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Paulo Rodrigues,Flavio O. Hering,Alex Meller 대한암학회 2011 Cancer Research and Treatment Vol.43 No.4
Purpose High-risk prostate cancer patients undergoing treatment often experience biochemical recurrence. The use of bisphosphonates as an adjuvant treatment delays skeletal events, yet whether or not bisphosphonates also delay metastastic development remains to be determined. Materials and Methods A total of 140 high-risk prostate cancer patients who were undergoing definitive treatment and who had clinically organ-confined disease and who suffered from biochemical recurrence were administered intravenous (IV) clodronate. The patients were treated with a radical retropubic prostatectomy (RP) or curative radiotherapy (RTx). Upon androgen deprivation therapy initiation,tri-monthly IV clodronate was added to the treatment to prevent bone demineralization. Twentysix out of 60 operated cases and 45 out of 80 irradiated cases received bisphosphonate. The length of time until the first bone metastasis was recorded and analyzed. Results No statistical difference was found for the type of primary treatment (RP or RTx) on the time to the first bone metastasis (95% confidence interval [CI], 0.40 to 2.43; p=0.98). However, there was a clear advantage favoring the group that received bisphosphonate (p<0.001). The addition of bisphosphonate delayed the appearance of the first bone metastasis by seven-fold (95% CI, 3.1to 15.4; p<0.001). Conclusion Treatment with tri-monthly IV clodronate delayed the time to the first bone metastasis in high-risk prostate cancer patients who were experiencing an increase in the prostate specific antigen level after definitive treatment.
Production and Subsequent Forming of Chip-Based Aluminium Sheets Without Remelting
André Schulze,Oliver Hering,A. Erman Tekkaya 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.4
Bent components and deep drawn cups are produced by direct usage of aluminium chips without melting following a new process chain: hot extrusion of aluminium chips to a cylindrical open profile, flattening, subsequent rolling and bending or deep drawing. The properties of the hot extruded chip-based AA6060 sheets are examined by tensile tests and microstructural investigations and the results are compared with those obtained from material extruded from conventional cast billets. The chip-based sheets were used to form components by bending or deep drawing. No significant differences between the bent components or deep-drawn cups made of chips and those from cast material are observed regarding their capability for further plastic forming operations. This makes the new process route a resource-efficient alternative for the production of aluminium sheet products.
Development of Standard Digital Images for Pneumoconiosis
이원정,최병순,김성진,박충기,박재성,태석,Kurt Georg Hering 대한의학회 2011 Journal of Korean medical science Vol.26 No.11
We developed the standard digital images (SDIs) to be used in the classification and recognition of pneumoconiosis. From July 3, 2006 through August 31, 2007, 531 retired male workers exposed to inorganic dust were examined by digital (DR) and analog radiography (AR) on the same day, after being approved by our institutional review board and obtaining informed consent from all participants. All images were twice classified according to the International Labour Office (ILO) 2000 guidelines with reference to ILO standard analog radiographs (SARs) by four chest radiologists. After consensus reading on 349 digital images matched with the first selected analog images, 120 digital images were selected as the SDIs that considered the distribution of pneumoconiosis findings. Images with profusion category 0/1, 1, 2, and 3 were 12, 50, 40, and 15, respectively, and a large opacity were in 43 images (A = 20, B = 22, C = 1). Among pleural abnormality,costophrenic angle obliteration, pleural plaque and thickening were in 11 (9.2%), 31(25.8%), and 9 (7.5%) images, respectively. Twenty-one of 29 symbols were present except cp, ef, ho, id, me, pa, ra, and rp. A set of 120 SDIs had more various pneumoconiosis findings than ILO SARs that were developed from adequate methods. It can be used as digital reference images for the recognition and classification of pneumoconiosis.
Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of &bgr;-Cell Replacement
Markmann, James F.,Bartlett, Stephen T.,Johnson, Paul,Korsgren, Olle,Hering, Bernhard J.,Scharp, David,Kay, Thomas W. H.,Bromberg, Jonathan,Odorico, Jon S.,Weir, Gordon C.,Bridges, Nancy,Kandaswamy, R Williams & Wilkins Co 2016 Transplantation Vol.100 No.7
SUMMARY: The International Pancreas and Islet Transplant Association (IPITA), in conjunction with the Transplantation Society (TTS), convened a workshop to consider the future of pancreas and islet transplantation in the context of potential competing technologies that are under development, including the artificial pancreas, transplantation tolerance, xenotransplantation, encapsulation, stem cell derived beta cells, beta cell proliferation, and endogenous regeneration. Separate workgroups for each topic and then the collective group reviewed the state of the art, hurdles to application, and proposed research agenda for each therapy that would allow widespread application. Herein we present the executive summary of this workshop that focuses on obstacles to application and the research agenda to overcome them; the full length article with detailed background for each topic is published as an online supplement to Transplantation.
Report from IPITA-TTS Opinion Leaders Meeting on the Future of &bgr;-Cell Replacement
Bartlett, Stephen T.,Markmann, James F.,Johnson, Paul,Korsgren, Olle,Hering, Bernhard J.,Scharp, David,Kay, Thomas W. H.,Bromberg, Jonathan,Odorico, Jon S.,Weir, Gordon C.,Bridges, Nancy,Kandaswamy, R Wolters Kluwer Health, Inc. All rights reserved. 2016 Transplantation Vol.100 No.2
Ihm, Sung-Hee,Matsumoto, Ippei,Zhang, Hui J.,Ansite, Jeffrey D.,Hering, Bernhard J. Wiley (Blackwell Publishing) 2009 Transplant international Vol.22 No.2
<P>The Edmonton protocol for islet transplantation utilizes fresh islet grafts but other protocols increasingly transplant short-term cultured grafts mainly for practical reasons. To improve our understanding of the impact of culture pretreatment of human islets, we assessed post-transplant function by nude mouse bioassay, islet ATP, activity of stress-activated MAP kinases, and expression of stress-related genes by focused cDNA array in freshly isolated and cultured islets. Mean blood glucose levels over 4 weeks after transplantation (2000 IE) of (i) freshly isolated, (ii) cultured and preculture counted (recovery rate; 78 +/- 6%), and (iii) cultured and postculture counted islets in diabetic mice were 330 +/- 40, 277 +/- 65, and 256 +/- 52 mg/dl (i versus ii, P = 0.004; i versus iii, P = 0.002). During culture, islet ATP/DNA and ATP/ADP increased; JNK and p38 MAPK activities decreased. Among 96 genes studied, mRNA expression of heat shock protein 70 genes decreased >twofold during culture in all four pairs; expression of cyclooxygenase-2, superoxide dismutase-2, interleukin-6 and cytochromes P450 1A1 genes increased. Our results show that culturing human islets before transplantation is not disadvantageous in regard of functional recovery from changes induced by nonphysiologic stimuli during islet isolation. The increase in expression of several stress-related genes during culture also shows that improving culture conditions may further enhance post-transplant islet function.</P>