http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jeffrey Yu,Jun Lian,Ruei-Hong Li,Chen-Sin Hung,Dong-Tai Chen,Yu-Kai Chang 대한운동학회 2024 아시아 운동학 학술지 Vol.26 No.1
Objectives In the past centuries, the concept of “physical education” has changed from a more general concepts including physical activities and sports, to specifically inferring “instruction of physical activity”. Instead, “sports” has become the comprehensive concept of sports, exercise, and physical education. Given to the inconsistent terminologies and English translations of “體育 (ti-yu)” (physical education) and “運 動 (yun-dong)” (sports or exercise) in Mandarin, the purpose of this study was to investigate in the current terminology usage, hierarchy, and the English translation of “體育 (ti-yu)” and “運動 (yun-dong)” in Taiwan. Met hods Three government authorities, two sport related universities, eight top sport and exercise journals, and nighty-six college departments in Taiwan were analyzed. Results “運動 (yun-dong)” was the most widely used terminology as “體育 (ti-yu)” occupied the majority usage among government authorities, sport related universities, and title of top sport and exercise journals. Regarding English translation, despite of “department of physical education”, “sports” remained the most common terminology. Moreover, “體育 (ti-yu)” and “sports” are the highest hierarchy among government authorities, and sport related university; “體育 (ti-yu)” and “physical education” are the highest hierarchy among traditional sport and exercise journals; “運動 (yun-dong)” and “sports” are the highest hierarchy among college departments also the mainstream of current translation and hierarchy. Conclusions “體育 (ti-yu)” was the highest hierarchy in the past. However, “運動 (yun-dong)” has been the mainstream of the highest hierarchy in Mandarin according to college departments. In English, “sport(s)” is the main term in Taiwan when translating “體育 (ti-yu)” and 運動 (yun-dong)”, also being the highest hierarchy. On the other hand, “體育 (ti-yu)” and “physical education” are utilized regarding those departments focusing on educating PE teachers. This study expects the terminology, English translations, and hierarchy being align with the mainstream of current translation and hierarchy in the future.
Cimiside E Arrests Cell Cycle and Induces Cell Apoptosis in Gastric Cancer Cells
Lian Yu Guo,Eun Ji Joo,손건호,Su Jin Jeon,Sehyun Jang,신은명,Hong Yu Zhou,Yeong Shik Kim 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10
Cimiside E was isolated from the Cimicifuga heracleifolia Komarov extract, which has been previously demonstrated to possess apoptotic action on gastric cancer cells. The IC50 value of cimiside E on gastric cancer cells for 24 h was 14.58 μM. The mechanism of apoptosis was further elucidated through western blot, RT-PCR, morphology, Annexin V-FITC/PI staining and cell cycle analysis. Cell cycle arrest was induced by cimiside E in S phase at a lower concentration (30 μM) and G2/M phase at higher concentrations (60 and 90 μM). Cimiside E mediated apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways. These findings suggest that cimiside E may be an effective chemopreventive agent against cancer.
Lian Yu Guo,Xing Fu Cai,Jung Joon Lee,강삼식,신은명,Hong Yu Zhou,Ji Won Jung,김영식 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.4
Demethoxycurcumin and bisdemethoxycurcumin are the main active ingredients isolated from Curcumae Longae Radix. Recent studies demonstrated that both compounds exhibit antioxidative and anti-inflammatory effects as well as effects on cancer cell lines. In this study, we compared the activities of demethoxycurcumin and bisdemethoxycurcumin, and both compounds were evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), cycloxygenase-2 (COX-2) and nuclear factor-kappaB (NF-κB) activity in a RAW 264.7 macrophage cell line. The evaluation:results suggested that the anti-inflammatory properties of demethoxycurcumin and bisdemethoxycurcumin were attributed to the inhibition of iNOS and COX-2 expression, as initiated by the inhibition of NF- κB activity. Additionally, both of them significantly inhibited carrageenan-induced paw edema in mice. Taken together, all of the results showed that the suppressive effect of demethoxycurcumin was stronger than that of bisdemethoxycurcumin, indicating that the methoxy group had enhanced demethoxycurcumin’s anti-inflammation effects.
Guo, Lian Yu,Cai, Xing Fu,Lee, Jung-Joon,Kang, Sam-Sik,Shin, Eun-Myoung,Zhou, Hong-Yu,Jung, Ji-Won,Kim, Yeong-Shik 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.4
Demethoxycurcumin and bisdemethoxycurcumin are the main active ingredients isolated from Curcumae Longae Radix. Recent studies demonstrated that both compounds exhibit antioxidative and anti-inflammatory effects as well as effects on cancer cell lines. In this study, we compared the activities of demethoxycurcumin and bisdemethoxycurcumin, and both compounds were evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), cycloxygenase-2 (COX-2) and nuclear factor-kappaB $(NF-{\kappa}B)$ activity in a RAW 264.7 macrophage cell line. The evaluation:results suggested that the anti-inflammatory properties of demethoxycurcumin and bisdemethoxycurcumin were attributed to the inhibition of iNOS and COX-2 expression, as initiated by the inhibition of $NF-{\kappa}B$ activity. Additionally, both of them significantly inhibited carrageenan-induced paw edema in mice. Taken together, all of the results showed that the suppressive effect of demethoxycurcumin was stronger than that of bisdemethoxycurcumin, indicating that the methoxy group had enhanced demethoxycurcumin's anti-inflammation effects.
Guo, Lian Yu,Hung, Tran Manh,Bae, Ki Hwan,Shin, Eun Myoung,Zhou, Hong Yu,Hong, Yoo Na,Kang, Sam Sik,Kim, Hyun Pyo,Kim, Yeong Shik Elsevier 2008 european journal of pharmacology Vol.591 No.1
<P><B>Abstract</B></P><P>Schisandrin is the main active ingredient isolated from the fruit of <I>Schisandra chinensis</I> Baill. Recent studies have demonstrated that schisandrin exhibits anti-oxidative effects <I>in vivo</I>. In the present study, the effect of schisandrin on plasma nitrite concentration in lipopolysaccharide (LPS)-treated mice was evaluated. It also significantly inhibited carrageenan-induced paw edema and acetic acid-induced vascular permeability in mice. Furthermore, schisandrin had a protective effect on lipopolysaccharide (LPS)-induced sepsis. <I>In vitro</I>, our results are the first that show that the anti-inflammatory properties of schisandrin result from the inhibition of nitric oxide (NO) production, prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) release, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, which in turn results from the inhibition of nuclear factor-kappaB (NF-κB), c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) activities in a RAW 264.7 macrophage cell line.</P>
Prediction of Lung Cancer Based on Serum Biomarkers by Gene Expression Programming Methods
Yu, Zhuang,Chen, Xiao-Zheng,Cui, Lian-Hua,Si, Hong-Zong,Lu, Hai-Jiao,Liu, Shi-Hai Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21
In diagnosis of lung cancer, rapid distinction between small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) tumors is very important. Serum markers, including lactate dehydrogenase (LDH), C-reactive protein (CRP), carcino-embryonic antigen (CEA), neurone specific enolase (NSE) and Cyfra21-1, are reported to reflect lung cancer characteristics. In this study classification of lung tumors was made based on biomarkers (measured in 120 NSCLC and 60 SCLC patients) by setting up optimal biomarker joint models with a powerful computerized tool - gene expression programming (GEP). GEP is a learning algorithm that combines the advantages of genetic programming (GP) and genetic algorithms (GA). It specifically focuses on relationships between variables in sets of data and then builds models to explain these relationships, and has been successfully used in formula finding and function mining. As a basis for defining a GEP environment for SCLC and NSCLC prediction, three explicit predictive models were constructed. CEA and NSE are requentlyused lung cancer markers in clinical trials, CRP, LDH and Cyfra21-1 have significant meaning in lung cancer, basis on CEA and NSE we set up three GEP models-GEP 1(CEA, NSE, Cyfra21-1), GEP2 (CEA, NSE, LDH), GEP3 (CEA, NSE, CRP). The best classification result of GEP gained when CEA, NSE and Cyfra21-1 were combined: 128 of 135 subjects in the training set and 40 of 45 subjects in the test set were classified correctly, the accuracy rate is 94.8% in training set; on collection of samples for testing, the accuracy rate is 88.9%. With GEP2, the accuracy was significantly decreased by 1.5% and 6.6% in training set and test set, in GEP3 was 0.82% and 4.45% respectively. Serum Cyfra21-1 is a useful and sensitive serum biomarker in discriminating between NSCLC and SCLC. GEP modeling is a promising and excellent tool in diagnosis of lung cancer.
Lian, Ji-Hu,Wang, Wei-Hua,Wang, Jia-Qiang,Zhang, Yu-Hong,Li, Yi Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9
Objective: MicroRNAs (miRNAs) are a small class of non-coding, single-stranded RNAs with a critical role in genesis and maintenance of renal cancer mainly through binding to 3'-untranslated regions (3'UTR) of target mRNAs, which causes a block of translation and/or mRNA degradation. The aim of the present study was to investigate the potential effects of miR-122 in human renal cell carcinomas. Methods: The expression level of miR-122 was quantified by qRT-PCR. MTT, colony formation, invasion and migration assays were used to explore the potential functions of miR-122 in human renal cell carcinoma cells. Results: Cellular growth, invasion and migration in two A498 and 786-O cells were significantly increased after miR-122 transfection. Further experiments demonstrated that overexpression of miR-122 resulted in the increase of phospho-Akt (Ser473) and phospho-mTOR (Ser2448), then activation of mTOR targets, p70S6K and 4E-BP1. Conclusions: The up-regulation of miR-122 may play an important role in the progress of renal cancer through activating PI3K/Akt signal pathway and could be a potential molecular target for anti-cancer therapeutics.