퇴폐흡충증 1에

박삼규,홍순표 조선의대 1984 The Medical Journal of Chosun University Vol.9 No.1

치수 치근단 병소의 전구 위험요인으로서의 제 2 형 당뇨의 역할에 관한 소고

김진희,배광식,서덕규,홍성태,이윤,홍삼표,금기연 大韓齒科保存學會 2009 Restorative Dentistry & Endodontics Vol.34 No.3

Diabetes Mellitus (DM) is a syndrome accompanied with the abnormal secretion or function of insulin, a hormone that plays a vital role in controlling the blood glucose level (BGL). Type 1 and 2 DM are most common form and the prevalence of the latter is recently increasing. The aim of this article was to assess whet her Type 2 DM could act as a predisposing risk factor on the pulpo-periapical pathogenesis. Previous literature on the pathologic changes of blood vessels in DM was thoroughly reviewed. Furthermore, a histopathologic analysis of artificially-induced periapical specimens obtained from Type 2 diabetic and DM-resistant rats was compared. Histopathologic results demonstrate that the size of periapical bone destruction was larger and the degree of pulpal inflammation was more severe in diabetic rats, indicating that Type 2 DM itself can be a predisposing risk factor that makes the host more susceptible to pulpal infection. The possible reasons may be that in diabetic state the lumen of pulpal blood vessels are thickened by atheromatous deposits, and microcirculation is hindered. The function of polymorphonuclear leukocyte is also impaired and the migration of immune cells is blocked. leading to increased chance of pulpal infection. Also, lack of collateral circulation of pulpal blood vessels makes the pulp more susceptible to infection. These decrease the regeneration capacity of pulpal cells or tissues, delaying the healing process. Therefore, when restorative treatment is needed in Type 2 DM patients, dentists should minimize irritation to the pulpal tissue under control of BGL. 당뇨(Diabetes Mellitus)란 혈당을 조절하는 인슐린의 분비나 기능에 장애를 야기하는 질환으로 인슐린 의존성 여부에 따라 제 1 형과 제 2 형으로 분류된다. 본 종설은 최근 증가 추세에 있는 제 2 형 당뇨가 치수 치근단 병소의 병인 과정에 전구 위험 요인으로 작용할 수 있는지를 평가 하고자 문헌고찰을 통해 당뇨의 병인 과정에서 특징적으로 나타나는 혈관 합병증에 관해 알아보고, 부가적으로 제 2 형 당뇨 쥐 모델에서 인위적인 치수감염 후 얻은 치근단 조직의 조직병리학적 분석을 시행하였다. 조직학적 관찰 결과 제 2 형 당뇨 쥐에서 대조군에 비해 치수 치근단 병소의 크기가 증가하였고, 치수 염증 반응도 심하게 나타난 것으로 보아 당뇨 자체가 숙주를 감염에 취약한 상태로 만드는 전구 위험요소로 작용하였음을 알 수 있었다. 이러한 이유로는 첫째, 당뇨 시 전반적으로 나타나는 혈관 내 죽상 침착(atheromatous deposits)에 의해 혈관 내벽의 두께가 두꺼워져 미세 순환의 장애는 물론 탐식 세포의 기능 저하, 면역 세포의 혈류 이동이 차단되어 치수 감염 시 쉽게 치근단 병소로 이환될 가능성이 높고, 둘째 치수 혈관에서 특징인 측부 순환(collateral circulation)의 부재에 따른 살균성 다형핵 백혈구의 활동 억제를 포함한 미세 혈관계의 취약성으로 인해 치수 조직의 재생능이 저하되어 추가적인 감염원의 공격에 대한 방어 및 치유 저하를 더욱 심화시키기 때문인 것으로 사료된다. 따라서 제 2 형 당뇨 환자의 수복치료 시 치과의사는 당뇨 조절 하에서 치수 조직의 자극을 최소화하기 위한 세심한 처치가 필요하다.

후천성 면역 결핍증 환자의 혀에 발생한 거대세포바이러스(CMV : cytomegalovirus) 감염

송노헌,이종호,정필훈,김명진,김수경,남일우,김종원,백세미,홍삼표 大韓顎顔面成形再建外科學會 1998 Maxillofacial Plastic Reconstructive Surgery Vol.20 No.1

Mast cells in nonneoplastic lesions of the surrounding tissue of teeth

Sam Pyo Hong 대한구강악안면병리학회 1981 대한구강악안면병리학회지 Vol.4 No.1

혼합모드 단일과대하중 하의 피로균열 전파거동에 관한 실험적 연구

송삼홍(Sam-Hong Song),이정무(Jeong-Moo Lee),홍석표(Suck-Pyo Hong) 대한기계학회 2003 대한기계학회 춘추학술대회 Vol.2003 No.4

In this study, retardation behavior of fatigue crack under single overloading of the mixed mode I+II state<br/> was experimentally investigated. To produce single overload in the mixed mode I+II state, the compact<br/> tension shear (CTS) specimen and loading device were used. The propagation tests for fatigue crack were<br/> performed under mode I loading overloading afterwards. We examined the observed deformation aspects,<br/> variation of fatigue life and crack propagation rate, and the aspects of retardation behavior from tests. The<br/> retardation effect of mixed-mode single overload on fatigue crack propagation behavior was smaller than that<br/> of mode I single overload. It has been confirmed that the retardation behavior did not immediately appear and<br/> the retardation length was short when the component of mixed-mode overload was changed.

도로포장 품질관리에 적합한 NoSQL 기반의 IoT 빅데이터 고속 수집 및 분석 시스템

홍성삼(Hong, Sung Sam),김동욱(Kim, Dong Wook),홍성표(Hong, Sung Pyo),김병곤(Kim, Byung Kon),이재강(Lee, Jae Kang) 대한공간정보학회 2020 대한공간정보학회지 Vol.28 No.4

토목 및 건설 현장관리는 사전 설계된 계획에 따라 진행하는 것이 일반적이다. 그러나 현실적으로 잦은 공기지연, 허위 문서처리, 부실공사 등의 문제가 존재하며 이를 모니터링하고, 실시간으로 파악하기에는 ICT 인프라가 부족한 것이 현실이다. 주로 종이로된 문서와 인력간의 소통(전화, 무전, 메신저)로 관리를 하고 있어 관리자 역량에 의존적이며, 비효율적인 인력 및 공정관리가 이루어지고 있다. 본 논문에서는 도로포장 건설현장에 IoT 위치기반 스마트 플랫폼을 적용하기 위해 빅데이터/클라우드 기반의 고속화된 데이터 수집 및 분석 시스템을 제안하였다. IoT 기반 시스템에서 사용하는 RDBMS 기반의 인프라를 분산/병렬 처리기반의 빅데이터 플랫폼으로 설계하여 고속화된 데이터 수집 및 분석이 가능하게 한다. NoSQL기반 데이터 베이스를 적용하여 실시간 고속 수집과 분석이 가능하도록 구조를 설계하고, 도로포장 건설 환경에 맞는 데이터 분석 기술을 적용하여 실시간 모니터링이 가능한 빅데이터 시스템을 연구하였다. 제안하는 시스템은 기존의 GIS기반 건설관리시스템의 속도문제를 개선하여 실시간으로 분석결과를 도출할 수 있도록 수집과 분석 속도 성능을 개선하였다. 실험결과 NoSQL 기반 시스템의 데이터 수집 처리 속도가 0.405ms로 기존 시스템의 21.146ms에 비해 상당히 높은 성능을 나타내었다. 제안하는 시스템은 실시간 도로포장 품질관리 모니터링에 적합한 시스템임을 증명할 수 있었다. Civil and construction site management is generally conducted according to a pre-designed plan. However, in reality, there are problems such as frequent delays, processing of false documents, and insolvent construction, and the reality is that ICT infrastructure is insufficient to monitor and understand them in real time. It is mainly managed by paper documents and communication between manpower (telephone, radio, messenger), which is dependent on the manager"s competence, and inefficient manpower and process management are being implemented. In this paper, we proposed a high-speed data collection and analysis system based on big data/cloud to apply IoT location-based smart platform to road pavement construction sites. The RDBMS-based infrastructure used in the IoT-based system is designed as a distributed/parallel processing-based big data platform to enable high-speed data collection and analysis. The structure was designed to enable real-time high-speed collection and analysis by applying a NoSQL-based database, and a big data system capable of real-time monitoring was studied by applying data analysis technology suitable for the road pavement construction environment. The proposed system improves the performance of collection and analysis speed so that analysis results can be derived in real time by improving the speed problem of the existing GIS-based construction management system. As a result of the experiment, the data collection processing speed of the NoSQL-based system was 0.405ms, which was significantly higher than the 21.146ms of the existing system. The proposed system could prove to be a system suitable for real-time road pavement quality control monitoring.

p-AKT Regulates Translocalization of Snail in Oral Cancer

Kyoung Ok Hong,Ji Soo Hong,Jae ll Lee,Sam Pyo Hong,Seong Doo Hong 대한구강악안면병리학회 2007 대한구강악안면병리학회지 Vol.31 No.2

Epithelial-mesenchymal transition(EMT) plays a pivotal role in the convers ion of earl y s tage tumors into invasive malignancies‘ and has been shown to be regulated hy the transcri ptional factor. Snail. Recent ly‘ actlvatlon of the phosphatidylinositol 3' kinase (PI3K)/따<:T axis is emerging as a centra l feature of EMT‘ However. it is unclear whether the phosphorylation of AKT regulate the expl'ession of s nail in ora l cancer cell underwent EMT. T。 investigate a role of p-AKT in EMT, we assessed the effects of inhibi ting p-AK1' activity in oral squamous can cer cells(KOSCC-25B) using PIAs, structurally modified phosphatidyli nositol ether lipid analogues(P1As) . PIAs de creased phosphorylation of c-Jun N-terrninal Kinase(JNK) and increased phosphorylation of glycogen synthase kinase 3beta(GSK-3beta). Inhibition of p-AKT ir빼ce d down regulation of Snail and Twist. but Sip1 regulated independent of p-AKT inhibition. Also inhibi tion of p-AKT dec reased cell migration and invas ion. Therefore our results implicate that p-AKT may contribute to the translocalization of sna il in the EMT associated with canceJ cell rnigration and invasion

균열발생단계와 균열전파단계에서의 모드 Ⅱ 의 영향

홍석표(Seok-Pyo Hong),송삼홍(Sam-Hong Song) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.6

To evaluate the effect of mode Ⅱ in the crack initiation step and crack propagation step, the effect of mode Ⅱ at the region of fatigue crack threshold under mixed-mode Ⅰ+Ⅱ loading state was experimentally investigated. Ⅰn the crack initiation step, in the case of mixed-mode Ⅰ+Ⅱ, as the loading application angle(Φ) is larger, the crack occurred in the lower load by effect of mode Ⅱ and the crack propagation rate increased too. The effect of mode Ⅱ by variation of multilevel loading direction was experimentally investigated in the crack propagation step. After mixed-mode Ⅰ+Ⅱ (0°<Φ≤60°), as the loading application angle(Φ) was growing larger, the fatigue crack propagation rate decreased and the fatigue crack propagation rate which occurred later also decreased. After mixed-mode Ⅰ+Ⅱ in case of(Φ≥75°), the fatigue crack propagation rate was found to be increasing and the fatigue life was found to be decreasing.

Poster Session : Cancer Biology ; Effects on proliferation, migration and invasion of CXCR-4 down-regulation in oral cancer cells

( Ji Soo Hong ),( KYoung Ok Hong ),( Jae Il Lee ),( Sam Pyo Hong ),( Seong Doo Hong ) 생화학분자생물학회 2007 생화학분자생물학회 춘계학술발표논문집 Vol.2007 No.-

Poster Session : Cancer Biology ; Downregulation of epithelial-mesenchymal transition-related Snail1 and Twist, not sip1 in oral squamous cell carcinoma cells by inhibition of Akt activity

( Kyoung Ok Hong ),( Ji Soo Hong ),( Jae Il Lee ),( Sam Pyo Hong ),( Seong Doo Hong ) 생화학분자생물학회 2007 생화학분자생물학회 춘계학술발표논문집 Vol.2007 No.-