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- 저자 : Hao Yu (검색결과 506 건)
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Shih-Hao Yu,Fu-Der Mai,Wei-Yu Kao,Hui-Yen Tsai,Yu-Chuan Liu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.127 No.-
Water is the most common solvent in our daily lives. This solvent has advantages of green environmentalprotection and low cost. Water is conventionally considered to be an inert solvent, yet it is relatively polarand can form a large number of hydrogen bonds (HBs). But this property also inhibits the dissolution ofmany non-polar gases, causing many important electrocatalytic reactions performed in it to have lowefficiencies. In this work, we propose an innovative application of solar energy-generated active purewater (APW) with reduced HBs to enhance chemical reactions and physical procedures. Compared toconventional deionized water (DIW), the generated APW possessed a lower specific heat of ca. 0.96. The swelling degree of artificial skin in APW significantly increased by ca. 29%. Moreover, the densityof an ethanol/APW solution significantly increased by 0.21% due to more free water molecules beingavailable in APW to form stronger HBs with ethanol. Encouragingly, efficiencies of hydrogen evolutionreactions performed in an APW-based acidic solution and oxygen evolution reactions performed in anAPW-based basic solution significantly increased by 42% and 17%, respectively, compared to DIWbasedsolutions. The developed APW based on utilizing solar energy can create a more-effective greenprocess.
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Han Ying-Hao,Mao Ying-Ying,Yu Nan-Nan,Jin Mei-Hua,Jin Ying-Hua,Wang Ai-Guo,Zhang Yong-Qing,Shen Gui-Nan,Cui Yu-Dong,Yu Li-Yun,Lee Dong-Seok,Jo Yu-Jin,Sun Hu-Nan,Kwon Jeongwoo,권태호 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
In this study, we used RNA sequencing (RNA-seq) to analyze and compare bulk cell samples from wild-type (WT) dermal mesenchymal stem cells (DMSCs) (n = 3) and Prx II knockout DMSCs (n = 3). The purpose of the study was to elucidate the role of Prx II on allogeneic immune rejection of transplanted DMSCs. The results revealed differential expression of 472 genes (176 up-regulated and 296 down-regulated; p ≤ 0.05) between the PrxII+/+ (WT) and PrxII−/− sample groups. When highly regulated genes were categorized according to the Gene Ontology (GO) molecular function classification and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the PrxII−/− samples showed a robust downward trend in allograft rejection. The study identified 43 all immunologically rejected differentially expressed genes, of which 41 showed lower expression in the PrxII−/− vs. PrxII+/+ (WT) samples. These findings suggest that Prx II gene knockout may down-regulate the allograft rejection that occurs during DMSCs transplantation and improve the survival rate of DMSCs in the host. This study provides a new perspective on the clinical treatment of stem cell transplantation.
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Hao Tang,Nian-Guang Li,Zhi-Hao Shi,Yu-Ping Tang,Qian-Ping Shi,Ze-Xi Dong,Peng-Xuan Zhang,Jin-ao Duan 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10
The binding abilities of scutellarin (Scu) andscutellarein (Scue) with bovine serum albumin (BSA) wereinvestigated using equilibrium dialysis, high performanceliquid chromatography, fluorescence spectroscopy, competitivesite marker and molecular docking. The resultsshowed that the average protein binding ratios of Scu andScue with BSA were (79.85 ± 1.83) and (85.49 ± 1.21) %respectively. Under simulated physiological conditions, thefluorescence data indicated that Scu and Scue bound withBSA through a static mechanism. The thermodynamicparameters indicated that the interactions of Scu-BSA andScue-BSA mainly occurred by van der Waals forces andhydrogen bonds and it was easier for Scue to bind withBSA than Scu, indicating that the glucuronic acid moleculein Scu decreased the binding affinity. Site competitivemarker experiments showed that the binding sites of Scuand Scue mainly located within the sub-domain IIA ofBSA. Furthermore, molecular docking studies indicatedthat one BSA could bind three Scue, while one BSA couldcarry only two Scu. All these results clearly indicated theinteractions of Scu and Scue with BSA, which will lay thefoundation for further research to determine the pharmacologyand pharmacodynamics of Scu and Scue for treatingischemic cerebrovascular disease.
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Hao, Yu-Xia,Wang, Jun-Ping,Zhao, Long-Feng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Aim: Associations between polymorphisms in miR-146aG>C, miR-196a2C>T and miR-499A>G and risk of HCC, and interaction with HBV infection in a Chinese population, were the target of the present research. Methods: The duplex polymerase-chain-reaction with confronting-two-pair primers (PCR-RFLP) was performed to determine the genotypes of the miR-146aG>C, miR-196a2C>T and miR-499A>G genotypes. Associations of polymorphisms with the risk of HCC were estimated by conditional logistic regression analysis. Results: Drinking, family history of cancer, HBsAg and HCV were risk factors for HCC. Multivariate regression analyses showed that subjects carrying the miR-196a2 CC genotype had significantly increased risk of HCC, with an adjusted OR (95% CI) of 2.18 (1.23-3.80). In addition, cases carrying the miR-196a2 C allele had a 1.64-fold increase in the risk for HCC (95%CI=1.03-2.49). The miR-196a2 CT and TT genotypes greatly significantly increased the risk of HCC in subjects with HBV infection, with adjusted ORs (95% CI) of 2.02 (1.12-3.68) and 2.69 (1.28-5.71), respectively. Conclusion: Our results demonstrate that miR-196a2 CC genotype and C allele have an important role in HCC risk in Chinese, especially in patients with HBV infection.
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Hao Yu 위기관리 이론과 실천 2015 Journal of Safety and Crisis Management Vol.5 No.2
Emergency assessment is an important field of the current emergency management research. Foreign related research started earlier and progress rapidly, has a wealth of practical experience, the domestic research is in the stage of exploration. This paper will be introduced to the Meta - analysis method for evaluation of emergency management research, from the perspective of the overall comprehensive analysis of emergency management evaluation and the research itself, the emergency management at home and abroad in the evaluation of excavated in a large number of research literature in the field of general trends and characteristics, by summing up experience and the existing research results, the theoretical research and practice of emergency management evaluation by weak links that exist in the analysis, in order to find the deficiencies in the study of emergency management assessment, for the future development strategy and establish and improve the basis for policy.
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Evaluation of Emergency Management Capability in Chinese College Based on CMM Model
Hao Yu 위기관리 이론과 실천 2015 Journal of Safety and Crisis Management Vol.5 No.2
Emergencies occur in colleges from time to time in recent years, which disturbs teaching and campus life seriously and causes pressure to students and teachers’ mind and hurt of their life. With emergencies happening frequently, it is the need of social development and also the need of maintaining the development and stability of higher education to constantly improve emergency management capability and to prevent and deal with the emergencies scientifically and efficiently. Emergency management capability decides the response level of a university when they emergencies happen. The improvement of the capacity is a process step by step with many stages for different stage requires different capability. This paper constructs the maturity model and evaluation index system of emergency management capability according to CMM and examines it with real data of a university in Henan Province. Result shows that the level of emergency management capability of the university is initial. Correspond with the university’s situation, the result is accurate and reliable and is able to provide reference for finding questions in the process of emergency management, reducing the risk of emergency and improving emergency management capability.
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Yu, Min,Men, Hai-Tao,Niu, Zhi-Min,Zhu, Yu-Xi,Tan, Ben-Xu,Li, Long-Hao,Jiang, Juan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
Background: The aim of this study was to analyze the prognostic implications of pretreatment circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPCs) for the survival of patients with lung cancer. Materials and Methods: Relevant literature was identified using Medline and EMBASE. Patient clinical characteristics, overall survival (OS) and progression-free survival (PFS) together with CEC and CEPC positive rates before treatment were extracted. STATA 12.0 was used for our analysis and assessment of publication bias. Results: A total of 13 articles (8 for CEC and 5 for CEPC, n=595 and n=244) were pooled for the global meta-analysis. The odds ratio (OR) for OS predicted by pretreatment CECs was 1.641 [0.967, 2.786], while the OR for PFS was 1.168 [0.649, 2.100]. The OR for OS predicted by pretreatment CEPCs was 12.673 [5.274, 30.450], while the OR for PFS was 4.930 [0.931, 26.096]. Subgroup analyses were conducted according to clinical staging. Odds ratio (OR) showed the high level of pretreatment CECs only correlated with the OS of patients with advanced lung cancer (stage III-IV). Conclusions: High counts of CECs seem to be associated only with worse 1-year OS in patients with lung cancer, while high level of pretreatment CEPCs correlate with both worse PFS and OS.
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Analysis of Dangerous Chemical Accident Cause Based on Apriori Algorithm
Hao Yu 위기관리 이론과 실천 2016 Journal of Safety and Crisis Management Vol.6 No.1
In order to identify the association between causes of accidents due to hazardous chemicals, clear and definite the key points of safety supervision, and improve the efficiency of security supervision, this study researches 150 accident investigation report as data source by data mining technology, A priori algorithm, and finds out the relationship between factors such as time, step, type, severity and cause. By analyzing the 8 valuable rules, it proposes 4 suggestions for improving key safety supervision, thus to promote the optimization of safety supervision strategy of hazardous chemicals.
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Initial Factors Influencing Duration of Hospital Stay in Adult Patients With Peritonsillar Abscess
Yu-Hsi Liu,Hsing-Hao Su,Yi-Wen Tsai,Yu-Yi Hou,Kuo-Ping Chang,Chao-Chuan Chi,Ming-Yee Lin,Pi-Hsiung Wu 대한이비인후과학회 2017 Clinical and Experimental Otorhinolaryngology Vol.10 No.1
Objectives. To review cases of peritonsillar abscess and investigate the initial clinical factors that may influence the duration of hospitalization. To determine the predictive factors of prolonged hospital stay in adult patients with peritonsillar abscess. Methods. Subjects were adults hospitalized with peritonsillar abscess. We retrospectively reviewed 377 medical records from 1990 to 2013 in a tertiary medical center in southern Taiwan. The association between clinical characteristics and the length of hospital stay was analyzed with independent t-test, univariate linear regression and multiple linear regression analysis. Results. The mean duration of hospitalization was 6.2±6.0 days. With univariate linear regression, a prolonged hospital stay was associated with several variables, including female gender, older ages, nonsmoking status, diabetes mellitus, hypertension, band forms in white blood cell (WBC) counts, and lower hemoglobin levels. With multiple linear regression analysis, four independent predictors of hospital stay were noted: years of age (P<0.001), history of diabetes mellitus (P<0.001), ratio of band form WBC (P<0.001), and hemoglobin levels (P<0.001). Conclusion. In adult patients with peritonsillar abscess, older ages, history of diabetes mellitus, band forms in WBC counts and lower hemoglobin levels were independent predictors of longer hospitalization.
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