Zhu, Ye,Hu, Hong-Wen,Xu, Jian-Hua Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.2

Photoinduced three-component reactions between tetracyanobenzene (TCNB), an alkene and water or a diol (as nucleophile) are initiated by electron transfer from the alkene to $^1TCNB^*$ and proceed via a photo-NOCAS reaction sequence by nucleophilic capture of the alkene cation radical and subsequent radical pair coupling of the resulting radical with TCNB anion radical with concomitant cyanide anion extrusion. These photo MCRs provide simple one pot access to isocoumarins and precursors of larger ring lactones with diversified structural features.

Entrepreneurial Intention of Two Patterns of Planned Behaviour and Alertness: Empirical Evidence in China

Hong Lu,Jiafure Wang 한국유통과학회 2018 The Journal of Asian Finance, Economics and Busine Vol.5 No.2

Researches based on the pattern of planned behavior holds that the three variables of entrepreneurial attitudes, subjective norms, and perceived behavior control influence each other and influence entrepreneurial intentions respectively. However, there are also different, even conflicting research conclusions that continue to emerge. Researches based on the pattern of alertness, believe that profit opportunities and individuals’ pursuit to truth are the driving forces. Many scholars have demonstrated the impact of individual entrepreneurial alertness on entrepreneurial intentions. However, as an exogenous causal agent, profit opportunities have a logical problem: if there are no other assumptions, the mere existence of opportunities does not adequately explain entrepreneurial alertness. To address this gap, this study considered samples from mainland China, where entrepreneurial activities are very active currently, to test the role that entrepreneurial alertness is assumed to play in the planned behavior model. The results show that the three dimensions of alertness, individually partly intermediate the influence of entrepreneurial attitude on entrepreneurial intention, the influence of subjective norms on entrepreneurial intention, and that of perceived behavior control on entrepreneurial intention. This article studied the production of entrepreneurial intention by integrating the two patterns of planned behavior and alertness through empirical analysis, and opened up a new field for subsequent research on entrepreneurial intention.

Poly(ethyleneimine) functionalized organic-inorganic hybrid silica by hydrothermalassisted surface grafting method for removal of nickel(II)

Lu He,Hong-Bo Xu,Bing-Bing Wang,Dan-Dan Liu,Ke-Sen Qian 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.2

Poly(ethyleneimine)-functionalized organic-inorganic hybrid silica adsorbent was synthesized by hydrothermal-assisted surface grafting technique for the removal of Ni(II) ions from aqueous solution, and was characterizedby FT-IR, nitrogen adsorption and the static adsorption-desorption experiment method. The results indicated thatthe maximum static adsorption capacity of Ni(II) on poly(ethyleneimine)-functionalized hybrid silica adsorbent byhydrothermal heating method was 1.6 times as much as the conventional heating method. The poly(ethyleneimine)-functionalized hybrid silica adsorbent offered a fast kinetics for the adsorption of Ni(II), had a substantial binding capacityin the range of pH 4-8 and could be used repeatedly. The Langmuir adsorption model was more favorable thanthe Freundlich and Dubinin-Radushkevich adsorption models. The adsorption followed a pseudo-second-order modelcompared with pseudo-first-order model. Various thermodynamic parameters such as ΔGo, ΔHo and ΔSo indicated thatthe adsorption process was spontaneous and endothermic. The results showed that poly(ethyleneimine)-functionalizedhybrid silica adsorbent could be employed as an effective material for the removal of Ni(II) ions from aqueous solution.